| 著者 | 山下 信子| |
|---|---|
| 発行日 | 2003-06-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| JaLCDOI | 10.18926/AMO/31961 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Yamashita, Nobuko| Kimura, Hiroshi| Morishima, Tsuneo| |
| 抄録 | Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). However, EBV has been linked to several refractory diseases such as EBV-associated hemophagocytic syndrome(EBV-AHS) and chronic active EBV infection (CAEBV). In these ectopic diseases, EBV infects T/NK cells, causing severe immunodeficiency with a very high EBV load. In recent years, the laboratory procedure to assess these types of EBV infections has been improved. In particular, real-time polymerase chain reaction (PCR) has been used to quantify the EBV load, and the MHC: peptide tetramer assay has been used to quantitate EBV-specific CTLs; these tests have been employed for the management of the illnesses associated with EBV infection. Here, we have reviewed the recent progress in the clinical application of these assays. The pathogenesis of EBV-infected T/NK cells, and the host immune response to infection, including the roles carried out by innate immunity and inflammatory cytokines, are likely to be revealed in the future. |
| キーワード | chronic active Epstein-Barr virus infection Epstein-Barr virus-associated hemophagocytic syndrome Real-time PCR tetramer |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2005-12 |
| 巻 | 59巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 239 |
| 終了ページ | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 16418766 |
| Web of Science KeyUT | 000234176600001 |
| 著者 | 山下 信子| |
|---|---|
| 発行日 | 2012-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 124巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| |
|---|---|
| 発行日 | 2013-01 |
| 出版物タイトル | Critical Care Medicine |
| 巻 | 41巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 八代 将登| 塚原 宏一| 松川 昭博| 山田 睦子| 藤井 洋輔| 長岡 義晴| 津下 充| 山下 信子| 伊藤 利洋| 山田 雅夫| 増谷 弘| 淀井 淳司| 森島 恒雄| |
|---|---|
| 発行日 | 2013-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/53674 |
|---|---|
| フルテキストURL | 69_5_279.pdf |
| 著者 | Saito, Yukie| Fujii, Yousuke| Yashiro, Masato| Tsuge, Mitsuru| Nosaka, Nobuyuki| Yamashita, Nobuko| Yamada, Mutsuko| Tsukahara, Hirokazu| Morishima, Tsuneo| |
| 抄録 | Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α＋IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS. |
| キーワード | pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-10 |
| 巻 | 69巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 279 |
| 終了ページ | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 26490025 |
| Web of Science KeyUT | 000365519600004 |
| フルテキストURL | JVMS81_8_1191.pdf |
|---|---|
| 著者 | Ogawa, Hirohito| Hirayama, Haruko| Tanaka, Satsuki| Yata, Norio| Namba, Hikaru| Yamashita, Nobuko| Yonemitsu, Kenzo| Maeda, Ken| Mominoki, Katsumi| Yamada, Masao| |
| キーワード | animal experimental facility domestic pig hepatitis E virus zoonosis |
| 発行日 | 2019-08-24 |
| 出版物タイトル | Journal of Veterinary Medical Science |
| 巻 | 81巻 |
| 号 | 8号 |
| 出版者 | The Japanese Society of Veterinary Science |
| 開始ページ | 1191 |
| 終了ページ | 1196 |
| ISSN | 0916-7250 |
| NCID | AA10796138 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2019 The Japanese Society of Veterinary Science |
| 論文のバージョン | publisher |
| PubMed ID | 31281141 |
| DOI | 10.1292/jvms.19-0086 |
| Web of Science KeyUT | 000492854900021 |
| 関連URL | isVersionOf https://doi.org/10.1292/jvms.19-0086 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ogawa, Hirohito| Fujikura, Daisuke| Namba, Hikaru| Yamashita, Nobuko| Honda, Tomoyuki| Yamada, Masao| |
| キーワード | HHV-6B nectin-2 CD112 CD134 virus entry glycoprotein B |
| 発行日 | 2022-01-16 |
| 出版物タイトル | Viruses-Basel |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | MDPI |
| 開始ページ | 160 |
| ISSN | 1999-4915 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35062364 |
| DOI | 10.3390/v14010160 |
| Web of Science KeyUT | 000746000400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/v14010160 |