JaLCDOI | 10.18926/AMO/32862 |
---|---|
フルテキストURL | 64_1_27.pdf |
著者 | Kobayashi, Yasuyuki| Saika, Takashi| Manabe, Daisuke| Nasu, Yasutomo| Kumon, Hiromi| |
抄録 | We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p0.0001), tumor grade (p0.0324), and venous invasion (p0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC. |
キーワード | nephroureterectomy transitional cell carcinoma upper urinary tract |
Amo Type | Original Article |
備考 | Erratum with Corrected and Republished Article| |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-02 |
巻 | 64巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 27 |
終了ページ | 31 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20200581 |
Web of Science KeyUT | 000274868300004 |
JaLCDOI | 10.18926/AMO/32868 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Arata, Ryoji| Saika, Takashi| Tsushima, Tomoyasu| Abarzua, Fernando| Nasu, Yasutomo| Kumon, Hiromi| |
抄録 | To compare the quality of life (QOL) in patients with ileal neobladder and sigmoidal neobladder, a retrospective survey was conducted using a formulated questionnaire. Between January and March 1999, a QOL survey was conducted using self-administered questionnaires (EORTC QLQ-C30, IPSS, supplemented with detailed questionnaires about continence, sexual function, and patient’s satisfaction with the selected urinary diversion method) for 78 patients with orthotopic urinary reservoir (OUR) who were followed-up for more than 3 months after cystectomy. Among 78 patients, 63 had OUR using an ileal segment (male/female=59/4, median age: 70.8 years old, median follow-up: 1.7 years). Fifteen patients had OUR using a sigmoidal segment (male/female=13/2, median age: 71.9, median follow-up: 3.9). The QLQ-C30 functional evaluation and the items in relation to sexual function showed no diff erences between the 2 groups. Concerning the voiding condition, bladder emptying, frequency, and urgency, scores in the sigmoidal OUR group were signifi cantly higher. The QOL score concerning voiding conditions, daytime, and nighttime continence and quantity of pad showed a better score in the ileal OUR group. Concerning the satisfaction with methods of urinary diversion, patients in the sigmoidal OUR group expressed less satisfaction than their preoperative expectations. Considering several postoperative voiding conditions, ileal OUR seems superior to sigmoidal OUR. |
キーワード | urinary diversion orthotopic urinary reservoirs bladder cancer quality of life |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-08 |
巻 | 61巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 229 |
終了ページ | 234 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 17726512 |
Web of Science KeyUT | 000248957100007 |
JaLCDOI | 10.18926/AMO/32875 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Namba, Yuzaburo| Sugiyama, Narushi| Yamashita, Shuji| Hasegawa, Kenjiro| Kimata, Yoshihiro| Ishii, Kazushi| Nasu, Yasutomo| |
抄録 | To date, many techniques have been reported for vaginoplasty in male-to-female trans-sexual (MTFTS) patients, such as the use of a rectum transfer, a penile-scrotal flap and a reversed penile flap. However, none of these procedures is without its disadvantages. We developed a newly kind of flap for vaginoplasty, the M-shaped perineo-scrotal flap (M-shaped flap), using skin from both sides of the scrotum, shorn of hair by preoperative laser treatment. We applied this new type of flap in 7 MTFTS patients between January 2006 and January 2007. None of the flaps developed necrosis, and the patients could engage in sexual activity within 3 months of the operation. The M-shaped flap has numerous advantages: it can be elevated safely while retaining good vascularity, it provides for the construction of a sufficient deep vagina without a skin graft, the size of the flap is not influenced entirely by the length of the penis, and it utilizes skin from both sides of the scrotal area, which is usually excised. |
キーワード | vaginoplasty male-to-female transsexual perineo-scrotal flap |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-12 |
巻 | 61巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 355 |
終了ページ | 360 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18183081 |
Web of Science KeyUT | 000251943800007 |
JaLCDOI | 10.18926/AMO/32878 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Ebara, Shin| Manabe, Daisuke| Kobayashi, Yasuyuki| Tanimoto, Ryuta| Saika, Takashi| Nasu, Yasutomo| Saito, Shirou| Satoh, Takefumi| Miki, Kenta| Hashine, Katsuyoshi| Kumon, Hiromi| |
抄録 | From September 2003 to December 2005, 188 patients who visited our hospital and allied institutions for the purpose of prostate brachytherapy were administrated hormonal therapy for volume reductions before brachytherapy. The pretreatment and posttreatment of prostate volume using a transrectal ultrasound volumetric study and the types and duration of hormonal therapy were analyzed. We administered 91 patients with Luteinizing hormone-releasing hormone (LH-RH) agonist, 49 patients with anti-androgen (bicaltamide/flutamide), and 48 patients with maximum androgen blockade (MAB). The duration of the hormonal therapy was 1-3 months for 49 patients, 4-6 months for 59 patients, 7-9 months for 40 patients, 10-12 months for 32 patients, and over 13 months for 8 patients. Before the initiation of hormonal therapy, the mean prostate volume was 35.12 ml (11.04-78.71 ml), and the average of prostate volume before and after hormonal therapy was 36.79 ml and 24.79 ml, respectively (a 32.4% reduction). The prostate volume reduction rate was 32.0% for the LH-RH agonist only, 18.1% for the anti-androgen only and 41.2% for the MAB. No statistically significant difference was observed for the duration of hormonal therapy between 3 groups. A three-month course of the neoadjuvant LH-RH agonist indicated a sufficient volume reduction effectiveness for a large prostate volume. |
キーワード | androgen deprivation therapy brachytherapy localized prostate cancer prostate volume reduction |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-12 |
巻 | 61巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 335 |
終了ページ | 340 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18183078 |
Web of Science KeyUT | 000251943800004 |
JaLCDOI | 10.18926/AMO/32881 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Murakami, Takanori| Ebara, Shin| Saika, Takashi| Irie, Shin| Takeda, Katsuji| Maki, Yoshio| Miyaji, Sadayuki| Manabe, Daisuke| Kaku, Haruki| Nasu, Yasutomo| Tsushima, Tomoyasu| Kumon, Hiromi| |
抄録 | We evaluated the need for transurethral biopsy at first follow-up after intravesical bacillus Calmette-Guerin (BCG) therapy for superficial bladder cancer. The records of 84 patients with superficial bladder cancer who received a 6- or 8-week course of BCG were reviewed. Pathological results before BCG, cystoscopic findings, urinary cytology, and biopsy results for evaluation of BCG therapy were reviewed. All 19 patients with positive urinary cytology had evidence of positive bladder biopsy results. Fifty-three of 54 patients (98.1%) with no visible recurrent tumor and negative urinary cytology demonstrated negative pathological results on bladder biopsy. When not found in conjunction with positive urinary cytology, erythematous mucosa on cystoscopy was not an indicator of tumor recurrence or residual cancer. In conclusion, routine transurethral biopsy of the bladder for evaluating the response to BCG intravesical therapy is not necessary in patients who have no visible tumor on cystoscopy and negative urinary cytology./ |
キーワード | bladder cancer BCG therapy transurethral biopsy cystoscopy urinary cytology |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2007-12 |
巻 | 61巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 341 |
終了ページ | 344 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 18183079 |
JaLCDOI | 10.18926/AMO/45274 |
---|---|
フルテキストURL | 65_2_143.pdf |
著者 | Kobayashi, Yasuyuki| Saika, Takashi| Manabe, Daisuke| Nasu, Yasutomo| Kumon, Hiromi| |
抄録 | We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p0.0001), tumor grade (p0.0324), and venous invasion (p0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC. |
キーワード | nephroureterectomy transitional cell carcinoma upper urinary tract |
Amo Type | Corrected and Republished Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-04 |
巻 | 65巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 143 |
終了ページ | 149 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20200581 |
Web of Science KeyUT | 000289818800011 |
JaLCDOI | 10.18926/AMO/47013 |
---|---|
フルテキストURL | 65_5_315.pdf |
著者 | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
抄録 | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR=0.58, 95%CI:0.35-0.97, p=0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR=0.27, 95%CI:0.12-0.61, p=0.002) and in patients with localized diseases (OR=0.36, 95%CI:0.19-0.70, p=0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
キーワード | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-10 |
巻 | 65巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 315 |
終了ページ | 323 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 22037267 |
Web of Science KeyUT | 000296116400005 |
JaLCDOI | 10.18926/AMO/48076 |
---|---|
フルテキストURL | 66_1_7.pdf |
著者 | Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi| |
抄録 | The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer. |
キーワード | REIC Dickkopf-3 gene therapy prostate cancer preclinical study |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2012-02 |
巻 | 66巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 7 |
終了ページ | 16 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 22358134 |
Web of Science KeyUT | 000300800700002 |
フルテキストURL | fulltext20230207-1.pdf |
---|---|
著者 | Matsumoto, Jun| Nishimoto, Anzu| Watari, Shogo| Ueki, Hideo| Shiromizu, Shoya| Iwata, Naohiro| Takeda, Tatsuaki| Ushio, Soichiro| Kajizono, Makoto| Fujiyoshi, Masachika| Koyama, Toshihiro| Araki, Motoo| Wada, Koichiro| Zamami, Yoshito| Nasu, Yasutomo| Ariyoshi, Noritaka| |
キーワード | Genetic variant Polymorphism Renal cell carcinoma Survival UDP-glucuronosyltransferase |
備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11010-022-04637-4| |
発行日 | 2022-12-26 |
出版物タイトル | Molecular and Cellular Biochemistry |
巻 | 478巻 |
号 | 8号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1779 |
終了ページ | 1790 |
ISSN | 0300-8177 |
NCID | AA00745800 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 |
論文のバージョン | author |
PubMed ID | 36571650 |
DOI | 10.1007/s11010-022-04637-4 |
Web of Science KeyUT | 000904010400001 |
関連URL | isVersionOf https://doi.org/10.1007/s11010-022-04637-4 |
タイトル(別表記) | Telemedicine in urology |
---|---|
フルテキストURL | 133_73.pdf |
著者 | 富永 悠介| 荒木 元朗| 那須 保友| |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2021-04-01 |
巻 | 133巻 |
号 | 1号 |
開始ページ | 73 |
終了ページ | 75 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.133.73 |
言語 | 日本語 |
著作権者 | Copyright (c) 2021 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.133.73 |
NAID | 130008034819 |
著者 | 那須 保友| |
---|---|
発行日 | 1986-03-31 |
出版物タイトル | |
資料タイプ | 学位論文 |