start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=329 end-page=334 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Taurine on Acinar Cell Apoptosis and Pancreatic Fibrosis in Dibutyltin Dichloride-induced Chronic Pancreatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between pancreatic fibrosis and apoptosis of pancreatic acinar cells has not been fully elucidated. We reported that taurine had an anti-fibrotic effect in a dibutyltin dichloride (DBTC)-chronic pancreatitis model. However, the effect of taurine on apoptosis of pancreatic acinar cells is still unclear. Therefore, we examined apoptosis in DBTC-chronic pancreatitis and in the AR42J pancreatic acinar cell line with/without taurine. Pancreatic fibrosis was induced by a single administration of DBTC. Rats were fed a taurine-containing diet or a normal diet and were sacrificed at day 5. The AR42J pancreatic acinar cell line was incubated with/without DBTC with taurine chloramines. Apoptosis was determined by using terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. The expression of Bad and Bcl-2 proteins in the AR42J cells lysates was detected by Western blot analysis. The apoptotic index of pancreatic acinar cells in DBTC-administered rats was significantly increased. Taurine treatment inhibited pancreatic fibrosis and apoptosis of acinar cells induced by DBTC. The number of TUNEL-positive cells in the AR42J pancreatic acinar cell lines was significantly increased by the addition of DBTC. Incubation with taurine chloramines ameliorated these changes. In conclusion, taurine inhibits apoptosis of pancreatic acinar cells and pancreatitis in experimental chronic pancreatitis. en-copyright= kn-copyright= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShirahigeAkinori en-aut-sei=Shirahige en-aut-mei=Akinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniokaHiroaki en-aut-sei=Tanioka en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=apoptosis kn-keyword=apoptosis en-keyword=chronic pancreatitis kn-keyword=chronic pancreatitis en-keyword=pancreatic acinar cells kn-keyword=pancreatic acinar cells en-keyword=taurine kn-keyword=taurine END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=239 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=New Large Bowel Segmentation on Plain Abdominal Radiography in Comparison with the Conventional Method en-subtitle= kn-subtitle= en-abstract= kn-abstract=Plain abdominal radiography is a very basic examination and plays an important role in primary care. The objectives of this study were to clarify colon distributions on plain abdominal radiographs. Forty-three healthy volunteers underwent gastric fluoroscopy, and 2 hours later, plain abdominal radiography in the supine position. A region of interest (ROI) was defined uniformly on each X-ray image to divide the image into 600 zones. The area corresponding to the large bowel within the ROI was divided into 4 segments (ascending colon, transverse colon, descending colon, and sigmoid colon＋rectum). The percentage of barium in each segment relative to the total volume of barium used was calculated to evaluate the percent ROI occupancy. The large bowel covered 76.7% of the entire ROI, with the percent duplication being 55%. The duplicated area corresponded to the transverse colon region. When the method proposed by Arhan et al. was used, the percentage of the colon actually present in each segment relative to that determined theoretically was 99.6% for the right colon segment, 92.2% for the left colon segment, and 92.2% for the sigmoid/rectal segment. However, in cases in which the transverse colon descended partially from the fifth lumbar vertebra, the percentage occupied by the sigmoid colon＋rectum decreased to 57.2%. We applied a new large bowel segmentation method especially for patients with ptosis, by devising a line joining the lateral side of the right lesser pelvis and the lower ends of both sacroiliac joints. en-copyright= kn-copyright= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShirahigeAkinori en-aut-sei=Shirahige en-aut-mei=Akinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=6 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine en-keyword=large bowel kn-keyword=large bowel en-keyword=segmentation kn-keyword=segmentation en-keyword=plain abdominal radiograph kn-keyword=plain abdominal radiograph en-keyword=classification method kn-keyword=classification method en-keyword=primary care kn-keyword=primary care END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=3 article-no= start-page=135 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar. en-subtitle= kn-subtitle= en-abstract= kn-abstract=The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR) amplified. Among them, 35 (31.8%) were of genotype 1, 52 (47.3%) were of genotype 3, and 23 (20.9%) were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed. en-copyright= kn-copyright= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KyawYi Yi en-aut-sei=Kyaw en-aut-mei=Yi Yi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GokanKatsunori en-aut-sei=Gokan en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaYasuhito en-aut-sei=Tanaka en-aut-mei=Yasuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KusanoNobuchika en-aut-sei=Kusano en-aut-mei=Nobuchika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=LwinAye Aye en-aut-sei=Lwin en-aut-mei=Aye Aye kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShiratoriYasushi en-aut-sei=Shiratori en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MizokamiMasashi en-aut-sei=Mizokami en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KhinMyo en-aut-sei=Khin en-aut-mei=Myo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MiyaharaMasayuki en-aut-sei=Miyahara en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OkadaShigeru en-aut-sei=Okada en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Lower Myanmar affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Nagoya City University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Okayama University affil-num=12 en-affil= kn-affil=Nagoya City University affil-num=13 en-affil= kn-affil=Medical Research(Lower Myanmar) affil-num=14 en-affil= kn-affil=Okayama Red Cross Blood Center affil-num=15 en-affil= kn-affil=Okayama University affil-num=16 en-affil= kn-affil=Okayama University en-keyword=hepatitis C virus(HCV)genotype kn-keyword=hepatitis C virus(HCV)genotype en-keyword=type 6 variant kn-keyword=type 6 variant en-keyword=Myanmar kn-keyword=Myanmar en-keyword=Southeast Asia kn-keyword=Southeast Asia en-keyword=phylogenetic analysis kn-keyword=phylogenetic analysis END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=1 article-no= start-page=55 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gastrobiliary Dysmotility in Patients with Chronic Pancreatitis as Assessed by a Single Noninvasive Test en-subtitle= kn-subtitle= en-abstract= kn-abstract=We simultaneously assessed gastric emptying and gallbladder contraction after oral administration of a liquid meal by noninvasive ultrasonography in 17 patients with chronic pancreatitis (CP) and in 17 healthy controls. Gastrointestinal (GI) transit was also assessed by a noninvasive radioopaque marker method. Exocrine pancreatic function was evaluated by analyzing pure pancreatic juice and by analyzing the autonomic nervous system by cardiovascular reflex tests. Patients with CP showed impaired gallbladder contraction at 15 min and hastened gastric emptying. The cause of the former is unclear, whereas the latter was closely related with decreased pancreatic lipase output, but not with autonomic dysfunction. GI transit time did not differ between controls and patients with CP. In conclusion, we succeeded in clearly demonstrating impaired gallbladder contraction and hastened gastric emptying in patients with CP by a single noninvasive test, ultrasonography. We also revealed for the first time that hastened gastric emptying is associated with insufficient pancreatic lipase output. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=chronic pancreatits kn-keyword=chronic pancreatits en-keyword=gastric emptying kn-keyword=gastric emptying en-keyword=gallbladder motility kn-keyword=gallbladder motility en-keyword=colonic transit kn-keyword=colonic transit en-keyword=lipase output kn-keyword=lipase output END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=65 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagonosis of pancreatic cyst using post-ERCP CT examination. kn-title=ERCP後CTによる膵嚢胞性疾患の診断 en-subtitle= kn-subtitle= en-abstract=Post-ERCP CT (computed tomography (CT) examination performed immediately after endoscopic retrograde cholangiopancreatography) detects the contrast medium injected into the pancreatic duct and cystic lesions at the time of ERCP and, therefore, has the advantage of obtaining information which cannot be obtained by ERCP alone. We have experienced four cases of pancreatic cysts in which post-ERCP CT was useful for diagnosis and in deciding on treatment plans. The post-ERCP CT was proved to be a useful method for examining the site and characteristics of the cysts which communicated with the main pancreatic duct. kn-abstract=ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoTosinobu en-aut-sei=Seno en-aut-mei=Tosinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=RiazChowdhury kn-aut-sei=Riaz kn-aut-mei=Chowdhury aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=12 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 affil-num=13 en-affil= kn-affil=勝山病院外科 en-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) kn-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) en-keyword=CT (Computed tomography) kn-keyword=CT (Computed tomography) en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=27 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tropical calcific pancreatitis.........An overview en-subtitle= kn-subtitle= en-abstract=熱帯地方の貧困層の小児や若干成人にみられる非アルコール性の慢性膵炎で,小児期に反復する腹痛で発症し,10～20歳で膵性糖尿病になり,20～ 30歳で死亡する類似の病像を示す症例をTropical calcific pancreatitis(熱帯性石灰化慢性膵炎)という｡高率に膵石を伴う｡成因は乳幼児期からの熱量,蛋白貰,micronutrients(亜鉛,銅,セレニウム)の摂取不足に加えて食事中シアン産生物質や環境中oxidantsなど複合因子によると推測されている｡病理像は世界各国にみられる慢性膵炎典型例に類似する｡最近は,生活環境や医療事情の改善により,全身栄養障害の減少や生存期間 の延長など病像が変貌しっつある｡糖尿病を重視する立場からはFibrocalculous pancreatic diabetesと呼ばれ,同一地域にみられるProtein-deficient pancreatic diabetesと合わせてMalnutrition-related diabetes mellitus(MRDM)と総称し,糖尿病の一亜型に分類されている。 kn-abstract=Tropical calcific pancreatitis is a nonalcoholic type of chronic pancreatitis affecting the childrens and young adults characterized clinically by recurrent abdominal pain in childhood, diabetes in adolescent and death in early childhood. Although the exact etiology is not known, malnutrition and chronic cassava toxicity either singly or in combination are presumed to be the prime factor in pancreatic injury unopposed by detoxification of free radical. Moreover micronutrients deficiency, oxidant stress and antioxidant deficiency might play substantial role. Diabetes secondary to tropical calcific pancreatitis is a distinctive and frequent problem, being named by W.H.O. study group as 'fibrocalculous pancreatic diabetes (FCPD) and classified as one of the variant of the so-called malnutrition related diabetes mellitus (MRDM). en-copyright= kn-copyright= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShooji en-aut-sei=Matsumoto en-aut-mei=Shooji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 en-keyword=Tropical calcific pancreatitis (TCP) kn-keyword=Tropical calcific pancreatitis (TCP) en-keyword=malnutrition kn-keyword=malnutrition en-keyword=cassava kn-keyword=cassava en-keyword=diabetes kn-keyword=diabetes en-keyword=abdominal pain kn-keyword=abdominal pain END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=22 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study of the preparation with sodium picosulfate and PEG intestinal lavage solution for total colonoscopy. kn-title=Sodium picosulfate,PEG腸管洗浄液併用によるTotal colonoscopyの前処置法に関する検討 en-subtitle= kn-subtitle= en-abstract=The following results were obtained from a total colonoscopic study of 50 patients who received preparation with 20mℓ of sodium picosulfate (Laxoberon®) and PEG intestinal lavage solution (Niflec®) prior to the examination. (l) The present method in combination with a mean of 1230mℓ of PEG intestinal lavage solution allowed colonic cleaning for which observation was available in 48 of 50 patients. (2) With this method. no adverse reactions were observed except for mild abdominal pain, nausea, and rugitus in a few patients. (3) This method was particularly as a preparation for colonoscopic examination in elderly patients. Thus, we conclude that preparation with 20mℓ of sodium picosulfate and PEG intestinal lavage solution is useful for colonoscopic examination. kn-abstract=Total colonoscopyの前処置における被検者の負担軽減と良好な腸管洗浄を得る目的で,50例の大腸内視鏡検査において,前日の食事制限せず, sodium picosulfate 20mℓ前夜服用,検査当日PEG腸管洗浄液1ℓ以上服用する前処置法の有用性について検討した。本前処置法によってPEG腸管洗浄液平均1230mℓの服用により,50例中48例で観察可能な腸管洗浄が得られ,PEG腸管洗浄液の服用量の減量が可能であった｡腹痛,嘔気,腹鳴などの症状出現例は認めたが,重篤な副作用は認めなかった｡腸管洗浄度の点で,高齢者の大腸内視鏡検査の前処置として有用である｡以上よりSodium Picosulfate 20mℓをPEG腸管洗浄液と併用することにより,優れた腸管洗浄度を得られると同時にPEG腸管洗浄液服用量の減量か可能であり,total colonoscopyの前処置として有用であることが示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=12 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=勝山病院 affil-num=13 en-affil= kn-affil=八幡浜医師会立双岩病院 en-keyword=大腸内視鏡検査 (colonoscopy) kn-keyword=大腸内視鏡検査 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental model of chronic pancreatitis, a review - Does it really exist? en-subtitle= kn-subtitle= en-abstract=疾患の実験モデルの作成は,その疾患の病因,病態の解明,さらに治療法の開発のために重要である｡筆者らの一人は厚生省難治性膵疾患調査研究班の班員として,慢性膵炎の病態の解明や治療法の開発に関する研究を行っており,その研究の一環として,慢性膵炎の実験モデルの作成を現在行っている｡そこで,これまで報告されている慢性膵炎の実験モデルについて概要を報告した｡種々の動物や方法でヒト慢性膵炎に病因,病態,組織像が類似するモデルの作成が試みられてきたが,そのすべてが合致するような慢性膵炎モデルは確 立されてはいない｡近年の分子生物学的研究の進歩は著しく,実験モデルへの応用が種々なされている現在,より簡便で再現性のある慢性膵炎モデルの作成が望まれるところである｡ kn-abstract=Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=5 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=8 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学第2内科 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=78 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Collagen degradation and in the pathogenesis of dieseases kn-title=コラーゲン分解系と疾患 en-subtitle= kn-subtitle= en-abstract=Fibrosis is the result of net accumulation of collagen in the organ. This may occur as a consequence of alterations in the synthesis of collagen, their degradation, or both. Recent investigations revealed that a decrease in collagen degradation plays a crucial role in fibrogenesis. Two pathways exist in collagen degradation : extracellular and intracellular. Each pathway has an important enzyme; that is, matrix metalloproteinases (MMP) and collagenolytic cathepsin, respectively. Collagenolytic activity is regulated at several levels. Expression of MMP and tissue inhibitors of metalloproteinase (TIMP), which act as inhibitors of MMP, is regulated independently by a number of cytokines and growth factors. MMP, which is synthesized in the cell, is secreted in a latent form. Activation of the latent MMP is controlled by TIMP and plasminogen activator inhibitor. TIMP also inhibits activated MMP which can degrade connective tissue matrices including collagens. In the condition where TIMP is predominant over MMP, activity of collagen breakdown is reduced, and consequently collagen deposition occurrs. kn-abstract=組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=3 ORCID= en-aut-name=YamashitaHaruhiro en-aut-sei=Yamashita en-aut-mei=Haruhiro kn-aut-name=山下晴弘 kn-aut-sei=山下 kn-aut-mei=晴弘 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学第2内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 en-keyword=線維化 (Fibrosis) kn-keyword=線維化 (Fibrosis) en-keyword=コラーゲン (Collagen) kn-keyword=コラーゲン (Collagen) en-keyword=TIMP (tissue inhibitor of metalloproteinase) kn-keyword=TIMP (tissue inhibitor of metalloproteinase) en-keyword=MMP (matrix metalloproteinase) kn-keyword=MMP (matrix metalloproteinase) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=121 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice kn-title=膵液のK-ras遺伝子の突然変異を認めた多発性膵嚢胞の1例 en-subtitle= kn-subtitle= en-abstract=Pancreatic cancer is the one of the leading causes of death among cancer deaths and the early diagnosis is one of the main topics of pancreatic research. Mutation of K-ras oncogene at codon 12 has been reported in pancreatic adenoma, hyperplasia of the pancreatic duct, and also in pancreatic cancer, Recently, detection of K-ras point mutation in pure pancreatic juice is underinvestigation as a potential tool of early diagnosis of pancreatic cancer by setting a certain cut-off value. We recently experienced a case of multiple pancreatic cysts without any malignant cells in pancreatic juice, but with a positve point mutation of K-ras oncogene. Operation was deferred after obtaining informed consent from the family, because the lesions were so multiple and extensive as to require total pancreatectomy. Eighteen months follow-up studies did not reveal any deterioration in imaging tests as well as clinical picture. kn-abstract=膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ en-copyright= kn-copyright= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第2内科 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2内科 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=K-ras遺伝子 (K-ras oncogene) kn-keyword=K-ras遺伝子 (K-ras oncogene) en-keyword=点突然変異 (point mutation) kn-keyword=点突然変異 (point mutation) en-keyword=細胞診 (cytology) kn-keyword=細胞診 (cytology) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=115 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanisms of pancreatic fibrosis kn-title=膵線維化のメカニズム en-subtitle= kn-subtitle= en-abstract=Pancreatic fibrosis is an outstanding morphological feature in chronic pancreatis although it is seen in pancreatic cancer and convalescent stage of acute pancreatitis. Progressive fibrosis in chronic pancreatitis leads to the destruction and contributes to irreversiblity of chronic pancreatitis. Exact mechanisms of pancreatic fibrosis is not yet unclear, although advances in molecular biology have revealed possible roles of cytokines and growth factors in it. We summarized our understanding of pancreatic fibrosis in the revIew. kn-abstract=膵の線維化は慢性膵炎に特徴的な病理組織所見の一つであるが,その発生機序については不明な点か多い｡慢性膵炎はいったん発症すれば,進行性かつ非可逆性であるとされるが,その非可逆性に膵の線維化が関与するとされる｡膵の線維化の発生機序を明らかにし,線維化に対する根本的な治療法の確立が望まれるところである｡そこで,本稿では今後の膵の線維化の研究課題を明らかにする目的で,現在までの膵臓線維化の発生機序に関する知見を整理した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2外科 affil-num=7 en-affil= kn-affil=岡山大学第2外科 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=膵臓 (pancreas) kn-keyword=膵臓 (pancreas) en-keyword=線維化 (fibrosis) kn-keyword=線維化 (fibrosis) en-keyword=サイトカイン (cytokine) kn-keyword=サイトカイン (cytokine) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=75 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gastro-biliary motility in patients with non-ulcer dyspepsia kn-title=上腹部不定愁訴患者の胃･胆嚢運動に関する研究 en-subtitle= kn-subtitle= en-abstract=Subjective symptoms are quite similar between cystic duct syndrome (CDS) and non-ulcer dyspepsia (NUD) : epigastralgia, hypochondralgia and vague complaints in the upper part of the abdomen. Recently, there has been several reports suggesting that the cause of these disorders is postprandial dysmotility in the gallbladder and stomach. However, there has been no report suggesting incoordination of postprandial gastrobilialy motility as the cause of tha above mentioned complaints in these disorders. The aim of this study was to define the difference of postprandial gastrobiliary motility between patients with NUD and controls. Eight patients with NUD and 10 controls were studied. Gastric emptying time of liquid meal and gallbladder contraction were measured, simultaneously. There was no significant difference between study patients and controls when gastric emptying time and gallbladder contraction rate were compared in isolation. However, when these two parameters were assessed in combination, gastric emptying time was linearly correlated with minimum ballbladder contraction time in controls but not in patients. We conclude that the incoordination between gastric emptying and minimal gallbladder contraction may be one of the major causes of the symptoms in NUD. kn-abstract=現在,上腹部不定愁訴の原因は特定されていない｡その原因を解明するため,上腹部不定愁訴患者8人と健常対照者10人に対して液体食の胃排出能と,食事負荷による胆嚢収縮能を測定した｡胃排出時間,胆嚢収縮能はいずれも両者に有意な差は認められなかった｡健常対照者では胃排出時間と胆嚢収縮時間に有意な相関関係が認められたが,上腹部不定愁訴群では相関関係は認められなかった｡上腹部不定愁訴の原因として胃･胆嚢協調運動障害の存在が示唆 された。 en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=胃運動 (Gastric motility) kn-keyword=胃運動 (Gastric motility) en-keyword=胆嚢運動 (Biliary motility) kn-keyword=胆嚢運動 (Biliary motility) en-keyword=不定愁訴 (indefinite complaint) kn-keyword=不定愁訴 (indefinite complaint) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=71 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Usefulness of retinol binding protein as a marker for the assessment of nutritional uptake for the preparation of colonosocpy kn-title=大腸前処置法の栄養評価としてのレチノール結合蛋白の有用性の検討 en-subtitle= kn-subtitle= en-abstract=The objective of this study was to evaluate the usefulness of retinol binding protein (RBP), one of rapid turnover proteins, for the assessment of nutritional aspect of the preparation for colonoscopy. Blood samples were drawed before the preparation and after the colonoscopic examination and serum RBP was determined by laser nephrometory. Group A consisted of 10 patients who were administered intestinal lavage solution (Niflec) without no low residual diet. Group B consisted of 27 patients who were adminstered low residual diet for 1 day. Group C consisted of 27 patients who were administered low residual diet for the two consecutive days before colonosocopic examination with intestinal lavage solution and magnesium citrate because sufficient cleanup of intestine were not expected by using the ordinary preparations. The values of serum RBP significantly decreased in group C after the preparation although no significant changes were observed in group A and Group B. We emphasized in estimating the preparation for the colonoscopy assessment of nutrition using serum RBP was needed as well as colonic cleaning. kn-abstract=大腸内視鏡検査の前処置を栄養面から評価する目的で前処置前後にrapid turnover proteinである血中レチノール結合蛋白の変動を検討した｡前日に普通食を用い,当日ニフレックを使用した10例,検査1日前に低残渣食を用いた27例,通常の前処置では良好な腸管洗浄が得られないために検査前2日間低残渣食を用いた27例の3群について,前処置開始前と検査終了後に血中レチノール結合蛋白の変動をみたところ,検査前2日間低残渣食服用群で有意の低下を認めた｡前日普通食群では検査前後で変化を認めず,1日低残渣食服用群では低下傾向を認めたが,有意差は認めなかった｡これまで前処置の成否は腸管洗浄度の面で評価されてきたが,血中レチノール結合蛋白を目標として用いることにより栄養面から評価することができることが考えられた。 en-copyright= kn-copyright= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=1 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=5 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=11 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=12 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=2 en-affil= kn-affil=勝山病院外科 affil-num=3 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=4 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=13 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=レチノール結合蛋白 (retinol binding protein) kn-keyword=レチノール結合蛋白 (retinol binding protein) en-keyword=大腸内視鏡 (colonoscopy) kn-keyword=大腸内視鏡 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) en-keyword=栄養評価 (nutritional assessment) kn-keyword=栄養評価 (nutritional assessment) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=94 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endoscopic aspiration of pure pancreatic juice is useful in diagnosis and treatment of chronic pancreatitis. kn-title=慢性膵炎診療における内視鏡的純粋膵液採取法の意義 en-subtitle= kn-subtitle= en-abstract=Endoscopical aspiration of pure pancreatic juice is useful in following aspects. Firstly, intraductal secretin test by using this method can be substituted for duodenal secretin test, which is a gold standard examination for estimation of exocrine pancreatic function. In addition, endoscopic aspiration of protein pluge eliminates abdominal pain of some painful patients with chronic pancreatitis. Cytological examination, determination of tumor marker, and detection of oncogene in the obtained pancreatic juice are complementary diagnostic approach to pancreatic cancer, which must be differentially diagnosed from chronic pancreatitis. kn-abstract=内視鏡的純粋膵液採取法の慢性膵炎診療における意義を検討した｡本法を用い,セクレパン100単位静注後10分間膵液を採取するintaraductal secretin test(IDST,膵管内セクレチン試験)はこれまで膵外分泌機能検査のgold standardである十二指腸液を採取するセクレチン試験に代用ができ,しかも10分間の採取時間で終了する利点を有する｡本法を施行することにより,蛋白栓が除去され,痔痛の消失に有用である｡また,慢性膵炎と鑑別を要する膵癌を除外診断するために,本法によって採取した膵液の細胞診,腫瘍マーカー,癌遺伝子の検出は有用である｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山赤十字病院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=内視鏡 (endoscopy) kn-keyword=内視鏡 (endoscopy) en-keyword=膵外分泌機能検査 (exocrine pancreatic function test) kn-keyword=膵外分泌機能検査 (exocrine pancreatic function test) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=64 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of eosinophilic gastroenteritis with stenosis in the colon kn-title=大腸の全周性狭窄を呈した好酸球性胃腸炎の1例 en-subtitle= kn-subtitle= en-abstract=We report a case of eosinophilic gastroenteritis with a stenosis in the transverse colon. A patient, 54 year-old-woman, presented to our clinic with abdominal pain and diarrhea. Esophagogastric endoscopy and biopsy were normal. Contrast barium enema examination and colonic endoscopy showed a stenotic segment in the transverce colon. Biopsy specimens obteind from the stenotic segment revealed moderate eosinophilic infiltration in the colonic mucosa. Oral intake of sea shells exacerbated her symptoms. Avoiding sea shells has resulted in the disappearance of symptoms and peripheral blood eosinophilia. The present case was discussed in comparison with the 124 cases heretofore reported in Japan. kn-abstract=大腸に全周性狭窄をきたした好酸球性胃腸炎の1例を報告した｡症例は54才の女性で,腹痛と下痢を主訴に来院した｡上部消化管検査では異常を認めなかったが,下部消化管造影検査と大腸内視鏡検査で横行結腸の全周性狭窄を認め,生検にて大腸粘膜の好酸球浸潤を認めた｡貝料理の摂取にて腹痛発作が出現したが,原因抗原は同定できなかった｡貝類の摂取を避けることにより,症状は消失し,末梢血液中の好酸球増多は消失した｡本邦ではこれまでに124例 の報告があるが,大腸に全周性の狭窄をきたす症例は稀であり,文献的考察を加え報告する｡ en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) kn-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) en-keyword=大腸 (colon) kn-keyword=大腸 (colon) en-keyword=狭窄 (stenosis) kn-keyword=狭窄 (stenosis) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=慢性膵炎患者の全消化管通過に関する研究 kn-title=Studies on whole gut transit in chronic pancreatitis patients en-subtitle= kn-subtitle= en-abstract=慢性膵炎の患者の自覚症状や消化不良には消化管の通過異常が関与している可能性がある｡慢性膵炎患者15例と対象群17例で全消化管通過を測定した｡さらに慢性膵炎患者は自律神経機能について評価した｡全消化管通過は慢性膵炎患者は対象群より早いことが示された｡しかしその機序として推定された自律神経機能異常の有無では全消化管通過に差は認められず,慢性膵炎の消化管機能異常の原因は自律神経異常ではないと推定された｡ kn-abstract=Abnormalities of whole gut transit could contribute to the maldigestion and　digestive symptoms of chronic pancreatitis patients. Whole gut transit was measured by radiopaque markers method. Fifteen chronic pancreatitis patients (2 females, 13 males; age range 40-78 years) and 17 controls (4 females, 13 males, 32-73 years) were studied. Additionally, we also looked for evidence of autonomic neuropathy in the chronic pancreatitis patients by using cardiovascular tests. In chronic pancreatitis, whole gut transit was shorter than controls. These abnormalities were not influenced by the degree of autonomic neuropathy. We conclude that whole gut transit is shorter in chronic pancreatitis patients. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=全消化管通過 (Whole gut transit) kn-keyword=全消化管通過 (Whole gut transit) END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=82 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵癌における癌遺伝子および癌抑制遺伝子 kn-title=Oncogenes and tumor suppressor genes in pancreatic cancer en-subtitle= kn-subtitle= en-abstract=膵癌の予後は惨憺たるものである｡一方で,最近の分子生物学の分野での研究の進歩により,遺伝子レベルでの異常が膵癌では数多く存在することも明らかになってきた｡膵癌の予後を改善するために,発展が期待される膵癌における遺伝子診断や遺伝子治療に向けて現在までの膵癌で明らかになった癌遺伝子(k-ras,erbB-2,Met),癌抑制遺伝子(p53,p16,APC,DDC)について,概説した。 kn-abstract=Recent advances in molecular biology have revealed that a number of oncogenes (K-ras, erbB-2, and Met) and tumor suppressor genes (p53, p16, APC, and DCC) contribute to the development of pancreatic cancer. This paper reviewed the present knowledge of oncogenes and tumor suppressor genes relevant to pancreatic cancer. Further studies on molecular alterations in pancreatic cancer may lead to a better understanding of tumor biology, offering a possibility of development of new diagnostic and therapeutic approaches in the future. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=6 ORCID= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=7 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=勝山病院 affil-num=7 en-affil= kn-affil=岡山赤十字病院 affil-num=8 en-affil= kn-affil=岡山赤十字病院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=Pancreatic cancer kn-keyword=Pancreatic cancer en-keyword=oncogene kn-keyword=oncogene en-keyword=tumor suppressor gene kn-keyword=tumor suppressor gene en-keyword=genetic mutation kn-keyword=genetic mutation END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=84 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interferon and pancreatitis kn-title=膵炎とインターフェロン en-subtitle= kn-subtitle= en-abstract=Pancreatitis is known to be one of the adverse effects of interferon, which has been widely used for treatment of chronic hepatitis and malignant diseases. In this paper, we reviewed pancreatitis as adverse effects of interferon and effect of interferon on the pancreas. kn-abstract=インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=勝山病院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=インターフェロン (interferon) kn-keyword=インターフェロン (interferon) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=79 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=臨床的および実験的側面からみた慢性膵炎とフリーラジカル kn-title=Clinical and experimental aspects of free radicals in chronic pancreatitis en-subtitle= kn-subtitle= en-abstract=慢性肺炎の発症機序は不明な点が多いが､フリーラジカルがそれに関与することが示唆する報告も多い｡しかし,その直接的な証明はなされていない｡慢性膵炎の病態にフリーラジカルがどのように関与するかを理解することは慢性膵炎の発症機序の解明の一助になると考え,臨床的および実験的側面から慢性膵炎とフリーラジカルの関係を概説した｡ kn-abstract=Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=フリーラジカル (free radicals) kn-keyword=フリーラジカル (free radicals) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=76 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=マトリックスメタロプロテアーゼと膵疾患 kn-title=Matrix metalloproteinases (MMPs) and pancreatic diseases en-subtitle= kn-subtitle= en-abstract=マトリックスメタロブロテアーゼ（MMP）は，コラーゲン分解能を有し，種々の疾患との関連性が示唆されている。とりわけ,癌の浸潤，転移には密接な関係があるとされている。また，MMP阻害剤を癌の治療に用いる試みもなされている。本稿ではMMPと膵疾患の関連性，MMP阻害剤の膵癌への応用の可能性について総説する。 kn-abstract=Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. en-copyright= kn-copyright= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=4 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=5 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学保険学科 affil-num=5 en-affil= kn-affil=岡山赤十字病院 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=matrix metalloproteinase(MMP) kn-keyword=matrix metalloproteinase(MMP) en-keyword=tissue inhibitor of metalloproteinase(TIMP) kn-keyword=tissue inhibitor of metalloproteinase(TIMP) en-keyword=pancreatic cancer (膵癌) kn-keyword=pancreatic cancer (膵癌) en-keyword=chronic pancreatitis (慢性膵炎) kn-keyword=chronic pancreatitis (慢性膵炎) END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue= article-no= start-page=60 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgG4-related disease kn-title=IgG4関連疾患 en-subtitle= kn-subtitle= en-abstract=IgG4-related disease is a new concept which was established in 21st century. Histologically, infiltrations of IgG4-positive plasma cells and lymphocytes occur in the lacrimal gland, salivary gland , retroperitoneum , pancreas , and biliary tract. IgG4-related disease is a systematic disease presenting symptoms such as Mikulicz's disease, retroperitoneal fibrosis, autoimmune pancreatitis, diabetes and sclerotic cholangitis, and oral steroid therapy is effective. In this paper, we propose diagnostic criteria for IgG4-related disease that have not been established yet. If two (or more) of three following features are fulfilled, IgG4-related disease is diagnosed ； elevated levels of serum IgG4, involvement of organs which is characteristic in IgG4-related disease (salivary gland, lacrimal gland, pancreas and retroperitonium) ,histological findings with IgG4-positive plasma cells and lymphocytes. kn-abstract=IgG4関連疾患は21世紀になって提唱された新しい疾患である｡組織学的にはIgG4陽性形質細胞やリンパ球浸潤が涙腺, 唾液腺, 後腹膜, 膵臓, 胆管などで起こり, 臨床的にはMikulicz病, 後腹膜線維症, 自己免疫膵炎, 糖尿病, 原発性硬化性胆管炎類似の胆管病変などを呈する全身性疾患であり, ステロイド治療に対する良好な反応性を認める｡その診断基準は確立されておらず, われわれは, ①血清IgG4の高値, ②本疾患に特徴的な臓器の障害(唾液腺,涙腺, 膵臓, 後腹膜), ③組織学的にIgG4陽性形質細胞とリンパ球の浸潤の確認, の３項目のうち２項目以上認めれば, IgG4関連疾患とするという診断基準を提言する｡ en-copyright= kn-copyright= en-aut-name=HiramatsuKazuhisa en-aut-sei=Hiramatsu en-aut-mei=Kazuhisa kn-aut-name=平松万尚 kn-aut-sei=平松 kn-aut-mei=万尚 aut-affil-num=1 ORCID= en-aut-name=AsanoMotoi en-aut-sei=Asano en-aut-mei=Motoi kn-aut-name=浅野基 kn-aut-sei=浅野 kn-aut-mei=基 aut-affil-num=2 ORCID= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name=松下公紀 kn-aut-sei=松下 kn-aut-mei=公紀 aut-affil-num=3 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name=三好智子 kn-aut-sei=三好 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=NakamuraSukio en-aut-sei=Nakamura en-aut-mei=Sukio kn-aut-name=中村好男 kn-aut-sei=中村 kn-aut-mei=好男 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=7 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=2 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=3 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=4 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=5 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=6 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=7 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=8 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=9 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=10 en-affil= kn-affil=岡山大学病院三朝医療センター en-keyword=IgG4関連疾患 (IgG4-related disease) kn-keyword=IgG4関連疾患 (IgG4-related disease) en-keyword=自己免疫膵炎 (autoimmune pancreatitis) kn-keyword=自己免疫膵炎 (autoimmune pancreatitis) en-keyword=Mikulicz病 (Mikulicz's disease) kn-keyword=Mikulicz病 (Mikulicz's disease) en-keyword=後腹膜線維症 (retroperitoneal fibrosis) kn-keyword=後腹膜線維症 (retroperitoneal fibrosis) END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue= article-no= start-page=57 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=6種類の血中膵酵素値に及ぼす加齢および性の影響 kn-title=Age and Gender-Related Alterations of Six Serum Pancreatic Enzymes in Healthy Subjects en-subtitle= kn-subtitle= en-abstract=ある種の血中膵酵素値は加齢や性により影響を受けることが知られている。現在膵疾患の診断に利用されている6種類の膵酵素，アミラーゼ，P－アミラーゼ，リパーゼ，トリプシン，フォスフォリパーゼA(2)（PIA(2)），そしてエラスターゼⅠの血中値に及ぼす加齢および性の影響を比較検討した。健常者327名（男性：155名，女性：172名，年齢：20－79歳）を対象として，年齢および性により層別化して検討した。PLA(2)とエラスターゼⅠはRIA，トリプシンはEIA，そして他の酵素は活性を測定した。PLA(2)以外の血中月率酵素値は加齢とともに有意に上昇した。しかし男性では60代以降低下した。性差はアミラーゼとP－アミラーゼとに有意差が認められた。すなわち，アミラーゼは60代以降に，P－アミラーゼは40－49歳群でそれぞれ男性より女性において有意の高値を示した。PLA(2)以外の血中膵酵素値を評価する際には加齢による影響を考慮すべきであり，アミラーゼおよびP－アミラーゼの血中値を評価する際には性を考慮すべきである。 kn-abstract=The serum levels of some pancreatic enzymes have been reported to be affected by age and gender. Currently, serum total amylase, pancreatic isoamylase (P-amylase) , lipase , trypsin (ogen) , pancreatic phospholipase A(2) (PLA(2)) , and elastase I are utilized in diagnosing pancreatic diseases. We here compared age and gender-related alterations of these six pancreatic enzymes in healthy subjects to delineate different properties among the enzymes. Subjects were 155 males and 172 females between ages 20 and 79 years who were apparently healthy, and were stratified by age and sex. PLA(2) and elastase I were assayed by RIA, trypsin (ogen) by EIA and others by activity. The pancreatic enzymes, except PLA(2), were significantly elevated with age, although they declined in males in the 260 age group. There were significant sex differences in total amylase and P-amylase. Total amylase was significantly higher in females than in males in the 260 age group, P-amylase in the 40-49 age group. Age should be considered in the valuation of serum enzymes except PLA(2), sex difference should be considered in the valuation of amylase (total and P-amylase). en-copyright= kn-copyright= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name=真治紀之 kn-aut-sei=真治 kn-aut-mei=紀之 aut-affil-num=4 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=2 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=3 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=4 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=5 en-affil= kn-affil=岡山大学医学部生休債報医学 en-keyword=pancreatic enzyme kn-keyword=pancreatic enzyme en-keyword=amylase kn-keyword=amylase en-keyword=phospholipase A(2) kn-keyword=phospholipase A(2) en-keyword=aging kn-keyword=aging en-keyword=gender kn-keyword=gender END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue= article-no= start-page=75 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討 kn-title=Frizzled Activation by Wnt-l Is Required for beta -Catenin -T Cell Factor Dependent Transcription in Esophageal Cancer en-subtitle= kn-subtitle= en-abstract=背景:食道癌細胞にベータカテニンの蓄積があることは報告されているが,大腸癌とことなり,ベータカテニン,Axin,APC変異の報告がなく,そのメカニズムは不明である｡ 方法:8種類の食道癌細胞株において,3種類のWntの刺激によるベータカテニンTCF系の活性化への影響をTCFプロモーターを持つルシュフフェラーゼプラスミドを癌細胞にトランスフェクションして検討した｡ 結果:代表的な食道癌細胞は変異ベータカテニン,変異APC,変異Axinのいずれも,TCFの活性化をおこした｡8種類中7種類の癌細胞はWnt1により量依存性のTCFの活性化が認められたが,Wnt5A,Wnt7Aでは活性化が認められなかった｡ 結語:食道癌の進展にWnt1の関与が示唆された｡ kn-abstract=Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=EmoriYasuyuki en-aut-sei=Emori en-aut-mei=Yasuyuki kn-aut-name=江盛康之 kn-aut-sei=江盛 kn-aut-mei=康之 aut-affil-num=3 ORCID= en-aut-name=TaniokaHiroaki en-aut-sei=Tanioka en-aut-mei=Hiroaki kn-aut-name=谷岡洋亮 kn-aut-sei=谷岡 kn-aut-mei=洋亮 aut-affil-num=4 ORCID= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name=澤公成 kn-aut-sei=澤 kn-aut-mei=公成 aut-affil-num=5 ORCID= en-aut-name=FujiokaShinichi en-aut-sei=Fujioka en-aut-mei=Shinichi kn-aut-name=藤岡真一 kn-aut-sei=藤岡 kn-aut-mei=真一 aut-affil-num=6 ORCID= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name=真治紀之 kn-aut-sei=真治 kn-aut-mei=紀之 aut-affil-num=7 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 en-keyword=esophageal carcinoma kn-keyword=esophageal carcinoma en-keyword=Wnt kn-keyword=Wnt en-keyword=TCF kn-keyword=TCF en-keyword=beta-catenin kn-keyword=beta-catenin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非侵襲的単回検査法による慢性膵炎患者の胃胆嚢運動機能異常の検討 kn-title=Gastrobiliary Motility in Patients with Chronic Pancreatitis as Assessed by a Single Noninvasive Test en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END