| ID | 67693 |
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| Author |
Gonçalves, Bronner P.
Department of Comparative Biomedical Sciences, Faculty of Health and Medical Sciences, University of Surrey
Suzuki, Etsuji
Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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| Abstract | The relevance of the epidemiologic concept of preventable fraction to the study of the population-level impact of preventive exposures is unequivocal. Here, we discuss how the preventable fraction can be usefully understood for the class of outcomes that relate to disease progression (e.g., clinical severity given diagnosis), and, under the principal stratification framework, derive an expression for this quantity for this type of outcome. In particular, we show that, in the context of disease progression, the preventable fraction is a function of the effect on the postdiagnosis outcome in the principal stratum in the unexposed group who would have disease regardless of exposure status. This work will facilitate an understanding of the contribution of principal effects to the impact of preventive exposures at the population level.
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| Keywords | Counterfactual framework
Disease progression
Disease severity
Preventable fraction
Principal stratification
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| Note | This is a non-final version of an article published in final form in Gonçalves, Bronner P.a; Suzuki, Etsujib,c. Preventable Fraction in the Context of Disease Progression. Epidemiology 35(6):p 801-804, November 2024. | DOI: 10.1097/EDE.0000000000001770.
This fulltext file will be available in Nov. 2025.
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| Published Date | 2024-11
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| Publication Title |
Epidemiology
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| Volume | volume35
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| Issue | issue6
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| Publisher | Ovid Technologies (Wolters Kluwer Health)
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| Start Page | 801
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| End Page | 804
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| ISSN | 1044-3983
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| NCID | AA10832184
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2024 Wolters Kluwer Health, Inc.
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| File Version | author
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| Related Url | isVersionOf https://doi.org/10.1097/ede.0000000000001770
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| Citation | Gonçalves, Bronner P.a; Suzuki, Etsujib,c. Preventable Fraction in the Context of Disease Progression. Epidemiology 35(6):p 801-804, November 2024. | DOI: 10.1097/EDE.0000000000001770
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| Funder Name |
Japan Society for the Promotion of Science
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| 助成番号 | JP19KK0418
JP23K09740
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