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ID 16623
Eprint ID
16623
FullText URL
Thumnail 93_657.pdf 458 KB
Title Alternative
Enzymological studies on rheumatoid arthritis. 2. Relationship between collagenase activity and the clinical course of patients with rheumatoid arthritis
Author
Toda, Shunsuke
Abstract
We examined the relationship between collagenase activity and the clinical course of the patients with rheumatoid arthritis (RA). The activity of active and inactive collagenase (treated by 3M-KI) was assayed several times for synovial fluid from twelve RA patients and one patient with osteoarthritis (OA). Rheumatoid factor, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocyte counts and acid-phosphatase activity in the synovial fluid were measured simultaneously. In seven of twelve cases, the change of inactive collagenase activity was parallel by changes in synovial leukocyte counts or acid-phosphatase activity. In five of seven cases, the change in inactive collagenase activity was paralleled by acid-phosphatase activity and leukocyte counts. These findings suggest that collagenase activity is intimately correlated with the grade of local inflammation of RA and that the change of collagenase activity is closely correlated with the clinical course of RA patients.
Keywords
慢性関節リウマチ
コラゲナーゼ活性
Published Date
1981-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
657
End Page
666
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/7-8/93_7-8_657/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma