| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| FullText URL | 78_2_123.pdf |
| Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext20240213-01.pdf |
|---|---|
| Author | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
| Published Date | 2023-12-14 |
| Publication Title | Blood Advances |
| Volume | volume7 |
| Issue | issue24 |
| Publisher | American Society of Hematology |
| Start Page | 7459 |
| End Page | 7470 |
| ISSN | 2473-9529 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by The American Society of Hematology. |
| File Version | publisher |
| PubMed ID | 37552496 |
| DOI | 10.1182/bloodadvances.2023010402 |
| Web of Science KeyUT | 001141306600001 |
| Related Url | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
| Author | Kondo, Takumi| Fujii, Keiko| Fujii, Nobuharu| Sumii, Yuichi| Urata, Tomohiro| Kimura, Maiko| Matsuda, Masayuki| Ikegawa, Shuntaro| Washio, Kana| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Matsuoka, Ken‐ichi| Otsuka, Fumio| Maeda, Yoshinobu| |
|---|---|
| Keywords | blood center operations cellular therapy therapeutic apheresis |
| Note | This is the peer reviewed version of the following article: [Kondo, T, Fujii, K, Fujii, N, Sumii, Y, Urata, T, Kimura, M, et al. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch. Transfusion. 2023. https://doi.org/10.1111/trf.17450], which has been published in final form at [https://doi.org/10.1111/trf.17450]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jun. 2024.| |
| Published Date | 2023-06-09 |
| Publication Title | Transfusion |
| Publisher | Wiley |
| ISSN | 0041-1132 |
| NCID | AA00868753 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 AABB. |
| File Version | author |
| PubMed ID | 37293978 |
| DOI | 10.1111/trf.17450 |
| Web of Science KeyUT | 001004560100001 |
| Related Url | isVersionOf https://doi.org/10.1111/trf.17450 |
| JaLCDOI | 10.18926/AMO/64367 |
|---|---|
| FullText URL | 77_1_85.pdf |
| Author | Matsuda, Yuki| Otani, Yoshihiro| Yasuhara, Takao| Ando, Mizuo| Higaki, Takaya| Makino, Takuma| Matsumoto, Hiroshi| Oyama, Tadashi| Nishimori, Hisakazu| Date, Isao| |
| Abstract | A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development. |
| Keywords | bone model skull base surgery radiation-induced osteosarcoma RB1 gene alteration |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 90 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849151 |
| Web of Science KeyUT | 000952978000001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Murakami, Hiroyuki| Matsuoka, Ken-Ichi| Asano, Takeru| Moriyama, Takashi| Matsumura, Akifumi| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Toji, Tomohiro| Yoshino, Tadashi| Maeda, Yoshinobu| |
| Keywords | Refractory acute myeloid leukemia Transplant B-cell lymphoma-2 Azacitidine Venetoclax |
| Published Date | 2022-11-08 |
| Publication Title | Case Reports In Oncology |
| Volume | volume15 |
| Issue | issue3 |
| Publisher | Karger |
| Start Page | 974 |
| End Page | 979 |
| ISSN | 1662-6575 |
| NCID | AA12780955 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36636684 |
| DOI | 10.1159/000526697 |
| Web of Science KeyUT | 000905485600025 |
| Related Url | isVersionOf https://doi.org/10.1159/000526697 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamasuji-Maeda, Yoshiko| Nishimori, Hisakazu| Seike, Keisuke| Yamamoto, Akira| Fujiwara, Hideaki| Kuroi, Taiga| Saeki, Kyosuke| Fujinaga, Haruko| Okamoto, Sachiyo| Matsuoka, Ken-Ichi| Fujii, Nobuharu| Tanaka, Takehiro| Fujii, Masahiro| Mominoki, Katsumi| Kanekura, Takuro| Maeda, Yoshinobu| |
| Published Date | 2022-09-09 |
| Publication Title | PLOS One |
| Volume | volume17 |
| Issue | issue9 |
| Publisher | Public Library Science |
| Start Page | e0273749 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Yamasuji-Maeda et al. |
| File Version | publisher |
| PubMed ID | 36084023 |
| DOI | 10.1371/journal.pone.0273749 |
| Web of Science KeyUT | 000892051000058 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0273749 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Wataru| Asada, Noboru| Tabata, Tetsuya| Shibata, Rei| Nishi, Tatsuya| Kato, Yuka| Takasuka, Hiroki| Fujiwara, Hideaki| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Kiura, Katsuyuki| Yoshino, Tadashi| Maeda, Yoshinobu| |
| Keywords | marginal zone lymphoma diffuse large B-cell lymphoma anterior mediastinum cystic lesions |
| Published Date | 2022 |
| Publication Title | Journal Of Clinical And Experimental Hematopatholo |
| Volume | volume62 |
| Issue | issue1 |
| Publisher | The Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 35 |
