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ID 11746
Eprint ID
11746
フルテキストURL
K003322.pdf 75.8 KB
タイトル(別表記)
虚血後線状体に出現する神経前駆細胞の起源
著者
山下 徹 岡山大学
抄録
Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.
キーワード
zone
cerebral ischemia
migration
neurogenesis
regeneration
striatum
備考
http://dx.doi.org/10.1523/JNEUROSCI.0149-06.2006
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3322号
学位授与年月日
2007-03-23
学位・専攻分野
博士(医学)
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16775151&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明