ID | 13219 |
Eprint ID | 13219
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FullText URL | |
Title Alternative | Apoe+/-ldlr+/- mice as a useful model to evaluate accelerated atherogenesis by Helicobacter pylori infection
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Author |
Cui, Jinhua
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Abstract | Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.
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Keywords | 動脈硬化 (atherosclerosis)
ヘリコバクター・ピロリ (Helicobacter pylori)
熱ストレスタンパク60 (heat shock protein 60)
Tリンパ球 (T-lymphocytes)
apoe+/-ldlr+/-ヘテロダブルノックアウトマウス (apoe+/-ldlr+/- mice)
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Note | 原著
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Published Date | 2008-01-04
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume119
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Issue | issue3
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 253
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End Page | 260
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ISSN | 00301558
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NCID | AN00032489
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Content Type |
Journal Article
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Related Url | http://www.okayama-u.ac.jp/user/oma/
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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DOI | |
Eprints Journal Name | joma
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