| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
| Published Date | 2021-12-09 |
| Publication Title | DEN Open |
| Volume | volume2 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e83 |
| ISSN | 2692-4609 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 35310725 |
| DOI | 10.1002/deo2.83 |
| Web of Science KeyUT | 001047024900091 |
| Related Url | isVersionOf https://doi.org/10.1002/deo2.83 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Terasawa, Hiroyuki| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Tanaka, Takehiro| Takaki, Akinobu| Okada, Hiroyuki| |
| Keywords | Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA |
| Published Date | 2021-11-07 |
| Publication Title | World Journal Of Gastroenterology |
| Volume | volume27 |
| Issue | issue41 |
| Publisher | Baishideng Publishing Group Inc |
| Start Page | 7134 |
| End Page | 7143 |
| ISSN | 1007-9327 |
| NCID | AA12048247 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 34887633 |
| DOI | 10.3748/wjg.v27.i41.7134 |
| Web of Science KeyUT | 000728118700010 |
| Related Url | isVersionOf https://doi.org/10.3748/wjg.v27.i41.7134 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kinugasa, Hideaki| Kanzaki, Hiromitsu| Tanaka, Takehiro| Yamamoto, Shumpei| Yamasaki, Yasushi| Nouso, Kazuhiro| Ichimura, Kouichi| Nakagawa, Masahiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki| |
| Published Date | 2021-11 |
| Publication Title | Clinical and Translational Gastroenterology |
| Volume | volume12 |
| Issue | issue11 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | e00424 |
| ISSN | 2155-384X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s). |
| File Version | publisher |
| PubMed ID | 34797780 |
| DOI | 10.14309/ctg.0000000000000424 |
| Web of Science KeyUT | 000720492100001 |
| Related Url | isVersionOf https://doi.org/10.14309/ctg.0000000000000424 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kinugasa, Hideaki| Hiraoka, Sakiko| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Terasawa, Hiroyuki| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Yamasaki, Yasushi| Inokuchi, Toshihiro| Takahara, Masahiro| Harada, Keita| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | IBD-associated neoplasia IBD-associated cancer Liquid biopsy ctDNA |
| Published Date | 2020-12-03 |
| Publication Title | BMC Cancer |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 1188 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 33272240 |
| DOI | 10.1186/s12885-020-07699-z |
| Web of Science KeyUT | 000597268700004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-020-07699-z |
| JaLCDOI | 10.18926/AMO/53520 |
|---|---|
| FullText URL | 69_3_137.pdf |
| Author | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
| Abstract | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
| Keywords | primary biliary cirrhosis keratin 7 hepatic failure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 144 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101189 |
| Web of Science KeyUT | 000356903000002 |
| Author | Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2014-05 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume29 |
| Issue | issue5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52894 |
|---|---|
| FullText URL | 68_5_263.pdf |
| Author | Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
| Abstract | Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p＝0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence. |
| Keywords | chronic hepatitis C nursing support interferon therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338482 |
| Web of Science KeyUT | 000343269300002 |
| Author | Matsushita, Hiroshi| Ikeda, Fusao| Iwasaki, Yoshiaki| Seki, Hiroyuki| Nanba, Shintaro| Takeuchi, Yasuto| Moritou, Yuki| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume29 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ohnishi, Atsuyuki| Miyake, Yasuhiro| Matsushita, Hiroshi| Matsumoto, Kazuyuki| Takaki, Akinobu| Yasunaka, Tetsuya| Koike, Kazuko| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012 |
| Publication Title | Digestion |
| Volume | volume86 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume26 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52139 |
|---|---|
| FullText URL | 68_1_17.pdf |
| Author | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
| Abstract | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
| Keywords | hepatic steatosis genetic polymorphism interferon HCV |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 22 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553484 |
| Web of Science KeyUT | 000331592800003 |
| Author | Kinugasa, Hideaki| Nouso, Kazuhiro| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Nakamura, Shin-ichiro| Shiraha, Hidenori| Kuwaki, Kenji| Hagihara, Hiroaki| Ikeda, Fusao| Miyake, Yasuhiro| Takaki, Akinobu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-04 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume47 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Matsubara, Minoru| Shiraha, Hidenori| Kataoka, Jyunro| Iwamuro, Masaya| Horiguchi, Shigeru| Nishina, Shin-ichi| Takaoka, Nobuyuki| Uemura, Masayuki| Takaki, Akinobu| Nakamura, Shinichiro| Kobayashi, Yoshiyuki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-10 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume27 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Nishimura, Mamoru| Takaki, Akinobu| Tamaki, Naofumi| Maruyama, Takayuki| Onishi, Hideki| Kobayashi, Sayo| Nouso, Kazuhiro| Yasunaka, Tetsuya| Koike, Kazuko| Hagihara, Hiroaki| Kuwaki, Kenji| Nakamura, Shinichiro| Ikeda, Fusao| Iwasaki, Yoshiaki| Tomofuji, Takaaki| Morita, Manabu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-01-30 |
| Publication Title | Hepatology Research |
| Volume | volume43 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Tsutsumi, Koichiro| Kawamoto, Hirofumi| Hirao, Ken| Sakakihara, Ichiro| Yamamoto, Naoki| Noma, Yasuhiro| Fujii, Masakuni| Kato, Hironari| Ogawa, Tsuneyoshi| Ishida, Etsuji| Kuwaki, Kenji| Nouso, Kazuhiro| Okada, Hiroyuki| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-09 |
| Publication Title | Pancreatology |
| Volume | volume12 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Kobayashi, Sayo| Nouso, Kazuhiro| Kinugasa, Hideaki| Takeuchi, Yasuto| Tomoda, Takeshi| Miyahara, Koji| Hagihara, Hiroaki| Kuwaki, Kenji| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-12 |
| Publication Title | Hepatology Research |
| Volume | volume42 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2012-12-01 |
| Publication Title | International Journal of Cancer |
| Volume | volume131 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Snyderwine, Elizabeth G.| Davis, Cindy D.| Nouso, Kazuhiro| RoIler, Peter P.| Schut, Herman A.J.| |
|---|---|
| Published Date | 1993-07 |
| Publication Title | Carcinogenesis |
| Volume | volume14 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Kanzaki, Hiromitsu| Nouso, Kazuhiro| Miyahara, Koji| Kajikawa, Naoko| Kobayashi, Sayo| Sakakihara, Ichiro| Iwadow, Shota| Uematsu, Shuji| Okamoto, Ryoichi| Shiraga, Kunihiro| Mizuno, Motowo| Araki, Yasuyuki| |
|---|---|
| Published Date | 2009-09-01 |
| Publication Title | Cases Journal |
| Volume | volume2 |
| Content Type | Journal Article |
| Author | Takuma, Yoshitaka| Nouso, Kazuhiro| |
|---|---|
| Published Date | 2010-03-28 |
| Publication Title | World Journal of Gastroenterology |
| Volume | volume16 |
| Issue | issue12 |
| Content Type | Journal Article |
