タイトル(別表記) | Investigation of neural mechanisms involved in pleasant and unpleasant emotions or motivation using behavioral pharmacological techniques |
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フルテキストURL | 133_23.pdf |
著者 | 千堂 年昭| |
キーワード | 脳内自己刺激行動 ドパミン 意欲 動機づけ 変異PC12細胞 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2021-04-01 |
巻 | 133巻 |
号 | 1号 |
開始ページ | 23 |
終了ページ | 29 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.133.23 |
言語 | 日本語 |
著作権者 | Copyright (c) 2021 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.133.23 |
NAID | 130008034814 |
タイトル(別表記) | Epidemiological characteristics of novel coronavirus infection in Okayama Prefecture |
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フルテキストURL | 133_43.pdf |
著者 | 東恩納 司| 千堂 年昭| 草野 展周| 塚原 宏一| |
キーワード | 疫学的調査 (epidemiological characteristics) 岡山 (Okayama Prefecture) 新型コロナウイルス感染症 (COVID-19) PCR検査 (PCR testing) SARS-CoV-2 |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2021-04-01 |
巻 | 133巻 |
号 | 1号 |
開始ページ | 43 |
終了ページ | 48 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.133.43 |
言語 | 日本語 |
著作権者 | Copyright (c) 2021 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.133.43 |
NAID | 130008034824 |
フルテキストURL | fulltext.pdf |
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著者 | Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi| |
キーワード | breast cancer drug resistance lung cancer neratinib YES1 |
発行日 | 2019-12-19 |
出版物タイトル | Cancer Science |
巻 | 111巻 |
号 | 3号 |
出版者 | Wiley |
開始ページ | 849 |
終了ページ | 856 |
ISSN | 1347-9032 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2019 The Authors. |
論文のバージョン | publisher |
PubMed ID | 31856375 |
DOI | 10.1111/cas.14289 |
Web of Science KeyUT | 000507433400001 |
関連URL | isVersionOf https://doi.org/10.1111/cas.14289 |
著者 | Hayashi, Keiichiro| Ueshima, Satoshi| Ouchida, Mamoru| Mashimo, Tomoji| Nishiki, Teiichi| Sendo, Toshiaki| Serikawa, Tadao| Matsui, Hideki| Ohmori, Iori| |
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発行日 | 2011-05 |
出版物タイトル | Epilepsia |
巻 | 52巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/63410 |
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フルテキストURL | 76_2_167.pdf |
著者 | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
抄録 | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
キーワード | febrile neutropenia cefozopran cefepime lung cancer retrospective |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2022-04 |
巻 | 76巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 167 |
終了ページ | 172 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 35503444 |
Web of Science KeyUT | 000792374900008 |
フルテキストURL | fulltext.pdf |
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著者 | Asanuma, Masato| Okumura-Torigoe, Nao| Miyazaki, Ikuko| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
キーワード | astrocyte neuroprotection region-specificity striatum mesencephalon oxidative stress 6-hydroxydopamine Nrf2 phase II detoxifying molecules |
発行日 | 2019-01-30 |
出版物タイトル | International Journal of Molecular Sciences |
巻 | 20巻 |
号 | 3号 |
出版者 | MDPI |
開始ページ | 598 |
ISSN | 1422-0067 |
NCID | AA12038549 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | publisher |
PubMed ID | 30704073 |
DOI | 10.3390/ijms20030598 |
Web of Science KeyUT | 000462412500142 |
関連URL | isVersionOf https://doi.org/10.3390/ijms20030598 |
著者 | Yamaji, Kazuhiko| Kawasaki, Yoichi| Yoshitome, Kei| Matsunaga, Hisashi| Sendo, Toshiaki| |
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発行日 | 2012-10 |
出版物タイトル | Biological & Pharmaceutical Bulletin |
巻 | 35巻 |
号 | 10号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/51868 |
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フルテキストURL | 67_5_319.pdf |
著者 | Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki| |
抄録 | Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs. |
キーワード | beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2013-10 |
巻 | 67巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 319 |
終了ページ | 324 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24145732 |
Web of Science KeyUT | 000325836100006 |
フルテキストURL | fulltext.pdf |
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著者 | Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.| |
発行日 | 2019-12-27 |
出版物タイトル | Scientific Reports |
巻 | 9巻 |
出版者 | Nature Publishing Group |
開始ページ | 20235 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2019 |
論文のバージョン | publisher |
PubMed ID | 31882673 |
DOI | 10.1038/s41598-019-56388-w |
Web of Science KeyUT | 000509351200002 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-019-56388-w |
JaLCDOI | 10.18926/AMO/30940 |
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フルテキストURL | fulltext.pdf |
著者 | Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka| |
抄録 | It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs. |
キーワード | intracranial self-stimulation runway nicotine priming stimulation motivational effect |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2008-08 |
巻 | 62巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 227 |
終了ページ | 233 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18766205 |
Web of Science KeyUT | 000258680900002 |
フルテキストURL | fulltext.pdf |
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著者 | Kikuoka, Ryo| Miyazaki, Ikuko| Kubota, Natsuki| Maeda, Megumi| Kagawa, Daiki| Moriyama, Masaaki| Sato, Asuka| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| Asanuma, Masato| |
発行日 | 2020-11-26 |
出版物タイトル | Scientific Reports |
巻 | 10巻 |
号 | 1号 |
出版者 | Nature Research |
開始ページ | 20698 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2020 |
論文のバージョン | publisher |
PubMed ID | 33244123 |
DOI | 10.1038/s41598-020-77652-4 |
Web of Science KeyUT | 000596329600054 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-020-77652-4 |
JaLCDOI | 10.18926/AMO/60368 |
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フルテキストURL | 74_4_301.pdf |
著者 | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
抄録 | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
キーワード | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-08 |
巻 | 74巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 301 |
終了ページ | 306 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32843761 |
Web of Science KeyUT | 000562508700005 |
NAID | 120006880207 |
著者 | 藤原 聡子| 千堂 年昭| |
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発行日 | 2007-09-03 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 119巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 江角 悟| 相良 英憲| 中本 秋彦| 河崎 陽一| 五味田 裕| 千堂 年昭| |
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発行日 | 2013-12-02 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 125巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
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著者 | Hagiya, Hideharu| Koyama, Toshihiro| Zamami, Yoshito| Tatebe, Yasuhisa| Funahashi, Tomoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Hinotsu, Shiro| Sendo, Toshiaki| Rakugi, Hiromi| Kano, Mitsunobu R.| |
キーワード | adult intensive & critical care epidemiology geriatric medicine health & safety health policy public health |
発行日 | 2019-12-11 |
出版物タイトル | BMJ OPEN |
巻 | 9巻 |
号 | 12号 |
出版者 | BMJ Publishing Group |
開始ページ | e033462 |
ISSN | 2044-6055 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Author(s) (or theiremployer(s)) 2019. |
論文のバージョン | publisher |
PubMed ID | 31831549 |
DOI | 10.1136/bmjopen-2019-033462 |
Web of Science KeyUT | 000512773400250 |
関連URL | isVersionOf https://doi.org/10.1136/bmjopen-2019-033462 |
フルテキストURL | K0005463_other1.pdf |
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著者 | Higuchi, Yuji | Uchitomi, Yosuke| Fujimori, Maiko| Koyama, Toshihiro| Kataoka, Hitomi| Kitamura, Yoshihisa| Sendo, Toshiaki| Inagaki, Masatoshi| |
キーワード | Empathy Hospital pharmacist Japan Pharmaceutical care |
備考 | The final publication is available at Springer| 岡山大学審査学位副論文| |
発行日 | 2015-12 |
出版物タイトル | International Journal of Clinical Pharmacy |
巻 | 37巻 |
号 | 6号 |
出版者 | Springer |
開始ページ | 1258 |
終了ページ | 1266 |
ISSN | 2210-7703 |
NCID | AA12633112 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
論文のバージョン | author |
PubMed ID | 26441314 |
DOI | 10.1007/s11096-015-0204-2 |
Web of Science KeyUT | 000363490100042 |
関連URL | https://doi.org/10.1007/s11096-015-0204-2 http://ousar.lib.okayama-u.ac.jp/55016 |
JaLCDOI | 10.18926/AMO/40501 |
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フルテキストURL | 64_5_267.pdf |
著者 | Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka| |
抄録 | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation. |
キーワード | intracranial self-stimulation behavior motivational effect methamphetamine nicotine |
Amo Type | Review |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-10 |
巻 | 64巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 267 |
終了ページ | 275 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20975759 |
Web of Science KeyUT | 000283563300001 |
JaLCDOI | 10.18926/AMO/40129 |
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フルテキストURL | 64_4_219.pdf |
著者 | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
抄録 | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
キーワード | ACTH imipramine lithium proliferation Ki-67 |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-08 |
巻 | 64巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 219 |
終了ページ | 223 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20802538 |
Web of Science KeyUT | 000281384400002 |
JaLCDOI | 10.18926/AMO/67197 |
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フルテキストURL | 78_3_227.pdf |
著者 | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
抄録 | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
キーワード | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-06 |
巻 | 78巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 227 |
終了ページ | 235 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38902210 |
Web of Science KeyUT | 001267351000003 |
著者 | Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki| |
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発行日 | 2013-04-15 |
出版物タイトル | Behavioural Brain Research |
巻 | 243巻 |
資料タイプ | 学術雑誌論文 |