ID | 31311 |
JaLCDOI | |
FullText URL | |
Author |
Tsuji, Hideyuki
Shimomura, Hiroyuki
Fujio, Kozo
Wato, Masaki
Kondo, Junichi
Hasui, Toshimi
Ishi, Yasushi
Fujioka, Shin-ichi
Tsuji, Takao
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Abstract | To evaluate viral interference between hepatitis B and C, we studied coinfected patients serologically and molecular biologically. Twenty-seven patients positive for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) antibody, were classified into Groups BC-L and BC-H according to DNA-polymerase activity (less or greater than 100 cpm, respectively). Patients with hepatitis B or C alone were also enrolled as controls. HCV-RNA was detected more often in Group BC-L than in Group BC-H. Genotype 1b of HCV was determined in 75% of Group BC-H, 87.5% of Group BC-L, and 70.7% of hepatitis C-only patients. Activity of DNA-polymerase in coinfected patients was lower in patients positive for HCV-RNA as compared with those negative. HBsAg titers tended to be lower in coinfected patients than in patients with hepatitis B virus (HBV) alone. In conclusion, in coinfection, HBV may suppress the replication of HCV and HCV appears to reduce the expression of HBsAg and probably suppresses HBV replication.</P> |
Keywords | hepatitis B virus
hepatitis C virus
double infection
hepatitis B surface antigen
hepatitis C virusRNA
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1998-04
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Volume | volume52
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Issue | issue2
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Publisher | Okayama University Medical School
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Start Page | 113
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End Page | 118
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |