Sakaguchi, Masakiyo - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis

FullText URL	fulltext.pdf
Author	Jiang, Fan\| Chen, Youyi\| Tomonobu, Nahoko\| Kinoshita, Rie\| Komalasari, Ni Luh Gede Yoni\| Kasano-Camones, Carlos Ichiro\| Ninomiya, Kazumi\| Murata, Hitoshi\| Yamamoto, Ken-Ichi\| Gohara, Yuma\| Ochi, Toshiki\| Ruma, I. Made Winarsa\| Sumardika, I. Wayan\| Zhou, Jin\| Honjo, Tomoko\| Sakaguchi, Yoshihiko\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Futami, Junichiro\| Kondo, Eisaku\| Inoue, Yusuke\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
Keywords	breast cancer invasion lysyl oxidase NF-κB MMP9
Published Date	2024-05-28
Publication Title	Frontiers in Oncology
Volume	volume14
Publisher	Frontiers Media
Start Page	1371307
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Jiang, Chen, Tomonobu, Kinoshita, Komalasari, Kasano-Camones, Ninomiya, Murata, Yamamoto, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Futami, Kondo, Inoue, Toyooka and Sakaguchi.
File Version	publisher
PubMed ID	38863623
DOI	10.3389/fonc.2024.1371307
Web of Science KeyUT	001242409800001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2024.1371307

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

FullText URL	fulltext.pdf
Author	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
Published Date	2024-06-06
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue11
Publisher	MDPI
Start Page	6269
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2024 by the authors.
File Version	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
Related Url	isVersionOf https://doi.org/10.3390/ijms25116269

Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells

FullText URL	fulltext.pdf
Author	Gohara, Yuma\| Tomonobu, Nahoko\| Kinoshita, Rie\| Futami, Junichiro\| Audebert, Léna\| Chen, Youyi\| Komalasari, Ni Luh Gede Yoni\| Jiang, Fan\| Yoshizawa, Chikako\| Murata, Hitoshi\| Yamamoto, Ken-ichi\| Watanabe, Masami\| Kumon, Hiromi\| Sakaguchi, Masakiyo\|
Keywords	Breast cancer REIC/Dkk-3 PD-L1 Immune checkpoint Cancer therapy
Note	The version of record of this article, first published in Journal of Molecular Medicine, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00109-023-02292-w\|
Published Date	2023-03-04
Publication Title	Journal of Molecular Medicine
Volume	volume101
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	431
End Page	447
ISSN	0946-2716
NCID	AA11034065
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	36869893
DOI	10.1007/s00109-023-02292-w
Web of Science KeyUT	000943221900001
Related Url	isVersionOf https://doi.org/10.1007/s00109-023-02292-w

Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration

FullText URL	fulltext.pdf
Author	Murata, Hitoshi\| Phoo, May Tha Zin\| Ochi, Toshiki\| Tomonobu, Nahoko\| Yamamoto, Ken-ichi\| Kinoshita, Rie\| Miyazaki, Ikuko\| Nishibori, Masahiro\| Asanuma, Masato\| Sakaguchi, Masakiyo\|
Keywords	JNK PARK2 Parkinson’sdisease Phosphorylation SARM1
Published Date	2023-09-19
Publication Title	The Journal of Biochemistry
Volume	volume174
Issue	issue6
Publisher	Oxford University Press (OUP)
Start Page	533
End Page	548
ISSN	0021-924X
NCID	AA00694073
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37725528
DOI	10.1093/jb/mvad068
Web of Science KeyUT	001079972500001
Related Url	isVersionOf https://doi.org/10.1093/jb/mvad068

Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface

FullText URL	fulltext.pdf
Author	Takahashi, Tetta\| Tomonobu, Nahoko\| Kinoshita, Rie\| Yamamoto, Ken-Ichi\| Murata, Hitoshi\| Komalasari, Ni Luh Gede Yoni\| Chen, Youyi\| Jiang, Fan\| Gohara, Yuma\| Ochi, Toshiki\| Ruma, I. Made Winarsa\| Sumardika, I. Wayan\| Zhou, Jin\| Honjo, Tomoko\| Sakaguchi, Yoshihiko\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Kondo, Eisaku\| Inoue, Yusuke\| Futami, Junichiro\| Toyooka, Shinichi\| Zamami, Yoshito\| Sakaguchi, Masakiyo\|
Keywords	breast cancer lysyl oxidase annexin A2 S100A11 plasmin cancer microenvironment
Published Date	2024-03-26
Publication Title	Frontiers in Oncology
Volume	volume14
Publisher	Frontiers Media
Start Page	1371342
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Takahashi, Tomonobu, Kinoshita, Yamamoto, Murata, Komalasari, Chen, Jiang, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Kondo, Inoue, Futami, Toyooka, Zamami and Sakaguchi.
File Version	publisher
PubMed ID	38595825
DOI	10.3389/fonc.2024.1371342
Web of Science KeyUT	001198366100001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2024.1371342

PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours

FullText URL	fulltext.pdf
Author	Takihira, Shota\| Yamada, Daisuke\| Osone, Tatsunori\| Takao, Tomoka\| Sakaguchi, Masakiyo\| Hakozaki, Michiyuki\| Itano, Takuto\| Nakata, Eiji\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\| Takarada, Takeshi\|
Note	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8\|
Published Date	2024-03-06
Publication Title	British Journal of Cancer
Volume	volume130
Issue	issue9
Publisher	Springer Science and Business Media LLC
Start Page	1493
End Page	1504
ISSN	0007-0920
NCID	AA00574355
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38448751
DOI	10.1038/s41416-024-02632-8
Web of Science KeyUT	001180796100003
Related Url	isVersionOf https://doi.org/10.1038/s41416-024-02632-8

日本組織培養学会第95回大会報告

Title Alternative	The 95th Annual Meeting of the Japanese Tissue Culture Association
Author	Sakaguchi, Masakiyo\|
Publication Title	Journal of Okayama Medical Association
Published Date	2023-12-01
Volume	volume135
Issue	issue3
Start Page	181
End Page	182
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.135.181
language	Japanese
Copyright Holders	Copyright (c) 2023 岡山医学会
File Version	publisher
DOI	10.4044/joma.135.181

Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2

FullText URL	fulltext.pdf
Author	Komalasari, Ni Luh Gede Yoni\| Tomonobu, Nahoko\| Kinoshita, Rie\| Chen, Youyi\| Sakaguchi, Yoshihiko\| Gohara, Yuma\| Jiang, Fan\| Yamamoto, Ken-Ich\| Murata, Hitoshi\| Ruma, I Made Winarsa\| Sumardika, I Wayan\| Zhou, Jin\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Inoue, Yusuke\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
Keywords	breast cancer lysyl oxidase annexin A2 integrin cancer microenvironment
Published Date	2023-04-04
Publication Title	Frontiers in Oncology
Volume	volume13
Publisher	Frontiers Media
Start Page	1142907
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Komalasari, Tomonobu, Kinoshita, Chen, Sakaguchi, Gohara, Jiang, Yamamoto, Murata, Ruma, Sumardika, Zhou, Yamauchi, Kuribayashi, Inoue, Toyooka and Sakaguchi.
File Version	publisher
PubMed ID	37091157
DOI	10.3389/fonc.2023.1142907
Web of Science KeyUT	000970195800001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2023.1142907

LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells

FullText URL	fulltext.pdf
Author	Hirabayashi, Daisuke\| Yamamoto, Ken-ichi\| Maruyama, Akihiro\| Tomonobu, Nahoko\| Kinoshita, Rie\| Chen, Youyi\| Komalasari, Ni Luh Gede Yoni\| Murata, Hitoshi\| Gohara, Yuma\| Jiang, Fan\| Zhou, Jin\| Ruma, I. Made Winarsa\| Sumardika, I. Wayan\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Toyooka, Shinichi\| Inoue, Yusuke\| Sakaguchi, Masakiyo\|
Keywords	epithelial-to-mesenchymal transition triple-negative breast cancer zinc ZEB1 metastasis
Published Date	2023-02-23
Publication Title	Frontiers in Oncology
Volume	volume13
Publisher	Frontiers Media
Start Page	1142886
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Hirabayashi, Yamamoto, Maruyama, Tomonobu, Kinoshita, Chen, Komalasari, Murata, Gohara, Jiang, Zhou, Ruma, Sumardika, Yamauchi, Kuribayashi, Toyooka, Inoue and Sakaguchi.
File Version	publisher
PubMed ID	36910659
DOI	10.3389/fonc.2023.1142886
Web of Science KeyUT	000945660600001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2023.1142886

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

FullText URL	fulltext.pdf
Author	Gao, Tong\| Yang, Xu\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Wang, Tianyi\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	cancer stem cells epithelial-mesenchymal transition ERK1/2-MAPK tumorigenesis
Published Date	2023-03-05
Publication Title	International Journal of Molecular Sciences
Volume	volume24
Issue	issue5
Publisher	MDPI
Start Page	4996
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36902429
DOI	10.3390/ijms24054996
Web of Science KeyUT	000947675000001
Related Url	isVersionOf https://doi.org/10.3390/ijms24054996

Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung

FullText URL	fulltext.pdf
Author	Nakata, Kentaro\| Okazaki, Mikio\| Sakaue, Tomohisa\| Kinoshita, Rie\| Komoda, Yuhei\| Shimizu, Dai\| Yamamoto, Haruchika\| Tanaka, Shin\| Suzawa, Ken\| Shien, Kazuhiko\| Miyoshi, Kentaroh\| Yamamoto, Hiromasa\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Matsukawa, Akihiro\| Sakaguchi, Masakiyo\| Toyooka, Shinichi\|
Keywords	ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns
Published Date	2022-11-10
Publication Title	Bioengineering
Volume	volume9
Issue	issue11
Publisher	MDPI
Start Page	673
ISSN	2306-5354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36354584
DOI	10.3390/bioengineering9110673
Web of Science KeyUT	000880897200001
Related Url	isVersionOf https://doi.org/10.3390/bioengineering9110673

Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells

FullText URL	fulltext.pdf
Author	Tomonobu, Nahoko\| Kinoshita, Rie\| Wake, Hidenori\| Inoue, Yusuke\| Ruma, I. Made Winarsa\| Suzawa, Ken\| Gohara, Yuma\| Komalasari, Ni Luh Gede Yoni\| Jiang, Fan\| Murata, Hitoshi\| Yamamoto, Ken-Ichi\| Sumardika, I. Wayan\| Chen, Youyi\| Futami, Junichiro\| Yamauchi, Akira\| Kuribayashi, Futoshi\| Kondo, Eisaku\| Toyooka, Shinichi\| Nishibori, Masahiro\| Sakaguchi, Masakiyo\|
Keywords	S100A8/A9 HRG metastasis
Published Date	2022-09-07
Publication Title	International Journal Of Molecular Sciences
Volume	volume23
Issue	issue18
Publisher	MDPI
Start Page	10300
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36142212
DOI	10.3390/ijms231810300
Web of Science KeyUT	000858719600001
Related Url	isVersionOf https://doi.org/10.3390/ijms231810300

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

FullText URL	fulltext.pdf
Author	Li, Chunning\| Yoshimura, Teizo\| Tian, Miao\| Wang, Yuze\| Kondo, Takamasa\| Yamamoto, Ken-Ichi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Matsukawa, Akihiro\|
Keywords	Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date	2022-09-12
Publication Title	Breast Cancer Research
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	60
ISSN	1465-5411
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36096830
DOI	10.1186/s13058-022-01557-5
Web of Science KeyUT	000853036400001
Related Url	isVersionOf https://doi.org/10.1186/s13058-022-01557-5

Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice

FullText URL	fulltext.pdf
Author	Xue, Ruizhi\| Lin, Wenfeng\| Fujita, Hirofumi\| Sun, Jingkai\| Kinoshita, Rie\| Ochiai, Kazuhiko\| Futami, Junichiro\| Watanabe, Masami\| Ohuchi, Hideyo\| Sakaguchi, Masakiyo\| Tang, Zhengyan\| Huang, Peng\| Nasu, Yasutomo\| Kumon, Hiromi\|
Keywords	Dkk3/REIC fibrous sheath knock-out RNA-seq spermiation sperm motility
Published Date	2022-01-31
Publication Title	Genes
Volume	volume13
Issue	issue2
Publisher	MDPI
Start Page	285
ISSN	2073-4425
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	35205329
DOI	10.3390/genes13020285
Web of Science KeyUT	000762788200001
Related Url	isVersionOf https://doi.org/10.3390/genes13020285

Multifaceted Analysis of IL-23A-and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes

FullText URL	fulltext.pdf
Author	Tachibana, Kota\| Tang, Nina\| Urakami, Hitoshi\| Kajita, Ai\| Kobashi, Mina\| Nomura, Hayato\| Sasakura, Minori\| Sugihara, Satoru\| Jiang, Fan\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Ouchida, Mamoru\| Morizane, Shin\|
Keywords	psoriasis vulgaris interleukin (IL) 23 IL-39 p19 Epstein-Barr virus-induced (EBI) 3 tildrakizumab
Published Date	2021-11-23
Publication Title	International Journal Of Molecular Sciences
Volume	volume22
Issue	issue23
Publisher	MDPI
Start Page	12659
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34884474
DOI	10.3390/ijms222312659
Web of Science KeyUT	000735457700001
Related Url	isVersionOf https://doi.org/10.3390/ijms222312659

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion (vol 11, 665273, 2021)

FullText URL	fulltext.pdf
Author	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| Rose, Jose La\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
Keywords	ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note	A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273 Erratum for https://ousar.lib.okayama-u.ac.jp/62214\|
Published Date	2021-07-20
Publication Title	Frontiers In Oncology
Volume	volume11
Publisher	Frontiers Media SA.
Start Page	729192
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version	publisher
PubMed ID	34354958
DOI	10.3389/fonc.2021.729192
Web of Science KeyUT	000680472200001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2021.729192

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion

FullText URL	fulltext.pdf
Author	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| La Rose, Jose\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
Keywords	ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note	Erratum in https://ousar.lib.okayama-u.ac.jp/62331\|
Published Date	2021-05-31
Publication Title	Frontiers In Oncology
Volume	volume11
Publisher	Frontiers Media S.A.
Start Page	665273
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version	publisher
PubMed ID	34136397
NAID	120007089841
DOI	10.3389/fonc.2021.665273
Web of Science KeyUT	000661158800001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2021.665273

Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats

FullText URL	fulltext20210630-1.pdf
Author	Nakamura, Kazufumi\| Akagi, Satoshi\| Ejiri, Kentaro\| Yoshida, Masashi\| Miyoshi, Toru\| Sakaguchi, Masakiyo\| Amioka, Naofumi\| Suastika, Luh Oliva Saraswati\| Kondo, Megumi\| Nakayama, Rie\| Takaya, Yoichi\| Higashimoto, Yuichiro\| Fukami, Kei\| Matsubara, Hiromi\| Ito, Hiroshi\|
Keywords	pulmonary artery smooth muscle cells RAGE aptamer
Note	This is an Accepted Manuscript published by Elsevier. ©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/\|
Published Date	2020-12-30
Publication Title	Journal of Cardiology
Volume	volume78
Issue	issue1
Publisher	Elsevier
Start Page	12
End Page	16
ISSN	09145087
NCID	AN10070473
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
File Version	author
PubMed ID	33386219
DOI	10.1016/j.jjcc.2020.12.009
Web of Science KeyUT	000661421700002
Related Url	isVersionOf https://doi.org/10.1016/j.jjcc.2020.12.009

Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility

FullText URL	fulltext.pdf
Author	Bajkowska, Karolina\| Sumardika, I. Wayan\| Tomonobu, Nahoko\| Chen, Youyi\| Yamamoto, Ken-ichi\| Kinoshita, Rie\| Murata, Hitoshi\| Gede Yoni Komalasari, Ni Luh\| Jiang, Fan\| Yamauchi, Akira\| Winarsa Ruma, I. Made\| Kasano-Camones, Carlos Ichiro\| Inoue, Yusuke\| Sakaguchi, Masakiyo\|
Keywords	Lung cancer Metastasis Epithelial-mesenchymal transition Solute carrier family 22 member 18 antisense S100A8/A9 Neuroplastin
Published Date	2020-07
Publication Title	Biochemistry and Biophysics Reports
Volume	volume22
Publisher	Elsevier
Start Page	100768
ISSN	24055808
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Authors
File Version	publisher
PubMed ID	32490214
DOI	10.1016/j.bbrep.2020.100768
Related Url	isVersionOf https://doi.org/10.1016/j.bbrep.2020.100768

Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells

JaLCDOI	10.18926/AMO/60371
FullText URL	74_4_327.pdf
Author	Yamamoto, Ken-ichi\| Kagawa, Hiroko\| Arimoto, Sakae\| Tan, Xian Wen\| Yasui, Kento\| Oshiki, Toshiyuki\| Sakaguchi, Masakiyo\|
Abstract	An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.
Keywords	plastic wrap plasticizer, cytotoxicity, liver cells in vitro
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2020-08
Volume	volume74
Issue	issue4
Publisher	Okayama University Medical School
Start Page	327
End Page	334
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32843764
Web of Science KeyUT	000562508700008
NAID	120006880210