| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ushio, Soichiro| Wada, Yudai| Nakamura, Mizuki| Matsumoto, Daiki| Hoshika, Kota| Shiromizu, Shoya| Iwata, Naohiro| Esumi, Satoru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Keywords | anxiolytic inflammation immunomodulation macrophages Kampo medicine |
| Published Date | 2022-08-12 |
| Publication Title | Frontiers In Pharmacology |
| Volume | volume13 |
| Publisher | Frontiers Media S.A. |
| Start Page | 890048 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Ushio, Wada, Nakamura, Matsumoto, Hoshika, Shiromizu, Iwata, Esumi, Kajizono, Kitamura and Sendo. |
| File Version | publisher |
| PubMed ID | 36034871 |
| DOI | 10.3389/fphar.2022.890048 |
| Web of Science KeyUT | 000860773600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2022.890048 |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| FullText URL | 76_2_167.pdf |
| Author | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Abstract | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| Keywords | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Asanuma, Masato| Okumura-Torigoe, Nao| Miyazaki, Ikuko| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Keywords | astrocyte neuroprotection region-specificity striatum mesencephalon oxidative stress 6-hydroxydopamine Nrf2 phase II detoxifying molecules |
| Published Date | 2019-01-30 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 598 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 30704073 |
| DOI | 10.3390/ijms20030598 |
| Web of Science KeyUT | 000462412500142 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20030598 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kikuoka, Ryo| Miyazaki, Ikuko| Kubota, Natsuki| Maeda, Megumi| Kagawa, Daiki| Moriyama, Masaaki| Sato, Asuka| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| Asanuma, Masato| |
| Published Date | 2020-11-26 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 20698 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33244123 |
| DOI | 10.1038/s41598-020-77652-4 |
| Web of Science KeyUT | 000596329600054 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-77652-4 |
| JaLCDOI | 10.18926/AMO/61215 |
|---|---|
| FullText URL | 74_6_545.pdf |
| Author | Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu| |
| Abstract | Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner. |
| Keywords | methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 550 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361876 |
| Web of Science KeyUT | 000601203600012 |
| NAID | 120006948942 |
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| FullText URL | 74_4_301.pdf |
| Author | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| Abstract | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| Keywords | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Masaoka, Yasuyuki| Kawasaki, Yoichi| Kikuoka, Ryo| Ogawa, Atsushi| Esumi, Satoru| Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Keywords | Valganciclovir Simple suspension method Stability HPLC Gavage tube |
| Published Date | 2020-07-07 |
| Publication Title | Journal of Pharmaceutical Health Care and Sciences |
| Volume | volume6 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 16 |
| ISSN | 2055-0294 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32655872 |
| DOI | 10.1186/s40780-020-00172-w |
| Web of Science KeyUT | 000549139200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40780-020-00172-w |
| Title Alternative | Drug interaction (47. Combination with general anesthetics) |
|---|---|
| FullText URL | 132_29.pdf |
| Author | Igawa, Yusuke| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2020-04-01 |
| Volume | volume132 |
| Issue | issue1 |
| Start Page | 29 |
| End Page | 33 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.132.29 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2020 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.132.29 |
| NAID | 130007840319 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi| |
| Keywords | breast cancer drug resistance lung cancer neratinib YES1 |
| Published Date | 2019-12-19 |
| Publication Title | Cancer Science |
| Volume | volume111 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 849 |
| End Page | 856 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31856375 |
| DOI | 10.1111/cas.14289 |
| Web of Science KeyUT | 000507433400001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.14289 |
| Title Alternative | Drug interaction（46. Blending change and interaction of an injection drug） |
|---|---|
| FullText URL | 131_161.pdf |
| Author | Morishita, Yosuke| Esumi, Satoru| Nishihara, Shigeki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-12-02 |
