JaLCDOI 10.18926/AMO/31850
フルテキストURL fulltext.pdf
著者 Ohmori, Takao| Endo, Hirosuke| Mitani, Shigeru| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
抄録

In 1957, Pavlik introduced the Pavlik harness as a useful treatment for developmental dislocation of the hip (DDH), and subsequent studies have documented favorable outcomes among patients treated with this device. However, there are only a few articles reporting how early radiographic measurements can be used to determine the prognosis after treatment with the Pavlik harness. In this study, 217 hips from 192 patients whose DDH treatment with the Pavlik harness was initiated before they were 6 months old and whose follow-up lasted at least 14 years (rate, 63.8%) were analyzed using measurements from radiographs taken immediately before and after harness treatment, and at 1, 2, and 3 years of age. Severin's classification at the final follow-up was I or II in 71.9% and III or IV in 28.1% of the hips, respectively. Avascular necrosis of the femoral head (AVN) was seen in 10% of the hips. Stepwise multiple regression analysis was performed to retrospectively determine whether any radiographic factors were related to the final classification as Severin I/II or III/IV. Receiver opera-ting characteristic (ROC) curves were drawn for these factors, and a Wiberg OE angle (Point O was the middle point of the proximal metaphyseal border of the femur) of 2 degrees on the 3-year radiographs was found to be the most useful screening value for judging the acetabular development of DDH cases after treatment with a Pavlik harness, with a sensitivity of 71% a specificity of 93%, and a likelihood ratio of 10.1.

キーワード developmental dislocation of the hip long-term follow up radiographic measurement stepwise multiple regression analysis acetabular development
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2009-06
63巻
3号
出版者 Okayama University Medical School
開始ページ 123
終了ページ 128
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 19571898
Web of Science KeyUT 000267388200001
JaLCDOI 10.18926/AMO/32621
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Sugihara, Shinsuke|
抄録

We evaluated the surgical problems encountered during treatment of 14 patients with malignant tumors originating in the pelvic region at our department. The tumor involved the iliac bone in 6 patients, the ischial bone in 2, the pubic bone in 2, and the gluteal region in 4. Invasion to the sacrum was observed in 7 patients. Twelve patients underwent surgical procedures consisting of intralesional resection in 6, marginal resection in 3, and wide margin resection in 3. Six of the 7 patients with sacral invasion developed local recurrence. Two patients with chondrosarcoma and one with parosteal osteosarcoma survived for 4 or more years, but the mean survival period in those with high grade malignant tumors was 11 months. These findings indicate the difficulties encountered in the treatment of malignant pelvic tumors.

キーワード bone neoplasms soft tissue neoplasms malignant neoplasms pelvis surgical treatment
Amo Type Article
出版物タイトル Acta Medica Okayama
発行日 1992-08
46巻
4号
出版者 Okayama University Medical School
開始ページ 265
終了ページ 271
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 1442150
Web of Science KeyUT A1992JL44200006
JaLCDOI 10.18926/AMO/32641
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Taguchi, Kohji| Sugihara, Shinsuke|
抄録

We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of the edematous area around the tumor was similar to or more marked than that of the tumor in 54% of the patients. Area showing inflammatory cells infiltration and edematous areas in the tumor tissue were also enhanced. Thus, the effect of preoperative chemotherapy in tumor tissues other than necrotic and cystic areas tended to be underestimated in T1-Gd. Its effect should be comprehensively evaluated based on not only T1-Gd but also T2-weighted images and findings of other imaging techniques.

キーワード gadolinium diethylenetriaminepentaacetic acid(DTPA) magnetic resonance(MR) bone neoplasms soft tissue neoplasms
Amo Type Article
出版物タイトル Acta Medica Okayama
発行日 1992-12
46巻
6号
出版者 Okayama University Medical School
開始ページ 471
終了ページ 477
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 1485542
Web of Science KeyUT A1992KE49600010
JaLCDOI 10.18926/AMO/32654
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Sugihara, Shinsuke| Sumii, Hiroshi|
抄録

Radiological findings on the fate of grafted Kiel bone implants for the treatment of bone tumors were evaluated in 25 lesions. The mean follow-up period was 14.8 years, ranging from 5 to 21.8 years. We classified the radiological findings into 4 grades; Excellent (4 lesions), Good (14 lesions), Fair (2 lesions), and Poor (5 lesions). All cases of the Poor grade were polyostotic fibrous dysplasia. The younger the patient at the time of the operation, the more rapidly Kiel bone grafts tended to be incorporated. The grafted bone can become enmeshed in the structure of the recipient bed (Good or Excellent grades) within 10 years in most cases, except in polyostotic fibrous dysplasia.

キーワード xenogeneic bone bone grafting bone neoplasms
Amo Type Article
出版物タイトル Acta Medica Okayama
発行日 1992-04
46巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 92
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 1575062
Web of Science KeyUT A1992HR48400005
JaLCDOI 10.18926/AMO/32851
フルテキストURL fulltext.pdf
著者 Shintani, Mai| Senda, Masuo| Takayanagi, Tomoko| Katayama, Yoshimi| Furusawa, Kazunari| Okutani, Tamami| Kataoka, Masaki| Ozaki, Toshifumi|
抄録

To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners.

キーワード service dog HRQOL SF-36v2 people with physical disability
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2010-04
64巻
2号
出版者 Okayama University Medical School
開始ページ 109
終了ページ 113
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 20424665
Web of Science KeyUT 000276996900004
JaLCDOI 10.18926/AMO/32853
フルテキストURL fulltext.pdf
著者 Endo, Hirosuke| Noda, Tomoyuki| Mitani, Shigeru| Nakahara, Ryuichi| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Ozaki, Toshifumi|
抄録

Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually. Here we report a rare case of surgically treated FAI, associated with an osseous protrusion on the acetabulum of a 30-year-old female. Plain computed tomography (CT) and reconstructive 3D-CT images clearly demonstrated an anterolateral bony protrusion. Hip arthroscopy showed no degeneration of the cartilage on either the femoral or acetabular side, but degeneration at the edge of labrum was observed in the region of the bony protrusion. The complete removal of the bony protrusion under hip arthroscopy was thus considered impracticable, and a small skin incision was therefore made anteriorly to approach the acetabulum. The Short-Form 36-Item Health Survey (SF-36) revealed improvement in all scores.

キーワード femoroacetabular impingement bony protrusion Pincer type hip arthroscopy SF36
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2010-04
64巻
2号
出版者 Okayama University Medical School
開始ページ 149
終了ページ 154
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 20424671
Web of Science KeyUT 000276996900010
JaLCDOI 10.18926/AMO/32855
フルテキストURL fulltext.pdf
著者 Shimamura, Yasunori| Nishida, Keiichiro| Imatani, Junya| Noda, Tomoyuki| Hashizume, Hiroyuki| Ohtsuka, Aiji| Ozaki, Toshifumi|
抄録

We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods:an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were:Group I, 98.9+/-32.6;Group II, 108.5+/-27.2;Group III, 50.0+/-7.5;and Group IV, 34.5+/-12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p0.05). In the extension loading test, the mean failure loads were:Group I, 34.0+/-12.4;Group II, 51.0+/-14.8;Group III, 19.3+/-6.0;and Group IV, 14.7+/-3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.

キーワード distal humerus fracture biomechanics internal fixation elderly
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2010-04
64巻
2号
出版者 Okayama University Medical School
開始ページ 115
終了ページ 120
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 20424666
Web of Science KeyUT 000276996900005
JaLCDOI 10.18926/AMO/32889
フルテキストURL fulltext.pdf
著者 Nakanishi, Kazuo| Tanaka, Masato| Sugimoto, Yoshihisa| Ozaki, Toshifumi|
抄録

We performed fixation using laminar screws in 2 patients in whom lateral mass screws, pedicle screws or transarticular screws could not be inserted. One was a 56-year-old woman who had anterior atlantoaxial subluxation (AAS). When a guide wire was inserted using an imaging guide, the hole bled massively. We thought the re-insertion of a guide wire or screw would thus increase the risk of vascular injury, so we used laminar screws. The other case was an 18-year-old man who had a hangman fracture. Preoperative magnetic resonance angiography showed occlusion of the left vertebral artery. A laminar screw was inserted into the patent side (i.e., the right side of C2). Cervical pedicle screws are the most biomechanically stable screws. However, their use carries a high risk of neurovascular complications during screw insertion, because the cervical pedicle is small and is adjacent laterally to the vertebral artery, medially to the spinal cord, and vertically to the nerve roots. Lateral mass screws are also reported to involve a risk of neurovascular injuries. The laminar screw method was thus thought to be useful, since arterial injuries could thus be avoided and it could also be used as a salvage modality for the previous misinsertion.

キーワード laminar screw neurovascular complications lateral mass screw pedicle screw transarticular
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2007-04
61巻
2号
出版者 Okayama University Medical School
開始ページ 115
終了ページ 119
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
PubMed ID 17471313
Web of Science KeyUT 000245875600010
著者 Ito, Tatsuo| Ouchida, Mamoru| Morimoto, Yuki| Yoshida, Aki| Jitsumori, Yoshimi| Ozaki, Toshifumi| Sonobe, Hiroshi| Inoue, Hajime| Shimizu, Kenji|
発行日 2005-06-28
出版物タイトル Cancer Letters
224巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/40007
フルテキストURL fulltext.pdf
著者 Furumatsu, Takayuki| Ozaki, Toshifumi|
抄録 Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
キーワード epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2010-06
64巻
3号
出版者 Okayama University Medical School
開始ページ 155
終了ページ 161
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20596126
Web of Science KeyUT 000279094300001
JaLCDOI 10.18926/AMO/40011
フルテキストURL fulltext.pdf
著者 Honda, Mitsugi| Arita, Seizaburo| Mitani, Shigeru| Takeda, Yoshihiro| Ozaki, Toshifumi| Inamura, Keiji| Kanazawa, Susumu|
抄録 Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH). The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images:the outward displacement rate, upward displacement rate, OE angle, and alpha angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%.
キーワード X-ray image developmental dislocation of the hip acetabular dysplasia radiographic findings nonlinear multivariate analysis infant hip joint diagnostic support system
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2010-06
64巻
3号
出版者 Okayama University Medical School
開始ページ 189
終了ページ 196
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20596130
Web of Science KeyUT 000279094300005
著者 古松 毅之| 尾﨑 敏文| 浅原 弘嗣|
発行日 2010-08-02
出版物タイトル 岡山医学会雑誌
122巻
2号
資料タイプ 学術雑誌論文
著者 藤原 一夫| 遠藤 裕介| 三宅 由晃| 尾﨑 敏文|
発行日 2010-08-02
出版物タイトル 岡山医学会雑誌
122巻
2号
資料タイプ 学術雑誌論文
タイトル(別表記) Japanese guidelines for the treatment of hip fractures in the elderly
フルテキストURL 122_253.pdf
著者 野田 知之| 尾﨑 敏文|
出版物タイトル 岡山医学会雑誌
発行日 2010-12-01
122巻
3号
開始ページ 253
終了ページ 257
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2010 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.122.253
NAID 130004903185
著者 尾崎 敏文|
発行日 1989-06
出版物タイトル 岡山医学会雑誌
101巻
5-6号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/46634
フルテキストURL 65_3_211.pdf
著者 Nakanishi, Kazuo| Yamane, Kentarou| Tanaka, Masato| Misawa, Haruo| Saiga, Kenta| Ozaki, Toshifumi|
抄録 Here we report a case of surgery for kyphosis of the thoracolumbar spine in an elderly patient, in whom surgery was performed because the patient had developed intractable digestive symptoms. The case was that of a 76-year-old female with complaints of back pain and dysphagia. When videofluoroscopic examination (VF) of swallowing was performed in the cardia of the stomach, images that indicated stagnation and the reflux of food were observed. It was easier for the patient to swallow food in the extension position. We performed corrective fusion of the posterior spine. After the surgery, the kyphosis angle was improved to 27°, the patient's back pain was alleviated, and it became easier for the patient to swallow food. VF also showed that the patient's difficulties with the passage of food had improved. We believe that surgery is a good treatment option for cases of kyphosis with digestive symptoms and deteriorating activities of daily living (ADL), even in the absence of pain and paralysis. VF is also useful for performing evaluations before and after surgery.
キーワード kyphosis dysphagia videofluoroscopic examination of swallowing (VF) fusion
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2011-06
65巻
3号
出版者 Okayama University Medical School
開始ページ 211
終了ページ 214
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21709720
Web of Science KeyUT 000292017500009
著者 島村 安則| 井上 円加| 小澤 正嗣| 金澤 智子| 斎藤 太一| 中原 龍一| 野田 知之| 西田 圭一郎| 尾﨑 敏文|
発行日 2011-08-01
出版物タイトル 岡山医学会雑誌
123巻
2号
資料タイプ 学術雑誌論文
著者 Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
発行日 2011-06-03
出版物タイトル Biochemical and Biophysical Research Communications
409巻
2号
資料タイプ 学術雑誌論文
著者 Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi|
発行日 2010-11-12
出版物タイトル Biochemical and Biophysical Research Communications
402巻
2号
資料タイプ 学術雑誌論文
著者 Furumatsu, Takayuki| Hachioji, Motomi| Saiga, Kenta| Takata, Naoki| Yokoyama, Yusuke| Ozaki, Toshifumi|
発行日 2010-01-01
出版物タイトル Biochemical and Biophysical Research Communications
391巻
1号
資料タイプ 学術雑誌論文