JaLCDOI | 10.18926/15500 |
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FullText URL | Mem_Fac_Eng_OU_25_2_1.pdf |
Author | Okada, Hiroyuki| Hida, Moritaka| Sakakibara, Akira| Takemoto, Yoshito| |
Abstract | Tensile strength and elongation of cast magnesium reinforced with titanium fiber were measured by tensile test. The pull-out test of a titanium rod partially embedded in a magnesium matrix was performed to evaluate interfacial bonding strength between magnesium and titanium. It was found that when the fiber volume fraction was changed from 1% to 14%, the tensile strength was improved with increase of volume fraction, while the improvement of elongation tended to be restrained beyond the volume fraction of 10%. The interfacial strength was revealed to be strong, and this was substantiated by the scanning electron microscopy showing an excellent wettability between the titanium fiber and the magnesium matrix. |
Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
Published Date | 1991-03-28 |
Volume | volume25 |
Issue | issue2 |
Start Page | 1 |
End Page | 8 |
ISSN | 0475-0071 |
language | English |
File Version | publisher |
NAID | 120002307559 |
JaLCDOI | 10.18926/AMO/31115 |
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FullText URL | fulltext.pdf |
Author | Ikeda, Nobumasa| Mizuno, Motowo| Okada, Hiroyuki| Tomoda, Jun| Tsuji, Takao| |
Abstract | To identify diffuse mucosal changes which may precede the development of colorectal cancer and a possible indicator for detecting high-risk populations, we immunohistochemically studied cell-cycle events in crypts of normal-appearing rectal mucosa of patients with colorectal adenoma and cancer using an in vitro labeling method with bromodeoxyuridine (BrdU). Biopsy specimens of endoscopically normal-appearing rectal mucosa were obtained during colonoscopy from 20 patients with colorectal adenocarcinoma, 20 with adenoma, and 15 without apparent colorectal diseases. The specimens were incubated with BrdU in vitro, and labeled S-phase cells were identified immunohistochemically using a monoclonal antibody to BrdU. Modification of the BrdU-labeling pattern in the normal appearing rectal mucosa, such as the presence of BrdU-labeled cells at the mucosal surface or in the upper one-fifth of the crypt column, was observed in 15 of the 20 patients with adenocarcinoma, 17 of the 20 patients with adenoma and 6 of the 15 controls. This upward shift in the frequency of proliferating cells in the crypt was significantly higher in the patients with colorectal adenoma and cancer than in the controls, and may be used to identify subjects at high risk for colorectal cancer. |
Keywords | colon cancer bromodeoxyuridine |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1994-10 |
Volume | volume48 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 243 |
End Page | 247 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 7863795 |
Web of Science KeyUT | A1994PP23600003 |
FullText URL | O003032.pdf |
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Author | 岡田 裕之| |
Published Date | 1996-06-30 |
Content Type | Thesis or Dissertation |
Grant Number | 乙第3032号 |
Granted Date | 1996-06-30 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | Japanese |
JaLCDOI | 10.18926/AMO/30499 |
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FullText URL | fulltext.pdf |
Author | Okada, Hiroyuki| Mizuno, Motowo| Yamamoto, Kazuhide| Tsuji, Takao| |
Abstract | To characterize primary sclerosing cholangitis (PSC) in Japanese patients and its association with inflammatory bowel disease (IBD), 155 reported cases of PSC, including 6 cases of our own, were reviewed. The prevalence of IBD was less in Japanese PSC patients than in Western patients (23% versus 62-100%). Japanese PSC patients with IBD were younger (mean age, 33.1 versus 51.8 years) and were more often women (51% versus 36%) than those without IBD. Seventy-four percent of PSC patients with IBD had extensive colonic lesions, and 89% of those developed IBD simultaneously, with or prior to PSC. There were 3 cases of neutrophilic cholangitis among the PSC patients with IBD but none in those without IBD. Based on these observations, we speculate that there may be subtypes of PSC which differ pathophysiologically. |
Keywords | primary sclerosing cholangitis inflammatory bowel disease |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1996-10 |
Volume | volume50 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 227 |
End Page | 235 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 8914675 |
Web of Science KeyUT | A1996VQ20600001 |
JaLCDOI | 10.18926/AMO/30787 |
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FullText URL | fulltext.pdf |
