result 47501 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sugimoto, Manabu| Watanabe, Toshiro| Takaoka, Motoko| Suzuki, Kyoko| Murakami, Tadatoshi| Murakami, Nobutada| Sumikawa, Shoichi| |
| Keywords | fermented plant extract microbiota dextran sulfate sodium inflammatory Clostridiales |
| Published Date | 2021-04-06 |
| Publication Title | Fermentation-Basel |
| Volume | volume7 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 55 |
| ISSN | 2311-5637 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| DOI | 10.3390/fermentation7020055 |
| Web of Science KeyUT | 000665199500001 |
| Related Url | isVersionOf https://doi.org/10.3390/fermentation7020055 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takabatake, Kiyofumi| Nakano, Keisuke| Kawai, Hotaka| Inada, Yasunori| Sukegawa, Shintaro| Shan, Qiusheng| Fushimi, Shigeko| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| |
| Keywords | dental pulp mesenchymal stem cells honeycomb TCP matrix formation dentin formation osteodentin |
| Published Date | 2021-06-20 |
| Publication Title | Materials |
| Volume | volume14 |
| Issue | issue12 |
| Publisher | MDPI |
| Start Page | 3409 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34202970 |
| DOI | 10.3390/ma14123409 |
| Web of Science KeyUT | 000666508000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ma14123409 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Lu, Yanyin| Eguchi, Takanori| Sogawa, Chiharu| Taha, Eman A.| Tran, Manh Tien| Nara, Toshiki| Wei, Penggong| Fukuoka, Shiro| Miyawaki, Takuya| Okamoto, Kuniaki| |
| Keywords | macrophage exosomes extracellular vesicles molecular transfer size exclusion chromatography and concentration filter (SEC-CF) method heat shock proteins oral carcinoma |
| Published Date | 2021-05-27 |
| Publication Title | Cells |
| Volume | volume10 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 1328 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34071980 |
| DOI | 10.3390/cells10061328 |
| Web of Science KeyUT | 000665278700001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells10061328 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakaida, Kyosuke| Omori, Kazuhiro| Nakayama, Masaaki| Mandai, Hiroki| Nakagawa, Saki| Sako, Hidefumi| Kamei, Chiaki| Yamamoto, Satoshi| Kobayashi, Hiroya| Ishii, Satoki| Ono, Mitsuaki| Ibaragi, Soichiro| Yamashiro, Keisuke| Yamamoto, Tadashi| Suga, Seiji| Takashiba, Shogo| |
| Keywords | (+)-terrein ovariectomy osteoporosis RANKL PKC |
| Published Date | 2021-06-08 |
| Publication Title | Frontiers In Pharmacology |
| Volume | volume12 |
| Publisher | Frontiers Media SA |
| Start Page | 674366 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Sakaida, Omori, Nakayama, Mandai, Nakagawa, Sako, Kamei, Yamamoto, Kobayashi, Ishii, Ono, Ibaragi, Yamashiro, Yamamoto, Suga and Takashiba. |
| File Version | publisher |
| PubMed ID | 34168561 |
| DOI | 10.3389/fphar.2021.674366 |
| Web of Science KeyUT | 000664090900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2021.674366 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer Faruk| Uctepe, Eyyup| Opoku, Gabriel| Wake, Hidenori| Ikemura, Kentaro| Ohtsuki, Takashi| Inagaki, Junko| Gunduz, Mehmet| Gunduz, Esra| Watanabe, Shogo| Nishinaka, Takashi| Takahashi, Hideo| Hirohata, Satoshi| |
| Keywords | Pulmonary fibrosis Osteopontin Epithelial-mesenchymal transition |
| Published Date | 2021-07 |
| Publication Title | Biomedicine & Pharmacotherapy |
| Volume | volume139 |
| Publisher | Elsevier France-Editions Scientifiques Medicales e |
| Start Page | 111633 |
| ISSN | 0753-3322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.biopha.2021.111633 |
| Web of Science KeyUT | 000663683300007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2021.111633 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kageyama, Misaki| Hagiya, Hideharu| Ueda, Yasutaka| Ohtani, Katsuki| Fukumori, Yasuo| Inoue, Norimitsu| Wakamiya, Nobutaka| Yoneda, Nanoka| Kimura, Keigo| Nagasawa, Motonori| Nakagami, Futoshi| Nishi, Isao| Sugimoto, Ken| Rakugi, Hiromi| |
| Keywords | complement addition test complement deficiency disseminated gonococcal infection genome analysis Neisseria gonorrhoeae sexually transmitted infection |
| Published Date | 2021-04-02 |
| Publication Title | Medicine |
| Volume | volume100 |
| Issue | issue13 |
| Publisher | LIPPINCOTT WILLIAMS & WILKINS |
| Start Page | e25265 |
| ISSN | 0025-7974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 the Author(s). |
| File Version | publisher |
| PubMed ID | 33787610 |
| NAID | 120007098535 |
| DOI | 10.1097/MD.0000000000025265 |
| Web of Science KeyUT | 000658960700045 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000025265 |
