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フルテキストURL K0006477_abstract_review.pdf K0006477_fulltext.pdf
著者 馮 田|
発行日 2021-09-24
資料タイプ 学位論文
学位授与番号 甲第6477号
学位授与年月日 2021-09-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006464_abstract_review.pdf K0006464_fulltext.pdf
著者 前原 貴典|
発行日 2021-09-24
資料タイプ 学位論文
学位授与番号 甲第6464号
学位授与年月日 2021-09-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2021 Urology Annals
フルテキストURL K0006453_abstract_review.pdf K0006453_fulltext.pdf
著者 村岡 聡介|
発行日 2021-09-24
資料タイプ 学位論文
学位授与番号 甲第6453号
学位授与年月日 2021-09-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
フルテキストURL K0006440_abstract_review.pdf K0006440_fulltext.pdf
著者 井上 博文|
発行日 2021-09-24
資料タイプ 学位論文
学位授与番号 甲第6440号
学位授与年月日 2021-09-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
フルテキストURL K0006436_abstract_review.pdf K0006436_fulltext.pdf
著者 依田 尚之|
発行日 2021-09-24
資料タイプ 学位論文
学位授与番号 甲第6436号
学位授与年月日 2021-09-24
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2021 Elsevier GmbH.
フルテキストURL fulltext.pdf
著者 Kinugasa, Hideaki| Kanzaki, Hiromitsu| Tanaka, Takehiro| Yamamoto, Shumpei| Yamasaki, Yasushi| Nouso, Kazuhiro| Ichimura, Kouichi| Nakagawa, Masahiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki|
発行日 2021-11
出版物タイトル Clinical and Translational Gastroenterology
12巻
11号
出版者 Lippincott Williams & Wilkins
開始ページ e00424
ISSN 2155-384X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Author(s).
論文のバージョン publisher
PubMed ID 34797780
DOI 10.14309/ctg.0000000000000424
Web of Science KeyUT 000720492100001
関連URL isVersionOf https://doi.org/10.14309/ctg.0000000000000424
フルテキストURL fulltext.pdf
著者 Han, Yanyan| Liu, Dandan| Li, Lianhong|
キーワード TAZ PD-L1 Cervical cancer
発行日 2021-11-04
出版物タイトル Cancer Cell International
21巻
1号
出版者 BMC
開始ページ 592
ISSN 1475-2867
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2021
論文のバージョン publisher
PubMed ID 34736474
DOI 10.1186/s12935-021-02287-y
Web of Science KeyUT 000714625000003
関連URL isVersionOf https://doi.org/10.1186/s12935-021-02287-y
フルテキストURL fulltext.pdf
著者 Aokage, Toshiyuki| Seya, Mizuki| Hirayama, Takahiro| Nojima, Tsuyoshi| Iketani, Masumi| Ishikawa, Michiko| Terasaki, Yasuhiro| Taniguchi, Akihiko| Miyahara, Nobuaki| Nakao, Atsunori| Ohsawa, Ikuroh| Naito, Hiromichi|
キーワード Acute respiratory distress syndrome Bleomycin-induced lung injury Macrophage Molecular hydrogen Lung fibrosis
発行日 2021-10-31
出版物タイトル BMC Pulmonary Medicine
21巻
1号
出版者 BMC
開始ページ 339
ISSN 1471-2466
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2021.
論文のバージョン publisher
PubMed ID 34719405
DOI 10.1186/s12890-021-01712-2
Web of Science KeyUT 000713091800001
関連URL isVersionOf https://doi.org/10.1186/s12890-021-01712-2
フルテキストURL fulltext.pdf Corrigendum.pdf
著者 Wang, Chen| Maeda, Masakazu| Chen, Jian| Wang, Mengxue| Naruse, Keiji| Takahashi, Ken|
キーワード TRPM4 Cardiomyocyte H9c2 CRISPR/Cas9 Confocal microscopy DNA sequencing Flow cytometry Western blotting
発行日 2021
出版物タイトル MethodsX
8巻
出版者 ELSEVIER
開始ページ 101404
ISSN 2215-0161
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Authors.
論文のバージョン publisher
PubMed ID 34430300
DOI 10.1016/j.mex.2021.101404
Web of Science KeyUT 000707187100026
関連URL isVersionOf https://doi.org/10.1016/j.mex.2021.101404
JaLCDOI 10.18926/AMO/62819
フルテキストURL 75_6_759.pdf
著者 Shimizu, Dai| Yamamoto, Hiromasa| Shien, Kazuhiko| Taniguchi, Kohei| Miyoshi, Kentaroh| Namba, Kei| Mesaki, Kumi| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi|
抄録 Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.
キーワード non-small cell lung cancer somatic mutations pulmonary adenocarcinoma with enteric differentiation non-V600E BRAF mutation next-generation sequencing
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 759
終了ページ 762
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955547
Web of Science KeyUT 000735319800005
NAID 120007180273
JaLCDOI 10.18926/AMO/62815
フルテキストURL 75_6_741.pdf
著者 Morita, Tetsuro| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki| Tabata, Masahiro| Morizane, Yuki|
抄録 A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient’s visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma.
キーワード adenoid cystic carcinoma choroidal metastasis sublingual gland
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 741
終了ページ 744
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955543
Web of Science KeyUT 000735319800001
NAID 120007180277
JaLCDOI 10.18926/AMO/62813
フルテキストURL 75_6_725.pdf
著者 Matsumoto, Hiroshi| Kimata, Yoshihiro| Ota, Tomoyuki| Sugiyama, Narushi| Onoda, Satoshi| Makino, Takuma| Takeda, Seiko| Mizukawa, Nobuyoshi|
抄録 The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.
キーワード skin flap mucosal flap oral reconstruction morphological change second primary carcinoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 725
終了ページ 734
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955541
NAID 120007180279
JaLCDOI 10.18926/AMO/62811
フルテキストURL 75_6_713.pdf
著者 Aoyama, Tatsuro| Ogiwara, Toshihiro| Ito, Kiyoshi| Miyaoka, Yoshinari| Fujii, Yu| Hanaoka, Yoshiki| Hasegawa, Takatoshi| Watanabe, Gen| Seguchi, Tatsuya| Hongo, Kazuhiro|
抄録 The consistency of spinal meningiomas is important to consider when performing tumor removal surgery. This study evaluated the correlations between spinal meningioma consistency and both preoperative computed tomography (CT) values and histopathological subtypes. Fifteen consecutive patients who underwent surgical resection of spinal meningioma at our institution were identified, and preoperative CT values and the signal intensity of T2-weighted magnetic resonance images of the tumor were determined retrospectively. The consistency of the spinal meningioma was defined based on the ultrasonic surgical aspirator output during tumor debulking. Patients were assigned to 2 groups: a soft group (n=4) and a hard group (n=11). The T2 signal intensity was significantly higher in the soft group than in the hard group (p=0.001). While the CT values were considerably higher in the hard group, the difference was not significant (p=0.19). Regarding the histopathological subtypes, psammomatous meningioma exhibited significantly higher CT values than meningothelial meningioma (p=0.019); however, there was a higher frequency of hard tumors in meningothelial meningioma cases than in psammomatous meningioma cases. Although neither robust correlations between tumor consistency and CT values nor a relationship between tumor consistency and histopathological subtype has been established, these results might help with the perioperative manegement of spinal tumors.
キーワード calcification computed tomography psammoma body spinal meningioma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 713
終了ページ 718
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955539
Web of Science KeyUT 000735297900007
NAID 120007180281
JaLCDOI 10.18926/AMO/62810
フルテキストURL 75_6_705.pdf
著者 Iwata, Takehiro| Maruyama, Yuki| Kawada, Tatsushi| Sadahira, Takuya| Katayama, Satoshi| Takamoto, Atsushi| Sako, Tomoko| Wada, Koichiro| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo|
抄録 Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients.
キーワード testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 705
終了ページ 711
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955538
Web of Science KeyUT 000735297900006
NAID 120007180282
JaLCDOI 10.18926/AMO/62806
フルテキストURL 75_6_677.pdf
著者 Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi|
抄録 Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
キーワード endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 677
終了ページ 684
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955534
Web of Science KeyUT 000735297900002
NAID 120007180286
JaLCDOI 10.18926/AMO/62805
フルテキストURL 75_6_671.pdf
著者 Gao, Shangze| Nishibori, Masahiro|
抄録 Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many verte-brates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant and well-characterized protein having a multidomain structure that enable it to interact with many ligands, func-tion as an adaptor molecule, and participate in numerous physiological and pathological processes. As a plasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis and angiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plas-minogen) and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets). This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogen-esis in various pathological conditions.
キーワード histidine-rich glycoprotein vascular biology coagulation angiogenesis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2021-12
75巻
6号
出版者 Okayama University Medical School
開始ページ 671
終了ページ 675
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34955533
Web of Science KeyUT 000735297900001
NAID 120007180287
フルテキストURL fulltext.pdf
著者 Kitamura, Wataru| Ennishi, Daisuke| Yukawa, Ryoya| Sasaki, Ryo| Yoshida, Chikamasa| Takasuka, Hiroki| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Abe, Koji| Yoshino, Tadashi| Maeda, Yoshinobu|
キーワード peripheral T-cell lymphoma chorea single photon-emission computed tomography
発行日 2021-10-01
出版物タイトル Internal Medicine
60巻
19号
出版者 The Japanese Society of Internal Medicine
開始ページ 3155
終了ページ 3160
ISSN 0918-2918
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Japanese Society of Internal Medicine
論文のバージョン publisher
PubMed ID 33814503
DOI 10.2169/internalmedicine.7180-21
Web of Science KeyUT 000706487700015
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.7180-21
JaLCDOI 10.18926/AMO/62781
フルテキストURL 75_5_659.pdf
著者 Ino, Riku| Sada, Ken-ei | Miyauchi, Atsushi| Hashimoto, Daisuke| Nojima, Shigeru| Yamanaka, Shingo| Kawamura, Masafumi|
抄録 A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient’s carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology.
キーワード leptomeningeal carcinomatosis gastric cancer carcinoembryonic antigen cerebrospinal fluid cytology
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-10
75巻
5号
出版者 Okayama University Medical School
開始ページ 659
終了ページ 661
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34703051
Web of Science KeyUT 000711568400006
NAID 120007166666
JaLCDOI 10.18926/AMO/62780
フルテキストURL 75_5_653.pdf
著者 Tsuchie, Hiroyuki | Miyakoshi, Naohisa| Nagasawa, Hiroyuki| Nanjo, Hiroshi| Shimada, Yoichi|
抄録 We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis.
キーワード deep angiomyxoma thigh desmoid-type fibromatosis
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-10
75巻
5号
出版者 Okayama University Medical School
開始ページ 653
終了ページ 657
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34703050
Web of Science KeyUT 000711568400005
NAID 120007166665
JaLCDOI 10.18926/AMO/62779
フルテキストURL 75_5_647.pdf
著者 Uotani, Koji| Yamauchi, Taro| Sano, Keisuke| Sonobe, Hiroshi| Fujiwara, Yoshihiro| Maste, Praful Suresh| Sonawane, Sumeet | Tanaka, Masato|
抄録 Sacral schwannoma is a rare tumor with relatively few symptoms; it thus tends to be large at diagnosis and is challenging to treat surgically. We present the case of a 12-year-old girl with a large sacral schwannoma that was successfully surgically resected using O-arm navigation in a two-stage operation. First, we performed tumor resection from the posterior aspect with assisted O-arm navigation. One week later, resection from the anterior aspect was conducted with posterior spinopelvic fixation and fibula graft. We performed partial resection of the tumor from the anterior and posterior aspects as much as possible. O-arm navigation contributed to precise and safe tumor resection and implant insertion.
キーワード sacral schwannoma cellular schwannoma spinal tumor intradural extramedullary tumor O-arm navigation
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2021-10
75巻
5号
出版者 Okayama University Medical School
開始ページ 647
終了ページ 652
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 34703049
Web of Science KeyUT 000711568400004
NAID 120007166664