| Author | Akagi, Kaoru| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Shinohara, Toshio| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Shinohara, Toshio| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50409 |
|---|---|
| FullText URL | 67_3_165.pdf |
| Author | Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro| |
| Abstract | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. |
| Keywords | breast cancer neoadjuvant chemotherapy predictors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804139 |
| Web of Science KeyUT | Pretreatment Specimen Predicts |
| JaLCDOI | 10.18926/AMO/50410 |
|---|---|
| FullText URL | 67_3_171.pdf |
| Author | Hashimoto, Atsunori| Ueda, Takahiro| Kuboyama, Kazutoshi| Yamada, Taihei| Terashima, Mariko| Miyawaki, Atsushi| Nakao, Atsunori| Kotani, Joji| |
| Abstract | On April 25, 2005, a Japanese express train derailed into a building, resulting in 107 deaths and 549 injuries. We used “First Impression Triage (FIT)”, our new triage strategy based on general inspection and palpation without counting pulse/respiratory rates, and determined the feasibility of FIT in the chaotic situation of treating a large number of injured people in a brief time period. The subjects included 39 patients who required hospitalization among 113 victims transferred to our hospital. After initial assessment with FIT by an emergency physician, patients were retrospectively reassessed with the preexisting the modified Simple Triage and Rapid Treatment (START) methodology, based on Injury Severity Score, probability of survival, and ICU stay. FIT resulted in shorter waiting time for triage. FIT designations comprised 11 red (immediate), 28 yellow (delayed), while START assigned six to red and 32 to yellow. There were no statistical differences between FIT and START in the accuracy rate calculated by means of probability of survival and ICU stay. Overall validity and reliability of FIT determined by outcome assessment were similar to those of START. FIT would be a simple and accurate technique to quickly triage a large number of patients. |
| Keywords | simple triage and rapid treatment injury severity score probability of survival |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 171 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804140 |
| Web of Science KeyUT | 000320747900006 |
| Author | Ohsumi, Michiko| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ohsumi, Michiko| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kitajima, Koichi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ichiyama, Takuji| |
|---|---|
| Published Date | 1963-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume75 |
| Issue | issue4-6 |
| Content Type | Journal Article |
| Author | Kitajima, Koichi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kitajima, Koichi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kiyama, Takashi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Shimizu, Hiroshi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ichiyama, Takuji| |
|---|---|
| Published Date | 1963-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume75 |
| Issue | issue4-6 |
| Content Type | Journal Article |
| Author | Shimizu, Hiroshi| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Higashi, Tohru| Mori, Akitane| Yoshikawa, Tamotsu| |
|---|---|
| Published Date | 1960-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50411 |
|---|---|
| FullText URL | 67_3_177.pdf |
| Author | Matsuo, Toshihiko| Yamasaki, Hanako| Yasuhara, Hirotaka| Hasebe, Kayoko| |
| Abstract | To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed statistically by repeated-measure analysis of variance. When subjectsｾ eyes were closed, the total linear length (cm) and the unit-time length (cm/sec) of the sway path were significantly shortened during the 60-minute prism-wearing (p＜0.05). No significant change was noted in any stabilometric parameters obtained with the eyes open during the time course. In conclusion, postural stability did not change with the eyes open in the condition of large vertical diplopia, induced by prism-wearing for 60min, while the stability became better when measured with the eyes closed. A postural control mechanism other than that derived from visual input might be reinforced under abnormal visual input such as non-fusionable diplopia. |
| Keywords | body sway postural stability (postural control) stabilometry prism vertical diplopia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 183 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804141 |
| Web of Science KeyUT | 000320747900007 |
| JaLCDOI | 10.18926/AMO/50412 |
|---|---|
| FullText URL | 67_3_185.pdf |
| Author | Misawa, Haruo| Tanaka, Masato| Sugimoto, Yoshihisa| Koshimune, Kouichiro| Ozaki, Toshifumi| |
| Abstract | Cervical misalignment after upper cervical fusion including the occipital bone may cause trismus or dysphagia, because the occipito-atlanto joint is associated with most of the flex and extended motion of the cervical spine. There are no reports of dysphagia and trismus after C1-2 fusion. The purpose of this paper is to demonstrate the potential risk of dysphagia and trismus even after upper cervical short fusion without the occipital bone. The patient was a 69-year-old man with myelopathy caused by os odontoideum and Klippel-Feil syndrome, who developed dysphagia and trismus immediately after C1-2 fusion and C3-6 laminoplasty. Radiographs and CT revealed that his neck posture was extended, but his symptoms still existed a week after surgery. The fixation angle was hyperextended 12 days after the first surgery. His symptoms disappeared immediately after revision surgery. The fixation in the neck-flexed position is thought to be the main cause of the patientʼs post-operative dysphagia and trismus. Dysphagia and trismus may occur even after short upper cervical fusion without the occipital bone or cervical fusion in the neck-extended position. The pre-operative cervical alignment and range of motion of each segment should be thoroughly evaluated. |
| Keywords | dysphagia trismus os odontoid Klippel-Feil syndrome atlantoaxial posterior fusion |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 190 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804142 |
| Web of Science KeyUT | 000320747900008 |
| Author | Kosaka, Kiyowo| Nagashima, Hideo| Shimada, Yoshihiro| Yamabuki, Takahiro| Kawaguchi, Masamitsu| Yamamoto, Shigeru| Ohta, Yasuyuki| Ujike, Mutsuo| Kusaka, Yoshiro| Mitsuda, Toshihiro| Kihara, Tsuyoshi| Kondo, Tadasuke| Haraoka, Syoichi| Amioka, Tadashi| Ishimitsu, Tetsusaburo| Kono, Hiroya| Mitsumoto, Toshiro| Aisaka, Tadakazu| Kosaka, Chuihiro| Moritani, Yui| Tabuchi, Hiroshi| Hashimoto, Kyoji| Kimura, Kenichi| Kono, Hiroshi| Tamao, Hiroyasu| Higuchi, Yosimitsu| Yahata, Katsumi| Imai, Harujiro| Kameyama, Ichiro| Ariji, Sumiro| Fujimori, Yasuhiko| Nakagawa, Syoso| Hirano, Yutaka| Kobayashi, Toshinari| Seido, Ichiro| Tanabe, Isao| Takeda, Kazuhisa| Hayashi, Shinichiro| |
|---|---|
| Published Date | 1960-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume72 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Namba, Katsuichi| |
|---|---|
| Published Date | 1963-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume75 |
| Issue | issue4-6 |
| Content Type | Journal Article |
