ID | 58212 |
Sort Key | 5
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Title Alternative | Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
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FullText URL | |
Author |
三浦 公
Department of Internal Medicine, Tsuyama Chuo Hospital
Iwamuro, Masaya
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences
ORCID
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Toyokawa, Tatsuya
Department of Gastroenterology, Fukuyama Medical Center
Takenaka, Ryuta
Department of Internal Medicine, Tsuyama Chuo Hospital
Inoue, Masafumi
Department of Gastroenterology, Okayama Red Cross Hospital
Ito, Mamoru
Department of Internal Medicine, Okayama Saiseikai General Hospital
Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences
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Abstract | To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
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Keywords | 機能性ディスペプシア (functional dyspepsia)
ヘリコバクター・ピロリ (Helicobacter pylori)
プロトンポンプ阻害剤 (proton pomp inhibitor)
消化管運動機能改善剤 (acotiamide)
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Note | 原著(Original)
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Publication Title |
Journal of Okayama Medical Association
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Published Date | 2019-12-02
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Volume | volume131
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Issue | issue3
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 139
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End Page | 143
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Related Url | isVersionOf https://doi.org/10.4044/joma.131.139
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OAI-PMH Set |
岡山大学
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language |
Japanese
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Copyright Holders | Copyright (c) 2019 岡山医学会
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File Version | publisher
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Refereed |
True
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DOI | |
NAID | |
Eprints Journal Name | joma
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