JaLCDOI 10.18926/AMO/51868
フルテキストURL 67_5_319.pdf
著者 Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki|
抄録 Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
キーワード beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation
Amo Type Case Report
発行日 2013-10
出版物タイトル Acta Medica Okayama
67巻
5号
出版者 Okayama University Medical School
開始ページ 319
終了ページ 324
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24145732
Web of Science KeyUT 000325836100006
フルテキストURL fulltext.pdf
著者 Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.|
発行日 2019-12-27
出版物タイトル Scientific Reports
9巻
出版者 Nature Publishing Group
開始ページ 20235
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31882673
DOI 10.1038/s41598-019-56388-w
Web of Science KeyUT 000509351200002
関連URL isVersionOf https://doi.org/10.1038/s41598-019-56388-w
JaLCDOI 10.18926/AMO/30940
フルテキストURL fulltext.pdf
著者 Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka|
抄録 <p>It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.</p>
キーワード intracranial self-stimulation runway nicotine priming stimulation motivational effect
Amo Type Original Article
発行日 2008-08
出版物タイトル Acta Medica Okayama
62巻
4号
出版者 Okayama University Medical School
開始ページ 227
終了ページ 233
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18766205
Web of Science KeyUT 000258680900002
JaLCDOI 10.18926/AMO/60368
フルテキストURL 74_4_301.pdf
著者 Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki|
抄録 Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex.
キーワード ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor
Amo Type Original Article
発行日 2020-08
出版物タイトル Acta Medica Okayama
74巻
4号
出版者 Okayama University Medical School
開始ページ 301
終了ページ 306
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32843761
著者 藤原 聡子| 千堂 年昭|
発行日 2007-09-03
出版物タイトル 岡山医学会雑誌
119巻
2号
資料タイプ 学術雑誌論文
著者 江角 悟| 相良 英憲| 中本 秋彦| 河崎 陽一| 五味田 裕| 千堂 年昭|
発行日 2013-12-02
出版物タイトル 岡山医学会雑誌
125巻
3号
資料タイプ 学術雑誌論文
フルテキストURL fulltext.pdf
著者 Hagiya, Hideharu| Koyama, Toshihiro| Zamami, Yoshito| Tatebe, Yasuhisa| Funahashi, Tomoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Hinotsu, Shiro| Sendo, Toshiaki| Rakugi, Hiromi| Kano, Mitsunobu R.|
キーワード adult intensive & critical care epidemiology geriatric medicine health & safety health policy public health
発行日 2019-12-11
出版物タイトル BMJ OPEN
9巻
12号
出版者 BMJ Publishing Group
開始ページ e033462
ISSN 2044-6055
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or theiremployer(s)) 2019.
論文のバージョン publisher
PubMed ID 31831549
DOI 10.1136/bmjopen-2019-033462
Web of Science KeyUT 000512773400250
関連URL isVersionOf https://doi.org/10.1136/bmjopen-2019-033462
フルテキストURL K0005463_other1.pdf
著者 iguchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi|
キーワード Empathy Hospital pharmacist Japan Pharmaceutical care
備考 The final publication is available at Springer| 岡山大学審査学位副論文|
発行日 2015-12
出版物タイトル International Journal of Clinical Pharmacy
37巻
6号
出版者 Springer
開始ページ 1258
終了ページ 1266
ISSN 2210-7703
NCID AA12633112
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 26441314
Web of Science KeyUT 000363490100042
関連URL https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016
JaLCDOI 10.18926/AMO/40501
フルテキストURL 64_5_267.pdf
著者 Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
抄録 In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
キーワード intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
発行日 2010-10
出版物タイトル Acta Medica Okayama
64巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 275
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2010 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20975759
Web of Science KeyUT 000283563300001
JaLCDOI 10.18926/AMO/40129
フルテキストURL 64_4_219.pdf
著者 Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
抄録 We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
キーワード ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
発行日 2010-08
出版物タイトル Acta Medica Okayama
64巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 223
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20802538
Web of Science KeyUT 000281384400002
著者 Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
発行日 2013-04-15
出版物タイトル Behavioural Brain Research
243巻
資料タイプ 学術雑誌論文
フルテキストURL fulltext.pdf
著者 Masaoka, Yasuyuki| Kawasaki, Yoichi| Kikuoka, Ryo| Ogawa, Atsushi| Esumi, Satoru| Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Sendo, Toshiaki|
キーワード Valganciclovir Simple suspension method Stability HPLC Gavage tube
発行日 2020-07-07
出版物タイトル Journal of Pharmaceutical Health Care and Sciences
6巻
1号
出版者 BMC
開始ページ 16
ISSN 2055-0294
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 32655872
DOI 10.1186/s40780-020-00172-w
Web of Science KeyUT 000549139200001
関連URL isVersionOf https://doi.org/10.1186/s40780-020-00172-w
フルテキストURL fulltext.pdf
著者 Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka|
キーワード Imipramine Carbamazepine ACTH 5-HT2A receptor Forced swim test Wet-dog shakes Treatment–resistant
備考 Published with permission from the copyright holder.<br> This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240.<br> |
発行日 2008-05-20
出版物タイトル Pharmacology Biochemistry and Behavior
89巻
3号
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
DOI 10.1016/j.pbb.2007.12.015
Web of Science KeyUT 000255311600001
JaLCDOI 10.18926/AMO/52893
フルテキストURL 68_5_255.pdf
著者 Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki|
抄録 Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
キーワード motivation reward dopamine operant behavior intracranial self-stimulation
Amo Type Review
発行日 2014-10
出版物タイトル Acta Medica Okayama
68巻
5号
出版者 Okayama University Medical School
開始ページ 255
終了ページ 262
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25338481
Web of Science KeyUT 000343269300001