藤原俊義

Multicentred surgical site infection surveillance using partitioning analysis

著者	Fujiwara, Y.\| Yamada, T.\| Naomoto, Y.\| Yamatsuji, T.\| Shirakawa, Y.\| Tanabe, S.\| Noma, K.\| Kimura, T.\| Aoki, H.\| Matsukawa, H.\| Kimura, M.\| Nonaka, Y.\| Sasaki, H.\| Onoda, T.\| Otawa, Y.\| Takaoka, M.\| Fukazawa, T.\| Ohno, Y.\| Fujiwara, T.\|
発行日	2013-12
出版物タイトル	Journal of Hospital Infection
巻	85巻
号	4号
資料タイプ	学術雑誌論文

食道原発悪性黒色腫の１切除例

タイトル（別表記）	A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
フルテキストURL	126_45.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
キーワード	食道（esophagus）悪性黒色腫（malignant melanoma）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	45
終了ページ	48
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.45
NAID	130004505808

術前DCF療法が著効した食道原発内分泌細胞癌の１切除例

タイトル（別表記）	Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
フルテキストURL	126_39.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
キーワード	食道癌（esophageal cancer）内分泌細胞癌（endocrine cell carcinoma） DCF療法（DCF treatment）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	39
終了ページ	43
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.39
NAID	130004505807

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
フルテキストURL	67_6_333.pdf
著者	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
キーワード	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2013-12
巻	67巻
号	6号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	342
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24356717
Web of Science KeyUT	000328915700001

第19回日本遺伝子治療学会学術集会学会報告

著者	藤原俊義\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	一般雑誌記事

腫瘍融解アデノウイルスによるE2F1-マイクロRNA-7-EGFR経路を介したオートファジー細胞死の誘導分子機構

著者	田澤大\| 矢野修也\| 吉田亮介\| 山崎泰源\| 佐々木剛\| 橋本悠里\| 黒田新士\| 大内正明\| 大西哲平\| 宇野太\| 香川俊輔\| 浦田泰生\| 藤原俊義\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

フルテキストURL	WorldJHepatology_5_4_189-195.pdf
著者	Satoh, Daisuke\| Yagi, Takahito\| Nagasaka, Takeshi\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Utsumi, Masashi\| Tanaka, Takehiro\| Sadamori, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells
発行日	2013-04-27
出版物タイトル	World Journal of Hepatology
巻	5巻
号	4号
開始ページ	189
終了ページ	195
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
論文のバージョン	publisher
DOI	10.4254/wjh.v5.i4.189
オフィシャル URL	http://www.wjgnet.com/1948-5182/full/v5/i4/189.htm\|
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/51448

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

著者	Hasei, Joe\| Sasaki, Tsuyoshi\| Tazawa, Hiroshi\| Osaki, Shuhei\| Yamakawa, Yasuaki\| Kunisada, Toshiyuki\| Yoshida, Aki\| Hashimoto, Yuuri\| Onishi, Teppei\| Uno, Futoshi\| Kagawa, Shunsuke\| Urata, Yasuo\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
発行日	2013-03
出版物タイトル	Molecular Cancer Therapeutics
巻	12巻
号	3号
資料タイプ	学術雑誌論文

Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice

著者	Nishikawa, Toshio\| Takaoka, Munenori\| Ohara, Toshiaki\| Tomono, Yasuko\| Hao, Huifang\| Bao, Xiaohong\| Fukazawa, Takuya\| Wang, Zhigang\| Sakurama, Kazufumi\| Fujiwara, Yasuhiro\| Motoki, Takayuki\| Shirakawa, Yasuhiro\| Yamatsuji, Tomoki\| Tanaka, Noriaki\| Fujiwara, Toshiyoshi\| Naomoto, Yoshio\|
発行日	2013-03
出版物タイトル	Cancer Biology & Therapy
巻	14巻
号	3号
資料タイプ	学術雑誌論文

消化器がんと分子標的治療薬

著者	永坂岳司\| 藤原俊義\|
発行日	2013-08-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	2号
資料タイプ	学術雑誌論文

Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy

著者	Nobuoka, Daisuke\| Yoshikawa, Toshiaki\| Takahashi, Mari\| Iwama, Tatsuaki\| Horie, Kazutaka\| Shimomura, Manami\| Suzuki, Shiro\| Sakemura, Noriko\| Nakatsugawa, Munehide\| Sadamori, Hiroshi\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Nakatsura, Tetsuya\|
発行日	2013-04
出版物タイトル	Cancer Immunology, Immunotherapy
巻	62巻
号	4号
資料タイプ	学術雑誌論文

Successfully Treated Pneumatosis Cystoides Intestinalis with Pneumoperitoneum Onset in a Patient Administered α-glucosidase Inhibitor

JaLCDOI	10.18926/AMO/49672
フルテキストURL	67_2_123.pdf
著者	Tanabe, Shunsuke\| Shirakawa, Yasuhiro\| Takehara, Yuko\| Maeda, Naoaki\| Katsube, Ryoichi\| Ohara, Toshiaki\| Sakurama, Kazufumi\| Noma, Kazuhiro\| Fujiwara, Toshiyoshi\|
抄録	An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital.
キーワード	pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	128
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603930
Web of Science KeyUT	000317801700008

Living Donor Liver Transplantation to a Survivor of LiverResection for Hepatocellular Carcinoma with Major Portal Vein Invasion

JaLCDOI	10.18926/AMO/49671
フルテキストURL	67_2_117.pdf
著者	Sadamori, Hiroshi\| Yagi, Takahito\| Shinoura, Susumu\| Umeda, Yuzo\| Yoshida, Ryuichi\| Sato, Daisuke\| Nobuoka, Daisuke\| Utsumi, Masashi\| Fujiwara, Toshiyoshi\|
抄録	We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion. A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patientʼs son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence.
キーワード	living donor liver transplantation hepatocellular carcinoma portal vein invasion liver resection
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	117
終了ページ	121
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603929
Web of Science KeyUT	000317801700007

The Maximum Standardized Uptake Value Is More Reliable Than Size Measurement in Early Follow-up to Evaluate Potential Pulmonary Malignancies Following Radiofrequency Ablation

JaLCDOI	10.18926/AMO/49669
フルテキストURL	67_2_105.pdf
著者	Alafate, Aierken\| Shinya, Takayoshi\| Okumura, Yoshihiro\| Sato, Shuhei\| Hiraki, Takao\| Ishii, Hiroaki\| Gobara, Hideo\| Kato, Katsuya\| Fujiwara, Toshiyoshi\| Miyoshi, Shinichiro\| Kaji, Mitsumasa\| Kanazawa, Susumu\|
抄録	We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA.
キーワード	fluorodeoxy glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) non-small cell lung cancer (NSCLC)
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	105
終了ページ	112
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603927
Web of Science KeyUT	000317801700005
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/50688

Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer

著者	Hao, Hui-fang\| Takaoka, Munenori\| Bao, Xiao-hong\| Wang, Zhi-gang\| Tomono, Yasuko\| Sakurama, Kazufumi\| Ohara, Toshiaki\| Fukazawa, Takuya\| Yamatsuji, Tomoki\| Fujiwara, Toshiyoshi\| Naomoto, Yoshio\|
発行日	2012-07-13
出版物タイトル	Biochemical and Biophysical Research Communications
巻	423巻
号	4号
資料タイプ	学術雑誌論文

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

著者	Hashimoto, Yuuri\| Tazawa, Hiroshi\| Teraishi, Fuminori\| Kojima, Toru\| Watanabe, Yuichi\| Uno, Futoshi\| Yano, Shuya\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2012-06-15
出版物タイトル	PLoS ONE
巻	7巻
号	6号
資料タイプ	学術雑誌論文

Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells

著者	Yoshida, Ryosuke\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Yano, Shuya\| Onishi, Teppei\| Sasaki, Tsuyoshi\| Shirakawa, Yasuhiro\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
発行日	2012-11
出版物タイトル	Cancer Immunology, Immunotherapy
巻	61巻
号	11号
資料タイプ	学術雑誌論文

術後感染予防のための抗菌薬使用ガイドライン

著者	篠浦先\| 藤原俊義\|
発行日	2013-04-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	1号
資料タイプ	学術雑誌論文

一次治療でセツキシマブ不耐となった後，三次治療での再使用により奏功した進行大腸癌の一例

著者	稲田涼\| 永坂岳司\| 母里淑子\| 楳田祐三\| 久保田暢人\| 森川達也\| 近藤喜太\| 宇野太\| 貞森裕\| 八木孝仁\| 藤原俊義\|
発行日	2013-04-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	1号
資料タイプ	学術雑誌論文

予後不良な経過をたどったBRAF遺伝子変異を伴うStage Ⅳ大腸癌の１例

著者	稲田涼\| 永坂岳司\| 竹原清人\| 杉原正大\| 母里淑子\| 楳田祐三\| 久保田暢人\| 森川達也\| 近藤喜太\| 宇野太\| 貞森裕\| 八木孝仁\| 藤原俊義\|
発行日	2013-04-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	1号
資料タイプ	学術雑誌論文

藤原 俊義