検索結果 582 件
| JaLCDOI | 10.18926/AMO/57955 |
|---|---|
| フルテキストURL | 74_1_65.pdf |
| 著者 | Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro| |
| 抄録 | To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine. |
| キーワード | antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099251 |
| Web of Science KeyUT | 000516606200010 |
| NAID | 120006795622 |
| フルテキストURL | JP60_8_1681.pdf |
|---|---|
| 著者 | Feyissa, Dejene Hailemariam| Kitagawa, Hiroshi| Bizuneh, Tesfaye Demissie| Tanaka, Ryoji| Kabeto, Kurkura| Nakamura, Eizo| |
| キーワード | Ethiopian Plateau Ethiopian rift Afar depression mantle source mantle melting |
| 発行日 | 2019-09-12 |
| 出版物タイトル | Journal of Petrology |
| 巻 | 60巻 |
| 号 | 8号 |
| 出版者 | Oxford University Press |
| 開始ページ | 1681 |
| 終了ページ | 1715 |
| ISSN | 0022-3530 |
| NCID | AA0070444X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1093/petrology/egz043 |
| Web of Science KeyUT | 000509550500007 |
| 関連URL | isVersionOf https://doi.org/10.1093/petrology/egz043 |
| フルテキストURL | CH38_1_14.pdf |
|---|---|
| 著者 | Tanabe, Shintaro| Kasuya, Eiiti| Miyatake, Takahisa| |
| キーワード | Habituation Hyla japonica individual variation sexual difference predation |
| 発行日 | 2019-02-28 |
| 出版物タイトル | Current Herpetology |
| 巻 | 38巻 |
| 号 | 1号 |
| 出版者 | Herpetological Society of Japan |
| 開始ページ | 14 |
| 終了ページ | 22 |
| ISSN | 1345-5834 |
| NCID | AA12410796 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.5358/hsj.38.14 |
| Web of Science KeyUT | 000483742900003 |
| 関連URL | isVersionOf https://doi.org/10.5358/hsj.38.14 |
| タイトル（別表記） | Sexuality in plants, unveiled from genome evolution |
|---|---|
| フルテキストURL | srfa_109_037_040.pdf |
| 著者 | 赤木 剛士| |
| 抄録 | Sexual polymorphism, a main strategy to maintain genetic diversity within a species, has long been a major focus in biology. Notwithstanding, in plants, evolution of sexual systems and mechanisms underlying these transitions have been little unveiled. We have elucidated the molecular mechanism of sex determination in persimmons (Diospyros spp.), where the Y-encoded smRNA gene OGI can repress the female-determining gene MeGI, and also in kiwifruits (Actinidia spp.), where the Y-encoded two sex determinants, Shy Girl and Friendly Boy, control gynoecium and androecium development, respectively. Although the molecular functions of these determinants are distinct, they have common evolutionary scenarios involving transitions of sexual systems. In persimmon, a recent genome triplication (hexaploidization) in cultivated persimmon (D. kaki) derived “flexible” sexuality via establishing epigenetic layers on the two sex determinants. On the other hand, an ancient Diospyros-specific paleo-genome duplication (paleo-tetraploidization) enabled neofunctionalization in the proto-MeGI, via positive selection, to establish a new function as a sex determinant. In kiwifruit, one of the two sex determinants, Shy Girl, was derived from neofunctionalization via Actinidia-specific duplication event. These findings exemplify how plant-specific numerous duplication events can drive flexible genetic material whose variation can be selected for development of new sexual systems. |
| キーワード | Sex determination Sex chromosome Polyploidization Genome evolution Tree crops |
| 出版物タイトル | 岡山大学農学部学術報告 |
| 発行日 | 2020-02-01 |
| 巻 | 109巻 |
| 開始ページ | 37 |
| 終了ページ | 40 |
| ISSN | 2186-7755 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Mathematical analysis of copy number variation of 2 μ-based plasmids in yeast cells |
|---|---|
| フルテキストURL | srfa_109_007_011.pdf |
| 著者 | 佐伯 望| 守屋 央朗| |
| 抄録 | Plasmids with the 2 μ plasmid origin are commonly-used in the genetic engineering of the budding yeast Saccharomyces cerevisiae. Intracellular copy numbers of 2 μ plasmids are different depending on the genes inserted into the plasmids. This difference is thought to occur from the difference in the growth efficiency （fitness） produced by the positive- and negative-selection biases of genes inserted in the plasmid. In this study, we made a mathematical model based on this assumption. Computational simulations of the model validated that copy numbers of the plasmids are rapidly settled depending on the fitness created by the gene on the plasmid. The copy number of a plasmid only contains a bias to keep the plasmid in a single copy became average 20copies per cell when the plasmid is randomly distributed, suggesting that no positive distribution mechanism is required for a plasmid to become multicopy. |
