伊達勲

Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma

著者	Kosaka, H\| Ichikawa, T\| Kurozumi, K\| Kambara, H\| Inoue, S\| Maruo, T\| Nakamura, K\| Hamada, H\| Date, I\|
発行日	2012-08
出版物タイトル	Cancer Gene Therapy
巻	19巻
号	8号
資料タイプ	学術雑誌論文

The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease

著者	Tayra, Judith Thomas\| Kameda, Masahiro\| Yasuhara, Takao\| Agari, Takashi\| Kadota, Tomohito\| Wang, Feifei\| Kikuchi, Yoichiro\| Liang, Hanbai\| Shinko, Aiko\| Wakamori, Takaaki\| Vcelar, Brigitta\| Weik, Robert\| Date, Isao\|
発行日	2013-03-28
出版物タイトル	Brain Research
巻	1502巻
資料タイプ	学術雑誌論文

The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus

著者	Fujii, K\| Kurozumi, K\| Ichikawa, T\| Onishi, M\| Shimazu, Y\| Ishida, J\| Chiocca, EA\| Kaur, B\| Date, I\|
発行日	2013-08
出版物タイトル	Cancer Gene Therapy
巻	20巻
号	8号
資料タイプ	学術雑誌論文

The Therapeutic Potential of Human Umbilical Cord Blood Transplantation for Neonatal Hypoxic-Ischemic Brain Injury and Ischemic Stroke

JaLCDOI	10.18926/AMO/48962
フルテキストURL	66_6_429.pdf
著者	Wang, Feifei\| Maeda, Nagamasa\| Yasuhara, Takao\| Kameda, Masahiro\| Tsuru, Emi\| Yamashita, Tatsuyuki\| Shen, Yuan\| Tsuda, Masayuki\| Date, Isao\| Sagara, Yusuke\|
抄録	Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
キーワード	umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2012-12
巻	66巻
号	6号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	434
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23254576
Web of Science KeyUT	000312966100001

Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke

フルテキストURL	fulltext.pdf correction.pdf
著者	Yabuno, Satoru\| Yasuhara, Takao\| Nagase, Takayuki\| Kawauchi, Satoshi\| Sugahara, Chiaki\| Okazaki, Yosuke\| Hosomoto, Kakeru\| Sasada, Susumu\| Sasaki, Tatsuya\| Tajiri, Naoki\| Borlongan, Cesar V.\| Date, Isao\|
キーワード	Cerebral ischemic infarct Rehabilitation Regenerative medicine SB623 Voluntary exercise
発行日	2023-01-24
出版物タイトル	STEM Cell Research & Therapy
巻	14巻
号	1号
出版者	BMC
開始ページ	10
ISSN	1757-6512
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	36691091
DOI	10.1186/s13287-023-03236-4
Web of Science KeyUT	000920132500001
関連URL	isVersionOf https://doi.org/10.1186/s13287-023-03236-4

Surgery in the Standing Position by a Surgeon with Achilles Tendon Rupture

JaLCDOI	10.18926/AMO/54813
フルテキストURL	70_6_493.pdf
著者	Yasuhara, Takao\| Kuwahara, Ken\| Sasada, Susumu\| Toyoshima, Atsuhiko\| Morimoto, Jun\| Kin, Kyohei\| Manabe, Hiroaki\| Miyoshi, Yasuyuki\| Kusumegi, Akira\| Takahashi, Yuichiro\| Ito, Kiyoshi\| Date, Isao\|
抄録	Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support.
キーワード	Achilles tendon rupture electromyogram genuflection injured leg standing position
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2016-12
巻	70巻
号	6号
出版者	Okayama University Medical School
開始ページ	493
終了ページ	496
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28003675

Successful Treatment of Epilepsy by Resection of Periventricular Nodular Heterotopia

JaLCDOI	10.18926/AMO/49045
フルテキストURL	66_6_487.pdf
著者	Agari, Takashi\| Mihara, Tadahiro\| Baba, Koichi\| Kobayashi, Katsuhiro\| Usui, Naotaka\| Terada, Kiyohito\| Nakamura, Fumihiro\| Matsuda, Kazumi\| Date, Isao\|
抄録	We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
キーワード	periventricular nodular heterotopia epilepsy surgery ictal electroencephalography
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2012-12
巻	66巻
号	6号
出版者	Okayama University Medical School
開始ページ	487
終了ページ	492
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23254583
Web of Science KeyUT	000312966100008

Spinal Surgery after Bilateral Subthalamic Stimulation for Patients with Parkinson's Disease: A Retrospective Outcome Analysis of Pain and Functional Control

フルテキストURL	fulltext.pdf
著者	Umakoshi, Michiari\| Yasuhara, Takao\| Morimoto, Jun\| Murai, Satoshi\| Sasaki, Tatsuya\| Kameda, Masahiro\| Kin, Kyohei\| Miyoshi, Yasuyuki\| Date, Isao\|
キーワード	abnormal posture lumbago neuromodulation pain spinal alignment
発行日	2021-10
出版物タイトル	Neurologia medico-chirurgica
巻	61巻
号	10号
出版者	The Japan Neurosurgical Society
開始ページ	607
終了ページ	618
ISSN	0470-8105
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japan Neurosurgical Society
論文のバージョン	publisher
PubMed ID	34408107
DOI	10.2176/nmc.oa.2021-0094
Web of Science KeyUT	000710287800007
関連URL	isVersionOf https://doi.org/10.2176/nmc.oa.2021-0094

Significance of High-frequency Electrical Brain Activity

JaLCDOI	10.18926/AMO/55201
フルテキストURL	71_3_191.pdf
著者	Kobayashi, Katsuhiro\| Akiyama, Tomoyuki\| Agari, Takashi\| Sasaki, Tatsuya\| Shibata, Takashi\| Hanaoka, Yoshiyuki\| Akiyama, Mari\| Endoh, Fumika\| Oka, Makio\| Date, Isao\|
抄録	Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
キーワード	fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2017-06
巻	71巻
号	3号
出版者	Okayama University Medical School
開始ページ	191
終了ページ	200
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28655938

Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas

著者	Iwado, Eiji\| Ichikawa, Tomotsugu\| Kosaka, Hiroshi\| Otsuka, Shinji\| Kambara, Hirokazu\| Tamiya, Takashi\| Kondo, Seiji\| Date, Isao\|
発行日	2012-12
出版物タイトル	Neuropathology
巻	32巻
号	6号
資料タイプ	学術雑誌論文

Proximal Vertebral Body Fracture after 4-Level Fusion Using L1 as the Upper Instrumented Vertebra for Lumbar Degenerative Disease: Report of 2 Cases with Literature Review

JaLCDOI	10.18926/AMO/50414
フルテキストURL	67_3_197.pdf
著者	Yasuhara, Takao\| Takahashi, Yuichi\| Kumamoto, Shinji\| Nakahara, Masayuki\| Yoneda, Kotaro\| Niimura, Tatsuomi\| Tanoue, Takashi\| Kusumegi, Akira\| Sennari, Takashi\| Hijikata, Yasukazu\| Manabe, Hiroaki\| Miyoshi, Yasuyuki\| Date, Isao\| Ogawa, Koichi\| Nishida, Kenki\|
抄録	Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at the levels of L1/2-4/5. After 4-level fusion using L1 as the upper instrumented vertebra, proximal vertebral body fractures were found along with the right pedicle fractures of L1 in both cases. One of these patients, aged 82 years, was treated as an outpatient using a hard corset for 24 months, but the fractures were exacerbated over time. In the other patient, posterolateral fusion was extended from Th10 to L5. Both patients can walk alone and have been thoroughly followed up. In both cases, the fracture of the right L1 pedicle might be related to the subsequent fractures and fusion failure. In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture.
キーワード	degenerative lumbar scoliosis osteoporosis pedicle fracture posterior lumbar interbody fusion vertebral body fracture
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	197
終了ページ	202
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804144
Web of Science KeyUT	000320747900010

Proteomics-based analysis of invasion-related proteins in malignant gliomas

著者	Maruo, Tomoko\| Ichikawa, Tomotsugu\| Kanzaki, Hirotaka\| Inoue, Satoshi\| Kurozumi, Kazuhiko\| Onishi, Manabu\| Yoshida, Koichi\| Kambara, Hirokazu\| Ouchida, Mamoru\| Shimizu, Kenji\| Tamaru, Seiji\| Chiocca, E. Antonio\| Date, Isao\|
発行日	2013-06
出版物タイトル	Neuropathology
巻	33巻
号	3号
資料タイプ	学術雑誌論文

Protein Transduction Method for Cerebrovascular Disorders

JaLCDOI	10.18926/AMO/31858
フルテキストURL	fulltext.pdf
著者	Ogawa, Tomoyuki\| Ono, Shigeki\| Ichikawa, Tomotsugu\| Arimitsu, Seiji\| Onoda, Keisuke\| Tokunaga, Koji\| Sugiu, Kenji\| Tomizawa, Kazuhito\| Matsui, Hideki\| Date, Isao\|
抄録	Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).
キーワード	cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP)
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2009-02
巻	63巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	7
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	19247417
Web of Science KeyUT	000263730300001

Precise MEP monitoring with a reduced interval is safe and useful for detecting permissive duration for temporary clipping

フルテキストURL	fulltext.pdf
著者	Kameda, Masahiro\| Hishikawa, Tomohito\| Hiramatsu, Masafumi\| Yasuhara, Takao\| Kurozumi, Kazuhiko\| Date, Isao\|
キーワード	Stroke
発行日	2020-02-26
出版物タイトル	Scientific Reports
巻	10巻
号	1号
出版者	Nature
開始ページ	3507
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2020
論文のバージョン	publisher
PubMed ID	32103082
DOI	10.1038/s41598-020-60377-9
Web of Science KeyUT	000563210400001
関連URL	isVersionOf https://doi.org/10.1038/s41598-020-60377-9

Novel 3D-CT evaluation of carotid stent volume: greater chronological expansion of stents in patients with vulnerable plaques

著者	Itami, Hisakazu\| Tokunaga, Koji\| Okuma, Yu\| Hishikawa, Tomohito\| Sugiu, Kenji\| Ida, Kentaro\| Date, Isao\|
発行日	2013-09
出版物タイトル	Neuroradiology
巻	55巻
号	9号
資料タイプ	学術雑誌論文

Neurosurgery for brain metastasis from breast cancer

フルテキストURL	fulltext.pdf
著者	Tomita, Yusuke\| Kurozumi, Kazuhiko\| Fujii, Kentaro\| Shimazu, Yosuke\| Date, Isao\|
キーワード	Metastatic brain tumor breast cancer neurosurgical technique
発行日	2020-08
出版物タイトル	Translational Cancer Research
巻	9巻
号	8号
出版者	AME Publishing Co.
開始ページ	5063
終了ページ	5076
ISSN	2218-676X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Translational Cancer Research. All rights reserved.
論文のバージョン	publisher
DOI	10.21037/tcr.2020.03.68
Web of Science KeyUT	000562138400063
関連URL	isVersionOf https://doi.org/10.21037/tcr.2020.03.68

Moyamoya Disease: A Review of Clinical Research

JaLCDOI	10.18926/AMO/54497
フルテキストURL	70_4_229.pdf
著者	Hishikawa, Tomohito\| Sugiu, Kenji\| Date, Isao\|
抄録	About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.
キーワード	clinical research moyamoya disease
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	229
終了ページ	236
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549666
Web of Science KeyUT	000384748600001

Mobile endovascular therapy for acute treatment of ruptured vertebral artery dissecting aneurysm in multiple hospitals

フルテキストURL	fulltext20210706-2.pdf
著者	Kidani, Naoya\| Sugiu, Kenji\| Terasaka, Kaoru\| Nakashima, Hiroyuki\| Tokunaga, Koji\| Kobayashi, Kazuki\| Kambara, Hirokazu\| Hishikawa, Tomohito\| Hiramatsu, Masafumi\| Date, Isao\|
備考	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00701-021-04885-1\|
発行日	2021-6-19
出版物タイトル	Acta Neurochirurgica
巻	164巻
号	2号
出版者	Springer Science and Business Media LLC
開始ページ	517
終了ページ	523
ISSN	0001-6268
NCID	AA0050885X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	34146152
DOI	10.1007/s00701-021-04885-1
Web of Science KeyUT	000663495400001
関連URL	isVersionOf https://doi.org/10.1007/s00701-021-04885-1

Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

フルテキストURL	fulltext.pdf
著者	Kegoya, Yasuhito\| Otani, Yoshihiro\| Inoue, Yohei\| Mizuta, Ryo\| Higaki, Fumiyo\| Washio, Kana\| Koizumi, Shinichiro\| Kurozumi, Kazuhiko\| Ishida, Joji\| Fujii, Kentaro\| Yamamoto, Norio\| Tanaka, Yoshihiro\| Date, Isao\|
キーワード	Diffuse hemispheric gliomas, H3 G34-mutation Midline invasion Frontal lobe Gross total resection
備考	The version of record of this article, first published in Journal of Neuro-Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11060-024-04587-5\|
発行日	2024-03-01
出版物タイトル	Journal of Neuro-Oncology
巻	167巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	201
終了ページ	210
ISSN	0167-594X
NCID	AA10633712
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38427132
DOI	10.1007/s11060-024-04587-5
Web of Science KeyUT	001181999000002
関連URL	isVersionOf https://doi.org/10.1007/s11060-024-04587-5

Mesenchymal Stem Cell Therapy for Ischemic Stroke

JaLCDOI	10.18926/AMO/55302
フルテキストURL	71_4_263.pdf
著者	Toyoshima, Atsuhiko\| Yasuhara, Takao\| Date, Isao\|
抄録	To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.
キーワード	mesenchymal stem cell ischemic stroke cell transplantation clinical trial
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2017-08
巻	71巻
号	4号
出版者	Okayama University Medical School
開始ページ	263
終了ページ	268
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28824181

伊達 勲