| JaLCDOI | 10.18926/AMO/52144 |
|---|---|
| フルテキストURL | 68_1_47.pdf |
| 著者 | Ishikawa, Tsutomu| Araki, Motoo| Hirata, Takeshi| Watanabe, Masami| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| Kumon, Hiromi| |
| 抄録 | We report 3 patients with the rare complication of an indwelling urethral catheter misdirected into the ureter. This is the largest series to date. Patients were referred to us for a variety of reasons following exchange of their chronic indwelling urinary catheters. CT in all cases demonstrated the urinary catheters residing in the left ureter. The ages of the patients were 37, 67 and 81 years old. All patients suffered from neurogenic bladder. Two patients were female, one was male, and 2 of the 3 had a sensory disorder inhibiting their pain response. The catheters were replaced with open-end Foley catheters. Extensive follow-up CT scans were obtained in one case, demonstrating improvement of hydronephrosis and no evidence of ureteral stenosis. Cystoscopy in this patient demonstrated normally positioned and functioning ureteral orifices. Although the placement of an indwelling urethral catheter is a comparatively safe procedure, one must keep in mind that this complication can occur, particularly in female patients with neurogenic bladder. CT without contrast is a noninvasive, definitive diagnostic tool. |
| キーワード | complication indwelling urethral catheter imaging computed tomography ureter |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 47 |
| 終了ページ | 51 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553489 |
| Web of Science KeyUT | 000331592800008 |
| JaLCDOI | 10.18926/AMO/52403 |
|---|---|
| フルテキストURL | 68_2_63.pdf |
| 著者 | Fujii, Yasuyuki| Hoshino, Tyuji| Kumon, Hiromi| |
| 抄録 | Dickkopf (DKK) proteins interact with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to modulate WNT signaling. The interaction is mediated by a cysteine-rich domain (C2) in the DKK protein and β-propeller domains (PD) of LRP5/6. However, the third member of the DKK family (DKK3) does not bind to LRP5/6. To determine why DKK3 does not bind to the receptor domains, we performed a molecular modeling simulation study including homology modeling, protein-protein docking and molecular dynamics (MD). The computed affinities (ΔGbinding) between the C2 and PD models were consistent with the previously reported experimental results. The C2 model of DKK3 showed the lowest affinity for PD models. Multiple sequence alignment of C2 domains revealed that the DKK3 genes have a unique 7-amino-acid insertion (L249-E255 in human DKK3) and P258 in a finger loop 1 (FL1). Interestingly, the insertion sequence is evolutionally conserved. MD simulations of high-affinity complex models of C2 and PD showed that FL1 directly interacts with the PD models and stabilizes the complex models. We also built a 7-amino-acid-deletion/P258G mutant model of DKK3C2 and estimated its affinities for the PD models. The affinity for human LRP5PD2 was increased by the substitution (ΔGbinding＝－48.9kcal/mol) and the affinity was compatible with that of high-affinity ligands. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. The sequence differences thus suggest an explanation for this unique property of DKK3. |
| キーワード | DKK3 molecular modeling protein-protein docking LRP5/6 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743782 |
| Web of Science KeyUT | 000334652700002 |
| JaLCDOI | 10.18926/AMO/52405 |
|---|---|
| フルテキストURL | 68_2_89.pdf |
| 著者 | Sako, Shinichi| Kariyama, Reiko| Mitsuhata, Ritsuko| Yamamoto, Masumi| Wada, Koichiro| Ishii, Ayano| Uehara, Shinya| Kokeguchi, Susumu| Kusano, Nobuchika| Kumon, Hiromi| |
| 抄録 | We conducted a study on molecular epidemiology and clinical implications of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolated from urine. Over a 10-year period from 2001 through 2010, a total of 92 MBL-producing P. aeruginosa urine isolates were collected from patients (one isolate per patient) who were admitted to 5 hospitals in Okayama Prefecture, Japan. When cross-infection was suspected in the hospital, pulsed-field gel electrophoresis was performed. In the resulting dendrogram of 79 MBL-producing P. aeruginosa urine isolates, no identical isolates and 7 pairs of isolates with ≥80% similarity were found. The biofilm-forming capabilities of 92 MBL-producing P. aeruginosa urine isolates were significantly greater than those of 92 non-MBL-producing urine isolates in a medium of modified artificial urine. The imipenem resistance transferred in 16 of 18 isolates tested, and these frequencies were in the range of 10－3 to 10－9. All of 18 isolates tested belonged to internationally spread sequence type 235 and had 3 gene cassettes of antimicrobial resistance genes in the class 1 integron. The strong biofilm-forming capabilities of MBL-producing P. aeruginosa urine isolates could be seriously implicated in nosocomial infections. To prevent spread of the organism and transferable genes, effective strategies to inhibit biofilm formation in medical settings are needed. |
| キーワード | Pseudomonas aeruginosa metallo-β-lactamase molecular epidemiology biofilm urinary tract infection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 89 |
| 終了ページ | 99 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743784 |
| Web of Science KeyUT | 000334652700004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52504 |
| 著者 | Ochiai, Kazuhiko| Watanabe, Masami| Ueki, Hideo| Huang, Peng| Fujii, Yasuyuki| Nasu, Yasutomo| Noguchi, Hirofumi| Hirata, Takeshi| Sakaguchi, Masakiyo| Huh, Nam-ho| Kashiwakura, Yuji| Kaku, Haruki| Kumon, Hiromi| |
|---|---|
| 発行日 | 2011-08-26 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 412巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Yokoyama, Teruhiko| Watanabe, Toyohiko| Saika, Takashi| Nasu, Yasutomo| Kumon, Hiromi| Miyaji, Yoshiyuki| Nagai, Atsushi| |
|---|---|
| 発行日 | 2007-10-02 |
| 出版物タイトル | International Journal of Urology |
| 巻 | 14巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nishiguchi, Jun| Hayashi, Yukio| Chancellor, Michael B| de Miguel, Fernando| de Groat, William C| Kumon, Hiromi| Yoshimura, Naoki| |
|---|---|
| 発行日 | 2005-12 |
| 出版物タイトル | Urology |
| 巻 | 66巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Sakaguchi, Masakiyo| Kataoka, Ken| Abarzua, Fernando| Tanimoto, Ryuta| Watanabe, Masami| Murata, Hitoshi| Than, Swe Swe| Kurose, Kaoru| Kashiwakura, Yuji| Ochiai, Kazuhiko| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-ho| |
|---|---|
| 発行日 | 2009-05-22 |
| 出版物タイトル | The Journal of Biological Chemistry |
| 巻 | 284巻 |
| 号 | 21号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Huang, P| Kaku, H| Chen, J| Kashiwakura, Y| Saika, T| Nasu, Y| Urata, Y| Fujiwara, T| Watanabe, M| Kumon, H| |
|---|---|
| 発行日 | 2010-07 |
| 出版物タイトル | Cancer Gene Therapy |
| 巻 | 17巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Tanimoto, Ryuta| Sakaguchi, Masakiyo| Abarzua, Fernando| Kataoka, Ken| Kurose, Kaoru| Murata, Hitoshi| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-Ho| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | International Journal of Cancer |
| 巻 | 126巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Bekku, Kensuke| Saika, Takashi| Kobayashi, Yasuyuki| Kioshimoto, Ryo| Kanbara, Taiki| Nasu, Yasutomo| Kumon, Hiromi| |
|---|---|
| 発行日 | 2013-02 |
| 出版物タイトル | International Journal of Clinical Oncology |
| 巻 | 18巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 公文 裕巳| |
|---|---|
| 発行日 | 2013-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 2号 |
| 資料タイプ | 一般雑誌記事 |
| フルテキストURL | fulltext.pdf Fig_1.pptx Fig_2.pptx |
|---|---|
| 著者 | Maruyama, Yuki| Araki, Motoo| Wada, Koichiro| Yoshinaga, Kasumi| Mitsui, Yosuke| Sadahira, Takuya| Nishimura, Shingo| Edamura, Kohei| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Monga, Manoj| Nasu, Yasutomo| Kumon, Hiromi| |
| キーワード | urothelial carcinoma urinary tract cancer ureteroscopy long-term survival renal pelvis ureter |
| 備考 | This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record Long-term ureteroscopic management of upper tract urothelial carcinoma: 28-year single-centre experience, Japanese Journal of Clinical Oncology, Volume 51, Issue 1, January 2021, Pages 130–137 is available online at: https://doi.org/10.1093/jjco/hyaa132.| |
| 発行日 | 2020-7-27 |
| 出版物タイトル | Japanese Journal of Clinical Oncology |
| 巻 | 51巻 |
| 号 | 1号 |
| 出版者 | Oxford University Press |
| 開始ページ | 130 |
| 終了ページ | 137 |
| ISSN | 0368-2811 |
| NCID | AA00690866 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 32715306 |
| DOI | 10.1093/jjco/hyaa132 |
| Web of Science KeyUT | 000608420900018 |
| 関連URL | isVersionOf https://doi.org/10.1093/jjco/hyaa132 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Xue, Ruizhi| Lin, Wenfeng| Fujita, Hirofumi| Sun, Jingkai| Kinoshita, Rie| Ochiai, Kazuhiko| Futami, Junichiro| Watanabe, Masami| Ohuchi, Hideyo| Sakaguchi, Masakiyo| Tang, Zhengyan| Huang, Peng| Nasu, Yasutomo| Kumon, Hiromi| |
| キーワード | Dkk3/REIC fibrous sheath knock-out RNA-seq spermiation sperm motility |
| 発行日 | 2022-01-31 |
| 出版物タイトル | Genes |
| 巻 | 13巻 |
| 号 | 2号 |
| 出版者 | MDPI |
| 開始ページ | 285 |
| ISSN | 2073-4425 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35205329 |
| DOI | 10.3390/genes13020285 |
| Web of Science KeyUT | 000762788200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/genes13020285 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyamoto, Ai| Honjo, Tomoko| Masui, Mirei| Kinoshita, Rie| Kumon, Hiromi| Kakimi, Kazuhiro| Futami, Junichiro| |
| キーワード | autoantibody biomarker protein engineering cancer-immunity cycle immune monitoring cancer testis antigens |
| 発行日 | 2022-05-04 |
| 出版物タイトル | Frontiers In Oncology |
| 巻 | 12巻 |
| 出版者 | FRONTIERS MEDIA SA |
| 開始ページ | 869393 |
| ISSN | 2234-943X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Miyamoto, Honjo, Masui, Kinoshita, Kumon, Kakimi and Futami. |
| 論文のバージョン | publisher |
| PubMed ID | 35600379 |
| DOI | 10.3389/fonc.2022.869393 |
| Web of Science KeyUT | 000797484100001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fonc.2022.869393 |
| JaLCDOI | 10.18926/AMO/30986 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ebara, Shin| Katayama, Yoshihisa| Tanimoto, Ryuta| Edamura, Kohei| Nose, Hiroyuki| Manabe, Daisuke| Kobayashi, Tomoko| Kobayashi, Yasuyuki| Kobuke, Makoto| Takemoto, Mitsuhiro| Saika, Takeshi| Nasu, Yasutomo| Kanazawa, Susumu| Kumon, Hiromi| |
| 抄録 | From January 2004 to March 2007, 308 patients with clinically localized prostate cancer were treated using iodine-125 (125I) seed implantation (permanent brachytherapy) at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. We evaluated the treatment’s effi cacy and morbidity in 300 prostate cancer patients who were followed up for more than 1 month after brachytherapy. Based on the National Comprehensive Cancer Network (NCCN) guidelines, patients with a prostate volume of less than 40 ml in transrectal ultrasound imaging were classifi ed as low or intermediate risk. The median patient age was 67 years (range 50 to 79 years), the median prostate-specific antigen (PSA) value before biopsy was 6.95 ng/ml (range 1.13 to 24.7 ng/ml), and the median prostate volume was 24.33 ml (range 9.3 to 41.76 ml). The median follow-up was 18 months (range 1 to 36 months) and the PSA levels decreased in almost all patients after brachytherapy. Although 194 of 300 patients (64.7%) complained of diffi culty in urination, pollakisuria/urgency, miction pain, and/or urinary incontinence, all of which might be associated with radiation prostatitis during the fi rst month after brachytherapy, these symptoms gradually improved. 125I seed implantation brachytherapy is safe and eff ective for localized prostate cancer within short-term follow up. |
| キーワード | localized prostate cancer brachytherapy prostate specific antigen urinary morbidity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2008-02 |
| 巻 | 62巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 13 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18323866 |
| Web of Science KeyUT | 000255297600011 |
| 著者 | 公文 裕巳| |
|---|---|
| 発行日 | 2008-01-04 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 119巻 |
| 号 | 3号 |
| 資料タイプ | 一般雑誌記事 |
| 著者 | 小武家 誠| 那須 保友| 公文 裕巳| |
|---|---|
| 発行日 | 2008-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 120巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 門田 晃一| 公文 裕巳| |
|---|---|
| 発行日 | 2005-01-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 116巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 永井 敦| 井口 裕樹| 津島 知靖| 公文 裕巳| |
|---|---|
| 発行日 | 2001-12-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 113巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/52142 |
|---|---|
| フルテキストURL | 68_1_35.pdf |
| 著者 | Araki, Motoo| Jeong, Wooju| Park, Sung Yul| Lee, Young Hoon| Nasu, Yasutomo| Kumon, Hiromi| Hong, Sung Joon| Rha, Koon Ho| |
| 抄録 | The purpose of this study was to compare the positive surgical margin (PSM) rates of 2 techniques of robot-assisted radical prostatectomy (RARP) for pT2 (localized) prostate cancer. A retrospective analysis was conducted of 361 RARP cases, performed from May 2005 to September 2008 by a single surgeon (KHR) at our institution (Yonsei University College of Medicine). In the conventional technique, the bladder neck was transected first. In the modified ultradissection, the lateral border of the bladder neck was dissected and then the bladder neck was transected while the detrusor muscle of the bladder was well visualized. Perioperative characteristics and outcomes and PSM rates were analyzed retrospectively for pT2 patients (n＝217), focusing on a comparison of those undergoing conventional (n＝113) and modified ultradissection (n＝104) techniques. There was no difference between the conventional and modified ultradissection group in mean age, BMI, PSA, prostate volume, biopsy Gleason score, and DʼAmico prognostic criteria distributions. The mean operative time was shorter (p＜0.001) and the estimated blood loss was less (p＜0.01) in the modified ultradissection group. The PSM rate for the bladder neck was significantly reduced by modified ultradissection, from 6.2% to 0% (p＜0.05). In conclusion, modified ultradissection reduces the PSM rate for the bladder neck. |
| キーワード | robot-assisted radical prostatectomy prostate cancer surgery surgical margin technique |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-02 |
| 巻 | 68巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 41 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24553487 |
| Web of Science KeyUT | 000331592800006 |