| ID | 817 |
| Eprint ID | 817
|
| FullText URL | |
| Title Alternative | グラヤノトキシンD環の化学修飾
|
| Author |
Iwasa, Junkichi
Kawanishi, Tetsuroh
Handa, Satoshi
Kamano, Hideki
Yamamoto, Shingo
Okamoto, Manabu
Takeda, Norimasa
Nakamura, Mikihiko
Masutani, Tetsuya
Shiro, Motoo
Baba, Naomichi
Seyama, Issei
|
| Abstract | Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from α-dihydro GTX- 11 . These new compounds and the previously prepared GTXS ere directly applied to the intracellular phase of internally perfused squid giant axons.
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| Published Date | 1992
|
| Publication Title |
岡山大学農学部学術報告
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| Publication Title Alternative | Scientific Reports of the Faculty of Agriculture Okayama University
|
| Volume | volume79
|
| Issue | issue1
|
| Publisher | 岡山大学農学部
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| Publisher Alternative | Faculty of Agriculture, Okayama University
|
| Start Page | 1
|
| End Page | 35
|
| ISSN | 0474-0254
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| NCID | AN00033029
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| Content Type |
Departmental Bulletin Paper
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| language |
English
|
| File Version | publisher
|
| Refereed |
False
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| Eprints Journal Name | srfa
|
