| JaLCDOI | 10.18926/15315 |
|---|---|
| タイトル（別表記） | Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations |
| フルテキストURL | 064_060_064.pdf |
| 著者 | 三牧 祐一| 藤井 義博| 古野 勝志| 五味田 裕| 荒木 泰典| 谷崎 勝朗| |
| 抄録 | 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる｡今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した｡溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した｡アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した｡また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した｡以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。 |
| キーワード | 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 60 |
| 終了ページ | 64. |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307434 |
| JaLCDOI | 10.18926/15333 |
|---|---|
| タイトル（別表記） | Spa therapy for bronchial asthma. Inhalation therapy with hot spnng water and iodine salt solution |
| フルテキストURL | 064_111_115.pdf |
| 著者 | 谷崎 勝朗| |
| 抄録 | 慢性閉塞性呼吸器疾患,特に気管支喘息に対する温泉療法は.温泉療法そのものの効果以外に,温泉保養地の周囲環境が疾患に極めて良好であるという利点を有している｡温泉水やヨードゾルによる吸入療法は,気管支喘息に対して有効であるが,治療効果をより良好なものにするためには,各喘息症例の気道内病態を十分把握しておく必要がある｡板状貯留を呈する過分泌型喘息や細気管支閉塞型喘息に対しては,吸入療法の効果は一般的に低い｡代表的なヨー ドゾル吸入療法の臨床効果は,気管支喘息20例中,著効4例(20%),有効11例(55%),やや有効4例(20%),無効1例であった。 |
| キーワード | 温泉療法 (Spa therapy) 吸入療法 (Inhalation therapy) 温泉水 (Hot spring water) ヨードゾル (lodine salt solution) 気管支喘息 (Bronchial asthma) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 111 |
| 終了ページ | 115 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307467 |
| JaLCDOI | 10.18926/15334 |
|---|---|
| タイトル（別表記） | Spa therapy for bronchial asthma. Spa therapies effective for bronchial asthma and problems in future. |
| フルテキストURL | 064_105_110.pdf |
| 著者 | 谷崎 勝朗| |
| 抄録 | 気管支喘息に対する温泉療法の作用,あるいは効果は,直接作用と間接作用,局所作用と全身作用,即時的効果と遠隔効果などに分類される｡気管支喘息に対する温泉療法の直接作用としては,呼吸器症状およびそれに関連した検査成績の改善として,また間接作用としては副腎皮質機能の改善作用がみられる｡一方,気管支喘息に有用な温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,および鉱泥湿布療法などが明らかにされており,現在これらの温泉療法を組み合わせた複合温泉療法が行われている｡気管支喘息はその臨床病態より,Ia-1.Ia-2,Ib,およびII型に分類される｡このうち,特にIb型やII型は薬物療法のみではコントロールし難い重症難治性喘息を多く含んでいる｡温泉療法は,気管支喘息全般に有効であるばかりでなく,特に薬物療法のみではコントロール困難なIb型やII型の喘息に対しても有効である。しかし,今後新たに気管支喘息に有用な温泉療法を考案して行かねばならない。 |
| キーワード | 温泉療法 (Spa therapy) 温泉プール水泳訓練 (Swimming training in a hot spring pool) ヨードゾル吸入 (Inhalation of iodine salt solution) 鉱泥湿布療法 (Fango therapy) 気管支喘息 (Bronchial asthma) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 105 |
| 終了ページ | 110 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307660 |
| JaLCDOI | 10.18926/15337 |
|---|---|
| タイトル（別表記） | Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans in bronchial asthma |
| フルテキストURL | 064_116_124.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御舩 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| |
| 抄録 | カレジダ特異的IgG及びIgG(4)抗体が,気管支喘息の発症病態に関与しているかどうかについて検討を加えた。カンジダ特異的IgGおよびIgG(4)抗体は, 0-30才の年齢層の症例ではアトピー性素因の強い症例で,また,31-60才の年齢層の症例ではストロイド依存性重症難治性喘息症例で,さらに61才以上の高年令の症例で,その産生亢進が観察される｡これらの症例におけるIgG及びIgG(4)抗体産生は,0-30才の年齢ではアトピーとの関連で,また31-60才の年齢では副腎皮質ホルモンの長期投与と関連して,さらに61才以上の症例では加齢と関連して,細胞性免疫能が低下し,そのためカンジダの発育が促進され,その結果として,IgG及びIgG(4)抗体の産生亢進が見られることが明らかにされている｡すなわち,気管支喘息におけるカンジダに対するIgG系抗体の産生亢進は,cell-mediated immunityの低下と言う共通の基盤を有しており,病因的意義とは必ずしも関連していないことを述べた。 |
| キーワード | カンジダ (Candida) lgG抗体 (IgG antibodies) IgG(4)抗体 (IgG(4) antibodies) アトピー (Atopy) 気管支喘息 (Bronchial asthma) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 116 |
| 終了ページ | 124 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307381 |
| 著者 | 岡山大学医学部附属病院三朝分院| |
|---|---|
| 発行日 | 1993-06 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 巻 | 64巻 |
| 資料タイプ | その他 |
| 著者 | 松原 扶美恵| 遠藤 裕井| 井上 妙子| 貴谷 光| 谷崎 勝朗| |
|---|---|
| 発行日 | 1993-06 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 巻 | 64巻 |
| 資料タイプ | データ・データベース |
| JaLCDOI | 10.18926/15314 |
|---|---|
| タイトル（別表記） | 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 |
| フルテキストURL | 064_052_059.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 中桐 善康| 多田 慎也| 木村 郁郎| |
| 抄録 | Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. |
| キーワード | Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 52 |
| 終了ページ | 59 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307805 |
| JaLCDOI | 10.18926/15299 |
|---|---|
| タイトル（別表記） | ステロイド依存性重症難治性喘息に対する温泉療法の重要性｡過去10年間の181例を対象に。 |
| フルテキストURL | 064_001_010.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 越智 浩二| 原田 英雄| 多田 慎也| 木村 郁郎| |
| 抄録 | Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C. |
| キーワード | swimming training in a hot spring pool (温泉プール水泳訓練) inhalation of iodine salt solution (ヨードゾル吸入) fango therapy (鉱泥湿布療法) SDIA |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 1 |
| 終了ページ | 10 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307391 |
| JaLCDOI | 10.18926/15319 |
|---|---|
| タイトル（別表記） | Effects of vitamin D and exercise on bone mineral density (BMD) measuured by QCT |
| フルテキストURL | 064_071_074.pdf |
| 著者 | 平松 順一| 瓦家 正志| 横田 聡| 杉本 啓介| 光延 文裕| 御舩 尚志| 梶本 和宏| 貴谷 光| 谷崎 勝朗| 中井 睦郎| 穐山 恒雄| |
| 抄録 | 40才～84才(平均64.1才)の患者38例における骨塩量を,ある期間(1～15カ月,平均8.2カ月)をおいて2回,定量的QCT(quantitative computed tomography)法を用いて測定し,その経時的変化によって,骨粗鬆症に対する治療法の効果判定を試みた｡その結果,(1)全体として骨塩量に有意の増加は認められなかった｡(2)骨強化剤使用例についても骨塩量に有意の増加は認められなかった｡(3)運動療法施行者においても骨塩量に有意の増加は認められなかった｡以上のことから骨粗鬆症の治療においては,約1年弱の経過では著明な反応は得られにくいものと思われた｡ただし,一部の運動療法施行者,骨強化剤使用者において,骨塩量の著明な上昇が認められており,さらに経時的な観察が必要と思われた。 |
| キーワード | 骨粗鬆症 (Osteoprosis) 定量的QCT法 (QCT) 加齢 (Aging) 運動療法 (Exercise) ビタミンD (Vitamin D) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 71 |
| 終了ページ | 74 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307358 |
| JaLCDOI | 10.18926/15301 |
|---|---|
| タイトル（別表記） | 気管支喘息における副腎皮質ホルモン長期投与による免疫抑制と気管支肺胞洗浄液中好中球増多との関連 |
| フルテキストURL | 064_017_023.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 原田 英雄| 木村 郁郎| |
| 抄録 | Cellular composition of bronchoalveolar lavage (BAL) fluid was compared between two age-matched steroid-dependent intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma. |
| キーワード | immunosuppression (免疫抑制) BAL neutrophilia (BAL好中球増多) glucocorticoids (副腎皮質ホルモン) bronchial asthma (気管支喘息) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 17 |
| 終了ページ | 23 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307882 |
| JaLCDOI | 10.18926/15308 |
|---|---|
| タイトル（別表記） | 老年者気管支喘息における液性および細胞性免疫反応について |
| フルテキストURL | 064_075_082.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 越智 浩二| 原田 英雄| 多田 慎也| 木村 郁郎| |
| 抄録 | Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging. |
| キーワード | IgE IgG(4) Immunoglobulings (免疫グロブリン) PPD Bronchial asthma (気管支喘息) 加齢 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 75 |
| 終了ページ | 82 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307261 |
| JaLCDOI | 10.18926/15307 |
|---|---|
| タイトル（別表記） | 気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連 |
| フルテキストURL | 064_031_035.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 越智 浩二| 原田 英雄| 多田 慎也| 木村 郁郎| |
| 抄録 | Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the values generally low in those over the age of 40. 2. High IgE antibody values to HDm were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm. |
| キーワード | Serum IgE (血清IgE) IgE antibodies (IgE抗体) house dust mite (ダニ) bronchial asthma (気管支喘息) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 31 |
| 終了ページ | 35 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307674 |
| JaLCDOI | 10.18926/15320 |
|---|---|
| タイトル（別表記） | 気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について |
| フルテキストURL | 064_089_096.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 原田 英雄| 木村 郁郎| |
| 抄録 | Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types. |
| キーワード | Ventilatory function (換気機能) Cellular composition in BAL fluid (気道内細胞成分) chemical mediators (化学伝達物質) aging (加齢) clinical asthma type (臨床病型) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 89 |
| 終了ページ | 96 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307744 |
| JaLCDOI | 10.18926/15317 |
|---|---|
| タイトル（別表記） | Diagonosis of pancreatic cyst using post-ERCP CT examination. |
| フルテキストURL | 064_065_070.pdf |
| 著者 | 越智 浩二| 原田 英雄| 松本 秀次| 妹尾 敏伸| 田中 淳太郎| Riaz Chowdhury| 水島 孝明| 杉本 啓介| 光延 文裕| 谷崎 勝朗| 中井 睦郎| 穐山 恒雄| 蓮岡 英明| |
| 抄録 | ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ |
| キーワード | ERCP (Endoscopic retrograde cholangiopancreatography) CT (Computed tomography) 膵嚢胞 (pancreatic cyst) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 65 |
| 終了ページ | 70 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307547 |
| JaLCDOI | 10.18926/15311 |
|---|---|
| タイトル（別表記） | 抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 |
| フルテキストURL | 064_043_051.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 越智 浩二| 原田 英雄| 中川 二郎| 宗田 良| 高橋 清| 木村 郁郎| |
| 抄録 | We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. |
| キーワード | histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 43 |
| 終了ページ | 51 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307677 |
| JaLCDOI | 10.18926/15305 |
|---|---|
| タイトル（別表記） | 気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討 |
| フルテキストURL | 064_024_030.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 越智 浩二| 原田 英雄| 多田 慎也| 木村 郁郎| |
| 抄録 | Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB. |
| キーワード | airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) lymphocytes (リンパ球) neutrophils (好中球) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 24 |
| 終了ページ | 30 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307730 |
| JaLCDOI | 10.18926/15310 |
|---|---|
| タイトル（別表記） | 気管支喘息の臨床分類とその細胞性および液性因子の特徴 |
| フルテキストURL | 064_036_042.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 中桐 善康| 多田 慎也| 木村 郁郎| |
| 抄録 | Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types. |
| キーワード | Bronchial asthma Asthma classification BAL fluid chemical mediators |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 36 |
| 終了ページ | 42 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307662 |
| JaLCDOI | 10.18926/15332 |
|---|---|
| タイトル（別表記） | 気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について |
| フルテキストURL | 064_097_104.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 木村 郁郎| |
| 抄録 | The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction. |
| キーワード | BAL lymphocytes patient age IgE-mediated allergic reaction bronchial asthma |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 97 |
| 終了ページ | 104 |
| ISSN | 0918-7839 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002307637 |
| JaLCDOI | 10.18926/15312 |
|---|---|
| タイトル（別表記） | 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 |
| フルテキストURL | 064_083_088.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 中桐 善康| 原田 英雄| 木村 郁郎| |
| 抄録 | Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. |
| キーワード | Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 83 |
| 終了ページ | 88 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307736 |
| JaLCDOI | 10.18926/15303 |
|---|---|
| タイトル（別表記） | 気管支喘息におけるActivated Tリンパ球について,喘息発作との関連 |
| フルテキストURL | 064_011_016.pdf |
| 著者 | 谷崎 勝朗| 貴谷 光| 御船 尚志| 光延 文裕| 梶本 和宏| 杉本 啓介| 横田 聡| 平松 順一| 瓦屋 正志| 原田 英雄| 多田 慎也| 木村 郁郎| |
| 抄録 | The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of activated T cells in the pathogenesis of asthma. |
| キーワード | CD4(+) T cells (CD4(+)リンパ球) CD4／CD8 ratio (CD4／CD8比) IL2R(+) T cells (IL2R(+)Tリンパ球) bronchial asthma (気管支喘息) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1993-06 |
| 巻 | 64巻 |
| 開始ページ | 11 |
| 終了ページ | 16 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002307394 |