| FullText URL | fulltext20210629-1.pdf |
|---|---|
| Author | Wang, Chen| Chen, Jian| Wang, Mengxue| Naruse, Keiji| Takahashi, Ken| |
| Published Date | 2021-8-20 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume566 |
| Publisher | Elsevier BV |
| Start Page | 190 |
| End Page | 196 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s) |
| File Version | publisher |
| PubMed ID | 34144257 |
| DOI | 10.1016/j.bbrc.2021.03.077 |
| Web of Science KeyUT | 000662063200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2021.03.077 |
| FullText URL | fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf |
|---|---|
| Author | Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5| |
| Published Date | 2021-6-10 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume88 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 513 |
| End Page | 524 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34114067 |
| DOI | 10.1007/s00280-021-04310-5 |
| Web of Science KeyUT | 000659839700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00280-021-04310-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shimanouchi, Toshinori| Iwamura, Miki| Deguchi, Shintaro| Kimura, Yukitaka| |
| Keywords | biocompatible polymer amyloid fibril amyloid beta nucleation quartz crystal microbalance hydration entanglement hydration |
| Published Date | 2021-05-13 |
| Publication Title | Applied Sciences-Basel |
| Volume | volume11 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 4408 |
| ISSN | 2076-3417 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| NAID | 120007098537 |
| DOI | 10.3390/app11104408 |
| Web of Science KeyUT | 000662593800001 |
| Related Url | isVersionOf https://doi.org/10.3390/app11104408 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nose, Naoko| Nogami, Suguru| Koshino, Kazuhiro| Chen, Xinyu| Werner, Rudolf A.| Kashima, Soki| Rowe, Steven P.| Lapa, Constantin| Fukuchi, Kazuki| Higuchi, Takahiro| |
| Published Date | 2021-05-25 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | NATURE RESEARCH |
| Start Page | 10896 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34035416 |
| NAID | 120007098536 |
| DOI | 10.1038/s41598-021-90383-4 |
| Web of Science KeyUT | 000659135700025 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-90383-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kim, Byeong-Su| |
| Keywords | small-scale capillary barrier lateral no-flow condition diversion length water-shielding water retention characteristics |
| Published Date | 2021-06-04 |
| Publication Title | Applied Sciences-Basel |
| Volume | volume11 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 5231 |
| ISSN | 2076-3417 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the author. |
| File Version | publisher |
| NAID | 120007089819 |
| DOI | 10.3390/app11115231 |
| Web of Science KeyUT | 000659611300001 |
| Related Url | isVersionOf https://doi.org/10.3390/app11115231 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukuyasu, Yusuke| Kataoka, Hitomi U.| Honda, Miwako| Iwase, Toshihide| Ogawa, Hiroko| Sato, Masaru| Watanabe, Mayu| Fujii, Chikako| Wada, Jun| DeSantis, Jennifer| Hojat, Mohammadreza| Gonnella, Joseph S.| |
| Keywords | Empathy Humanitude Medical education |
| Published Date | 2021-06-04 |
| Publication Title | BMC Medical Education |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 316 |
| ISSN | 1472-6920 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2021 |
| File Version | publisher |
| PubMed ID | 34088308 |
| NAID | 120007089818 |
| DOI | 10.1186/s12909-021-02773-x |
| Web of Science KeyUT | 000660873600001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12909-021-02773-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yasutomi, Eriko| Inokuchi, Toshihiro| Hiraoka, Sakiko| Takei, Kensuke| Igawa, Shoko| Yamamoto, Shumpei| Ohmori, Masayasu| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Furukawa, Masaki| Itoshima, Kouichi| Okada, Ken| Otsuka, Fumio| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Kato, Jun| Okada, Hiroyuki| |
| Published Date | 2021-05-27 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 11086 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34045529 |
| NAID | 120007089817 |
| DOI | 10.1038/s41598-021-90441-x |
| Web of Science KeyUT | 000658389400001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-90441-x |
| FullText URL | fulltext20210625-1.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Tanaka, Takehiro| Nakamura, Aya| Wada, Koichiro| |
