| ID | 33002 |
| フルテキストURL | |
| 著者 |
Yano, Masaaki
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
publons
Ouchida, Mamoru
Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University
Kaken ID
publons
researchmap
Shigematsu, Hisayuki
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Tanaka, Noriyoshi
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Ichimura, Koichi
Department of Pathology, Graduate School of Medicine and Dentistry, Okayama University
Kaken ID
publons
Kobayashi, Kazuyasu
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Inaki, Yasuhiko
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Toyooka, Shinichi
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Tsukuda, Kazunori
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
ORCID
Kaken ID
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researchmap
Shimizu, Nobuyoshi
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University
Shimizu, Kenji
Department of Molecular Genetics, Graduate School of Medicine and Dentistry, Okayama University
Kaken ID
publons
researchmap
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| 抄録 | In an attempt to identify tumor suppressor genes on chromosome 10 in non-small cell lung
cancers, we isolated 10 types of splicing variants of the HELLS/ SMARCA6 gene transcripts.
HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular function like chromatin remodeling. Variant 1 was an alternatively spliced isoform containing
an insertion of a 44-ntd intronic sequence between exons 3 and 4, giving rise to a premature
termination of translation. The expression of the variant 1 was detected exclusively in the
lung cancer specimens (11 of 43 cases, 26%), but was not detected in corresponding normal tissues. D10S520 marker in the proximity of the HELLS/SMARCA6 gene showed prevalent allelic loss (41%) as compared with flanking markers (25-31%). These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading the lung cells to malignancy or its progression.
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| キーワード | alternative splicing
HELLS
loss of heterozygosity
lung cancer
SMARCA6
|
| 備考 | Digital Object Identifer:10.1002/ijc.20407
Published with permission from the copyright holder. This is the author's copy, as published in the Journal of International Journal of Cancer, October 2004, Volume 112, Issue 1, Pages 8-13. Publisher URL:http://dx.doi.org/10.1002/ijc.20407 Direct access to Thomson Web of Science record Copyright © 2004 Wiley-Liss, Inc. All rights reserved. |
| 発行日 | 2004-10-20
|
| 出版物タイトル |
International Journal of Cancer
|
| 巻 | 112巻
|
| 号 | 1号
|
| 出版者 | Wiley-Liss, Inc.
|
| 開始ページ | 8
|
| 終了ページ | 13
|
| ISSN | 0020-7136
|
| NCID | AA00680002
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| OAI-PMH Set |
岡山大学
|
| 著作権者 | Wiley-Liss, Inc.
|
| 論文のバージョン | author
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT |
