ID | 13758 |
Eprint ID | 13758
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FullText URL | |
Title Alternative | Expression of β(1) integrin and fibronectin in the glomeruli in patients with glomerulonephritis
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Author |
Kashitani, Tadatoshi
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Abstract | Integrins are a family of adhesion molecules which mediate adhesion and interaction between cells and extracellular matrix. The renal glomerulus is composed of cellular components and extracellular matrix. To clarify the role of integrins in the progression of glomer-ulonephritis, we examined the expression of β(1) integrin and fibronectin, which is a ligand of β(1) integrin, in the glomeruli in patients with IgA nephropathy and membranous nephropathy by an indirect immunofluorescence study and immunoelectron microscopic study using specific antibodies. β(1) integrin was expressed on the surface of mesangial cells, glomerular epithelial cells, endothelial cells and Bowman's capsullar epithelial cells in normal control glomeruli. The expression of β(1) integrin and fibronectin was increased in the mesangial area in patients with IgA nephropathy showing mesangial proliferation and mesangial matrix increase. β(1) integrin may play an important role in the construction of the glomerulus and also in the deposition of immunecomplex, proliferation of mesangial cells, and increase in extracellular matrix in IgA nephropathy.
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Keywords | β(1)インテグリン
フィブロネクチン
lgA腎症
膜性腎症
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Note | 原著
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Published Date | 1995-10-31
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume107
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Issue | issue9-10
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 195
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End Page | 204
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/107/9-10/107_9-10_195/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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