検索結果 2260 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yokomizo, Akemi| Nagae, Hiroko| Athurupana, Rukmali| Nakatsuka, Mikiya| |
| 発行日 | 2023-03-06 |
| 出版物タイトル | PLoS ONE |
| 巻 | 18巻 |
| 号 | 3号 |
| 出版者 | Public Library of Science |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Yokomizo et al. |
| 論文のバージョン | publisher |
| PubMed ID | 36877696 |
| DOI | 10.1371/journal.pone.0281362 |
| Web of Science KeyUT | 000945977800034 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0281362 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wang, Han| Salaipeth, Lakha| Miyazaki, Naoyuki| Suzuki, Nobuhiro| Okamoto, Kenta| |
| 発行日 | 2023-02-27 |
| 出版物タイトル | PLoS Pathogens |
| 巻 | 19巻 |
| 号 | 2号 |
| 出版者 | Public Library of Science |
| 開始ページ | e1011162 |
| ISSN | 1553-7366 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Wang et al. |
| 論文のバージョン | publisher |
| PubMed ID | 36848381 |
| DOI | 10.1371/journal.ppat.1011162 |
| Web of Science KeyUT | 000942039200002 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.ppat.1011162 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsuda, Yui| Tokumasu, Kazuki| Otsuka, Yuki| Sunada, Naruhiko| Honda, Hiroyuki| Sakurada, Yasue| Nakano, Yasuhiro| Hasegawa, Toru| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio| |
| キーワード | dysgeusia dysosmia fatigue hypozincemia long COVID |
| 発行日 | 2023-03-06 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 12巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 2062 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36902849 |
| DOI | 10.3390/jcm12052062 |
| Web of Science KeyUT | 000947564300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm12052062 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Irie, Masao| Okada, Masahiro| Maruo, Yukinori| Nishigawa, Goro| Matsumoto, Takuya| |
| キーワード | shear bond strength flexural strength flexural modulus of elasticity resin luting materials durability dual-cure vs self-cure |
| 発行日 | 2023-02-23 |
| 出版物タイトル | Polymers |
| 巻 | 15巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 1128 |
| ISSN | 2073-4360 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36904369 |
| DOI | 10.3390/polym15051128 |
| Web of Science KeyUT | 000947687600001 |
| 関連URL | isVersionOf https://doi.org/10.3390/polym15051128 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Asano, Yosuke| Matsumoto, Yoshinori| Wada, Jun| Rottapel, Robert| |
| キーワード | E3-ubiquitin ligases ubiquitylation proteasomal degradation osteoimmunology cherubism |
| 発行日 | 2023-02-23 |
| 出版物タイトル | Frontiers in Immunology |
| 巻 | 14巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 1120710 |
| ISSN | 1664-3224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Asano, Matsumoto, Wada and Rottapel. |
| 論文のバージョン | publisher |
| PubMed ID | 36911671 |
| DOI | 10.3389/fimmu.2023.1120710 |
| Web of Science KeyUT | 000945836300001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fimmu.2023.1120710 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Hata, Nanako| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| キーワード | robotic surgery minimally invasive surgery hepato-pancreato-biliary surgery Pfannenstiel incision |
| 発行日 | 2023-03-02 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 12巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 1971 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36902758 |
| DOI | 10.3390/jcm12051971 |
| Web of Science KeyUT | 000947498100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm12051971 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanabe, Yoshinori| Kiritani, Michiru| Deguchi, Tomomi| Hira, Nanami| Tomimoto, Syouta| |
| キーワード | Patient-specific respiratory motion management Stereotactic body radiotherapy Four-dimensional computed tomography Fiducial marker Lung cancer Gating window |
| 発行日 | 2023-01 |
| 出版物タイトル | Physics and Imaging in Radiation Oncology |
| 巻 | 25巻 |
| 出版者 | Elsevier |
| 開始ページ | 100405 |
| ISSN | 2405-6316 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36655212 |
| DOI | 10.1016/j.phro.2022.12.002 |
| Web of Science KeyUT | 000974743600001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.phro.2022.12.002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanabe, Yoshinori| Tanaka, Hidekazu| |
| キーワード | Fiducial marker Respiratory gating method Stereotactic body radiotherapy Tumor tracking Lung cancer 4DCT |
| 発行日 | 2022-10-12 |
| 出版物タイトル | Physics and Imaging in Radiation Oncology |
| 巻 | 24巻 |
| 出版者 | Elsevier B.V. |
| 開始ページ | 82 |
| 終了ページ | 87 |
| ISSN | 24056316 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36267878 |
| DOI | 10.1016/j.phro.2022.10.001 |
| Web of Science KeyUT | 000876945200001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.phro.2022.10.001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanaka, Hiroyoshi Y.| Nakazawa, Takuya| Enomoto, Atsushi| Masamune, Atsushi| Kano, Mitsunobu R.| |
