Nagatsuka, Hitoshi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Effect of Oral Peritumoral Tissue on Infiltration and Differentiation of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma

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Author	Piao, Tianyan\| Takabatake, Kiyofumi\| Arashima, Takuma\| Zhao, Yulu\| Kawai, Hotaka\| Eain, Htoo Shwe\| Soe, Yamin\| Min, Zin Zin\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	oral squamous cell carcinoma (OSCC) gingival connective tissue cells (GCTCs) periodontal ligament cells (PDLCs) tumor-associated macrophages (TAMs) macrophage polarity tumor microenvironment (TME)
Published Date	2025-09-22
Publication Title	Cells
Volume	volume14
Issue	issue18
Publisher	MDPI AG
Start Page	1481
ISSN	2073-4409
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	41002446
DOI	10.3390/cells14181481
Web of Science KeyUT	001579644200001
Related Url	isVersionOf https://doi.org/10.3390/cells14181481

Refining the Role of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma

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Author	Takabatake, Kiyofumi\| Tianyan, Piao\| Arashima, Takuma\| Chang, Anqi\| Kawai, Hotaka\| Eain, Htoo Shwe\| Soe, Yamin\| Min, Zin Zin\| Fujii, Masae\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	tumor-associated macrophage (TAM) oral squamous cell carcinoma (OSCC) macrophage polarity invasion carcinogenesis
Published Date	2025-08-25
Publication Title	Cancers
Volume	volume17
Issue	issue17
Publisher	MDPI AG
Start Page	2770
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40940867
DOI	10.3390/cancers17172770
Web of Science KeyUT	001569623700001
Related Url	isVersionOf https://doi.org/10.3390/cancers17172770

CXCR4 Inhibition Induces Tumor Necrosis by Selectively Targeting the Proliferating Blood Vessels in Oral Squamous Cell Carcinoma

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Author	Soe, Yamin\| Kawai, Hotaka\| Eain, Htoo Shwe\| Yoshida, Saori\| Oo, May Wathone\| Min, Zin Zin\| Takabatake, Kiyofumi\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	CXCR4 tumor angiogenesis chemokine receptors tumor microenvironment oral squamous cell carcinoma (OSCC) AMD3100
Published Date	2025-09-22
Publication Title	Journal of Cancer
Volume	volume16
Issue	issue14
Publisher	Ivyspring International Publisher
Start Page	4055
End Page	4070
ISSN	1837-9664
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The author(s).
File Version	publisher
PubMed ID	41210695
DOI	10.7150/jca.115847
Web of Science KeyUT	001588093500002
Related Url	isVersionOf https://doi.org/10.7150/jca.115847

Histopathological Study of Regenerative Endodontic Therapy on an Immature Mandibular Second Premolar With Pulp Necrosis: A Case Report

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Author	Sako, Hidefumi\| Omori, Kazuhiro\| Shinoda-Ito, Yuki\| Takabatake, Kiyofumi\| Nagatsuka, Hitoshi\| Takashiba, Shogo\|
Keywords	calcium hydroxide immature permanent teeth pulp necrosis regenerative endodontic therapy revascularization
Published Date	2025-10-29
Publication Title	Cureus
Volume	volume17
Issue	issue10
Publisher	Springer Science and Business Media LLC
Start Page	e95647
ISSN	2168-8184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Copyright 2025 Sako et al.
File Version	publisher
DOI	10.7759/cureus.95647
Related Url	isVersionOf https://doi.org/10.7759/cureus.95647

Coronal Cementum and Reduced Enamel Epithelium on Occlusal Surface of Impacted Wisdom Tooth in a Human

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Author	Horie, Naohiro\| Murata, Masaru\| Minamida, Yasuhito\| Nagayasu, Hiroki\| Shimo, Tsuyoshi\| Akazawa, Toshiyuki\| Tsujigiwa, Hidetsugu\| Haikel, Youssef\| Nagatsuka, Hitoshi\|
Keywords	coronal cementum human reduced epithelium impacted tooth
Published Date	2024-10-30
Publication Title	Dentistry Journal
Volume	volume12
Issue	issue11
Publisher	MDPI AG
Start Page	348
ISSN	2304-6767
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39590398
DOI	10.3390/dj12110348
Web of Science KeyUT	001364726900001
Related Url	isVersionOf https://doi.org/10.3390/dj12110348

Impacts of Dental Follicle Cells and Periodontal Ligament Cells on the Bone Invasion of Well-Differentiated Oral Squamous Cell Carcinoma

