ID | 33002 |
FullText URL | |
Author |
Yano, Masaaki
publons
Shigematsu, Hisayuki
Tanaka, Noriyoshi
Kobayashi, Kazuyasu
Inaki, Yasuhiko
Toyooka, Shinichi
Shimizu, Nobuyoshi
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Abstract | In an attempt to identify tumor suppressor genes on chromosome 10 in non-small cell lung
cancers, we isolated 10 types of splicing variants of the HELLS/ SMARCA6 gene transcripts.
HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular function like chromatin remodeling. Variant 1 was an alternatively spliced isoform containing
an insertion of a 44-ntd intronic sequence between exons 3 and 4, giving rise to a premature
termination of translation. The expression of the variant 1 was detected exclusively in the
lung cancer specimens (11 of 43 cases, 26%), but was not detected in corresponding normal tissues. D10S520 marker in the proximity of the HELLS/SMARCA6 gene showed prevalent allelic loss (41%) as compared with flanking markers (25-31%). These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading the lung cells to malignancy or its progression.
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Keywords | alternative splicing
HELLS
loss of heterozygosity
lung cancer
SMARCA6
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Note | Digital Object Identifer:10.1002/ijc.20407
Published with permission from the copyright holder. This is the author's copy, as published in the Journal of International Journal of Cancer, October 2004, Volume 112, Issue 1, Pages 8-13. Publisher URL:http://dx.doi.org/10.1002/ijc.20407 Direct access to Thomson Web of Science record Copyright © 2004 Wiley-Liss, Inc. All rights reserved. |
Published Date | 2004-10-20
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Publication Title |
International Journal of Cancer
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Volume | volume112
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Issue | issue1
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Publisher | Wiley-Liss, Inc.
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Start Page | 8
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End Page | 13
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ISSN | 0020-7136
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NCID | AA00680002
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | Wiley-Liss, Inc.
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File Version | author
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PubMed ID | |
DOI | |
Web of Science KeyUT |