| キーワード | pancreatic cancer tumor microenvironment nanomedicine fibrosis extracellular matrix fibroblast |
| 発行日 | 2023-01-24 |
| 出版物タイトル | Cancers |
| 巻 | 15巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 724 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36765684 |
| DOI | 10.3390/cancers15030724 |
| Web of Science KeyUT | 000929314700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers15030724 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Aikawa, Shohei| Tanaka, Hironori| Ueda, Hiroshi| Maruyama, Masato| Higaki, Kazutaka| |
| キーワード | amorphous co-amorphous crystallization sodium taurocholate glass transition temperature intermolecular interaction dissolution testing |
| 発行日 | 2022-12-27 |
| 出版物タイトル | Pharmaceutics |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | MDPI |
| 開始ページ | 84 |
| ISSN | 1999-4923 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36678713 |
| DOI | 10.3390/pharmaceutics15010084 |
| Web of Science KeyUT | 000927227300001 |
| 関連URL | isVersionOf https://doi.org/10.3390/pharmaceutics15010084 |
| JaLCDOI | 10.18926/AMO/64372 |
|---|---|
| フルテキストURL | 77_1_117.pdf |
| 著者 | Obara, Takafumi| Yumoto, Tetsuya| Aoshima, Kenji| Tsukahara, Kohei| Naito, Hiromichi| Nakao, Atsunori| |
| 抄録 | A 38-year-old primipara Japanese woman suffered cardiac arrest due to a pulmonary thromboembolism 1 day after undergoing a cesarean section. Extracorporeal cardiopulmonary resuscitation was initiated and extracorporeal membrane oxygenation support was needed for 24 h. Despite intensive care, the patient was diagnosed with brain death on day 6. With the family’s consent, comprehensive end-of-life care including organ donation was discussed based on our hospital’s policy. The family decided to donate her organs. Specific training and education are required for emergency physicians to optimize the process of incorporating organ donation into end-of-life care while respecting the patient’s and family’s wishes. |
| キーワード | brain death end-of-life extracorporeal cardiopulmonary resuscitation organ donation potential organ donor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 117 |
| 終了ページ | 120 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849156 |
| Web of Science KeyUT | 000953005500003 |
| JaLCDOI | 10.18926/AMO/64371 |
|---|---|
| フルテキストURL | 77_1_111.pdf |
| 著者 | Amano, Katsuhiko| Sugauchi, Akinari| Yamada, Chiaki| Kogo, Mikihiko| Iida, Seiji| |
| 抄録 | Medication-related osteonecrosis of the jaw (MRONJ) is a side effect in patients taking bone-modifying agents (BMAs), which are highly beneficial for treating osteoporosis and cancer. Bisphosphonates are prescribed to treat secondary osteoporosis in patients with rheumatoid arthritis (RA). We recently encountered two unusual cases of intraoral ONJ in RA patients who had not been treated with a BMA and did not have features of methotrexate- associated lymphoproliferative disorder. Their ONJ stage II bone exposures were treated by conservative therapy, providing good prognoses. These cases indicate that ONJ can occur in RA patients not treated with bisphosphonates. Several risk factors are discussed. |
| キーワード | osteonecrosis of the jaw rheumatoid arthritis risk factor bisphosphonate |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 111 |
| 終了ページ | 116 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849155 |
| Web of Science KeyUT | 000953005500002 |
| JaLCDOI | 10.18926/AMO/64370 |
|---|---|
| フルテキストURL | 77_1_105.pdf |
| 著者 | Iwasaki, Yoshiaki| Higuchi, Chigusa| |
| 抄録 | The inactivated coronavirus disease 2019 vaccine CoronaVac has not been approved in Japan. Little information is available on cases in Japan in which an approved mRNA vaccine was administered as the initial (first or second) dose after two doses of CoronaVac. Furthermore, the safety and efficacy of this combination are not established. We here evaluated the safety and efficacy in a patient who showed an antibody response to an approved vaccine, mRNA-1273, after a previous vaccination with CoronaVac. The adverse events consisted of only mild local and systemic common reactions and were transient. In addition, a strong and persistent antibody response was observed. |
| キーワード | coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 vaccine adverse events antibody response |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 105 |
| 終了ページ | 109 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849154 |
| Web of Science KeyUT | 000953005500001 |
| JaLCDOI | 10.18926/AMO/64369 |
|---|---|
| フルテキストURL | 77_1_97.pdf |
| 著者 | Hoshijima, Mitsuhiro| Oka, Naoki| Matsumura, Tatsushi| Iida, Seiji| Kamioka, Hiroshi| |
| 抄録 | Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases. |
| キーワード | anterior open bite short roots severe crowding four-piece segmental horseshoe Le Fort I osteotomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 97 |
| 終了ページ | 104 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849153 |
| Web of Science KeyUT | 000952978000003 |
| JaLCDOI | 10.18926/AMO/64368 |
|---|---|
| フルテキストURL | 77_1_91.pdf |
| 著者 | Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described. |
| キーワード | annular pancreas gastric cancer laparoscopic distal gastrectomye |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849152 |
| Web of Science KeyUT | 000952978000002 |
| JaLCDOI | 10.18926/AMO/64367 |
|---|---|
| フルテキストURL | 77_1_85.pdf |
| 著者 | Matsuda, Yuki| Otani, Yoshihiro| Yasuhara, Takao| Ando, Mizuo| Higaki, Takaya| Makino, Takuma| Matsumoto, Hiroshi| Oyama, Tadashi| Nishimori, Hisakazu| Date, Isao| |
| 抄録 | A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development. |
| キーワード | bone model skull base surgery radiation-induced osteosarcoma RB1 gene alteration |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 85 |
| 終了ページ | 90 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849151 |
| Web of Science KeyUT | 000952978000001 |
| JaLCDOI | 10.18926/AMO/64365 |
|---|---|
| フルテキストURL | 77_1_75.pdf |
| 著者 | Iwamuro, Masaya| Tanaka, Takehiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| 抄録 | Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis. |
| キーワード | autoimmune gastritis esophagogastroduodenoscopy scattered lesions small white protrusions mucosal lesions |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849149 |
| Web of Science KeyUT | 000952973200001 |
| JaLCDOI | 10.18926/AMO/64364 |
|---|---|
| フルテキストURL | 77_1_71.pdf |
| 著者 | Yamakawa, Yasuaki| Kamatsuki, Yusuke| Noda, Tomoyuki| Kure, Miho| Miyazawa, Shinichi| Ozaki, Toshifumi| |
| 抄録 | We report a case of ipsilateral periprosthetic fractures above and below the knee that occurred at different times due to navigation tracker pin and bone fragility. A 66-year-old Japanese woman with rheumatoid arthritis (RA) underwent a total knee arthroplasty. Four months post-surgery, a periprosthetic fracture above the knee at the navigation pin hole was detected. She underwent osteosynthesis and could walk independently, but she developed an ipsilateral tibial component fracture. Conservative treatment with a splint was followed by bone union. Patients with RA treated with oral steroids tend to develop ipsilateral periprosthetic fractures around the knee due to bone fragility. |
| キーワード | periprosthetic fracture total knee arthroplasty navigation system bone fragility |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 71 |
| 終了ページ | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849147 |
| Web of Science KeyUT | 000952992100005 |
| JaLCDOI | 10.18926/AMO/64363 |
|---|---|
| フルテキストURL | 77_1_65.pdf |
| 著者 | Sato, Ken| Takigawa, Nagio| Kubo, Toshio| Katayama, Hideki| Kishino, Daizo| Okada, Toshiaki| Hisamoto, Akiko| Mimoto, Junko| Ochi, Nobuaki| Yoshino, Tadashi| Ueoka, Hiroshi| Tanimoto, Mitsune| Maeda, Yoshionobu| Kiura, Katsuyuki| |
| 抄録 | We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors. |
| キーワード | celecoxib cisplatin EGCG lung tumor polyphenon E |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849147 |
| Web of Science KeyUT | 000952992100004 |
| JaLCDOI | 10.18926/AMO/64362 |
|---|---|
| フルテキストURL | 77_1_57.pdf |
| 著者 | Katsumata, Ryo| Manabe, Noriaki| Monobe, Yasumasa| Ayaki, Maki| Suehiro, Mitsuhiko| Fujita, Minoru| Kamada, Tomoari| Kawamoto, Hirofumi| Haruma, Ken| |
| 抄録 | Melanosis coli (MC) is an acquired colorectal disorder visualized as colonic mucosa pigmentation. Disease severity is confirmed based on MC depth, shape, and coloration, although the clinical course is not fully understood. This study sought to clarify characteristics of MC development and disappearance and to investigate its clinical course and severity. Contributors to MC grade progression were explored. This study reviewed MC cases discovered via colonoscopy at a single institution over a 10-year period. Of all 216 MC cases, 17 developing and 10 disappearing cases were detected. Anthranoid laxative use was a key factor: 29.4% of the developing cases had used such agents before the initial MC diagnosis, whereas 40% of disappearing cases had discontinued anthranoids prior to detection of MC disappearance. Among 70 grade I cases, progression to grade II occurred in 16 cases during a mean follow-up of 3.67±2.1 years (rate of progression=22.8%). Males more commonly showed progressive than stable grade I cases, and the probability of progression was higher for male than for female cases. An association between anthranoid administration and MC presence was presumed, and grade I MC was found to progress in severity over 5 years. |
| キーワード | melanosis sex characteristics laxatives colorectal neoplasms colonoscopy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 57 |
| 終了ページ | 64 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849146 |
| Web of Science KeyUT | 000952992100003 |