ID | 31311 |
JaLCDOI | |
フルテキストURL | |
著者 |
Tsuji, Hideyuki
Okayama University
Shimomura, Hiroyuki
Okayama University
Fujio, Kozo
Okayama Univeristy
Wato, Masaki
Okayama University
Kondo, Junichi
Okayama University
Hasui, Toshimi
Okayama University
Ishi, Yasushi
Okayama University
Fujioka, Shin-ichi
Okayama University
Tsuji, Takao
Okayama University
|
抄録 | To evaluate viral interference between hepatitis B and C, we studied coinfected patients serologically and molecular biologically. Twenty-seven patients positive for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) antibody, were classified into Groups BC-L and BC-H according to DNA-polymerase activity (less or greater than 100 cpm, respectively). Patients with hepatitis B or C alone were also enrolled as controls. HCV-RNA was detected more often in Group BC-L than in Group BC-H. Genotype 1b of HCV was determined in 75% of Group BC-H, 87.5% of Group BC-L, and 70.7% of hepatitis C-only patients. Activity of DNA-polymerase in coinfected patients was lower in patients positive for HCV-RNA as compared with those negative. HBsAg titers tended to be lower in coinfected patients than in patients with hepatitis B virus (HBV) alone. In conclusion, in coinfection, HBV may suppress the replication of HCV and HCV appears to reduce the expression of HBsAg and probably suppresses HBV replication.</P> |
キーワード | hepatitis B virus
hepatitis C virus
double infection
hepatitis B surface antigen
hepatitis C virusRNA
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1998-04
|
巻 | 52巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 113
|
終了ページ | 118
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |