ID | 53064 |
FullText URL | |
Author |
Kobayashi, Satoru
Kobayashi, Naoya
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Abstract | Background/Aims: PuraMatrix is a synthetic material consisting of 16-amino acid peptides that self-assemble into nanofibers, previously used as a scaffold for functional cell cultures. We conducted a clinical study to determine the safety and sealing properties of PuraMatrix in post-operative lymphorrhea following pelvic surgery in humans. Methodology: A total of 20 patients who underwent rectal cancer resection were analyzed. The study group (n = 10) consisted of patients who received PuraMatrix, matched with a control group (n = 10) of patients operated on conventionally. Results: During the 2 to 3 month follow-up period, there were no abnormal findings or adverse events in any the patients who received PuraMatrix. We found that the patients who received PuraMatrix had significantly reduced post-operative drainage volumes compared with the patients in the control group. Conclusions: PuraMatrix is a safe and effective bio-compatible sealing material for the management of post-operative peritoneal effusion following pelvic surgery.
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Keywords | Peritoneal effusion
Nanofiber polypeptide
Lymphorrhea
Pelvic surgery
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Published Date | 2014-03
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Publication Title |
Hepato-Gastroenterology
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Volume | volume61
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Issue | issue130
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Start Page | 349
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End Page | 353
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ISSN | 0172-6390
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Content Type |
Journal Article
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Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/51449
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language |
English
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File Version | author
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Refereed |
True
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Web of Science KeyUT |