検索結果 - 岡山大学学術成果リポジトリ

Serum 1,25-dihydroxyvitamin D3 Levels in Patients with Eosinophilic Chronic Rhinosinusitis

JaLCDOI	10.18926/AMO/64033
フルテキストURL	76_5_527.pdf
著者	Makihara, Seiichiro\| Kariya, Shin\| Miyamoto, Shotaro\| Uraguchi, Kensuke\| Oka, Aiko\| Tsumura, Munechika\| Noda, Yohei\| Ando, Mizuo\| Okano, Mitsuhiro\|
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	527
終了ページ	533
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352799
Web of Science KeyUT	000884907100005

Gestational Outcomes and Birth Weight in Japanese Women at the Upper and Lower limits of the Normal BMI range

JaLCDOI	10.18926/AMO/64032
フルテキストURL	76_5_519.pdf
著者	Ishioka, Yoko\| Yamashita, Hiroyuki\| Hamaguchi, Kinya\| Kuwahara, Yoshitaka\| Nakamura, Kaoru\| Nakatsuka, Mikiya\|
抄録	To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014–December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5≤BMI<21 kg/m2), normal (21≤BMI<23 kg/m2), slightly overweight (23≤BMI<25 kg/m2) and overweight (≤ 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ≥13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain.
キーワード	birth weight blood pressure normal body weight pregnancy pre-pregnancy BMI
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	519
終了ページ	526
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352798
Web of Science KeyUT	000884907100004

Effects of Model-Based Iterative Reconstruction in Low-Dose Paranasal Computed Tomography: A Comparison with Filtered Back Projection and Hybrid Iterative Reconstruction

JaLCDOI	10.18926/AMO/64031
フルテキストURL	76_5_511.pdf
著者	Tomita, Hayato\| Kuramochi, Kenji\| Fujikawa, Atsuko\| Ikeda, Hirotaka\| Komita, Midori\| Kurihara, Yoshiko\| Kobayashi, Yasuyuki\| Mimura, Hidefumi\|
抄録	Iterative reconstruction (IR) improves image quality compared with filtered back projection (FBP). This study investigated the usefulness of model-based IR (forward-projected model-based iterative reconstruction solution [FIRST]) in comparison with FBP and hybrid IR (adaptive iterative dose reduction three-dimensional processing [AIDR 3D]) in low-dose paranasal CT. Twenty-four patients with paranasal sinusitis who underwent standard-dose CT (120 kV) and low-dose CT (100 kV) scanning before and after medical treatment were enrolled. Standard-dose CT scans were reconstructed with FBP (FBP120), and low-dose CT scans with FBP (FBP100), AIDR 3D, and FIRST. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in three anatomical structures and effective doses were compared using Mann–Whitney U test. Two radiologists independently evaluated the visibility of 16 anatomical structures, overall image quality, and artifacts. Effective doses in lowdose CT were significantly reduced compared with those in standard-dose CT (0.24 vs 0.43 mSv, p<0.001). FIRST achieved significantly higher SNR (p<0.01, respectively) and CNR (p<0.001, respectively) of evaluated structures and significant improvement in overall image quality (p<0.001), artifacts (p<0.001), and visibility related to muscles (p<0.05) compared to FBP120, FBP100, and AIDR 3D. FIRST allowed radiation-dose reduction, while maintaining objective and subjective image quality in low-dose paranasal CT.
キーワード	paranasal sinuses iterative reconstruction dose reduction low dose
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	511
終了ページ	517
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352797
Web of Science KeyUT	000884907100003

Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements

JaLCDOI	10.18926/AMO/64025
フルテキストURL	76_5_503.pdf
著者	Ogawa, Hirohito\| Honda, Tomoyuki\|
抄録	Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches.
キーワード	EVE nrEVE bornavirus filovirus antiviral
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	503
終了ページ	510
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352796
Web of Science KeyUT	000884907100002

Current Insights into Mesenchymal Signatures in Glioblastoma

JaLCDOI	10.18926/AMO/64024
フルテキストURL	76_5_489.pdf
著者	Matsumoto, Yuji\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
キーワード	glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	489
終了ページ	502
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352795
Web of Science KeyUT	000884907100001

Affine Kac-Moody Groups as Twisted Loop Groups obtained by Galois Descent Considerations

フルテキストURL	mjou_065_035_081.pdf
著者	Morita, Jun\| Pianzola, Arturo\| Shibata, Taiki\|
抄録	We provide explicit generators and relations for the affine Kac-Moody groups, as well as a realization of them as (twisted) loop groups by means of Galois descent considerations. As a consequence, we show that the affine Kac-Moody group of type X(r) N is isomorphic to the fixed-point subgroup of the affine Kac-Moody group of type X(1) N under an action of the Galois group.
キーワード	Affine Kac-Moody groups Loop groups Twisted Chevalley groups
発行日	2023-01
出版物タイトル	Mathematical Journal of Okayama University
巻	65巻
号	1号
出版者	Department of Mathematics, Faculty of Science, Okayama University
開始ページ	35
終了ページ	81
ISSN	0030-1566
NCID	AA00723502
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright ©2023 by the Editorial Board of Mathematical Journal of Okayama University

Commodity momentum decomposition

フルテキストURL	fulltext20221017-5.pdf
著者	Iwanaga, Yasuhiro\| Sakemoto, Ryuta\|
キーワード	commodity futures decomposition momentum
備考	This is the peer reviewed version of the following article: [Iwanaga, Y., & Sakemoto, R. (2023). Commodity momentum decomposition. Journal of Futures Markets, 43, 198–216. https://doi.org/10.1002/fut.22382], which has been published in final form at [ https://doi.org/10.1002/fut.22382]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext is available in Oct. 2024.\|
発行日	2022-10
出版物タイトル	Journal of Futures Markets
巻	43巻
号	2号
出版者	Wiley
開始ページ	198
終了ページ	216
ISSN	0270-7314
NCID	AA10621291
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Wiley Periodicals LLC.
論文のバージョン	author
DOI	10.1002/fut.22382
Web of Science KeyUT	000862234100001
関連URL	isVersionOf https://doi.org/10.1002/fut.22382

Successful and Prompt Treatment with Tepotinib for Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation Combined with Lung Abscess Formation: A Case Report

フルテキストURL	fulltext.pdf
著者	Makimoto, Go\| Shimonishi, Atsushi\| Ohashi, Kadoaki\| Ninomiya, Kiichiro\| Higo, Hisao\| Kato, Yuka\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
キーワード	MET Tepotinib Non-small-cell lung cancer
発行日	2022
出版物タイトル	Case Reports In Oncology
巻	15巻
号	2号
出版者	Karger
開始ページ	494
終了ページ	498
ISSN	1662-6575
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s).
論文のバージョン	publisher
PubMed ID	35702678
DOI	10.1159/000524326
Web of Science KeyUT	000864085100005
関連URL	isVersionOf https://doi.org/10.1159/000524326

Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis

フルテキストURL	fulltext.pdf
著者	Minematsu, Hideki\| Afify, Said M.\| Sugihara, Yuki\| Hassan, Ghmkin\| Zahra, Maram H.\| Seno, Akimasa\| Adachi, Masaki\| Seno, Masaharu\|
発行日	2022-09-17
出版物タイトル	Scientific Reports
巻	12巻
号	1号
出版者	Nature Portfolio
開始ページ	15628
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	36115905
DOI	10.1038/s41598-022-19265-7
Web of Science KeyUT	000854870500011
関連URL	isVersionOf https://doi.org/10.1038/s41598-022-19265-7

Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Takahashi, Takahide\| Watanabe, Natsuki\| Abe, Makoto\| Sakae, Hiroyuki\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Tanaka, Takehiro\| Kawano, Seiji\| Otsuka, Fumio\| Kawahara, Yoshiro\| Yanai, Hiroyuki\| Okada, Hiroyuki\|
キーワード	eradication flow cytometry Helicobacter pylori T lymphocytes
発行日	2022-08-26
出版物タイトル	Medicine
巻	101巻
号	34号
出版者	Lippincott Williams & Wilkins
開始ページ	e30241
ISSN	0025-7974
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 the Author(s).
論文のバージョン	publisher
PubMed ID	36042652
DOI	10.1097/MD.0000000000030241
Web of Science KeyUT	000847532100050
関連URL	isVersionOf https://doi.org/10.1097/MD.0000000000030241