Author | Mikami, Yuichirou| Mizuno, Motowo| Maga, Toshirou| Kihara, Yasuhiro| Yoshinaga, Fumiya| Tanaka, Shouichi| Yunoki, Naoko| Kawahara, Toshiaki| Okada, Hiroyuki| Tsuji, Takao| |
Abstract | UDP-galactosyltransferase (UDP-Gal-T) is a key enzyme in the synthesis of mucus glycoprotein which plays an important role in gastric mucosal defensive mechanisms. Analysis of gastric UDP-Gal-T activity should clarify the mechanisms of the action of antiulcer drugs regarding gastric defensive factors. Here, we examined UDP-Gal-T activity in rat gastric mucosa treated with the antiulcer drugs geranylgeranylacetone (GGA) and cetraxate hydrochloride (CET). The effects of coadministration of indomethacin and exogenous administration of prostaglandins (PGs) were also studied. GGA and CET significantly increased UDP-Gal-T activity, and coadministration of indomethacin inhibited the increase of enzyme activity. UDP-Gal-T activity level with GGA was significantly higher than the control level, even in the presence of indomethacin. With CET, however, this was not the case. Among PGs, PGE1 significantly increased enzyme activity. Concomitant administration of PGE1 and GGA or CET increased UDP-Gal-T activity even with indomethacin to the levels achieved when these antiulcer drugs were administered without indomethacin. Our findings suggest that GGA and CET exert antiulcer effects by increasing mucus glycoprotein synthesis and that endogenous PG synthesis may be involved in this process. However, mechanisms not mediated by endogenous PGs may also exist in the stimulatory action of GGA on UDP-Gal-T activity. |
Keywords | antiulcer drug galactosyltransferase prostaglandin mucin |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1997-10 |
Volume | volume51 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 245 |
End Page | 249 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 9359921 |
Web of Science KeyUT | A1997YD65300002 |
JaLCDOI | 10.18926/AMO/31695 |
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FullText URL | fulltext.pdf |
Author | Yoshioka, Masao| Mizuno, Motowo| Morisue, Yoshiko| Shimada, Morizou| Hirai, Michio| Nasu, Junichirou| Okada, Hiroyuki| Sakaguchi, Kousaku| Yamamoto, Kazuhide| Tsuji, Takao| |
Abstract | In autoimmune chronic active hepatitis (AIH) and primary biliary cirrhosis (PBC), various autoantibodies including anti-asialoglycoprotein receptor (ASGPR) antibodies have been found in patients' sera. We have previously developed a mouse monoclonal antibody against rat and human ASGPR. In this study, we developed a capture enzyme-linked immunosorbent assay (ELISA) for detection of anti-ASGPR antibodies using this monoclonal antibody and investigated the occurrence of anti-ASGPR antibodies in the sera of patients with various liver diseases. Serum samples were obtained from 123 patients with various liver diseases, including 21 patients with AIH and 40 patients with PBC. In this capture ELISA, the target antigen in the crude rat liver membrane extracts was captured on the ELISA wells by the ASGPR-specific mouse monoclonal antibody. Thus, the cumbersome process of antigen purification was rendered unnecessary. Using this capture ELISA, we detected the anti-ASGPR antibody in 67% of the patients with AIH, in 100% of the patients with PBC, and in 57% of the patients with acute hepatitis type A. However, the anti-ASGPR antibody was rarely detected in patients with other liver diseases such as primary sclerosing cholangitis and obstructive jaundice. Our findings suggest that this capture ELISA would be useful for the detection of anti-ASGPR antibodies in autoimmune liver diseases. |
Keywords | autoimmue hepatitis primary biliary cirrhosis asialoglycoprotein receptor autoantibodies |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-04 |
Volume | volume56 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 99 |
End Page | 105 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12002624 |
Web of Science KeyUT | 000175176900006 |
JaLCDOI | 10.18926/AMO/31715 |
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FullText URL | fulltext.pdf |
Author | Hirai, Michio| Mizuno, Motowo| Morisue, Yoshiko| Yoshioka, Masao| Shimada, Morizou| Nasu, Junichirou| Okada, Hiroyuki| Shimomura, Hiroyuki| Yamamoto, Kazuhide| Tsuji, Takao| |
