ID | 13758 |
Eprint ID | 13758
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フルテキストURL | |
タイトル(別表記) | Expression of β(1) integrin and fibronectin in the glomeruli in patients with glomerulonephritis
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著者 |
柏谷 忠俊
岡山大学医学部第三内科学教室
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抄録 | Integrins are a family of adhesion molecules which mediate adhesion and interaction between cells and extracellular matrix. The renal glomerulus is composed of cellular components and extracellular matrix. To clarify the role of integrins in the progression of glomer-ulonephritis, we examined the expression of β(1) integrin and fibronectin, which is a ligand of β(1) integrin, in the glomeruli in patients with IgA nephropathy and membranous nephropathy by an indirect immunofluorescence study and immunoelectron microscopic study using specific antibodies. β(1) integrin was expressed on the surface of mesangial cells, glomerular epithelial cells, endothelial cells and Bowman's capsullar epithelial cells in normal control glomeruli. The expression of β(1) integrin and fibronectin was increased in the mesangial area in patients with IgA nephropathy showing mesangial proliferation and mesangial matrix increase. β(1) integrin may play an important role in the construction of the glomerulus and also in the deposition of immunecomplex, proliferation of mesangial cells, and increase in extracellular matrix in IgA nephropathy.
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キーワード | β(1)インテグリン
フィブロネクチン
lgA腎症
膜性腎症
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備考 | 原著
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発行日 | 1995-10-31
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 107巻
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号 | 9-10号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 195
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終了ページ | 204
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/107/9-10/107_9-10_195/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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