ID | 11746 |
Eprint ID | 11746
|
FullText URL | |
Title Alternative | 虚血後線状体に出現する神経前駆細胞の起源
|
Author |
Yamashita, Toru
|
Abstract | Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.
|
Keywords | zone
cerebral ischemia
migration
neurogenesis
regeneration
striatum
|
Note | http://dx.doi.org/10.1523/JNEUROSCI.0149-06.2006
|
Published Date | 2007-03-23
|
Publication Title | |
Content Type |
Thesis or Dissertation
|
Grant Number | 甲第3322号
|
Granted Date | 2007-03-23
|
Thesis Type |
Doctor of Philosophy in Medical Science
|
Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16775151&dopt=Abstract
|
language |
Japanese
|
File Version | none
|
Refereed |
Unknown
|