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Author	Chang, Anqi\| Takabatake, Kiyofumi\| Piao, Tianyan\| Arashima, Takuma\| Kawai, Hotaka\| Eain, Htoo Shwe\| Soe, Yamin\| Min, Zin Zin\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	oral squamous cell carcinoma dental follicle cells periodontal ligament cells bone invasion receptor activator of NF-kappa B ligand parathyroid hormone-related peptide
Published Date	2025-05-03
Publication Title	Cancers
Volume	volume17
Issue	issue9
Publisher	MDPI
Start Page	1559
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40361486
DOI	10.3390/cancers17091559
Web of Science KeyUT	001486000900001
Related Url	isVersionOf https://doi.org/10.3390/cancers17091559

Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome

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Author	Ono-Minagi, Hitomi\| Nohno, Tsutomu\| Takabatake, Kiyofumi\| Tanaka, Takehiro\| Katsuyama, Takayuki\| Miyawaki, Kohta\| Wada, Jun\| Ibaragi, Soichiro\| Iida, Seiji\| Yoshino, Tadashi\| Nagatsuka, Hitoshi\| Sakai, Takayoshi\| Ohuchi, Hideyo\|
Keywords	Autoimmune disease Xerostomia Multiplex immunostaining Spatial analysis Autophagy
Note	The version of record of this article, first published in BMC Oral Health, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12903-024-04869-4\|
Published Date	2024-09-16
Publication Title	BMC Oral Health
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	1099
ISSN	1472-6831
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	39285388
DOI	10.1186/s12903-024-04869-4
Web of Science KeyUT	001314744100005
Related Url	isVersionOf https://doi.org/10.1186/s12903-024-04869-4

Effect of Scaffold Geometrical Structure on Macrophage Polarization during Bone Regeneration Using Honeycomb Tricalcium Phosphate

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Author	Takabatake, Kiyofumi\| Tsujigiwa, Hidetsugu\| Nakano, Keisuke\| Chang, Anqi\| Piao, Tianyan\| Inada, Yasunori\| Arashima, Takuma\| Morimatsu, Ayumi\| Tanaka, Ayumi\| Kawai, Hotaka\| Nagatsuka, Hitoshi\|
Keywords	honeycomb TCP bone formation macrophages polarization
Published Date	2024-08-19
Publication Title	Materials
Volume	volume17
Issue	issue16
Publisher	MDPI
Start Page	4108
ISSN	1996-1944
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39203286
DOI	10.3390/ma17164108
Web of Science KeyUT	001304704200001
Related Url	isVersionOf https://doi.org/10.3390/ma17164108

Training high-performance deep learning classifier for diagnosis in oral cytology using diverse annotations

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Author	Sukegawa, Shintaro\| Tanaka, Futa\| Nakano, Keisuke\| Hara, Takeshi\| Ochiai, Takanaga\| Shimada, Katsumitsu\| Inoue, Yuta\| Taki, Yoshihiro\| Nakai, Fumi\| Nakai, Yasuhiro\| Ishihama, Takanori\| Miyazaki, Ryo\| Murakami, Satoshi\| Nagatsuka, Hitoshi\| Miyake, Minoru\|
Keywords	Deep learning Oral cytology Classification Convolutional neural network Probabilistic labeling
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-67879-w\|
Published Date	2024-07-30
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	17591
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39080384
DOI	10.1038/s41598-024-67879-w
Web of Science KeyUT	001281320200004
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-67879-w

Efficacy of Cisplatin-CXCR4 Antagonist Combination Therapy in Oral Cancer

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Author	Yoshida, Saori\| Kawai, Hotaka\| Soe, Yamin\| Eain, Htoo Shwe\| Sanou, Sho\| Takabatake, Kiyofumi\| Takeshita, Yohei\| Hisatomi, Miki\| Nagatsuka, Hitoshi\| Asaumi, Junichi\| Yanagi, Yoshinobu\|
Keywords	oral squamous cell carcinoma CXCR4 cisplatin antitumor vascular therapy
Published Date	2024-06-25
Publication Title	Cancers
Volume	volume16
Issue	issue13
Publisher	MDPI
Start Page	2326
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39001388
DOI	10.3390/cancers16132326
Web of Science KeyUT	001269922500001
Related Url	isVersionOf https://doi.org/10.3390/cancers16132326

Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma

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Author	Eain, Htoo Shwe\| Kawai, Hotaka\| Nakayama, Masaaki\| Oo, May Wathone\| Ohara, Toshiaki\| Fukuhara, Yoko\| Takabatake, Kiyofumi\| Shan, Quisheng\| Soe, Yamin\| Ono, Kisho\| Nakano, Keisuke\| Mizukawa, Nobuyoshi\| Iida, Seiji\| Nagatsuka, Hitoshi\|
Published Date	2024-05-22
Publication Title	JCI Insight
Volume	volume9
Issue	issue10
Publisher	American Society for Clinical Investigation
Start Page	e174618
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024, Eain et al.
File Version	publisher
PubMed ID	38775151
DOI	10.1172/jci.insight.174618
Web of Science KeyUT	001230441500001
Related Url	isVersionOf https://doi.org/10.1172/jci.insight.174618

EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma

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Author	Umemori, Koki\| Ono, Kisho\| Eguchi, Takanori\| Kawai, Hotaka\| Nakamura, Tomoya\| Ogawa, Tatsuo\| Yoshida, Kunihiro\| Kanemoto, Hideka\| Sato, Kohei\| Obata, Kyoichi\| Ryumon, Shoji\| Yutori, Hirokazu\| Katase, Naoki\| Okui, Tatsuo\| Nagatsuka, Hitoshi\| Ibaragi, Soichiro\|
Keywords	Cetuximab epithelial cell adhesion molecule (EpCAM) EpEX EpICD epidermal growth factor receptor (EGFR) Drug resistance Head and neck squamous cell carcinoma (HNSC)
Published Date	2023-07
Publication Title	Oral Oncology
Volume	volume142
Publisher	Elsevier
Start Page	106433
ISSN	1368-8375
NCID	AA10846349
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Author(s).
File Version	publisher
PubMed ID	37236125
DOI	10.1016/j.oraloncology.2023.106433
Web of Science KeyUT	001012354300001
Related Url	isVersionOf https://doi.org/10.1016/j.oraloncology.2023.106433

Ligneous periodontitis exacerbated by Behçet’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C > T: a case report

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Author	Shinoda-Ito, Yuki\| Hirai, Anna\| Omori, Kazuhiro\| Ideguchi, Hidetaka\| Yamamoto, Hideki\| Kato, Fumino\| Obata, Kyoichi\| Ogawa, Tatsuo\| Nakano, Keisuke\| Nakadoi, Takato\| Katsuyama, Eri\| Ibaragi, Soichiro\| Yamamoto, Tadashi\| Nagatsuka, Hitoshi\| Hirasawa, Akira\| Takashiba, Shogo\|
Keywords	Ligneous periodontitis Plasminogen deficiency PLG Behcet's disease Gingival hyperplasia
Note	The version of record of this article, first published in BMC Oral Health, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12903-023-03586-8\|
Published Date	2023-11-08
Publication Title	BMC Oral Health
Volume	volume23
Issue	issue1
Publisher	BMC
Start Page	843
ISSN	1472-6831
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37940896
DOI	10.1186/s12903-023-03586-8
Web of Science KeyUT	001101860500001
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Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model

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Author	Shan, Qiusheng\| Takabatake, Kiyofumi\| Omori, Haruka\| Kawai, Hotaka\| Oo, May Wathone\| Sukegawa, Shintaro\| Fujii, Masae\| Inada, Yasunori\| Sano, Sho\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	oral squamous cell carcinoma bone invasion gingival ligament tissue‑derived stromal cell periodontal ligament tissue‑derived stromal cell xenograft model microarray
Published Date	2022-09-13
Publication Title	Oncology Letters
Volume	volume24
Issue	issue5
Publisher	Spandidos Publications
Start Page	382
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Shan et al.
File Version	publisher
PubMed ID	36238359
DOI	10.3892/ol.2022.13502
Web of Science KeyUT	000859364100001
Related Url	isVersionOf https://doi.org/10.3892/ol.2022.13502

Significance of cancer stroma for bone destruction in oral squamous cell carcinoma using different cancer stroma subtypes

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Author	Shan, Qiusheng\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Oo, May Wathone\| Inada, Yasunori\| Sukegawa, Shintaro\| Fushimi, Shigeko\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	oral squamous cell carcinoma bone invasion osteoclast receptor activator of NF‑κB ligand parathyroid hormone‑related peptide microarray cancer‑associated stromal cells
Published Date	2022-02-24
Publication Title	Oncology Reports
Volume	volume47
Issue	issue4
Publisher	Spandidos Publications
Start Page	81
ISSN	1021-335X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Shan et al.
File Version	publisher
PubMed ID	35211756
DOI	10.3892/or.2022.8292
Web of Science KeyUT	000764236000001
Related Url	isVersionOf https://doi.org/10.3892/or.2022.8292

Lip pleomorphic adenomas: case series and literature review

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Author	Umemori, Koki\| Ono, Kisho\| Kanemoto, Hideka\| Obata, Kyoichi\| Kawai, Hotaka\| Nakamura, Tomoya\| Nakano, Keisuke\| Ibaragi, Soichiro\| Nagatsuka, Hitoshi\| Sasaki, Akira\|
Keywords	Pleomorphic adenoma (PA) upper lip lower lip minor salivary gland tumor case series
Published Date	2022-10-27
Publication Title	Gland Surgery
Volume	volume11
Issue	issue10
Publisher	AME Publishing Company
Start Page	1730
End Page	1740
ISSN	2227-684X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Gland Surgery.
File Version	publisher
PubMed ID	36353586
DOI	10.21037/gs-22-308
Web of Science KeyUT	000860255900001
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Effectiveness of deep learning classifiers in histopathological diagnosis of oral squamous cell carcinoma by pathologists

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Author	Sukegawa, Shintaro\| Ono, Sawako\| Tanaka, Futa\| Inoue, Yuta\| Hara, Takeshi\| Yoshii, Kazumasa\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Katsumitsu, Shimada\| Nakai, Fumi\| Nakai, Yasuhiro\| Miyazaki, Ryo\| Murakami, Satoshi\| Nagatsuka, Hitoshi\| Miyake, Minoru\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y\|
Published Date	2023-07-19
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	11676
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37468501
DOI	10.1038/s41598-023-38343-y
Web of Science KeyUT	001033545700013
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-38343-y

Novel Artificial Scaffold for Bone Marrow Regeneration: Honeycomb Tricalcium Phosphate

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Author	Inada, Yasunori\| Takabatake, Kiyofumi\| Tsujigiwa, Hidetsugu\| Nakano, Keisuke\| Shan, Qiusheng\| Piao, Tianyan\| Chang, Anqi\| Kawai, Hotaka\| Nagatsuka, Hitoshi\|
Keywords	honeycomb TCP bone marrow formation scaffold hematopoietic stem cell (HSC) N-cadherin-positive spindle-shaped osteoblasts (SNO cells)
Published Date	2023-02-07
Publication Title	Materials
Volume	volume16
Issue	issue4
Publisher	MDPI
Start Page	1393
ISSN	1996-1944
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36837023
DOI	10.3390/ma16041393
Web of Science KeyUT	000953562700001
Related Url	isVersionOf https://doi.org/10.3390/ma16041393

Is attention branch network effective in classifying dental implants from panoramic radiograph images by deep learning?

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Author	Sukegawa, Shintaro\| Yoshii, Kazumasa\| Hara, Takeshi\| Tanaka, Futa\| Yamashita, Katsusuke\| Kagaya, Tutaro\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Nagatsuka, Hitoshi\| Furuki, Yoshihiko\|
Published Date	2022-07-27
Publication Title	Plos One
Volume	volume17
Issue	issue7
Publisher	Public Library Science
Start Page	e0269016
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Sukegawa et al.
File Version	publisher
PubMed ID	35895591
DOI	10.1371/journal.pone.0269016
Web of Science KeyUT	000880183400018
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0269016

SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma

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Author	Oo, May Wathone\| Kawai, Hotaka\| Eain, Htoo Shwe\| Soe, Yamin\| Takabatake, Kiyofumi\| Sanou, Sho\| Shan, Qiusheng\| Inada, Yasunori\| Fujii, Masae\| Fukuhara, Yoko\| Wang, Ziyi\| Sukegawa, Shintaro\| Ono, Mitsuaki\| Nakano, Keisuke\| Nagatsuka, Hitoshi\|
Keywords	oral squamous cell carcinoma tumor microenvironment tumor stroma tumor vascularization extracellular superoxide dismutase (SOD3) vascular endothelial cadherin (Ve-cadherin)
Published Date	2022-10-28
Publication Title	Biomedicines
Volume	volume10
Issue	issue11
Publisher	MDPI
Start Page	2729
ISSN	2227-9059
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36359248
DOI	10.3390/biomedicines10112729
Web of Science KeyUT	000881045700001
Related Url	isVersionOf https://doi.org/10.3390/biomedicines10112729