Abstract | Anti-idiotype antibodies (Ab2) play an important role in the homeostasis of immune responses and are related to the development and the disease activity of certain autoimmune diseases. The asialoglycoprotein receptor (ASGPR) is considered one of the target antigens in the pathogenesis of autoimmune chronic active hepatitis (AIH). We previously developed a mouse monoclonal antibody (clone 8D7) which recognizes rat and human ASGPR. In this study, to help investigate the anti-ASGPR antibody-anti-idiotype antibody network in patients with AIH, we developed a syngeneic mouse monoclonal Ab2 to the 8D7 anti-ASGPR antibody (Ab1). One clone, designated as 3C8, tested positive for specific reactivity to 8D7-Ab1 and did not bind to other irrelevant immunoglobulins. By competitive inhibition assays, the binding of 8D7-Ab1 to liver membrane extracts, i.e., the crude antigen preparation, was inhibited by 3C8-Ab2 in a dose-dependent manner, and the binding of 8D7-Ab1 to 3C8-Ab2 was inhibited by the liver membrane extracts. In the immunohistochemical analysis, 3C8-Ab2 blocked the specific staining of sinusoidal margins of rat hepatocytes by 8D7-Ab1. These results suggest that 3C8 anti-idiotype antibody recognizes the specific idiotypic determinants within the antigen-binding site of 8D7-Ab1. |
Keywords | anti-idiotype antibody autoimmune hepatitis asialoglycoprotein receptor monoclonall antibody |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-06 |
Volume | volume56 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 135 |
End Page | 139 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12108584 |
Web of Science KeyUT | 000176521200003 |
JaLCDOI | 10.18926/AMO/31686 |
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FullText URL | fulltext.pdf |
Author | Ohya, Shogen| Mizuno, Motowo| Kawada, Mikihiro| Nasu, Junichirou| Okada, Hiroyuki| Shimomura, Hiroyuki| Yamamoto, Kazuhide| Fujita, Teizou| Tsuji, Takao| |
Abstract | We have previously developed an enzyme-linked immunosorbent assay (ELISA) to measure stool decay-accelerating factor (DAF) and found that stool DAF concentrations were significantly elevated in patients with colorectal cancer, suggesting that the measurement of stool DAF may be valuable for the detection of colorectal cancer. In order to refine the assay for the measurement of stool DAF, we investigated 1) effects of centrifugation of stool samples, 2) effects of detergents, and 3) adequate combination of various anti-DAF monoclonal antibodies for the ELISA system using only monoclonal antibodies. We found that high-speed centrifugation could be omitted and that only the removal of large undigested food residues by centrifugation of short duration in a low-speed benchtop microcentrifuge sufficed to adequately prepare the stool samples. Addition of 2 detergents, octyl beta-glucoside and sodium deoxycholate, known to solubilize glycosyl-phosphatidylinositol-anchored proteins such as DAF, did not influence stool DAF values. By using 2 mouse anti-DAF monoclonal antibodies (clone 4F11 and 1C6), we were able to achieve a stable ELISA for the measurement of stool DAF using a uniform source of antibodies. The results should allow us to consistently apply the DAF assay for routine use in the detection of colorectal cancer. |
Keywords | decay-accelerating factor (DAF) colorectal cancer enzyme-linked immunosorbent assay (ELISA). monoclonal sntibodies |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-08 |
Volume | volume56 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 171 |
End Page | 176 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12199521 |
Web of Science KeyUT | 000177382600001 |
JaLCDOI | 10.18926/AMO/31684 |
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FullText URL | fulltext.pdf |
Author | Ariyoshi, Masanori| MIzuno, Motowo| Morisue, Yoshiko| Shimada, Morizou| Fujita, Shirou| Nasu, Junichirou| Okada, Hiroyuki| Shimomura, Hiroyuki| Yamamoto, Kazuhide| Tsuji, Takao| |
Abstract | We developed a monoclonal antibody (MoAb) (clone 5E8) against an antigen on the bile canalicular membrane of rat hepatocyte. By immunoblotting, MoAb 5E8 detected a band of 110 kD. In this study, we used the phage display technique to identify the target antigen recognized by MoAb 5E8. We screened a random phage display library expressing 12-mer peptide sequences and identified a peptide sequence, FHFNPYTGHPLT, as an epitope. We compared this peptide sequence with those of dipeptidyl peptidase IV (DPP IV, E.C.3.4.14.5) and Cell-CAM105, which proteins were located by a database search based on the information of tissue localization and approximate molecular weight of the MoAb 5E8 antigen, and sequence similarity with a region in DPP IV (amino acids 225-233) but not with Cell-CAM105 was found. In addition, we immunohistochemically stained various tissues (liver, small intestine, and kidney) of Japanese Fischer 344 rats, known to be deficient for DPP IV, with MoAb 5E8 and showed that the expression of MoAb 5E8 antigen was negligible or weak. In contrast, tissues sampled from the same organs of Sprague-Dawley rats, known to express DPP IV, were positively stained. These findings suggest that the antigen recognized by MoAb 5E8 is DDPIV and its major epitope is located in amino acids at positions 225-233. |
Keywords | random phage display library dipeptidyl petidase IV monoclonal antibody epitope bile canalicular membrane |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-08 |
Volume | volume56 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 187 |
End Page | 191 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12199523 |
Web of Science KeyUT | 000177382600003 |
Author | Morimoto, Yoshinori| Iwagaki, Hiromi| Morishita, Norio| Nakagawa, Hitoshi| Matsubara, Nagahide| Isozaki, Hiroshi| Kaji, Eisuke| Okada, Hiroyuki| Mizuno, Motoo| Shiratori, Yasushi| Tnaka, Noriaki| |
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Published Date | 2005-09-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume115 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/32894 |
---|---|
FullText URL | fulltext.pdf |
Author | Mifune, Hirofumi| Akaki, Shiro| Ida, Kentaro| Sei, Tetsuro| Kanazawa, Susumu| Okada, Hiroyuki| |
Abstract | <P>To evaluate the ability of multidetector-row CT (MDCT) to predict a risk of hemorrhage in patients with esophageal varices, a total of 40 MDCT scans were performed in 29 patients who had been diagnosed with esophageal varices by conventional upper gastrointestinal tract endoscopy. In 11 patients, MDCT was performed both before and after endoscopic injection sclerotherapy (EIS). Endoscopically, the red color sign (RC sign) was present in 28 scans. Of the 11 patients who underwent EIS, the RC sign disappeared after EIS in 9. The MDCT scans were obtained in the arterial, portal, and equilibrial phases, and the portal phase images were used in this study. Subsequently, the extent of esophageal varices was categorized into four MDCT scores. The variceal score, the maximum short axis of the varices, and the presence of palisade vein dilatation obtained from MDCT had significant correlation with endoscopic variceal forms, and the presence and severity of RC sign, respectively (p<0.01). All cases with a maximum minor axis of more than 4 mm showed positive RC sign. MDCT was useful in the evaluation of esophageal varices for predicting a risk of hemorrhage. |
Keywords | esophageal varices red color sign MDCT |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2007-10 |
Volume | volume61 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 247 |
End Page | 254 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 17971841 |
Web of Science KeyUT | 000250431700002 |
Author | Yagi, Toru| Kawahara, Yoshiro| Okada, Hiroyuki| Takemoto, Koji| Kato, Jun| Kobayashi, Yoshiyuki| Kawamoto, Hirofumi| Yamamoto, Kazuhide| |
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Published Date | 2008-01-04 |
Publication Title | 岡山医学会雑誌 |
Volume | volume119 |
Issue | issue3 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/30992 |
---|---|
FullText URL | fulltext.pdf |
Author | Ishikawa, Shigenao| Inaba, Tomoki| Mizuno, Motowo| Okada, Hiroyuki| Kuwaki, Kenji| Kuzume, Toshiaki| Yokota, Hitomi| Fukuda, Yasuyo| Takeda, Kou| Nagano, Hiroshi| Wato, Masaki| Kawai, Kozo| |
Abstract | Upper gastrointestinal bleeding is a major adverse event of non-steroidal anti-inflammatory drugs (NSAIDs), and co-administration of proton pump inhibitors and H2 receptor antagonists has been established as a means of preventing such an eff ect. However, the incidence of bleeding associated with NSAID-induced ulcers under conditions where such strong anti-acid agents are used for prevention has yet to be clarified. We aimed to determine the annual incidence of serious upper gastrointestinal ulcer bleeding among Japanese patients in whom NSAIDs were used in our hospital. Before commencing the study, we recommended to all the physicians in our hospital the best method for caring for NSAID users, focusing on the concomitant use of proton pump inhibitors or H2 receptor antagonists. We conducted a cohort study involving 17,270 patients for whom NSAIDs had been newly prescribed. Bleeding from gastric ulcers was observed in 8 of the 17,270 patients using NSAIDs (0.05%). The pooled incidence rate for bleeding was calculated as 2.65 (95% confidence interval, 2.56-2.74) and 1.29 (1.27-1.31) per 1,000 patient years for low-dose aspirin and non-aspirin NSAID users, respectively. None of the bleeding ulcer patients required blood transfusion or were in serious condition. In conclusion, gastric ulcer bleeding occurred in low-dose aspirin or non-aspirin NSAID users, but its incidence was low and outcomes were not serious when adequate preventive measures were taken. |
Keywords | hemorrhage non-steroidal anti-inflammatory drugs peptic ulcer prevention |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2008-02 |
Volume | volume62 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 29 |
End Page | 36 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 18323869 |
Web of Science KeyUT | 000253549500005 |
Author | Inoue, Masafumi| Okada, Hiroyuki| Kawahara, Yoshiro| Kawano, Seiji| Yamamoto, Kazuhide| |
---|---|
Published Date | 2009-08-03 |
Publication Title | 岡山医学会雑誌 |
Volume | volume121 |
Issue | issue2 |
Content Type | Journal Article |
Author | Kawano, Seiji| Okada, Hiroyuki| Kawahara, Yoshiro| Inoue, Masafumi| Yamamoto, Kazuhide| |
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Published Date | 2009-08-03 |
Publication Title | 岡山医学会雑誌 |
Volume | volume121 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/45269 |
---|---|
FullText URL | 65_2_105.pdf |
Author | Tsuzuki, Takao| Okada, Hiroyuki| Nasu, Junichiro| Takenaka, Ryuta| Inoue, Masafumi| Kawano, Seiji| Kita, Masahide| Hori, Keisuke| Yamamoto, Kazuhide| |
Abstract | The objectives of this study were to evaluate the accuracy of endoscopic ultrasonography (EUS) in local and regional staging of early gastric cancer, to analyze the factors influencing the accuracy of EUS, and to reveal the usefulness and problems of EUS in pre-treatment staging of gastric cancer. We examined 105 lesions in 104 patients with histologically confirmed gastric cancer and retrospectively evaluated them with EUS. The diagnostic accuracy, sensitivity, and specificity of EUS were determined by comparing the pre-treatment EUS with the postoperative histopathological findings. The overall diagnostic accuracy of EUS for the depth of cancer invasion was 86%. The overall sensitivity and specificity were 60% and 96%, respectively. The accuracy significantly declined in lesions located in the upper-third of the stomach (70%). Type 0-I lesions tended to be over-staged (12&), and the upper-third lesions tended to be under-staged (23%). The accuracy significantly declined in differentiated adenocarcinoma with massive submucosal invasion (56.5%). EUS is useful for evaluating the depth of gastric cancer invasion which determines the feasibility of endoscopic treatment. However, it is noteworthy that the diagnostic accuracy of the invasion depth diminished for lesions in the upper third of the stomach. |
Keywords | endoscopic ultrasonography early gastric cancer accuracy sensitivity specificity |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-04 |
Volume | volume65 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 105 |
End Page | 112 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21519368 |
Web of Science KeyUT | 000289818800006 |
Author | Okada, Hiroyuki| |
---|---|
Published Date | 2012-12-03 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue3 |
Content Type | Journal Article |
Author | Takata, Katsuyoshi| Sato, Yasuharu| Nakamura, Naoya| Tokunaka, Mami| Miki, Yukari| Kikuti, Yara Yukie| Igarashi, Kazuhiko| Ito, Etsuro| Harigae, Hideo| Kato, Seiichi| Hayashi, Eiko| Oka, Takashi| Hoshii, Yoshinobu| Tari, Akira| Okada, Hiroyuki| Mohamado, ABD Alkader Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Kinoshita, Tomohiro| Yoshino, Tadashi| |
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Published Date | 2013-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue2 |
Content Type | Journal Article |
Author | Nakarai, Asuka| Kato, Jun| Hiraoka, Sakiko| Kuriyama, Motoaki| Inokuchi, Toshihiro| Takei, Daisuke| Moritou, Yuki| Akita, Mitsuhiro| Takahashi, Sakuma| Harada, Keita| Okada, Hiroyuki| Yamamoto, Kazuhide| |
---|---|
Published Date | 2013-12-02 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue3 |
Content Type | Journal Article |
Title Alternative | Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars |
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FullText URL | 126_127.pdf |
Author | Iwamuro, Masaya| Okamoto, Yuko| Murata, Toshihiro| Kawai, Yoshinari| Shiraha, Hidenori| Okada, Hiroyuki| Yamamoto, Kazuhide| |
Abstract | The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm-1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars. |
Keywords | 柿胃石(gastric phytobezoar) タンニン酸(tannic acid) 消化管異物(gastrointestinal foreign body) 成分分析(component analysis) |
Publication Title | 岡山医学会雑誌 |
Published Date | 2014-08-01 |
Volume | volume126 |
Issue | issue2 |
Start Page | 127 |
End Page | 131 |
ISSN | 0030-1558 |
language | Japanese |
Copyright Holders | Copyright (c) 2014 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.126.127 |
NAID | 130004685263 |