ID | 40501 |
JaLCDOI | |
フルテキストURL | |
著者 |
Sagara, Hidenori
Department of Pharmacy, Okayama University Hospital
Gomita, Yutaka
School of Pharmacy, Shujitsu University
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抄録 | In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
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キーワード | intracranial self-stimulation behavior
motivational effect
methamphetamine
nicotine
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Amo Type | Review
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2010-10
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巻 | 64巻
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号 | 5号
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出版者 | Okayama University Medical School
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開始ページ | 267
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終了ページ | 275
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2010 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |