ID | 16623 |
Eprint ID | 16623
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FullText URL | |
Title Alternative | Enzymological studies on rheumatoid arthritis. 2. Relationship between collagenase activity and the clinical course of patients with rheumatoid arthritis
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Author |
Toda, Shunsuke
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Abstract | We examined the relationship between collagenase activity and the clinical course of the patients with rheumatoid arthritis (RA). The activity of active and inactive collagenase (treated by 3M-KI) was assayed several times for synovial fluid from twelve RA patients and one patient with osteoarthritis (OA). Rheumatoid factor, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocyte counts and acid-phosphatase activity in the synovial fluid were measured simultaneously. In seven of twelve cases, the change of inactive collagenase activity was parallel by changes in synovial leukocyte counts or acid-phosphatase activity. In five of seven cases, the change in inactive collagenase activity was paralleled by acid-phosphatase activity and leukocyte counts. These findings suggest that collagenase activity is intimately correlated with the grade of local inflammation of RA and that the change of collagenase activity is closely correlated with the clinical course of RA patients.
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Keywords | 慢性関節リウマチ
コラゲナーゼ活性
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Published Date | 1981-08-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume93
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Issue | issue7-8
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 657
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End Page | 666
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/93/7-8/93_7-8_657/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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