| キーワード | yeast 2 μ plasmid mathematical model |
| 出版物タイトル | 岡山大学農学部学術報告 |
| 発行日 | 2020-02-01 |
| 巻 | 109巻 |
| 開始ページ | 7 |
| 終了ページ | 11 |
| ISSN | 2186-7755 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | JE36_161.pdf JE37_135.pdf |
|---|---|
| 著者 | Matsumura, Kentarou| Miyatake, Takahisa| |
| キーワード | Artificial selection Quantitative trait Relaxation of selection Reverse selection Tonic immobility Tribolium castaneum |
| 備考 | Matsumura, K., Miyatake, T. Correction to: Responses to relaxed and reverse selection in strains artificially selected for duration of death‑feigning behavior in the red flour beetle, Tribolium castaneum. J Ethol 37, 135 (2019) doi:10.1007/s10164-018-0579-3| |
| 発行日 | 2018-04-04 |
| 出版物タイトル | Journal of Ethology |
| 巻 | 36巻 |
| 号 | 2号 |
| 出版者 | Springer |
| 開始ページ | 161 |
| 終了ページ | 168 |
| ISSN | 0289-0771 |
| NCID | AA10754455 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.1007/s10164-018-0548-x |
| Web of Science KeyUT | 000431173000007 |
| 関連URL | isVersionOf https://doi.org/10.1007/s10164-018-0548-x isVersionOf https://doi.org/10.1007/s10164-018-0579-3 |
| フルテキストURL | GCA252_107.pdf |
|---|---|
| 著者 | Kunihiro, Takuya| Ota, Tsutomu| Nakamura, Eizo| |
| キーワード | Lithium Oxygen Chondrule Chondrite Asteroid Allende Igneous rim SIMS |
| 発行日 | 2019-05-01 |
| 出版物タイトル | Geochimica et Cosmochimica Acta |
| 巻 | 252巻 |
| 出版者 | Elsevier |
| 開始ページ | 107 |
| 終了ページ | 125 |
| ISSN | 0016-7037 |
| NCID | AA00655038 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.gca.2019.02.038 |
| Web of Science KeyUT | 000462774200006 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.gca.2019.02.038 |
| フルテキストURL | JGPP_79_5_307.pdf |
|---|---|
| 著者 | Tamada, Tetsuo| Kondo, Hideki| |
| キーワード | Soil-borne viruses Benyvirus Furovirus Pecluvirus Pomovirus Bymovirus Vector transmission Plasmodiophorids Polymyxa Spongospora |
| 発行日 | 2013-05-28 |
| 出版物タイトル | Journal of General Plant Pathology |
| 巻 | 79巻 |
| 号 | 5号 |
| 出版者 | Springer |
| 開始ページ | 307 |
| 終了ページ | 320 |
| ISSN | 1345-2630 |
| NCID | AA11449093 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1007/s10327-013-0457-3 |
| Web of Science KeyUT | 000323517200003 |
| 関連URL | isVersionOf https://doi.org/10.1007/s10327-013-0457-3 |
| JaLCDOI | 10.18926/AMO/57370 |
|---|---|
| フルテキストURL | 73_5_403.pdf |
| 著者 | Ando, Akemi| Mitsuhashi, Toshiharu| Honda, Mitsugi| Hanayama, Yoshihisa| Hasegawa, Kou| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio| |
| 抄録 | Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level. |
| キーワード | bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-10 |
| 巻 | 73巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 403 |
| 終了ページ | 411 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31649366 |
| Web of Science KeyUT | 000491886600005 |
| フルテキストURL | VirusRes_262_37.pdf FIG_S1-7_revised.pdf TableS1-3.pdf |
|---|---|
| 著者 | Kondo, Hideki| Chiba, Sotaro| Maruyama, Kazuyuki| Andika, Ida Bagus| Suzuki, Nobuhiro| |
| キーワード | Bumblebee Endogenous viral element Evolution Insect Plant alpha-like virus Transcriptome shotgun assembly Whole genome shotgun assembly |
| 発行日 | 2019-03-31 |
| 出版物タイトル | Virus Research |
| 巻 | 262巻 |
| 出版者 | Elsevier Science |
| 開始ページ | 37 |
| 終了ページ | 47 |
| ISSN | 01681702 |
| NCID | AA10642076 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2017 Elsevier B.V. All rights reserved. |
| 論文のバージョン | author |
| PubMed ID | 29169832 |
| DOI | 10.1016/j.virusres.2017.11.020 |
| Web of Science KeyUT | 000459523800007 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.virusres.2017.11.020 |
| フルテキストURL | NatCom_10_1_3022.pdf |
|---|---|
| 著者 | Belay, Iyasu Getachew| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Nakamura, Eizo| |
| 発行日 | 2019-07 |
| 出版物タイトル | Nature Communications |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Springer Nature Publishing AG |
| 開始ページ | 3022 |
| ISSN | 20411723 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2019 |
| 論文のバージョン | publisher |
| PubMed ID | 31289264 |
| DOI | 10.1038/s41467-019-10832-7 |
| Web of Science KeyUT | 000474506700008 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41467-019-10832-7 |
| フルテキストURL | InfectGenetEvol_54_47.pdf |
|---|---|
| 著者 | Ghosh, Priyanka| Kumar, Dhirendra| Chowdhury, Goutam| Singh, Puneeta| Samanta, Prosenjit| Dutta, Shanta| Ramamurthy, T.| Sharma, N. C.| Sinha, Preety| Prasad, Yogendra| Shinoda, Sumio| Mukhopadhyay, Asish K.| |
| キーワード | Cholera Vibrio cholerae ctxAB promoter ctxB gyrA rstB rtxA tcpA |
| 発行日 | 2017-10 |
| 出版物タイトル | Infection, Genetics and Evolution |
| 巻 | 54巻 |
| 出版者 | Elsevier Science |
| 開始ページ | 47 |
| 終了ページ | 53 |
| ISSN | 15671348 |
| NCID | AA11697619 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 28625543 |
| DOI | 10.1016/j.meegid.2017.06.015 |
| Web of Science KeyUT | 000411461400006 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.meegid.2017.06.015 |
| JaLCDOI | 10.18926/ESR/56694 |
|---|---|
| フルテキストURL | esr_025_031_038.pdf |
| 著者 | Amano, Hideki| Suzuki, Shigeyuki| Sato, Masaru| Yanagida, Makoto| |
| 抄録 | The study area is situated in Japan Sea side margin of the Shakotan Peninsula, Hokkaido, Japan, where MIS5e Terrace is preserved along the cost. Numbers of tight drilling have done to establish new method for terrace analysis. Buried wave cut terrace and sea cliff (when the MIS5e Terrace was formed) are reconstructed by distribution of the terrace deposits and these bottom of unconformity planes. The precise site and altitude of former shoreline was also obtained. Altitudes of the former shoreline from the 7 sections are almost the same 22 to 27m in height. Previous data of the height of shoreline are obtained from the topographic MIS5e Terrace surface. The altitudes have variation from 30m to 60m. It suggests that the traditional method for the MIS5e terrace analysis had some errors in the study area. |
| キーワード | MIS5e marine terrace terrace deposits tight drilling shoreline |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2018-12-27 |
| 巻 | 25巻 |
| 号 | 1号 |
| 開始ページ | 31 |
| 終了ページ | 38 |
| ISSN | 1340-7414 |
| 言語 | 英語 |
| 著作権者 | © 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/ESR/56692 |
|---|---|
| タイトル（別表記） | Synoptic climatological analyses on the large day-to-day variation of air temperature around Germany in winter (Relating to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away) |
| フルテキストURL | esr_025_007_017.pdf |
| 著者 | 濱木 達也| 加藤 内藏進 | 大谷 和男| 加藤 晴子| 松本 健吾| |
| 抄録 | Synoptic climatological analyses associated with the large day-to-day variation of air temperature around Germany in winter were performed based mainly on the NCEP/NCAR reanalysis data for 2000/2001 to 2010/2011 winters, with an interest in the relationship to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away. The intermittent appearance of the extremely cold days with rather large day-to-day variation in winter as pointed out by Kato et al. (2017) for around Germany was seen also to the north and to the east of Germany. According to a case study for the 2000/2001 winter, such large daily mean temperature fluctuation was closely related to the intraseasonal variation of the Icelandic low with about one month period, i.e., while the temperature around Germany was relatively higher at the eastward shift phase of the Icelandic low due to the strong warm air advection by the SW-ly wind, the temperature was extremely low there when the Icelandic low was weakened and retreated westward. |
| キーワード | Comparative climatology Climate around Europe Synoptic climatology on daily temperature variation in winter around Germany seasonal cycle and “seasonal feeling” |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2018-12-27 |
| 巻 | 25巻 |
| 号 | 1号 |
| 開始ページ | 7 |
| 終了ページ | 17 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| フルテキストURL | Vaccine_32_A20-8.pdf |
|---|---|
| 著者 | Mullick, Satarupa| Mandal, Paulami| Mukti Kant Nayak| Ghosh, Souvik| De, Papiya| Rajendran, K.| Bhattacharya, Mihir K.| Mitra, Utpala| Ramamurthy, Thandavarayan| Kobayashi, Nobumichi| Chawla-Sarkar, Mamta| |
| キーワード | Diarrhea Rotavirus India Kolkata G9 strains G2 strains |
| 発行日 | 2014-08-11 |
| 出版物タイトル | Vaccine |
| 巻 | 32巻 |
| 号 | supplment 1号 |
| 出版者 | Elsevier Science |
| 開始ページ | A20 |
| 終了ページ | A28 |
| ISSN | 0264410X |
| NCID | AA10491877 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 25091674 |
| DOI | 10.1016/j.vaccine.2014.03.018 |
| Web of Science KeyUT | 000340977500007 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.vaccine.2014.03.018 |
| フルテキストURL | Front_Microbiol_7_1250.pdf |
|---|---|
| 著者 | Ghosh, Raikamal| Sharma, Naresh C.| Halder, Kalpataru| Bhadra, Rupak K.| Chowdhury, Goutam| Pazhani, Gururaja P.| Shinoda, Sumio| Mukhopadhyay, Asish K.| Nair, G. Balakrish| Ramamurthy, Thadavarayan| |
| キーワード | V.cholerae O139 ribotypes CT genotype CTX prophage PFGE |
| 発行日 | 2016-08-09 |
| 出版物タイトル | frontiers in Microbiology |
| 巻 | 7巻 |
| 出版者 | Frontiers Media S.A. |
| 開始ページ | 1250 |
| ISSN | 1664302X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 27555841 |
| DOI | 10.3389/fmicb.2016.01250 |
| Web of Science KeyUT | 000381079700001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fmicb.2016.01250 |
| フルテキストURL | Plos_Negl_Trop_Dis_5386.pdf |
|---|---|
| 著者 | Imamura, Daisuke| Morita, Masatomo| Sekizuka, Tsuyoshi| Mizuno, Tamaki| Takemura, Taichiro| Yamashiro, Tetsu| Chowdhury, Goutam| Pazhani, Gururaja P.| Mukhopadhyay, Asish K.| Ramamurthy, Thandavarayan| Miyoshi, Shin-ichi| Kuroda, Makoto| Shinoda, Sumio| Ohnishi, Makoto| |
| 備考 | This research is supported by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan, and Japan Agency for Medical Research and Development (AMED).| |
| 発行日 | 2017-02-13 |
| 出版物タイトル | PLOS Neglected Tropical Diseases |
| 巻 | 11巻 |
| 号 | 2号 |
| 出版者 | PLOS |
| 開始ページ | e0005386 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 28192431 |
| DOI | 10.1371/journal.pntd.0005386 |
| Web of Science KeyUT | 000396406600020 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pntd.0005386 |
| フルテキストURL | Geochem_Cosmochi_Act_235_76.pdf |
|---|---|
| 著者 | Inoue, Mayuri| Nakamura, Takashi| Tanaka, Yasuaki| Suzuki, Atsushi| Yokoyama, Yusuke| Kawahata, Hodaka| Sakai, Kazuhiko| Gussone, Nikolaus| |
| キーワード | Coral symbiosis calcification pH geochemical tracers |
| 備考 | This is an Accepted Manuscript of an article published by Elsevier B.V.| |
| 発行日 | 2018-08-15 |
| 出版物タイトル | Geochimica et Cosmochimica Acta |
| 巻 | 235巻 |
| 出版者 | Elsevier B.V. |
| 開始ページ | 76 |
| 終了ページ | 88 |
| ISSN | 00167037 |
| NCID | AA00655038 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.gca.2018.05.016 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.gca.2018.05.016 |
| フルテキストURL | PhysRevB_97_094525.pdf |
|---|---|
| 著者 | Terashima, K.| Paris, E.| Simonelli, L.| Salas-Colera, E.| Puri, A.| Wakita, T.| Yamada, Y.| Nakano, S.| Idei, H.| Kudo, K.| Nohara, M.| Muraoka, Y.| Mizokawa, T.| Yokoya, T.| Saini, N. L.| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2018-09-28 |
| 出版物タイトル | Physical Review B |
| 巻 | 98巻 |
| 号 | 9号 |
| 出版者 | American Physical Society |
| 開始ページ | 094525 |
| ISSN | 24699950 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevB.98.094525 |
| Web of Science KeyUT | 000446178800008 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevB.98.094525 |
| JaLCDOI | 10.18926/AMO/56182 |
|---|---|
| フルテキストURL | 72_4_423.pdf |
| 著者 | Sakakida, Kourin| Wei, Fan-Yan| Senokuchi, Takafumi| Shimoda, Seiya| Kakuma, Tatsuyuki| Araki, Eiichi| Tomizawa, Kazuhito| The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group| |
| 抄録 | Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity. |
| キーワード | diabetes insulin secretion single nucleotide polymorphism glucose |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-08 |
| 巻 | 72巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 426 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30140092 |