| JaLCDOI | 10.18926/15001 |
|---|---|
| Title Alternative | アトピー型および非アトピー型気管支喘息の発作発症機序の差異について･･･ロイコトリエンC4の役割について |
| FullText URL | 067_021_027.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | Concentrations of main bronchoconstricting chemical mediators, histamine and leukotriene C4 (LTC4), were measured in bronchoalveolar lavage (BAL) fluid, and when cells (peripheral leukocytes and BAL cells) were stimulated by Ca ionophore A23187, in 7 atopic and 7 nonatopic asthma patients. 1. The proportion of basophilic cells was significantly larger in atopic than in nonatopic asthma (p<0.05), however no significant difference was present in the other BAL cells between the two asthma types. 2. Concentration of histamine in BAL fluid was significantly higher in atopic than that in nonatopic asthma, however, difference in that of LTC4 was not found between them. 4. The release of LTC 4 from BAL cells was higher in nonatopic than that in atopic asthma, but this was not significant. In contrast, the release of histamine was significantly higher in atopic compared to that in nonatopic asthma (p<0.001) when the cells were stimulated by Ca ionophore A23187. These results suggest that both histamine and LTC4 participate in the onset mechanism of atopic asthma, and only LTC4 in that of nonatopic asthma. |
| Keywords | Histamine LTC4 atopic nonatopic BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307446 |
| JaLCDOI | 10.18926/15002 |
|---|---|
| Title Alternative | Ia型(単純気管支れん縮型)喘息における気道過敏性について…年齢および気管支肺胞洗浄液中の細胞成分との関連について |
| FullText URL | 067_028_034.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Bronchial hyperresponsiveness was examined in relation to age, ventilatory function, and the proportion of bronchoalveolar lavage (BAL) cells in 39 patients with type Ia asthma (simple bronchoconstriction) (25 with type Ia-1 and 14 with type Ia-2), classified by clinical symptoms. 1. The proportion of BAL eosinophils was significantly higher in type Ia-2 than that in type Ia-1 asthma patients. 2. Bronchial reactivity to methacholine was not different between type Ia-1 and type Ia-2 asthma patients. 3. Bronchial hyperreactivity tended to decrease as patient age was higher in both types of asthma. Neither ventilatory function (FEV1.0%) nor the proportions of BAL lymphocytes and neutrophils was not correlated with bronchial hyperresponsiveness in both types of asthma. 4. Bronchial reactivity to methacholine more dereased with the increase in the proportion of BAL eosinophils in both type Ia-1 and Ia-2 asthma patients. The results show that bronchial hyperresponsiveness in patients with type Ia asthma is correlated to patients age and the proportion of BAL eosinophils. |
| Keywords | Bronchial hyperresponsiveness Type Ia asthma Patient age BAL eosinophiIs |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 28 |
| End Page | 34 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307134 |
| JaLCDOI | 10.18926/15006 |
|---|---|
| Title Alternative | 気管支喘息におけるエゴマ油と白血球のロイコトリエンB4,C4合成 |
| FullText URL | 067_035_042.pdf |
| Author | Ashida, Kozo| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| Yamamoto, Junko| Tsuji, Takao| |
| Abstract | In recent years, it has been noted that there is a close correlation between leukotrienes and late asthmatic reaction (LAR). In this study, effects of dietary supplementation with perilla seed oil rich in alpha-linolenic acid, which is speculated to affect the generation of leukotrienes through metabolism of arachidonic acid (AA), were evaluated in 6 patients with asthma. The symptoms and ventilatory function were improved after 2-week dietary supplementation with perilla seed oil. The generation of LTB4 and LTC4 by peripheral leucocytes stimulated with Ca ionophore A23187 was significantly suppressed by the dietary supplementation (LTB4 and LTC4 ; p<0.05). Regarding the composition of fatty acids in serum phospholipids, the concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and AA tended to increase after the supplementation, accompanied with an increase in the ratio of EPA to AA. These results suggest that dietary supplementation with perilla seed oil brings beneficial effects in the treatment of asthma. |
| Keywords | n-3系脂肪酸 (n-3 fatty acids) 気管支喘息 (bronchial asthma) アラキドン酸 (arachidonic acid) LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 35 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307804 |
| JaLCDOI | 10.18926/15007 |
|---|---|
| Title Alternative | 温泉療法による気管支喘息患者の心理的障害の改善 |
| FullText URL | 067_043_049.pdf |
| Author | Yokota, Satoshi| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine| |
| Abstract | To evaluate improvement of mental disorders by spa therapy for 1-2 months, three kinds of psychological examinations, CMI (Cornel Medical Index), SDS (Selfrating Depression Scale) and CAI (Comprehensive Asthma Inventory) tests, were performed in 37 patients with asthma before and after spa therapy. 1. In CMI test, the scores of physical symptoms, respiratory symptoms, and CIJ symptoms significantly decreased after spa therapy. The score of psychical symptoms tended to decrease after the therapy, however, this was not significant. 2. The mean score of the subjects over 40 points in SDS test significantly decreased from 45.7 points before spa therapy to 37.5 after the therapy. 3. Mental disorders evaluated by various categories in CAI test were significantly improved after spa therapy. The average score in CAI test significantly decreased from 37.1 to 27.8 after the therapy. These results demonstrate that psychological disorders in patients with asthma are improved by spa therapy. |
| Keywords | 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 心理テスト（CMI, SDS, CAI) (CMI test, SDS test, CAI test) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 43 |
| End Page | 49 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307273 |
| JaLCDOI | 10.18926/15008 |
|---|---|
| Title Alternative | 中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化 |
| FullText URL | 067_050_056.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/mℓ was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma. |
| Keywords | IgE RAST 吸入抗原 (inhalant Allergen) 気管支喘息 (Bronchial asthma) 加令 (aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 50 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307989 |
| JaLCDOI | 10.18926/15087 |
|---|---|
| Title Alternative | 気管支喘息症例に対する鼻腔内ステロイド療法 |
| FullText URL | 067_057_062.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100mℓ a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity. |
| Keywords | bronchial asthma (気管支喘息) rhinitis (鼻炎) intranasal steroid therapy (鼻腔内吸入ステロイド療法) expectoration (喀痰排出) peak expiratory flow (ピークフロー) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307814 |
| JaLCDOI | 10.18926/15088 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 |
| FullText URL | 067_063_070.pdf |
| Author | Hosaki, Yasuhiro| Nawa, Yuichiro| Takeuchi, Kazuaki| Tsugeno, Hirofumi| Ashida, Kozo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. |
| Keywords | Thermography (サーモグラフィー) Diabetes Mellitus (糖尿病) Peripheral Circulation (末梢循環) Cold Loading (冷水負荷) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307566 |
| JaLCDOI | 10.18926/15091 |
|---|---|
| Title Alternative | Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数 |
| FullText URL | 067_079_084.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging. |
| Keywords | Asthma classification (喘息分類) BAL lymphocytes (BALリンパ球) BAL neutrophils (BAL好中球) % V25 value Ⅱ型喘息 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307924 |
| JaLCDOI | 10.18926/15092 |
|---|---|
| Title Alternative | Spa therapy and drug therapy in patients with bronchial asthma |
| FullText URL | 067_107_114.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kouzou| Yokota, Satoshi| Takeuchi, Kazuaki| Nawa, Yuichiro| |
| Abstract | 気管支喘息は,その臨床病態より,Ia.単純性気管支攣縮型,Ib.気管支痙攣縮+過分泌型,Ⅱ.細気管支閉塞型の3つの基本病型に分けることができる｡また,発症病態からは,アトピー型と非アトピー型に分けられる｡気管支喘息に対する温泉療法や薬物療法の際には,これらの臨床病態や発症病態を十分把握した上で最も適切な治療法を選ぶ必要がある｡気管支喘息に対する薬物療法では,気管支拡張薬,去痰薬,抗アレルギー薬,副腎皮質ホルモンなどがその主たるものであるが,特に薬物療法では気管支拡張作用と抗炎症作用が重要である｡一方,温泉療法では,気道の浄化作用や気管支粘膜の正常化作用などが得られ,臨床病型では,過分泌型や細気管支閉塞型に対してより効果的である｡また,発症病態からすれば,アトピー型ではヒスタミンとロイコトリエンが,非アトピー型ではロイコトリエンがより優勢な化学伝達物質であり,このような発症病態を十分把握した上で,適切な抗アレルギー薬を選ぶ必要が ある｡ |
| Keywords | 気管支喘息 (bronchial asthma) 臨床病型 (clinicaI classification) アトピー型 (atopic asthma) 温泉療法 (spa therapy) 薬物療法 (drug therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 107 |
| End Page | 114 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307684 |