| End Page | 40 |
| ISSN | 1346-4280 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 34840205 |
| DOI | 10.3960/jslrt.21010 |
| Web of Science KeyUT | 000766876600003 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.21010 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Wataru| Ennishi, Daisuke| Yukawa, Ryoya| Sasaki, Ryo| Yoshida, Chikamasa| Takasuka, Hiroki| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Abe, Koji| Yoshino, Tadashi| Maeda, Yoshinobu| |
| Keywords | peripheral T-cell lymphoma chorea single photon-emission computed tomography |
| Published Date | 2021-10-01 |
| Publication Title | Internal Medicine |
| Volume | volume60 |
| Issue | issue19 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 3155 |
| End Page | 3160 |
| ISSN | 0918-2918 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 33814503 |
| DOI | 10.2169/internalmedicine.7180-21 |
| Web of Science KeyUT | 000706487700015 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.7180-21 |
| JaLCDOI | 10.18926/AMO/61904 |
|---|---|
| FullText URL | 75_2_219.pdf |
| Author | Sugiura, Hiroyuki| Nishimori, Hisakazu| Matsuoka, Hirofumi| Nakamura, Keiichiro| Fujii, Keiko| Fujii, Nobuharu | Matsuoka, Ken-ichi | Maeda, Yoshinobu| |
| Abstract | Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer. |
| Keywords | acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 224 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953429 |
| NAID | 120007029883 |
| FullText URL | 20210318nejmAPL-2paper.pdf |
|---|---|
| Author | Hillmen, Peter| Szer, Jeff| Weitz, Ilene| Röth, Alexander| Höchsmann, Britta| Panse, Jens| Usuki, Kensuke| Griffin, Morag| Kiladjian, Jean-Jacques| de Castro, Carlos| Nishimori, Hisakazu| Tan, Lisa| Hamdani, Mohamed| Deschatelets, Pascal| Francois, Cedric| Grossi, Federico| Ajayi, Temitayo| Risitano, Antonio| Peffault de la Tour, Régis| |
| Note | From New England Journal of Medicine, Peter Hillmen et. al., Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria, 384, 1028-1037 Copyright © 2021 Massachusetts Medical Society. Reprinted with permission. | |
| Published Date | 2021-03-18 |
| Publication Title | New England Journal of Medicine |
| Volume | volume384 |
| Publisher | Massachusetts Medical Society |
| Start Page | 1028 |
| End Page | 1037 |
| ISSN | 0028-4793 |
| NCID | AA00755156 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Massachusetts Medical Society |
| File Version | publisher |
| PubMed ID | 33730455 |
| DOI | 10.1056/NEJMoa2029073 |
| Related Url | isVersionOf https://doi.org/10.1056/NEJMoa2029073 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sugiura, Hiroyuki| Nishimori, Hisakazu| Nishii, Kazuya| Toji, Tomohiro| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Nakata, Koh| Kiura, Katsuyuki| Maeda, Yoshinobu| |
| Keywords | pulmonary alveolar proteinosis primary myelofibrosis autopsy ruxolitinib |
| Published Date | 2020-08-15 |
| Publication Title | Internal Medicine |
| Volume | volume59 |
| Issue | issue16 |
| Start Page | 2023 |
| End Page | 2028 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 32448830 |
| DOI | 10.2169/internalmedicine.4082-19 |
| Web of Science KeyUT | 000563078400014 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.4082-19 |
| Author | Kobayashi, Hiroki| Asada, Noboru| Igawa, Takuro| Abe, Masaya| Meguri, Yusuke| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-ichi| Yoshino, Tadashi| Maeda, Yoshinobu| |
|---|---|
| Keywords | adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography |
| Published Date | 2020-11-01 |
| Publication Title | Internal Medicine |
| Volume | volume59 |
| Issue | issue21 |
| Publisher | 日本内科学会 |
| Start Page | 2757 |
| End Page | 2761 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| DOI | 10.2169/internalmedicine.5077-20 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.5077-20 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sando, Yasuhisa| Matsuoka, Ken-Ichi| Sumii, Yuichi| Kondo, Takumi| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Nakamura, Makoto| Iwamoto, Miki| Meguri, Yusuke| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Utsunomiya, Atae| Oka, Takashi| Maeda, Yoshinobu| |
| Keywords | T-cell lymphoma Targeted therapies |
| Published Date | 2020-10-14 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 17237 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33057055 |
| DOI | 10.1038/s41598-020-74174-x |
| Web of Science KeyUT | 000582678700031 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-74174-x |
| FullText URL | Blood advances 2018.pdf |
|---|---|
| Author | Inamoto, Yoshihiro| Matsuda, Tomohiro| Tabuchi, Ken| Kurosawa, Saiko| Nakasone, Hideki| Nishimori, Hisakazu| Yamasaki, Satoshi| Doki, Noriko| Iwato, Koji| Mori, Takehiko| Takahashi, Satoshi| Yabe, Hiromasa| Kohno, Akio| Nakamae, Hirohisa| Sakura, Toru| Hashimoto, Hisako| Sugita, Junichi| Ago, Hiroatsu| Fukuda, Takahiro| Ichinohe, Tatsuo| Atsuta, Yoshiko| Yamashita, Takuya| Japan Society for Hematopoietic Cell Transplantation Late Effects and Quality of Life Working Group| |
| Published Date | 2018-08 |
| Publication Title | Blood Advances |
| Volume | volume2 |
| Issue | issue15 |
| Publisher | American Society of Hematology |
| Start Page | 1901 |
| End Page | 1903 |
| ISSN | 2473-9529 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 30087108 |
| DOI | 10.1182/bloodadvances.2018020966 |
| Related Url | isVersionOf https://doi.org/10.1182/bloodadvances.2018020966 |
| FullText URL | blood_119_1_285.pdf |
|---|---|
| Author | Nishimori, Hisakazu| Maeda, Yoshinobu| Teshima, Takanori| Sugiyama, Haruko| Kobayashi, Koichiro| Yamasuji, Yoshiko| Kadohisa, Sachiyo| Uryu, Hidetaka| Takeuchi, Kengo| Tanaka, Takehiro| Yoshino, Tadashi| Iwakura, Yoichiro| Tanimoto, Mitsune| |
| Note | This research was originally published in Blood. 2012. © the American Society of Hematology.| |
| Published Date | 2012-01-05 |
| Publication Title | Blood |
| Volume | volume119 |
| Issue | issue1 |
| Start Page | 285 |
| End Page | 295 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 22077062 |
| DOI | 10.1182/blood-2011-01-332478 |
| Web of Science KeyUT | 000299012400035 |
| Related Url | https://doi.org/10.1182/blood-2011-01-332478 |
| FullText URL | Int_J_Hematol_105_6_812.pdf |
|---|---|
| Author | Nishimori, Hisakazu| Fujii, Nobuharu| Fujii, Keiko| Ikeda, Tohru| Asano, Naomi| Ogo, Hiroaki| Yamakawa, Miwa| Takagi, Naoe| Otsuka, Fumio| Ikeda, Kazuma| |
| Keywords | Autologous blood donation Vasovagal reactions |
| Note | This is an Accepted Manuscript of an article published by Springer| |
| Published Date | 2017-06 |
| Publication Title | International Journal of Hematology |
| Volume | volume105 |
| Issue | issue6 |
| Publisher | Elsevier Science |
| Start Page | 812 |
| End Page | 818 |
| ISSN | 0925-5710 |
| NCID | AA10797094 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 28271415 |
| DOI | 10.1007/s12185-017-2204-6 |
| Web of Science KeyUT | 000401324100014 |
| Related Url | isVersionOf https://doi.org/10.1007/s12185-017-2204-6 |
| FullText URL | s12885-017-3295-4.pdf |
|---|---|
| Author | Yokota, T.| Ogawa, T.| Takahashi, S.| Okami, K.| Fujii, T.| Tanaka, K.| Iwae, S.| Ota, I.| Ueda, T.| Monden, N.| Matsuura, K.| Kojima, H.| Ueda, S.| Sasaki, K.| Fujimoto, Y.| Hasegawa, Y.| Beppu, T.| Nishimori, Hisakazu| Hirano, S.| Naka, Y.| Matsushima, Y.| Fujii, M.| Tahara, M.| |
| Keywords | Chemoradiotherapy Head and neck cancer Oral mucositis Placebo-controlled Randomized Rebamipide liquid |
| Published Date | 2017-05-05 |
| Publication Title | BMC cancer |
| Volume | volume17 |
| Issue | issue1 |
| Publisher | BioMed Central |
| Start Page | 314 |
| End Page | 322 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 28476132 |
| DOI | 10.1186/s12885-017-3295-4 |
| Web of Science KeyUT | 000401614700001 |
| Related Url | https://doi.org/10.1186/s12885-017-3295-4 |
| JaLCDOI | 10.18926/AMO/54603 |
|---|---|
| FullText URL | 70_5_409.pdf |
| Author | Maeda, Yoshinobu| Nishimori, Hisakazu| Inamoto, Yoshihiro| Nakamae, Hirohisa| Sawa, Masashi| Mori, Yasuo| Ohashi, Kazuteru| Fujiwara, Shin-ichiro| Tanimoto, Mitsune| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD. |
| Keywords | Am80 tamibarotene retinoid chronic GVHD steroid-refractory GVHD |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 409 |
| End Page | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777437 |
| Web of Science KeyUT | 000388098700014 |
| Title Alternative | An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease |
|---|---|
| FullText URL | 127_133.pdf |
| Author | Nishimori, Hisakazu| Maeda, Yoshinobu| |
| Keywords | 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 133 |
| End Page | 137 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.133 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.133 |
| NAID | 130005096255 |
| Author | Sugiyama, Haruko| Maeda, Yoshinobu| Nishimori, Hisakazu| Yamasuji, Yoshiko| Matsuoka, Ken-ichi| Fujii, Nobuharu| Kondo, Eisei| Shinagawa, Katsuji| Tanaka, Takehiro| Takeuchi, Kengo| Teshima, Takanori| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | Biology of Blood and Marrow Transplantation |
| Volume | volume20 |
| Issue | issue2 |
| Content Type | Journal Article |
