| FullText URL | fulltext.pdf |
|---|---|
| Author | Vu, Thuy Ha| Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Kashino, Chiaki| Okamoto, Kazuhiro| Kubo, Kotaro| Kamada, Yasuhiko| Masuyama, Hisashi| |
| Keywords | Apolipoprotein-B mRNA-editing complex 3B Endometriosis Apoptosis Potential therapeutic target |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-76589-2| |
| Published Date | 2024-10-23 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 24968 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39443671 |
| DOI | 10.1038/s41598-024-76589-2 |
| Web of Science KeyUT | 001341352800136 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-76589-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Keiichiro| Matsuoka, Hirofumi| Yorimitsu, Masae| Ogawa, Mariko| Kanemori, Miho| Sueoka, Kotaro| Kozai, Ayumi| Nakamura, Hiroko| Haruma, Tomoko| Shiroyama, Yuko| Hayata, Yuu| Sugii, Hirokazu| Ueda, Akiko| Kurihara, Shuichi| Urayama, Saiko| Shimizu, Miyuki| Masuyama, Hisashi| |
| Keywords | olaparib olaparib plus bevacizumab niraparib renal function |
| Published Date | 2023-09-14 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume54 |
| Issue | issue1 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37721176 |
| DOI | 10.1093/jjco/hyad125 |
| Web of Science KeyUT | 001068527100001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad125 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Keiichiro| Matsuoka, Hirofumi| Kubo, Kotaro| Shirakawa, Shinsuke| Ida, Naoyuki| Haraga, Junko| Ogawa, Chikako| Okamoto, Kazuhiro| Nagao, Shoji| Masuyama, Hisashi| |
| Keywords | returning to the same workplace gynecologic neoplasms sick leave |
| Published Date | 2023-11-23 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume54 |
| Issue | issue3 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 292 |
| End Page | 296 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37995280 |
| DOI | 10.1093/jjco/hyad159 |
| Web of Science KeyUT | 001108594700001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad159 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Masuyama, Hisashi| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-30452-y| |
| Published Date | 2023-03-23 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4720 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36959226 |
| DOI | 10.1038/s41598-023-30452-y |
| Web of Science KeyUT | 001024033600064 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-30452-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hata, Nanako| Shigeyasu, Kunitoshi| Umeda, Yuzo| Yano, Shuya| Takeda, Sho| Yoshida, Kazuhiro| Fuji, Tomokazu| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Hibiki| Takahashi, Toshiaki| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Mori, Yoshiko| Teraishi, Fuminori| Yamamoto, Hideki| Michiue, Hiroyuki| Nakamura, Keiichiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z| |
| Published Date | 2023-02-06 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 2078 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36747029 |
| DOI | 10.1038/s41598-023-29397-z |
| Web of Science KeyUT | 000989985700018 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-29397-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshio, Kotaro| Ihara, Hiroki| Okamoto, Kazuhiro| Suzuki, Etsuji| Ogata, Takeshi| Sugiyama, Soichi| Nakamura, Keiichiro| Nagao, Shoji| Masuyama, Hisashi| Hiraki, Takao| |
| Keywords | cervical cancer tumor size squamous cell carcinoma image-guided brachytherapy (IGBT) central shielding (CS) |
| Published Date | 2022-07-05 |
| Publication Title | Journal Of Radiation Research |
| Publisher | Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology |
| ISSN | 0449-3060 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35791439 |
| DOI | 10.1093/jrr/rrac040 |
| Web of Science KeyUT | 000820941900001 |
| Related Url | isVersionOf https://doi.org/10.1093/jrr/rrac040 |
| JaLCDOI | 10.18926/AMO/63406 |
|---|---|
| FullText URL | 76_2_129.pdf |
| Author | Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi| |
| Abstract | Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC. |
| Keywords | D-dimer gynecologic cancer venous thromboembolism |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503440 |
| Web of Science KeyUT | 000792374900004 |
| JaLCDOI | 10.18926/AMO/62806 |
|---|---|
| FullText URL | 75_6_677.pdf |
| Author | Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy. |
| Keywords | endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 677 |
| End Page | 684 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955534 |
| Web of Science KeyUT | 000735297900002 |
| NAID | 120007180286 |
| JaLCDOI | 10.18926/AMO/61904 |
|---|---|
| FullText URL | 75_2_219.pdf |
| Author | Sugiura, Hiroyuki| Nishimori, Hisakazu| Matsuoka, Hirofumi| Nakamura, Keiichiro| Fujii, Keiko| Fujii, Nobuharu | Matsuoka, Ken-ichi | Maeda, Yoshinobu| |
| Abstract | Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer. |
| Keywords | acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 224 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953429 |
| NAID | 120007029883 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okamoto, Kazuhiro| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Ogawa, Chikako| Masuyama, Hisashi| |
| Keywords | gynecological cancer chronic diseases occurrence risk factors |
| Published Date | 2020-01-29 |
| Publication Title | Molecular and Clinical Oncology |
| Volume | volume12 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 336 |
| End Page | 342 |
| ISSN | 2049-9450 |
| NCID | AA12610944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Okamoto et al. |
| File Version | publisher |
| PubMed ID | 32190316 |
| DOI | 10.3892/mco.2020.1989 |
| Web of Science KeyUT | 000523727300007 |
| Related Url | isVersionOf https://doi.org/10.3892/mco.2020.1989 |
| JaLCDOI | 10.18926/AMO/58268 |
|---|---|
| FullText URL | 74_2_109.pdf |
| Author | Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi| |
| Abstract | This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients. |
| Keywords | second primary cancer gynecologic cancer prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 114 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341584 |
| Web of Science KeyUT | 000528278500003 |
| NAID | 120006839447 |
| JaLCDOI | 10.18926/AMO/53526 |
|---|---|
| FullText URL | 69_3_183.pdf |
| Author | Haruma, Tomoko| Ogawa, Chikako| Nishida, Takeshi| Kusumoto, Tomoyuki| Nakamura, Keiichiro| Seki, Noriko| Katayama, Takaaki| Hiramatsu, Yuji| |
| Abstract | Pure ovarian choriocarcinoma is an extremely rare malignancy that can be gestational or non-gestational in origin. Silver-Russell syndrome (SRS) is a rare congenital developmental disorder characterized by pre- and postnatal growth failure, relative macrocephaly, a triangular face, hemihypotrophy, and fifth-finger clinodactyly. We report a rare case of pure ovarian choriocarcinoma occurring in a 19-year-old woman with SRS. Following surgery, multiple chemotherapy courses were effective and she was free of disease at the 10-month follow-up. |
| Keywords | choriocarcinoma ovary Silver-Russell syndrome |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 183 |
| End Page | 188 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101195 |
| Web of Science KeyUT | 000356903000008 |
| Title Alternative | A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer |
|---|---|
| FullText URL | 126_11.pdf |
| Author | Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji| |
| Keywords | endometrial cancer SUVmax PET/CT predictor of poor prognosis |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 11 |
| End Page | 15 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.11 |
| JaLCDOI | 10.18926/AMO/50413 |
|---|---|
| FullText URL | 67_3_191.pdf |
| Author | Binti Md Nor, Nurliza| Kusumoto, Tomoyuki| Inoue, Seiji| Nakamura, Keiichiro| Seki, Noriko| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji| |
| Abstract | Struma ovarii is a rare neoplasm that accounts for approximately 0.3ｵ of ovarian tumors. Due to its ultrasound morphology, which is quite similar to that of malignant ovarian carcinoma, most struma ovarii cases are open operated with laparotomy rather than laparoscopy. We present 3 cases of struma ovarii, which were diagnosed preoperatively by imaging studies and removed by laparoscopic surgery. All patients were premenopausal women between ages 31‒50. The magnetic resonance imaging (MRI) findings were complex masses composed of multiple cysts and solid components with T2-hypointense regions as well as multiple T1-hyperintense cystic areas, findings that are typical for struma ovarii. A combination of plain computed tomography (CT), positron emission tomography (PET)-CT, and scintigraphy was useful for diagnosis. Laboratory examination revealed elevated serum thyroglobulin, which led to the diagnosis of struma ovarii. Laparoscopic surgeries were performed without rupturing the tumors. Although it has been difficult to differentiate between struma ovarii and malignant tumors by conventional methods, recently MRI techniques appear make it possible to diagnose struma ovarii preoperatively from the abovementioned imaging characteristic, together with laboratory data. As for treatment, we think laparoscopy could be successful for struma ovarii, but the surgeon must be careful not to rupture the tumor intra-abdominally in order to prevent dissemination, which could lead to malignancy. |
| Keywords | struma ovarii ovarian neoplasms MRI laparoscopic surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 191 |
| End Page | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804143 |
| Web of Science KeyUT | 000320747900009 |
| JaLCDOI | 10.18926/AMO/48081 |
|---|---|
| FullText URL | 66_1_53.pdf |
| Author | Nakamura, Keiichiro| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji| |
| Abstract | The purpose of this study was to evaluate prognostic factors for epithelial ovarian cancer. We found that the pretreatment values of maximum standardized uptake (SUVmax) of the primary tumor by positron emission tomography/computed tomography (PET/CT), tumor marker CA125 and C-reactive protein (CRP) were correlated with clinical characteristics and prognosis for such patients. The clinical parameters and prognoses and their correlations with SUVmax of primary tumor, CA125 and CRP were examined for 51 patients with primary ovarian cancer. The SUVmax of the primary tumor had a statistically significant association with stage (p＝0.010) and histology (p＝0.001). CA125 was significant associated with stage (p＝0.011), histology (p＝0.005) and lymph node metastasis (p＝0.025). CRP was also significantly associated with stage (p＝0.049). Disease-free survival rates of patients exhibiting a high SUVmax, CA125 and CRP were significantly lower than those exhibiting a low SUVmax, CA125 and CRP levels (p＝0.008, 0.034, and 0.037, respectively). Furthermore, overall survival rates of patients exhibiting a high SUVmax were significantly lower than those exhibiting a low SUVmax (p＝0.049).The high SUVmax of primary tumor is an important factor for identifying ovarian cancer patients with a predictor for poor prognosis. |
| Keywords | ovarian cancer SUVmax of primary tumor CA125 C-reactive protein predictor for poor prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 60 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358139 |
| Web of Science KeyUT | 000300800700007 |
| JaLCDOI | 10.18926/AMO/30944 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Kuramoto, Hiroyuki| Hongo, Atsushi| Liu, Yi-xuan| Ojima, Yojiro| Nakamura, Keiichiro| Seki, Noriko| Kodama, Junichi| Hiramatsu, Yuji| |
| Abstract | The insulin-like growth factor I receptor (IGF-IR) is exceptionally overexpressed in many cervicalcancer-derived cell lines. It is postulated that a decrease of p53 protein levels due to human papillomavirus (HPV) infection may contribute to the up-regulation of IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53. To evaluate this fact in clinical cervical cancer specimens, we checked the expression levels and activated status of IGF-IR by immunohistochemistry. Formalin-fixed and paraffin-embedded specimens obtained by conization or hysterectomy were stained with anti-IGF-IR and with an antibody recognizing phosphorylated tyrosine at its c-terminus. The expression levels of IGF-IR were significantly high in cervical intraepithelial neoplasia (CIN) III and invasive cancer specimens. Phosphorylation of IGF-IR was promoted in all CIN and invasive cancer specimens, and its intensity was related to the promotion of lesions. Interestingly, IGF-IR overexpression was missing in the basal layer of CIN I and II lesions, whereas it was evenly distributed in CIN III and invasive cancer lesions. This IGF-IR overexpression pattern may be utilized in the diagnosis of HPV infection status in CIN lesions. |
| Keywords | insulin-like growth factor I receptor cervical cancer human papillomavirus tyrosil phosphorylation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2008-08 |
| Volume | volume62 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 251 |
| End Page | 259 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 18766208 |
| Web of Science KeyUT | 000258680900005 |
| Author | 中村 圭一郎| |
|---|---|
| Published Date | 2000-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
