ID | 31898 |
JaLCDOI | |
FullText URL | |
Author |
Yamamoto, Michio
Tanimoto, Junichi
Kojima, Sumikazu
Nobuki, Shigeo
Hagitani, Akira
Iguchi, Yoshiko
Akagi, Eiko
Ofuji, Tadashi
Asaka, Takakazu
Kamura, Junta
Shibata, Tsuneo
|
Abstract | The unsaturated fatty acid fraction extracted from the liver of rabbit irradiated with X-rays exerts a strong cytotoxic effect on human coelothelioma cells and Yoshida sarcoma cells both in vitro and in vivo. The cell damage seems to initiate at the nucleus, finally leading to the complete cytolysis. The inhibiting effect of this substance on the mitosis of Yoshida sarcoma cells can be observed, especially marked from prophase up to metaphase giving almost the same results obtained after X-ray irradiation. From these results and the observations reported by several authors on the cell damage by X-ray irradiation, weshould call special attention to the fact that the essential mechanism of X-ray irradiation can be attributed to the cell toxin produced after the irradiation. |
Amo Type | Article
|
Publication Title |
Acta Medicinae Okayama
|
Published Date | 1960-04
|
Volume | volume14
|
Issue | issue1
|
Publisher | Okayama University Medical School
|
Start Page | 55
|
End Page | 67
|
NCID | AA00041342
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
NAID |