著者 | Tomotsuka, Naoto| Kaku, Ryuji| Obata, Norihiko| Matsuoka, Yoshikazu| Kanzaki, Hirotaka| Taniguchi, Arata| Muto, Noriko| Omiya, Hiroki| Itano, Yoshitaro| Sato, Tadasu| Ichikawa, Hiroyuki| Mizobuchi, Satoshi| Morimatsu, Hiroshi| |
---|---|
発行日 | 2014-07-11 |
出版物タイトル | Journal of Pain Research |
巻 | 7巻 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Tani, Makiko| Matsuoka, Yoshikazu| Sugihara, Mayu| Fujii, Ayaka| Kanazawa, Tomoyuki| Morimatsu, Hiroshi| |
キーワード | Esophagogastric junction carcinoma Intra-mediastinal valvuloplastic esophagogastrostomy Hemodynamic instability Tension pneumothorax Anesthetic management |
発行日 | 2021-02-10 |
出版物タイトル | JA Clinical Reports |
巻 | 7巻 |
号 | 1号 |
出版者 | Springer |
開始ページ | 16 |
ISSN | 2363-9024 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s). 2021 |
論文のバージョン | publisher |
PubMed ID | 33566182 |
DOI | 10.1186/s40981-021-00419-x |
Web of Science KeyUT | 000617122800001 |
関連URL | isVersionOf https://doi.org/10.1186/s40981-021-00419-x |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Taninishi, Hideki| Matsusaki, Takashi| Morimatsu, Hiroshi| |
発行日 | 2020-02-28 |
出版物タイトル | Scientific Reports |
巻 | 10巻 |
号 | 1号 |
出版者 | Nature |
開始ページ | 282 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2020 |
論文のバージョン | publisher |
PubMed ID | 32111916 |
DOI | 10.1038/s41598-020-60687-y |
Web of Science KeyUT | 000563058200004 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-020-60687-y |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Kojima, Nana| Kuroda, Kosuke| Tani, Makiko| Kanazawa, Tomoyuki| Shimizu, Kazuyoshi| Maki, Jota| Masuyama, Hisashi| Morimatsu, Hiroshi| |
キーワード | HELLP syndrome Postpartum Plasma exchange therapy Thrombotic microangiopathy |
発行日 | 2023-02-20 |
出版物タイトル | JA Clinical Reports |
巻 | 9巻 |
号 | 1号 |
出版者 | Springer |
開始ページ | 9 |
ISSN | 2363-9024 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023. |
論文のバージョン | publisher |
PubMed ID | 36805852 |
DOI | 10.1186/s40981-023-00602-2 |
Web of Science KeyUT | 000934508200002 |
関連URL | isVersionOf https://doi.org/10.1186/s40981-023-00602-2 |
著者 | Tani, Makiko| Morimatsu, Hiroshi| Takatsu, Fumiaki| Morita, Kiyoshi| |
---|---|
発行日 | 2012 |
出版物タイトル | The Scientific World Journal |
巻 | 2012巻 |
資料タイプ | 学術雑誌論文 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Shen, Zhangtian| Kuroda, Kosuke| Morimatsu, Hiroshi| |
キーワード | blood glucose hemoglobin A1c hypothermia thermoregulation laparoscopy type 2 diabetes |
発行日 | 2023-02-17 |
出版物タイトル | Medicina |
巻 | 59巻 |
号 | 2号 |
出版者 | MDPI |
開始ページ | 395 |
ISSN | 1010-660X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 by the authors. |
論文のバージョン | publisher |
PubMed ID | 36837596 |
DOI | 10.3390/medicina59020395 |
Web of Science KeyUT | 000940707700001 |
関連URL | isVersionOf https://doi.org/10.3390/medicina59020395 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Yasutomi, Nanako| Shimizu, Tatsuhiko| Kanazawa, Tomoyuki| Shimizu, Kazuyoshi| Iwasaki, Tatsuo| Morimatsu, Hiroshi| |
キーワード | Congenital heart disease Fontan circulation Esophageal varices Endoscopic injection sclerotherapy |
発行日 | 2022-07-05 |
出版物タイトル | Ja Clinical Reports |
巻 | 8巻 |
号 | 1号 |
出版者 | Springer |
開始ページ | 48 |
ISSN | 2363-9024 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2022. |
論文のバージョン | publisher |
PubMed ID | 35789440 |
DOI | 10.1186/s40981-022-00538-z |
Web of Science KeyUT | 000820644400001 |
関連URL | isVersionOf https://doi.org/10.1186/s40981-022-00538-z |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Tani, Makiko| Kanazawa, Tomoyuki| Shioji, Naohiro| Shimizu, Kazuyoshi| Iwasaki, Tatsuo| Morimatsu, Hiroshi| |
キーワード | Pneumopericardium Pericardiocentesis Recurrent nerve palsy Pleural pressure Positive pressure ventilation |
発行日 | 2020-10-07 |
出版物タイトル | JA Clinical Reports |
巻 | 6巻 |
号 | 1号 |
出版者 | Springer |
開始ページ | 79 |
ISSN | 2363-9024 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s). 2020 |
論文のバージョン | publisher |
PubMed ID | 33029685 |
DOI | 10.1186/s40981-020-00384-x |
Web of Science KeyUT | 000575851100001 |
関連URL | isVersionOf https://doi.org/10.1186/s40981-020-00384-x |
JaLCDOI | 10.18926/AMO/57948 |
---|---|
フルテキストURL | 74_1_17.pdf |
著者 | Ishii, Kenzo| Morimatsu, Hiroshi| Ono, Kazumi| Miyasho, Koji| |
抄録 | We performed a retrospective cohort study of 911 high-energy trauma patients who underwent chest CT scans at least twice after admission. We hypothesized that in high-energy trauma patients, a high-inspired oxygen concentration delivered after admission results in dorsal atelectasis. The study’s primary outcome was dorsal atelectasis formation diagnosed based on CT images. We defined dorsal atelectasis as the presence of atelectasis at ≥ 10 mm thick on CT images. We defined high-inspired oxygen concentration as >60% oxygen delivered between two CT scans. Four hundred sixty-five patients (51.0%) developed atelectasis according to the second CT scan, and 338 (37.1%) received a high-inspired oxygen concentration. A univariate analysis showed that the rate of the high-inspired oxygen concentration in the atelectasis group was significantly higher than that in the non-atelectasis group (43.4% vs. 30.1%, p<0.001). However, a logistic regression analysis showed that there was no significant relationship between the oxygen concentration and the formation of dorsal atelectasis (OR: 1.197, 95%CI: 0.852-1.683, p=0.30). Age, the Injury Severity Score, BMI, and smoking were found to be risk factors of dorsal atelectasis formation in high-energy trauma patients. There was no relationship between the oxygen concentration and atelectasis formation in our series of high-energy trauma patients. |
キーワード | trauma patient dorsal atelectasis oxygen concentration |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-02 |
巻 | 74巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 17 |
終了ページ | 26 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32099244 |
Web of Science KeyUT | 000516606200003 |
NAID | 120006795615 |
JaLCDOI | 10.18926/AMO/60370 |
---|---|
フルテキストURL | 74_4_319.pdf |
著者 | Isoyama, Satoshi| Kimura, Satoshi| Morimatsu, Hiroshi| |
抄録 | Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data. |
キーワード | acid-base phenomena Stewart approach strong ion difference chlorine ion partial carbon dioxide pressure |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2020-08 |
巻 | 74巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 319 |
終了ページ | 325 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 32843763 |
Web of Science KeyUT | 000562508700007 |
NAID | 120006880209 |
フルテキストURL | fulltext20210601-1.pdf |
---|---|
著者 | Soga, Yoshihiko| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| Ashiwa, Takako| Morimatsu, Hiroshi| |
キーワード | perioperative management nutrition dental oral management |
備考 | This is a post-peer-review, pre-copyedit version of an article published in Current Oral Health Reports. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40496-019-0217-3.| |
発行日 | 2019-04-15 |
出版物タイトル | Current Oral Health Reports |
巻 | 6巻 |
号 | 2号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 70 |
終了ページ | 75 |
ISSN | 2196-3002 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
NAID | 120007042397 |
DOI | 10.1007/s40496-019-0217-3 |
関連URL | isVersionOf https://doi.org/10.1007/s40496-019-0217-3 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Ohtani, Shinkichi| Shimizu, Hiroko| Yamaoka, Masakazu| Takahashi, Toru| Omori, Emiko| Morimatsu, Hiroshi| |
発行日 | 2022-03-16 |
出版物タイトル | PLOS ONE |
巻 | 17巻 |
号 | 3号 |
出版者 | Public Library Science |
開始ページ | e0265512 |
ISSN | 1932-6203 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022 Ohtani et al. |
論文のバージョン | publisher |
PubMed ID | 35294485 |
DOI | 10.1371/journal.pone.0265512 |
Web of Science KeyUT | 000779047400043 |
関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0265512 |
JaLCDOI | 10.18926/AMO/65145 |
---|---|
フルテキストURL | 77_2_161.pdf |
著者 | Yamanoi, Tomoko| Suzuki, Satoshi| Kaku, Ryuji| Morimatsu, Hiroshi| |
抄録 | An intraoperative double-low condition is defined as concurrent low values for bispectral index (BIS) and mean arterial pressure (MAP), and may predict perioperative outcomes. We hypothesized that prolonged double-low times might be associated with an increased incidence of postoperative delirium. We conducted a single-center retrospective observational study on patients who had been admitted to our hospital’s intensive care unit (ICU) after surgery and whose BIS and MAP data had been recorded during general anesthesia. The primary outcome was the incidence of postoperative delirium. A double-low condition was defined as BIS < 45 and MAP <75 mmHg. The total double-low time was calculated in 1-min increments and used to divide the patients into quintiles. Multiple logistic regression analyses were conducted. Among the 334 patients included in the study, the incidence of postoperative delirium was 15.6% (n=52). Multiple logistic regression analysis revealed that a prolonged double-low time, defined as a total double-low time of > 42 min (i.e., third, fourth, and fifth quintiles), was significantly associated with an increased incidence of postoperative delirium (adjusted odds ratio: 2.61, 95% confidence interval: 1.27-5.37, p=0.009). Prolonged double-low time during general anesthesia was independently associated with an increased incidence of postoperative delirium in surgical ICU patients. |
キーワード | postoperative delirium bispectral index hypotension double-low condition general anesthesia |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2023-04 |
巻 | 77巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 161 |
終了ページ | 167 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 37094953 |
Web of Science KeyUT | 000982503800005 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Hiroi, Kazumasa| Matsusaki, Takashi| Kaku, Ryuji| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi| |
発行日 | 2019-10-31 |
出版物タイトル | Transplantation Proceedings |
巻 | 51巻 |
号 | 8号 |
出版者 | Elsevier |
開始ページ | 2750 |
終了ページ | 2754 |
ISSN | 00411345 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2019 The Authors. Published by Elsevier Inc. |
論文のバージョン | publisher |
PubMed ID | 31563245 |
DOI | 10.1016/j.transproceed.2019.01.199 |
Web of Science KeyUT | 000490063000048 |
関連URL | isVersionOf https://doi.org/10.1016/j.transproceed.2019.01.199 |
フルテキストURL | fulltext.pdf |
---|---|
著者 | Matsumoto, Naohisa| Matsusaki, Takashi| Hiroi, Kazumasa| Kaku, Ryuji| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi| |
備考 | 11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)| |
発行日 | 2020-03-31 |
出版物タイトル | Transplantation Proceedings |
巻 | 52巻 |
号 | 2号 |
出版者 | Elsevier |
開始ページ | 630 |
終了ページ | 633 |
ISSN | 00411345 |
NCID | AA00868957 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2020 The Authors. Published by Elsevier Inc. |
論文のバージョン | publisher |
PubMed ID | 32029317 |
DOI | 10.1016/j.transproceed.2019.11.032 |
Web of Science KeyUT | 000518473000059 |
関連URL | isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032 |
JaLCDOI | 10.18926/AMO/54809 |
---|---|
フルテキストURL | 70_6_461.pdf |
著者 | Shiozaki, Kyoko| Morimatsu, Hiroshi| Matsusaki, Takashi| Iwasaki, Tatsuo| |
抄録 | Many patients suffer from postoperative serious adverse events (SAEs). Here we sought to determine the incidence of SAEs, assess the accuracy of currently used scoring systems in predicting postoperative SAEs, and determine whether a combination of scoring systems would better predict postoperative SAEs. We prospectively evaluated patients who underwent major surgery. We calculated 4 scores: American Society of Anesthesiologists physical status (ASA-PS) score, the Charlson Score, the POSSUM (Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity) score, and the Surgical Apgar Score (SAS). We assessed the occurrence of SAEs. We assessed the association between each score and SAEs. We combined these scoring systems to find the best combination to predict the occurrence of SAEs. Among 284 patients, 43 suffered SAEs. All scoring systems could predict SAEs. However, their predictive power was not high (the area under the receiver operating characteristic curves [AUROC] 0.6-0.7). A combination of the ASA-PS score and the SAS was the most predictive of postoperative SAEs (AUROC 0.714). The incidence of postoperative SAEs was 15.1 . The combination of the ASA-PS score and the SAS may be a useful tool for predicting postoperative serious adverse events after major surgery. |
キーワード | serious adverse events preoperative assessment intraoperative assessment ASA-PS surgical Apgar score |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2016-12 |
巻 | 70巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 461 |
終了ページ | 467 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 28003671 |
JaLCDOI | 10.18926/AMO/53027 |
---|---|
フルテキストURL | 68_6_375.pdf |
著者 | Yamanaka, Reiko| Soga, Yoshihiko| Moriya, Yoshie| Okui, Akemi| Takeuchi, Tetsuo| Sato, Kenji| Morimatsu, Hiroshi| Morita, Manabu| |
抄録 | We encountered a 74-year-old male patient with tongue laceration after convulsive seizures under intensive care. The tongue showed severe swelling, and the right ventral surface had been lacerated by his isolated and pointed right lower canine. Our university hospital has established a perioperative management center, and is promoting interprofessional collaboration, including dentists, in perioperative management. Dentists collaborating in the perioperative management center took dental impressions, with the support of anesthesiologists who opened the patientʼs jaw under propofol sedation, to produce a mouth protector. By raising the patientʼs bite, the completed mouth protector prevented the isolated tooth from contacting the tongue and protected the lacerated wound. Use of the mouth protector prevented the lacerated tongue from coming into contact with the pointed tooth, and the tongue healed gradually. These findings underscore that interprofessional collaboration including dentists can improve the quality of medical care. |
キーワード | mouth protector tongue laceration |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-12 |
巻 | 68巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 375 |
終了ページ | 378 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25519032 |
Web of Science KeyUT | 000346882200008 |
JaLCDOI | 10.18926/AMO/57721 |
---|---|
フルテキストURL | 73_6_543.pdf |
著者 | Kubo, Asuka| Shimizu, Kazuyoshi| Kuroda, Kosuke| Kanazawa, Tomoyuki| Kobayashi, Motomu| Morimatsu, Hiroshi| |
抄録 | We here report that a 71-year-old Japanese woman with a history of anaphylaxis induced by muscle relaxants had local anesthetic systemic toxicity (LAST) following an abdominal surgery under general anesthesia with combined spinal-epidural anesthesia without muscle relaxants. The total dosages of local anesthetics reached 0.67 mg/kg of ropivacaine and 11.5 mg/kg of lidocaine over 12.5 h to obtain sufficient muscle relaxation for surgery. Regional anesthesia is useful in cases in which muscle relaxants are to be avoided during a surgery. However, especially for a patient with risk factors and prolonged surgery, precautions should be taken to prevent LAST. |
キーワード | muscle relaxant-induced anaphylaxis local anesthetic systemic toxicity epidural anesthesia abdominal surgery |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2019-12 |
巻 | 73巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 543 |
終了ページ | 546 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 31871339 |
Web of Science KeyUT | 000503431400012 |
JaLCDOI | 10.18926/AMO/53023 |
---|---|
フルテキストURL | 68_6_339.pdf |
著者 | Nishie, Hiroyuki| Mizobuchi, Satoshi| Suzuki, Etsuji| Sato, Kenji| Toda, Yuichiro| Matsuoka, Junji| Morimatsu, Hiroshi| |
抄録 | The main purpose of this study was to determine the relationships between Japanese individualsʼ interest in living wills and their preferred end-of-life care and death locations. Questionnaires were mailed to 1,000 individuals aged ァ50 to measure these 2 factors. We examined the associations between the respondentsʼ characteristics and their preferred care and death locations by using multinomial logistic regression models. The response rate was 74%. Home was the most frequently preferred place for end-of-life care (64%), and a palliative care unit (PCU) was the most commonly preferred place to die (51%). Living will interest was associated with a preference for care (odds ratio [OR] 4.74, 95% confidence interval [CI] 1.95-12.1) and death (OR 2.75, 95% CI 1.70-4.47) in a PCU rather than a hospital, but it was not associated with the choice between receiving care or dying at home instead of a hospital. We must consider why Japanese people think home death is impracticable. The Japanese palliative care system should be expanded to meet patientsʼ end-of-life needs, and this includes not only facilitating home care but also increasing access to PCU care. |
キーワード | advance healthcare directive living will end-of-life care palliative care unit place of death |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-12 |
巻 | 68巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 339 |
終了ページ | 348 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25519028 |
Web of Science KeyUT | 000346882200004 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/53134 |
JaLCDOI | 10.18926/AMO/54808 |
---|---|
フルテキストURL | 70_6_455.pdf |
著者 | Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi| |
抄録 | Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats. |
キーワード | postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2016-12 |
巻 | 70巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 455 |
終了ページ | 460 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 28003670 |