A case of endoscopic retrograde cholangiopancreatography-related main pancreatic duct perforation salvaged by endoscopic ultrasonography-guided pancreatic duct drainage

フルテキストURL	fulltext20220922-2.pdf Table1_20220922-2.pdf Table2_20220922-2.pdf figure20220922-2.pdf
著者	Sato, Ryosuke\| Matsumoto, Kazuyuki\| Matsumi, Akihiro\| Morimoto, Kosaku\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Tsutsumi, Koichiro\| Horiguchi, Shigeru\| Kato, Hironari\|
キーワード	EUS-guided pancreatic duct drainage Pancreatic duct perforation ERCP-related perforation
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12328-022-01699-1 This fulltext is available in Sep. 2023.\|
発行日	2022-09-12
出版物タイトル	Clinical Journal of Gastroenterology
巻	15巻
号	6号
出版者	Springer Science and Business Media LLC
開始ページ	1179
終了ページ	1184
ISSN	1865-7257
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Japanese Society of Gastroenterology 2022
論文のバージョン	author
PubMed ID	36094734
DOI	10.1007/s12328-022-01699-1
Web of Science KeyUT	000852906700001
関連URL	isVersionOf https://doi.org/10.1007/s12328-022-01699-1

The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study

フルテキストURL	fulltext.pdf
著者	Matsuoka-Uchiyama, Natsumi\| Tsuji, Kenji\| Sang, Yizhen\| Takahashi, Kensaku\| Fukushima, Kazuhiko\| Takeuchi, Hidemi\| Inagaki, Kenichi\| Uchida, Haruhito A.\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Wada, Jun\|
発行日	2022-09-02
出版物タイトル	Scientific Reports
巻	12巻
号	1号
出版者	Nature Portfolio
開始ページ	14999
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	36056164
DOI	10.1038/s41598-022-19226-0
Web of Science KeyUT	000849436000046
関連URL	isVersionOf https://doi.org/10.1038/s41598-022-19226-0

A Rare Presentation of Invasive Aspergillosis: An Asymptomatic Man with an Abscess Localized to a Parietal Pleura

JaLCDOI	10.18926/AMO/63909
フルテキストURL	76_4_485.pdf
著者	Takahashi, Yuya\| Watanabe, Mototsugu\| Furukawa, Shinichi\| Shiotani, Toshio\| Kataoka, Kazuhiko\|
抄録	Aspergillosis is an infection caused by Aspergillus species, and it manifests in various clinical presentations. We describe the case of a 73-year-old man with a small area of thickening on the thoracic wall detected by computed tomography. Surgical resection confirmed the diagnosis of an Aspergillus abscess. We report this case in view of the rarity of Aspergillus abscess localized to a parietal pleura without any signs of lung parenchymal involvement. After a thorough literature review, we consider this could be the first report of this manifestation. Accumulation of similar cases will be necessary to help spread recognition of this condition.
キーワード	Aspergillus abscess empyema fungal infection pulmonary aspergillosis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	485
終了ページ	488
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123165

Liquid Biopsy Revealed HBOC Pedigree and Led to Medical Management Among the Relatives

JaLCDOI	10.18926/AMO/63908
フルテキストURL	76_4_479.pdf
著者	Ogawa, Chikako\| Hirasawa, Akira\| Sogawa, Reimi\| Hasuoka, Kayoko\| Tomida, Shuta\| Futagawa, Mashu\| Urakawa, Yusaku\| Kochi, Mariko\| Yamamoto, Hideki\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
抄録	A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance.
キーワード	hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	479
終了ページ	483
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123164
Web of Science KeyUT	000882167300012

Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

JaLCDOI	10.18926/AMO/63907
フルテキストURL	76_4_473.pdf
著者	Tsuboi, Nobushige\| Ishida, Joji\| Shimazu, Yosuke\| Edaki, Hisanori\| Uneda, Atsuhito\| Otani, Yoshihiro\| Fujii, Kentaro\| Kurozumi, Kazuhiko\| Ennishi, Daisuke\| Yanai, Hiroyuki\| Date, Isao\|
抄録	Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.
キーワード	glioneuronal tumor with neuropil-like islands genomic profiling
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	473
終了ページ	477
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123163

Molecular-targeted Therapy for Metastatic Renal Cell Carcinoma As First-line Therapy: A Single Institution 13-year Experience

JaLCDOI	10.18926/AMO/63906
フルテキストURL	76_4_465.pdf
著者	Bekku, Kensuke\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Noda, Gaku\| Inoue, Yousuke\| Murao, Wataru\| Ebara, Shin\|
抄録	We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk.
キーワード	metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	465
終了ページ	472
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123162

Efficacy of 0.01% Atropine Eye Drops in Controlling Myopia Progression and Axial Elongation in Children: A Meta-analysis Based on Randomized Controlled Trials

JaLCDOI	10.18926/AMO/63905
フルテキストURL	76_4_457.pdf
著者	Sun, Weiying\| Hasebe, Satoshi\|
抄録	To clarify the preventive effects of 0.01% atropine eye drops against myopia progression and axial elongation in children, a meta-analysis was carried out based on data obtained from PubMed and Web of Science as of August 1, 2021. Randomized controlled trials (RCTs) that enrolled myopic children who had received atropine for at least one year were included in this study, Key search terms included myopia, children, and 0.01% or low-dose atropine. Heterogeneity was quantified by I2 statistics, and meta-analyses were performed using the fixed-effect model. Five RCTs involving 809 unique children were analyzed. One trial was excluded because of a poor Jadad score and markedly rapid myopia progression in controls. The mean effect sizes for 12 months in myopia progression and axial elongation synthesized from the remaining 4 RCTs were 0.20 (95% CI: 0.13 to 0.27) D and −0.08 (−0.11 to −0.04) mm, respectively (p<0.0001). The corresponding inhibition ratios were 28% and 19%. I2 statistics were 6% or less. Sensitivity analysis and funnel plots demonstrated the robustness of the estimation. The 0.01% atropine-induced inhibition ratio for myopia progression in Asian children was roughly half of that originally reported and did not reach the minimum requirement for clinical treatment.
キーワード	myopia 0.01% atropine low-dose atropine axial length myopia progression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	457
終了ページ	463
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123161
Web of Science KeyUT	000882167300011

Elucidation of the Mechanism and Significance of the Erythrocyte Sedimentation Rate from Clinical Laboratory Data

JaLCDOI	10.18926/AMO/63904
フルテキストURL	76_4_447.pdf
著者	Umemura, Hiroshi\| Fukuda, Yoshiaki\| Miyashita, Tetsuo\| Nakayama, Tomohiro\|
抄録	The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner.
キーワード	complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	447
終了ページ	455
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123160

Social Capital and Post-traumatic Stress Disorder among Heavy Rainfall and Flood Victims in Japan

JaLCDOI	10.18926/AMO/63903
フルテキストURL	76_4_439.pdf
著者	Miyaji, Chikara\| Takao, Soshi\| Noguchi, Masayuki\| Okazaki, Tsubasa\| Sato, Shunsuke\| Yorifuji, Takashi\|
抄録	This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex.
キーワード	social capital post-traumatic stress disorder disaster flooding
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	439
終了ページ	446
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123159
Web of Science KeyUT	000882167300010

The Association between Preoperative Blood Pressure Elevations and Postoperative Adverse Outcomes after Non-cardiac Surgery: A Single-center Retrospective Observational Study

JaLCDOI	10.18926/AMO/63902
フルテキストURL	76_4_429.pdf
著者	Yamadori, Yusuke\| Hirao, Tomohiro\| Nlandu R. Ngatu\| Kanda, Kanae\| Syed Mahfuz Al Hasan\| Murakami, Akitsu\| Mashima, Yukinori\| Shirakami, Gotaro\|
抄録	Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice.
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	437
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123158
Web of Science KeyUT	000882167300009