ID | 53515 |
FullText URL | |
Title Alternative | Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
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Author |
Fujiwara, Hiroki
Hosoda, Miho
Hino, Hayato
Hirai, Kazuhiro
Okamoto, Kazuaki
金 鑫
高取 真吾
高木 志真
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Abstract | Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance.
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Keywords | propolis
insulin resistance
Otsuka Long-Evans Tokushima Fatty rat
periarterial nerve function
mesenteric vascular bed
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Note | コンテンツの著作権は日本薬学会が有します。
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Published Date | 2010-06-01
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Publication Title |
藥學雜誌
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Publication Title Alternative | Yakugaku zasshi
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Volume | volume130
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Issue | issue6
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Publisher | 日本薬学会
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Publisher Alternative | The Pharmaceutical Society of Japan
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Start Page | 833
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End Page | 840
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ISSN | 0031-6903
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NCID | AN00284903
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Content Type |
Journal Article
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language |
Japanese
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Copyright Holders | 日本薬学会
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |