JaLCDOI 10.18926/AMO/48081
FullText URL 66_1_53.pdf
Author Nakamura, Keiichiro| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji|
Abstract The purpose of this study was to evaluate prognostic factors for epithelial ovarian cancer. We found that the pretreatment values of maximum standardized uptake (SUVmax) of the primary tumor by positron emission tomography/computed tomography (PET/CT), tumor marker CA125 and C-reactive protein (CRP) were correlated with clinical characteristics and prognosis for such patients. The clinical parameters and prognoses and their correlations with SUVmax of primary tumor, CA125 and CRP were examined for 51 patients with primary ovarian cancer. The SUVmax of the primary tumor had a statistically significant association with stage (p=0.010) and histology (p=0.001). CA125 was significant associated with stage (p=0.011), histology (p=0.005) and lymph node metastasis (p=0.025). CRP was also significantly associated with stage (p=0.049). Disease-free survival rates of patients exhibiting a high SUVmax, CA125 and CRP were significantly lower than those exhibiting a low SUVmax, CA125 and CRP levels (p=0.008, 0.034, and 0.037, respectively). Furthermore, overall survival rates of patients exhibiting a high SUVmax were significantly lower than those exhibiting a low SUVmax (p=0.049).The high SUVmax of primary tumor is an important factor for identifying ovarian cancer patients with a predictor for poor prognosis.
Keywords ovarian cancer SUVmax of primary tumor CA125 C-reactive protein predictor for poor prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-02
Volume volume66
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 60
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22358139
Web of Science KeyUT 000300800700007
JaLCDOI 10.18926/AMO/53526
FullText URL 69_3_183.pdf
Author Haruma, Tomoko| Ogawa, Chikako| Nishida, Takeshi| Kusumoto, Tomoyuki| Nakamura, Keiichiro| Seki, Noriko| Katayama, Takaaki| Hiramatsu, Yuji|
Abstract Pure ovarian choriocarcinoma is an extremely rare malignancy that can be gestational or non-gestational in origin. Silver-Russell syndrome (SRS) is a rare congenital developmental disorder characterized by pre- and postnatal growth failure, relative macrocephaly, a triangular face, hemihypotrophy, and fifth-finger clinodactyly. We report a rare case of pure ovarian choriocarcinoma occurring in a 19-year-old woman with SRS. Following surgery, multiple chemotherapy courses were effective and she was free of disease at the 10-month follow-up.
Keywords choriocarcinoma ovary Silver-Russell syndrome
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-06
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 183
End Page 188
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101195
Web of Science KeyUT 000356903000008
JaLCDOI 10.18926/AMO/58268
FullText URL 74_2_109.pdf
Author Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi|
Abstract This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients.
Keywords second primary cancer gynecologic cancer prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 114
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341584
Web of Science KeyUT 000528278500003
NAID 120006839447
JaLCDOI 10.18926/AMO/61904
FullText URL 75_2_219.pdf
Author Sugiura, Hiroyuki| Nishimori, Hisakazu| Matsuoka, Hirofumi| Nakamura, Keiichiro| Fujii, Keiko| Fujii, Nobuharu | Matsuoka, Ken-ichi | Maeda, Yoshinobu|
Abstract Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.
Keywords acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 219
End Page 224
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953429
NAID 120007029883
JaLCDOI 10.18926/AMO/62806
FullText URL 75_6_677.pdf
Author Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
Keywords endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-12
Volume volume75
Issue issue6
Publisher Okayama University Medical School
Start Page 677
End Page 684
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34955534
Web of Science KeyUT 000735297900002
NAID 120007180286
JaLCDOI 10.18926/AMO/63406
FullText URL 76_2_129.pdf
Author Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi|
Abstract Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
Keywords D-dimer gynecologic cancer venous thromboembolism
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-04
Volume volume76
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 135
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35503440
Web of Science KeyUT 000792374900004
FullText URL fulltext.pdf
Author Okamoto, Kazuhiro| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Ogawa, Chikako| Masuyama, Hisashi|
Keywords gynecological cancer chronic diseases occurrence risk factors
Published Date 2020-01-29
Publication Title Molecular and Clinical Oncology
Volume volume12
Issue issue4
Publisher Spandidos Publications
Start Page 336
End Page 342
ISSN 2049-9450
NCID AA12610944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Okamoto et al.
File Version publisher
PubMed ID 32190316
DOI 10.3892/mco.2020.1989
Web of Science KeyUT 000523727300007
Related Url isVersionOf https://doi.org/10.3892/mco.2020.1989
FullText URL fulltext.pdf
Author Yoshio, Kotaro| Ihara, Hiroki| Okamoto, Kazuhiro| Suzuki, Etsuji| Ogata, Takeshi| Sugiyama, Soichi| Nakamura, Keiichiro| Nagao, Shoji| Masuyama, Hisashi| Hiraki, Takao|
Keywords cervical cancer tumor size squamous cell carcinoma image-guided brachytherapy (IGBT) central shielding (CS)
Published Date 2022-07-05
Publication Title Journal Of Radiation Research
Publisher Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology
ISSN 0449-3060
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35791439
DOI 10.1093/jrr/rrac040
Web of Science KeyUT 000820941900001
Related Url isVersionOf https://doi.org/10.1093/jrr/rrac040
Title Alternative A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer
FullText URL 126_11.pdf
Author Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji|
Keywords endometrial cancer SUVmax PET/CT predictor of poor prognosis
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 11
End Page 15
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.11
FullText URL fulltext.pdf
Author Hata, Nanako| Shigeyasu, Kunitoshi| Umeda, Yuzo| Yano, Shuya| Takeda, Sho| Yoshida, Kazuhiro| Fuji, Tomokazu| Yoshida, Ryuichi| Yasui, Kazuya| Umeda, Hibiki| Takahashi, Toshiaki| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Mori, Yoshiko| Teraishi, Fuminori| Yamamoto, Hideki| Michiue, Hiroyuki| Nakamura, Keiichiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z|
Published Date 2023-02-06
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 2078
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36747029
DOI 10.1038/s41598-023-29397-z
Web of Science KeyUT 000989985700018
Related Url isVersionOf https://doi.org/10.1038/s41598-023-29397-z
FullText URL fulltext.pdf
Author Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Masuyama, Hisashi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-30452-y|
Published Date 2023-03-23
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 4720
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36959226
DOI 10.1038/s41598-023-30452-y
Web of Science KeyUT 001024033600064
Related Url isVersionOf https://doi.org/10.1038/s41598-023-30452-y
JaLCDOI 10.18926/AMO/50413
FullText URL 67_3_191.pdf
Author Binti Md Nor, Nurliza| Kusumoto, Tomoyuki| Inoue, Seiji| Nakamura, Keiichiro| Seki, Noriko| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji|
Abstract Struma ovarii is a rare neoplasm that accounts for approximately 0.3オ of ovarian tumors. Due to its ultrasound morphology, which is quite similar to that of malignant ovarian carcinoma, most struma ovarii cases are open operated with laparotomy rather than laparoscopy. We present 3 cases of struma ovarii, which were diagnosed preoperatively by imaging studies and removed by laparoscopic surgery. All patients were premenopausal women between ages 31‒50. The magnetic resonance imaging (MRI) findings were complex masses composed of multiple cysts and solid components with T2-hypointense regions as well as multiple T1-hyperintense cystic areas, findings that are typical for struma ovarii. A combination of plain computed tomography (CT), positron emission tomography (PET)-CT, and scintigraphy was useful for diagnosis. Laboratory examination revealed elevated serum thyroglobulin, which led to the diagnosis of struma ovarii. Laparoscopic surgeries were performed without rupturing the tumors. Although it has been difficult to differentiate between struma ovarii and malignant tumors by conventional methods, recently MRI techniques appear make it possible to diagnose struma ovarii preoperatively from the abovementioned imaging characteristic, together with laboratory data. As for treatment, we think laparoscopy could be successful for struma ovarii, but the surgeon must be careful not to rupture the tumor intra-abdominally in order to prevent dissemination, which could lead to malignancy.
Keywords struma ovarii ovarian neoplasms MRI laparoscopic surgery
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 195
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804143
Web of Science KeyUT 000320747900009
JaLCDOI 10.18926/AMO/30944
FullText URL fulltext.pdf
Author Kuramoto, Hiroyuki| Hongo, Atsushi| Liu, Yi-xuan| Ojima, Yojiro| Nakamura, Keiichiro| Seki, Noriko| Kodama, Junichi| Hiramatsu, Yuji|
Abstract

The insulin-like growth factor I receptor (IGF-IR) is exceptionally overexpressed in many cervicalcancer-derived cell lines. It is postulated that a decrease of p53 protein levels due to human papillomavirus (HPV) infection may contribute to the up-regulation of IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53. To evaluate this fact in clinical cervical cancer specimens, we checked the expression levels and activated status of IGF-IR by immunohistochemistry. Formalin-fixed and paraffin-embedded specimens obtained by conization or hysterectomy were stained with anti-IGF-IR and with an antibody recognizing phosphorylated tyrosine at its c-terminus. The expression levels of IGF-IR were significantly high in cervical intraepithelial neoplasia (CIN) III and invasive cancer specimens. Phosphorylation of IGF-IR was promoted in all CIN and invasive cancer specimens, and its intensity was related to the promotion of lesions. Interestingly, IGF-IR overexpression was missing in the basal layer of CIN I and II lesions, whereas it was evenly distributed in CIN III and invasive cancer lesions. This IGF-IR overexpression pattern may be utilized in the diagnosis of HPV infection status in CIN lesions.

Keywords insulin-like growth factor I receptor cervical cancer human papillomavirus tyrosil phosphorylation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2008-08
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 251
End Page 259
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 18766208
Web of Science KeyUT 000258680900005