| JaLCDOI | 10.18926/14782 |
|---|---|
| Title Alternative | Spa therapy for patients with respiratory disease. Analysis of 2295 patients admitted at Misasa Medical Center for last 22 years from 1982 to 2003 |
| FullText URL | 74_001_010.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| |
| Abstract | 1982年から2003年までの22年間に当医療センターで入院加療した2295例を対象に5年間毎にその年次推移を検討した｡2295例のうちわけは,気管支喘息1400例(61.0%),COPD510例(22.2%),その他385例であった｡1.気管支喘息は,第1期(1982-1986年)の5年間では,平均11.4例/年であったが第4期(1997-2001年)では平均93例と初期と比べ8.2倍の増加が見られた｡また,第5期(最近の2年間)では87.0例/年であった｡そのなかのSDIA(steroid-dependentintractableasthma)の頻度は初期の68.4%から第4期では29.0%,第5期23.6%にまで低下する傾向を示した｡ 2.COPD症例は,初期の5年間(1982-1986年)では平均5.2例/年から第4期には44.6例/年へと8.7倍の,また第5期では47.5例/年へと9.1倍の増加が見られた｡また,そのなかの肺気腫が占める割合は初期の19.2%から第4期では76.7%,第5期では87.4%と明らかな増加傾向を示した. 3.気管支喘息およびCOPD症例の年齢別検討では,60歳以上の症例の頻度は第1期では30.1%であったが,第4期では68.0%,そして第5期では87.4%と,年々その頻度は高くなっていく傾向が見られた｡すなわち,最近22年間の年次推移からは,温泉療法を必要とする呼吸器疾患患者が増加しつつあること,そしてその年令は年々高くなる傾向にあることが示されている｡ |
| Keywords | 喘息 COPD 温泉療法 高齢者 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308446 |
| JaLCDOI | 10.18926/14783 |
|---|---|
| FullText URL | 74_011_017.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | Clinical effects of long-term spa therapy for 4 years were estimated in 8 patients of pulmonary emphysema (4 with spa therapy and 4 without spa therapy) by pulmonary function and morphological changes of peripheral airspaces of the lung on
high - resolution computed tomography (HRCT).
1 . The values of % FVC, % FEV1.0, and FEV 1.0% did not significantly change for 4year observation both in patients with spa therapy and those without spa therapy.
2. The OLco value significantly decreased from 69.9% at the initial level to 48.8% after 4-year observation in patients without spa therapy (p |
| Keywords | spa therapy (温泉療法) pulmonary emphysema (,肺気腫) % RV % DLco % low attenuation area of the lung |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 11 |
| End Page | 17 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308395 |
| JaLCDOI | 10.18926/14784 |
|---|---|
| Title Alternative | 長期間の喫煙は高齢者気管支喘息における気道過敏性と関連した白血球LTB4産生を亢進させる |
| FullText URL | 74_018_025.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | Abstract : Influence of cigarette smoking on leukotriene 84 (LTB4) generation by leucocytes associated with bronchial hyperresponsiveness was examined in 110 patients with asthma. l. The frequency of positive RAST score for inhalant allergens and LTB4 generation by leucocytes were significantly larger in previous and current smokers than in nonsmokers. 2. In nonsmokers, bronchial hyperresponsiveness was significantly higher in asthmatics under the age of 49 years compared with that in patients between 50 and 59 years, between 60 and 69 years, and those over age 70 years. In contrast, no significant differences were present between bronchial hyperresponsiveness and patient age in previous and current smokers. 3. In patients over age 60, bronchial hyperresponsiveness was significantly higher in previous and current smokers than in nonsmokers. In these patients, LTB4 generation was significantly more increased in previous and current smokers than in nonsmokers. 4. A significant correlation was observed in asthmatics of nonsmokers between LTB4 generation and bronchial hyperresponsiveness . 5. LTC4 generation was significantly higher in previous and current smokers than in nonsmokers in patients under age 49 years. These results show that in patients over age 60 years, cigarette smoking induces an increase in the generation of LTB4, leading to an increase in bronchial hyperresponsiveness . |
| Keywords | cigarette smoking asthma LTB4 generation LTC4 generation bronchial hyperresponsiveness |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 18 |
| End Page | 25 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308359 |
| JaLCDOI | 10.18926/14787 |
|---|---|
| FullText URL | 74_026_034.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | To determine the characteristics of the elderly in high - resolution computed tomography (HRCT) lung densitometry, mean lung density (MLD) and relative area of the lungs showing attenuation values less than -950 HU (RA(950)) on HRCT were evaluated in nonsmoking control subjects (n = 80) and patients with asthma (n = 80) in relation to their age and pulmonary function. MLD was significantly decreased, and RAW was significantly increased with increasing age in both asthmatics and controls. The MLD values were significantly lower in asthmatics compared with controls in subjects aged between 60 and 69 years and over age 70. RAgsov alues were significantly higher in asthmatics compared with controls in subjects aged between 50 and 59 years, between 60 and 69, and over 70. % FEV(1) and FEV(1) / FVC were significantly decreased in elderly asthmatic patients over 70 years of age compared with the values in those under 49. Percent residual volume (% RV) was significantly larger in patients over 70 years of age than in those between 50 and 59, and under 49 years. RAW was significantly larger in patients with steroid-dependent intractable asthma (SDIA) between 50 and 59 years of age, and between 60 and 69 compared with RA 950 in those without SDIA. However, RAW did not differ significantly between SDIA and non-SDIA in patients over age 70. The results suggested that in % LAA of the lungs on HRCT was significantly increased in the elderly subjects with and without asthma, and it was significantly higher in the elderly asthmatics than the elderly controls. |
| Keywords | aging (加齢) high-resolution computed tomography (高分解能CT) low attenuation area (低吸収域) mean lung density (平均CT値) pulmonary function (肺機能) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 26 |
| End Page | 34 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308286 |
| JaLCDOI | 10.18926/14788 |
|---|---|
| Title Alternative | 肺気腫と喘息のHRCT上のlow attenuation are（LAA）の性質の差。喫煙との関連を含めて |
| FullText URL | 74_035_041.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | The low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) was evaluated in 20 asthmatics (10 ex-smokers and 10 never-smokers) and 10 patients with pulmonary emphysema (all ex-smokers) by ventilatory function, lung volume, DLco, and a ratio of expiratory LAA/inspiratory LAA. 1 . The % LAA of the lungs on HRCT was significantly larger in patients with pulmonary emphysema(PE) than in those with asthma, but there was not significant difference in % LAA between ex-smokers and never-smokers of asthmatics. 2. A ratio of expiratory Winspiratory LAA was significantly higher in patients with PE than in those with asthma , and the ratio was significantly higher in ex-smokers of asthmatics than in never-smokers (p<0.05). 3 . The difference in % residual volume and % DLco was significant between asthma and PE , and between ex - smokers and never-smokers of asthmatics (% RV : p<0.05, DLco : p<0.05) . 4 . The difference in the values of % FVC, % FEV(1) .O, and FEV1.0% was significant between asthma and PE, but not significant between ex-smokers and never- smokers of asthmatics. The results suggest that the difference in a ratio of expiratory W inspiratory LAA, % RV and % DLco was significant between ex - smokers and never - smokers of asthmatics , and cigarette smoking induces more irreversible changes of the lungs. |
| Keywords | low attenuation area asthma pulmonary emphysema cigarette smoking |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 35 |
| End Page | 41 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308507 |
| JaLCDOI | 10.18926/14789 |
|---|---|
| Title Alternative | IgE系アレルギー反応はアトピー型気管支喘息の白血球ロイコトリエンB4（LTB4）およびC4（LTC4）産生を促進させ，喫煙は気道過敏性を亢進させる |
| FullText URL | 74_042_047.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | Influences of IgE-mediated allergy and cigarette smoking on pathophysiology, evaluated by bronchial hyperresponsiveness and the generation of LTB4 and LTC4, of asthma were examined in 69 patients with asthma sensitive to inhalant allergens such as house dust mite and Candida albicans.
1 . Bronchial byperresponsiveness was significantly higher in previous and current smokers of asthmatics than in never-smokers. 2 . The generation of leukotrienes 84 (LTB4) and C4 (LTC4) by leucocytes was significantly larger in patients with serum IgE over 350 IU/ml than in those with serum IgE less than 150 IU/ml (LTB4 : p |
| Keywords | lgE-mediated allergy bronchial hyperresponsiveness LTB4 LTC4 asthma cigarette smoking |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 42 |
| End Page | 47 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308637 |
| JaLCDOI | 10.18926/14800 |
|---|---|
| Title Alternative | QOL in LBP patients |
| FullText URL | 74_048_050.pdf |
| Author | Yokoi, Tadashi| Senda, Masuo| Hamada, Masanori| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Tanizaki, Yoshiro| Inoue, Hajime| |
| Abstract | 近年QOLが重視されるようになってきている。MOS short form 36 health survey（以下SF-36と略す）は，国際的レベルでの基準とされるべく開発された非疾患特異的HRQOL尺度である。今回，我々は当院でリハビリテーションをうけている腰痛症患者を対象に温泉療法のQOLに対する効果をSF－36を用いて調べた。SFL36の8項目をそれぞれ算出し，温泉療法前後での比較を行った。PCSは41.1から43.6へ, MCSは49.1から5l.0へ上昇したことより，身体・精神面ともに効果があると考えられた。 |
| Keywords | SF-36 生活の質 (QuaIity of Life) 腰痛症 (Low back Pain) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 48 |
| End Page | 50 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308493 |
| JaLCDOI | 10.18926/14809 |
|---|---|
| FullText URL | 74_051_056.pdf |
| Author | 北村 佳久| 三宅 悟| 横山 紀子| 川上 英治| 荒木 博陽| 柴田 和彦| 五味田 裕| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 新規ロイコトリエン（LT）受容体桔抗薬であるモンテルカスト服用によるテオフイリン服用患者の処方動向，臨床検査値ならびに患者の服用に対する意識について検討を行った。 その結果，テオフイリン服用患者177名の内，51％がLT受容体抵抗薬を併用しており，併用率はモンテルカストが最も多く，プランルカスとザフィルルカストの順であった。また，プランルカストからモンテルカストに変更された症例が多かった。臨床検査値はモンテルカスト服用により血中好酸球数の減少作用が認められた。肝機能検査値（AST・ALT・ALP）は影響しなかった。テオフイリン服用量はモンテルカスト併用服用により減量され，それに伴い血中濃度も低下した。しかしながら，血中濃度／投与量比は影響しなかったことより，モンテルカストはテオフイリンクリアランスに影響しないと考えられる。モンテルカストヘの変更により，患者の服薬コンプライアンスは良好に維持され，自覚する副作用の発現は認められ なかった。以上の結果，テオフイリン服用患者へのモンテルカスト併用投与は良好な服薬コンプライアンスを維持させ，さらにテオフイリンの体内動態に影響を及ぼすことなく，テオフイリンの投与量を減少させ，患者のQOLの向上につながると考えられる。 |
| Keywords | モンテルカスト テオフイリン 服薬コンプライアンス 血中濃度 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 51 |
| End Page | 56 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308033 |
| JaLCDOI | 10.18926/14810 |
|---|---|
| Title Alternative | 6種類の血中膵酵素値に及ぼす加齢および性の影響 |
| FullText URL | 74_057_061.pdf |
| Author | Seno, Toshinobu| Ochi, Koji| Mizushima, Takaaki| Shinji, Toshiyuki| Koide, Norio| |
| Abstract | The serum levels of some pancreatic enzymes have been reported to be affected by age and gender. Currently, serum total amylase, pancreatic isoamylase (P-amylase) , lipase , trypsin (ogen) , pancreatic phospholipase A(2) (PLA(2)) , and elastase I are utilized in diagnosing pancreatic diseases. We here compared age and gender-related alterations of these six pancreatic enzymes in healthy subjects to delineate different properties among the enzymes. Subjects were 155 males and 172 females between ages 20 and 79 years who were apparently healthy, and were stratified by age and sex. PLA(2) and elastase I were assayed by RIA, trypsin (ogen) by EIA and others by activity. The pancreatic enzymes, except PLA(2), were significantly elevated with age, although they declined in males in the 260 age group. There were significant sex differences in total amylase and P-amylase. Total amylase was significantly higher in females than in males in the 260 age group, P-amylase in the 40-49 age group. Age should be considered in the valuation of serum enzymes except PLA(2), sex difference should be considered in the valuation of amylase (total and P-amylase). |
| Keywords | pancreatic enzyme amylase phospholipase A(2) aging gender |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 57 |
| End Page | 61 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308272 |
| JaLCDOI | 10.18926/14811 |
|---|---|
| Title Alternative | Emphysematous changes of the lungs in asthmatics in the elderly. Differences between hyperinflation of the lungs by aging and pulmonary emphysema |
| FullText URL | 74_062_067.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | 高齢者喘息の病態的特徴を臨床的に観察した。その結果は以下のごとくであった。 1．血清IgE値や抗原に対するIgE抗体の陽性率は一般的に低いが，しかしアレルギー疾患の家族歴を有する症例の頻度は高く，アトピー性の素因を有する症例の頻度がかなり高いこと，そして，このような症例ではIgE系反応の関与が示唆された。 2．気道過敏性は加齢とともに低下する傾向が見られた。 3．換気機能，ガス交換能は加齢とともに低下し，特に70才以上 の症例では若青年者喘息と比べ有意の低下が見られた。 4．肺容積は，加齢とともに増大し，70才以上の症例では有意の増大傾向が見られた。また，この肺容積の増大は，HRCT上の－950HU以下の肺% UIAと有意の相関が見られ，肺の過膨張の状態が存在することが示唆された。 |
| Keywords | lgE系反応 (IgE-mediated allergy) 気道過敏性 (bronchial hyperresponsiveness) 換気機能 (ventilatory function) ガス交換能 (gas exchange) 気腫化傾向 (emphysematous changes) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 62 |
| End Page | 67 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308645 |
| Author | 西村 伸子| |
|---|---|
| Published Date | 2004-02-01 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Volume | volume74 |
| Content Type | Others |
| Author | 三朝医療センター| |
|---|---|
| Published Date | 2004-02-01 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Volume | volume74 |
| Content Type | Others |
