検索結果 108 件
| JaLCDOI | 10.18926/AMO/68647 |
|---|---|
| フルテキストURL | 79_2_093.pdf |
| 著者 | Tsuchie, Rina| Fukuda, Mari| Tsumura, Hideki| Kinuta, Minako| Hisamatsu, Takashi| Kanda, Hideyuki| |
| 抄録 | School teachers are subject to both physical and mental health problems. We examined cross-sectional relationships between work engagement and major health outcomes among junior and senior high school teachers in Japan via a nationwide survey in 2019-2020. A total of 3,160 respondents were included in the analyses (19.9% response rate). Work engagement was assessed with the Utrecht Work Engagement Scale-9 (UWES-9), and we thus divided the teachers into quartiles according to their UWES-9 scores. Based on validated questionnaires, we assessed insomnia, psychological distress, and neck pain as health outcomes. A binomial logistic regression adjusted for age, gender, school type, teacher’s roles, involvement in club activities, division of duties, employment status, and whether they lived with family demonstrated that the teachers with lower UWES-9 scores had higher burdens of insomnia, psychological distress, and neck pain (odds ratios [95% confidence intervals] in 4th vs. 1st quartile, 2.92 (2.34-3.65), 3.70 (2.81-4.88), and 2.12 (1.68-2.68), respectively; all trend p<0.001). There were no significant differences in these associations between full-time and part-time teachers. Our findings indicate that low work engagement may contribute to physical and mental health issues among junior and senior high school teachers, thus providing insights for preventing health problems in this profession. |
| キーワード | work engagement school teachers insomnia psychological distress neck pain |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-04 |
| 巻 | 79巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 93 |
| 終了ページ | 100 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamane, Takahiro| Fujii, Masanori| Morita, Mizuki| |
| キーワード | Disease screening Sleep apnea syndrome (SAS) Single-lead ECG Artificial intelligence Machine learning |
| 発行日 | 2025-04-11 |
| 出版物タイトル | Sleep and Breathing |
| 巻 | 29巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 156 |
| ISSN | 1520-9512 |
| NCID | AA11703981 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 40214940 |
| DOI | 10.1007/s11325-025-03316-0 |
| Web of Science KeyUT | 001463756600001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s11325-025-03316-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mukunoki, Hiroshi| Okoshi, Hirofumi| |
| キーワード | free trade agreements managerial incentives rules of origin transfer pricing |
| 発行日 | 2025-01-28 |
| 出版物タイトル | Review of International Economics |
| 出版者 | Wiley |
| ISSN | 0965-7576 |
| NCID | AA10959196 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| DOI | 10.1111/roie.12790 |
| Web of Science KeyUT | 001406893100001 |
| 関連URL | isVersionOf https://doi.org/10.1111/roie.12790 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ueda, Masataka| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Takatori, Ryo| Shitozawa, Hisakazu| Uotani, Koji| Shinohara, Kennsuke| Oda, Yoshiaki| Ozaki, Toshifumi| |
| キーワード | AIS cognitive-behavioral therapy EQ5D HADS insomnia pain-liaison outpatient clinic sleep disorders |
| 発行日 | 2024-08-09 |
| 出版物タイトル | Medicine |
| 巻 | 103巻 |
| 号 | 32号 |
| 出版者 | Lippincott, Williams & Wilkins |
| 開始ページ | e39113 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39121265 |
| DOI | 10.1097/MD.0000000000039113 |
| Web of Science KeyUT | 001287977800045 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000039113 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tokumoto, Kana| Mino, Takuya| Tosa, Ikue| Omori, Ko| Yamamoto, Michiyo| Takaoka, Kazuki| Maekawa, Kenji| Kuboki, Takuo| Kishimoto, Hiromitsu| |
| キーワード | Parkinson's disease Older people Implant overdenture Nursing homes Implant-related troubles Peri-implantitis |
| 備考 | The version of record of this article, first published in International Journal of Implant Dentistry, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40729-024-00557-8| |
| 発行日 | 2024-07-29 |
| 出版物タイトル | International Journal of Implant Dentistry |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Springer |
| 開始ページ | 37 |
| ISSN | 2198-4034 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024. |
| 論文のバージョン | publisher |
| PubMed ID | 39073725 |
| DOI | 10.1186/s40729-024-00557-8 |
| Web of Science KeyUT | 001279622000001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40729-024-00557-8 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| フルテキストURL | 78_3_259.pdf |
| 著者 | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| 抄録 | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| キーワード | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| フルテキストURL | K0007002_abstract_review.pdf K0007002_fulltext.pdf |
|---|---|
| 著者 | 砂田 匠彦| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第7002号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2022 by the authors. |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yoshii, Taishi| Saito, Aika| Yokosako, Tatsuya| |
| キーワード | Drosophila Seasonal adaptation Photoperiod Oscillator Activity rhythm |
| 備考 | The version of record of this article, first published in Journal of Comparative Physiology A, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00359-023-01639-5| |
| 発行日 | 2023-05-23 |
| 出版物タイトル | Journal of Comparative Physiology A |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0340-7594 |
| NCID | AA00695972 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023 |
| 論文のバージョン | publisher |
| PubMed ID | 37217625 |
| DOI | 10.1007/s00359-023-01639-5 |
| Web of Science KeyUT | 000991306800001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00359-023-01639-5 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mitsuhashi, Toshiharu| |
| キーワード | COVID-19 Metabolic syndrome Healch check up Conditional average treatment effect CATE Public health Pandemic |
| 発行日 | 2024-04-05 |
| 出版物タイトル | PeerJ |
| 巻 | 12巻 |
| 出版者 | PeerJ |
| 開始ページ | e17013 |
| ISSN | 2167-8359 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Mitsuhashi |
| 論文のバージョン | publisher |
| PubMed ID | 38590703 |
| DOI | 10.7717/peerj.17013 |
| Web of Science KeyUT | 001203244800004 |
| 関連URL | isVersionOf https://doi.org/10.7717/peerj.17013 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Soejima, Yoshiaki| Iwata, Nahoko| Yamamoto, Koichiro| Suyama, Atsuhito| Nakano, Yasuhiro| Otsuka, Fumio| |
| キーワード | bone morphogenetic protein (BMP) orexin catecholamine and adrenal |
| 発行日 | 2024-01-27 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 25巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 1585 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 38338864 |
| DOI | 10.3390/ijms25031585 |
| Web of Science KeyUT | 001160350600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms25031585 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Asada, Saori| Morita, Hiroshi| Mizuno, Tomofumi| Masuda, Takuro| Ueoka, Akira| Miyamoto, Masakazu| Kawada, Satoshi| Nakagawa, Koji| Nishii, Nobuhiro| |
| キーワード | Brugada syndrome Implantable cardioverter-defibrillator Syncope Neurally mediated syncope Epilepsy Ventricular tachyarrhythmia |
| 発行日 | 2023-10 |
| 出版物タイトル | Heart Rhythm O2 |
| 巻 | 4巻 |
| 号 | 10号 |
| 出版者 | Elsevier |
| 開始ページ | 641 |
| 終了ページ | 649 |
| ISSN | 2666-5018 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Heart Rhythm Society. |
| 論文のバージョン | publisher |
| PubMed ID | 37936673 |
| DOI | 10.1016/j.hroo.2023.09.007 |
| Web of Science KeyUT | 001163451500001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.hroo.2023.09.007 |
| JaLCDOI | 10.18926/AMO/66156 |
|---|---|
| フルテキストURL | 77_6_635.pdf |
| 著者 | Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku| |
| 抄録 | In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted. |
| キーワード | whey protein electrical stimulation muscle strength healthy volunteers |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 635 |
| 終了ページ | 645 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145938 |
| Web of Science KeyUT | 001164631200009 |
| JaLCDOI | 10.18926/AMO/65970 |
|---|---|
| フルテキストURL | 77_5_479.pdf |
| 著者 | Murata, Akiko| Matsumoto, Naomi| Miyaji, Chikara| Takao, Soshi| Yorifuji, Takashi| |
| 抄録 | For decades, the notion has persisted in developed countries that exclusive care by the mothers is best for the development of children up to 3 years of age. To examine the veracity of this “myth of the first three years” in Japan, we examined the effects of childcare facility use for children younger than 3 years on their development using the cohorts of the Longitudinal Survey of Newborns in the 21st Century conducted in Japan. Of the 47,015 respondents to the survey, we studied the children of 5,508 mothers with university/professional education to evaluate the relationships between primary early (< 2.5 years) childcare providers during weekday daytime hours and specific development indices for the ages of 2.5, 5.5, and 8 years. At the age of 2.5 and 5.5 years, children attending childcare facilities were judged as having more advanced developmental behaviors by their parents, such as being able to compose a two-word sentence (adjusted odds ratio [aOR]: 0.22) or to express emotions (aOR: 0.81), compared with those cared for by mothers. However, at the age of 8 years, children who attended childcare facilities as infants < 2.5 years showed more aggressive behavior in interrupting people (aOR: 1.20) and causing disturbances in public (aOR: 1.26) than those cared for by mothers (after adjustment for numerous child and parental factors). Although these results are generally consistent with previous studies, issues potentially involved with problem behavior such as quality of childcare require further investigation, as does the case of children of mothers with more modest educational attainment. |
| キーワード | “myth of the first three years” childcare child development problem behavior educational attainment |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-10 |
| 巻 | 77巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 479 |
| 終了ページ | 490 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37899259 |
| Web of Science KeyUT | 001108661600005 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Soejima, Yoshiaki| Iwata, Nahoko| Nishioka, Ran| Honda, Mako| Nakano, Yasuhiro| Yamamoto, Koichiro| Suyama, Atsuhito| Otsuka, Fumio| |
| キーワード | bone morphogenetic protein (BMP) orexin steroidogenesis and adrenal |
| 発行日 | 2023-08-08 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 24巻 |
| 号 | 16号 |
| 出版者 | MDPI |
| 開始ページ | 12559 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 37628739 |
| DOI | 10.3390/ijms241612559 |
| Web of Science KeyUT | 001056982200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms241612559 |
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| フルテキストURL | 77_4_395.pdf |
| 著者 | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| 抄録 | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| キーワード | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 395 |
| 終了ページ | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Imura, Issei| Gotoh, Yusuke| Sakai, Koji| Ohara, Yu| Tazoe, Jun| Miura, Hiroshi| Hirota, Tatsuya| Uchiyama, Akira| Nomura, Yoshinari| |
| キーワード | heart rate variability LF/HF Society 5.0 stress wearable sensor devices working style |
| 発行日 | 2022-08-02 |
| 出版物タイトル | Sensors and Materials |
| 巻 | 34巻 |
| 号 | 8号 |
| 出版者 | MYU K.K. |
| 開始ページ | 2955 |
| 終了ページ | 2971 |
| ISSN | 0914-4935 |
| NCID | AA10790969 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © MYU K.K. |
| 論文のバージョン | publisher |
| DOI | 10.18494/sam3908 |
| Web of Science KeyUT | 000835430600001 |
| 関連URL | isVersionOf https://doi.org/10.18494/SAM3908 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Toyama, Naoki| Ekuni, Daisuke| Fukuhara, Daiki| Sawada, Nanami| Yamashita, Miho| Komiyama, Momoe| Nagahama, Takahiko| Morita, Manabu| |
| キーワード | sleep bruxism dietary fiber electromyography young adult biostatistics nutrition assessment |
| 発行日 | 2023-03-31 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 12巻 |
| 号 | 7号 |
| 出版者 | MDPI |
| 開始ページ | 2623 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 37048706 |
| DOI | 10.3390/jcm12072623 |
| Web of Science KeyUT | 000968798300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm12072623 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sunada, Naruhiko| Nakano, Yasuhiro| Otsuka, Yuki| Tokumasu, Kazuki| Honda, Hiroyuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Hagiya, Hideharu| Ueda, Keigo| Kataoka, Hitomi| Otsuka, Fumio| |
| キーワード | insomnia myalgic encephalomyelitis chronic fatigue long COVID Omicron variant post COVID-19 condition |
| 発行日 | 2022-12-09 |
| 出版物タイトル | Journal Of Clinical Medicine |
| 巻 | 11巻 |
| 号 | 24号 |
| 出版者 | MDPI |
| 開始ページ | 7332 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36555948 |
| DOI | 10.3390/jcm11247332 |
| Web of Science KeyUT | 000901154300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm11247332 |
| JaLCDOI | 10.18926/AMO/64123 |
|---|---|
| フルテキストURL | 76_6_723.pdf |
| 著者 | Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan| |
| 抄録 | The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response. |
| キーワード | microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 723 |
| 終了ページ | 730 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549775 |
| Web of Science KeyUT | 000905195100013 |
| JaLCDOI | 10.18926/AMO/64111 |
|---|---|
| フルテキストURL | 76_6_617.pdf |
| 著者 | Kobayashi, Katsuhiro| Shibata, Takashi| Tsuchiya, Hiroki| Akiyama, Tomoyuki| |
| 抄録 | We developed an artificial intelligence (AI) technique to identify epileptic discharges (spikes) in pediatric scalp electroencephalograms (EEGs). We built a convolutional neural network (CNN) model to automatically classify steep potential images into spikes and background activity. For the CNN model’ training and validation, we examined 100 children with spikes in EEGs and another 100 without spikes. A different group of 20 children with spikes and 20 without spikes were the actual test subjects. All subjects were ≥ 3 to < 18 years old. The accuracy, sensitivity, and specificity of the analysis were >0.97 when referential and combination EEG montages were used, and < 0.97 with a bipolar montage. The correct classification of background activity in individual patients was significantly better with a referential montage than with a bipolar montage (p=0.0107). Receiver operating characteristic curves yielded an area under the curve > 0.99, indicating high performance of the classification method. EEG patterns that interfered with correct classification included vertex sharp transients, sleep spindles, alpha rhythm, and low-amplitude ill-formed spikes in a run. Our results demonstrate that AI is a promising tool for automatically interpreting pediatric EEGs. Some avenues for improving the technique were also indicated by our findings. |
| キーワード | neural network deep learning electroencephalogram children spike |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 617 |
| 終了ページ | 624 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549763 |
| Web of Science KeyUT | 000905195100001 |