| Author | Ino, Takayoshi| |
|---|---|
| Published Date | 1985-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume3 |
| Content Type | Others |
| Title Alternative | Pharmacokinetic analysis of drug absorption following nasal application to rats |
|---|---|
| FullText URL | poalas_033_003_007.pdf |
| Author | 古林 呂之| |
| Abstract | Since a drug applied to the nose in an in vivo physiologic condition is translocated to the gastrointestinal (GI) tract by mucociliary clearance (MC), the drug undergoes absorption both from the nasal cavity and from the GI tract. The detailed MC of the rat was examined, using inulin as a marker of the applied solution. Inulin disappeared monoexponentially from the nasal cavity, indicating that the MC can be assumed to follow first-order kinetics. In the proposed kinetic model, the fractional absorption of the drug following nasal application is predicted as the sum of fractional absorption from the nasal cavity and fractional absorption from the GI tract, both of which are estimated indirectly from the permeability to the Caco-2 monolayer. This kinetic model is the first estimation system for nasal drug absorption based on drug disposition after nasal application and is useful for the development of nasal dosage forms. |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Published Date | 2017-04 |
| Volume | volume33 |
| Start Page | 3 |
| End Page | 7 |
| language | Japanese |
| File Version | publisher |
| Author | 金田 平八郎| |
|---|---|
| Published Date | 1985-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume3 |
| Content Type | Others |
| Author | Sasaoka, Eiji| |
|---|---|
| Published Date | 1982-11-01 |
| Publication Title | 岡山大学環境管理センター報 |
| Volume | volume4 |
| Content Type | Others |
| Author | Ohwada, Kazuo| |
|---|---|
| Published Date | 2013-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume29 |
| Content Type | Others |
| Author | 梅本 春次| |
|---|---|
| Published Date | 1957-03 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume18 |
| Content Type | Others |
| Author | Shimizu, Nobuyoshi| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Others |
| Author | 王 楠田| |
|---|---|
| Published Date | 1999-09 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume16 |
| Content Type | Others |
| Author | Takahashi, Sumio| |
|---|---|
| Published Date | 1995-07 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume12 |
| Content Type | Others |
| Author | 岡山大学経済学会| |
|---|---|
| Published Date | 2009-03-10 |
| Publication Title | 岡山大学経済学会雑誌 |
| Volume | volume40 |
| Issue | issue4 |
| Content Type | Others |
| Author | Okitsu, Osamu| Miyake, Kaoru| |
|---|---|
| Published Date | 2002-09 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume19 |
| Content Type | Others |
| Author | Iwachido, Tadashi| |
|---|---|
| Published Date | 1990 |
| Publication Title | 環境制御 |
| Volume | volume12 |
| Content Type | Others |
| Author | Satoh, Akira| |
|---|---|
| Published Date | 2011-05 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume27 |
| Content Type | Others |
| Author | Kamishima, Yoshihisa| |
|---|---|
| Published Date | 1999-09 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume16 |
| Content Type | Others |
| Author | 林田 実| |
|---|---|
| Published Date | 2001-06-09 |
| Publication Title | 岡山大学算数・数学教育学会誌 : パピルス |
| Volume | volume8 |
| Content Type | Others |
| Author | Liu, Yan Wei| |
|---|---|
| Published Date | 1994-07 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume11 |
| Content Type | Others |
| Author | 龍味 哲夫| |
|---|---|
| Published Date | 1993-06 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume10 |
| Content Type | Others |
| FullText URL | olj_68_3-4_949_961.pdf |
|---|---|
| Publication Title | Okayama Law Journal |
| Published Date | 2019-03-19 |
| Volume | volume68 |
| Issue | issue3-4 |
| Start Page | 949 |
| End Page | 961 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| Title Alternative | Professor Ryohei Nakamura＇s Brief Biography and List of Publications |
|---|---|
| FullText URL | oer_049_2_127_135.pdf |
| Author | 岡山大学経済学会| |
| Publication Title | Okayama Economic Review |
| Published Date | 2018-02-26 |
| Volume | volume49 |
| Issue | issue2 |
| Start Page | 127 |
| End Page | 135 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2018 岡山大学経済学会 |
| File Version | publisher |
| FullText URL | olj_67_3-4_565.pdf |
|---|---|
| Author | 岡山大学法学会| |
| Publication Title | Okayama Law Journal |
| Published Date | 2018-03-20 |
| Volume | volume67 |
| Issue | issue3・4 |
| Start Page | 565 |
| End Page | 568 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