| Volume | volume131 |
| Issue | issue3 |
| Start Page | 161 |
| End Page | 164 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.161 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.161 |
| NAID | 130007782628 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hagiya, Hideharu| Koyama, Toshihiro| Zamami, Yoshito| Tatebe, Yasuhisa| Funahashi, Tomoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Hinotsu, Shiro| Sendo, Toshiaki| Rakugi, Hiromi| Kano, Mitsunobu R.| |
| Keywords | adult intensive & critical care epidemiology geriatric medicine health & safety health policy public health |
| Published Date | 2019-12-11 |
| Publication Title | BMJ OPEN |
| Volume | volume9 |
| Issue | issue12 |
| Publisher | BMJ Publishing Group |
| Start Page | e033462 |
| ISSN | 2044-6055 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or theiremployer(s)) 2019. |
| File Version | publisher |
| PubMed ID | 31831549 |
| DOI | 10.1136/bmjopen-2019-033462 |
| Web of Science KeyUT | 000512773400250 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjopen-2019-033462 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.| |
| Published Date | 2019-12-27 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 20235 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31882673 |
| DOI | 10.1038/s41598-019-56388-w |
| Web of Science KeyUT | 000509351200002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-56388-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Isooka, Nami| Miyazaki, Ikuko| Kikuoka, Ryo| Wada, Kouichi| Nakayama, Erika| Shin, Kotaro| Yamamoto, Daichi| Kitamura, Yoshihisa| Asanuma, Masato| |
| Keywords | Astrocyte Dopamine agonist Metallothionein Parkinson's disease Rotigotine Serotonin 1A receptor |
| Published Date | 2020-01-31 |
| Publication Title | Neurochemistry International |
| Volume | volume132 |
| Publisher | Elsevier |
| Start Page | 104608 |
| ISSN | 01970186 |
| NCID | AA0032399X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Ltd. |
| File Version | publisher |
| PubMed ID | 31765686 |
| DOI | 10.1016/j.neuint.2019.104608 |
| Web of Science KeyUT | 000508747200014 |
| Related Url | isVersionOf https://doi.org/10.1016/j.neuint.2019.104608 |
| Title Alternative | Drug interaction (39. Drug interaction in prostate cancer therapy) |
|---|---|
| FullText URL | 129_131.pdf |
| Author | Kanzaki, Hirotaka| Tanaka, Yuta| Maruo, Akinori| Nishihara, Shigeki | Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-08-01 |
| Volume | volume129 |
| Issue | issue2 |
| Start Page | 131 |
| End Page | 136 |
| ISSN | 0030-1558 |
| Related Url | https://doi.org/10.4044/joma.129.131 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.131 |
| NAID | 130006039378 |
| FullText URL | K0005463_other1.pdf |
|---|---|
| Author | Higuchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi| |
| Keywords | Empathy Hospital pharmacist Japan Pharmaceutical care |
| Note | The final publication is available at Springer| 岡山大学審査学位副論文| |
| Published Date | 2015-12 |
| Publication Title | International Journal of Clinical Pharmacy |
| Volume | volume37 |
| Issue | issue6 |
| Publisher | Springer |
| Start Page | 1258 |
| End Page | 1266 |
| ISSN | 2210-7703 |
| NCID | AA12633112 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26441314 |
| DOI | 10.1007/s11096-015-0204-2 |
| Web of Science KeyUT | 000363490100042 |
| Related Url | https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016 |
| Title Alternative | Drug interaction (38. Combination with novel hypnotic drugs : ramelteon and suvorexant) |
|---|---|
| FullText URL | 129_53.pdf |
| Author | Kubo, Kazuko| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 53 |
| End Page | 57 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.53 |
| NAID | 130005632075 |
| Author | Miyamoto, Masashi| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Article |
| Title Alternative | Drug interaction (36. Combination with oral molecular target drugs in lung cancer) |
|---|---|
| FullText URL | 128_141.pdf |
| Author | Higashionna, Tsukasa| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 141 |
| End Page | 146 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.141 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.141 |
| NAID | 130005262644 |
| Title Alternative | Drug interaction (35. Opioid-analgesic drug interactions) |
|---|---|
| FullText URL | 128_53.pdf |
| Author | Sada, Hikaru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 53 |
| End Page | 59 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.53 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.53 |
| NAID | 130005149610 |