| Keywords | prostate cancer choroidal/uveal tumor choroidal/uveal metastasis radiation surgical castration complete remission hormonal therapy literature review prostate-specific antigen PSA positron emission tomography PET |
| Published Date | 2021-06-23 |
| Publication Title | Journal of Investigative Medicine High Impact Case Reports |
| Volume | volume8 |
| Publisher | American Federation for Medical Research |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 2324-7096 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 American Federation for Medical Research |
| File Version | publisher |
| PubMed ID | 34159819 |
| NAID | 120007089816 |
| DOI | 10.1177/23247096211026471 |
| Related Url | isVersionOf https://doi.org/10.1177/23247096211026471 |
| JaLCDOI | 10.18926/AMO/62237 |
|---|---|
| FullText URL | 75_3_397.pdf |
| Author | Sekito, Takanori| Takamoto, Atsushi| Kobayashi, Yasuyuki| Mitsui, Masao| Watari, Shogo| Kubota, Risa| Sadahira, Takuya| Iwata, Takehiro| Nishimura, Shingo| Edamura, Kohei| Sako, Tomoko| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Shibata, Rei| Ennishi, Daisuke| Nasu, Yasutomo| |
| Abstract | We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient–like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/ Nivo) was initiated. Four cycles of Ipi/Nivo and 5 cycles of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cycles of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC. |
| Keywords | fumarate hydratase fumarate hydratase-deficient renal cell carcinoma renal cell carcinoma ipilimumab nivolumab |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 397 |
| End Page | 402 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176946 |
| Web of Science KeyUT | 000667147700017 |
| NAID | 120007089822 |
| JaLCDOI | 10.18926/AMO/62236 |
|---|---|
| FullText URL | 75_3_391.pdf |
| Author | Fujiwara, Miyuki| Kimura, Shuhei| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki | Morizane, Yuki| |
| Abstract | A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair. |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 395 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176945 |
| Web of Science KeyUT | 000667147700016 |
| NAID | 120007089821 |
| JaLCDOI | 10.18926/AMO/62235 |
|---|---|
| FullText URL | 75_3_385.pdf |
| Author | Okita, Atsushi| Fujimura, Masaki| Sato, Isao| Chino, Yoshihide| Yuba, Takafumi| Mizutani, Makoto| Tabata, Tomotake| Iida, Minoru| Kumano, Kimitsuka| |
| Amo Type | Case Report |
| Note | We report an extremely rare case of a centenarian with acute appendicitis that was successfully managed via emergent surgery. A 109-year-old woman was referred to Daiichi Towakai Hospital with a high fever and nausea. She presented with peritoneal irritation, and computed tomography showed a swollen appendix with intraluminal fecolith. She was diagnosed with acute appendicitis and underwent appendectomy, which was performed via an open approach under spinal anesthesia. The patient’s postoperative course was uneventful. As for treatment planning for centenarians, comprehensive and exhaustive discussions with the patient and family members should be encouraged under the principals of narrative medicine.| |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176944 |
| Web of Science KeyUT | 000667147700015 |
| NAID | 120007089820 |
| JaLCDOI | 10.18926/AMO/62234 |
|---|---|
| FullText URL | 75_3_381.pdf |
| Author | Yamamoto, Ken-ichi| Oshiki, Toshiyuki| Kagawa, Hiroko| Namba, Masayoshi| Sakaguchi, Masakiyo| |
| Abstract | The worldwide microplastic pollution in our environment is a matter of great concern. Harmful effects of plastics have been reported in various types of organisms including murine animals. We examined the presence of microplastics in four types of shellfish purchased from fish markets in Okayama, Japan and served to the public: short-neck clam (Ruditapes philippinarum, asari in Japanese), hard-shell clam (Meretrix lusoria, hamaguri), brackishwater clam (Cyrenidae, shijimi), and oyster (Crassostrea gigas, kaki). Our analyses demonstrated that approx. 3 pieces of microplastics were present per single shellfish, based on the division of the total number of pieces of microplastic obtained from all 4 types of shellfish by the total number of shellfish examined. Since health problems in humans due to microplastics have not yet been confirmed, further examinations of the effects of ingested microplastics are needed. |
| Keywords | microplastics, shellfish Japan health effect pollution |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 381 |
| End Page | 384 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176943 |
| Web of Science KeyUT | 000667147700014 |
| NAID | 120007089831 |
| JaLCDOI | 10.18926/AMO/62233 |
|---|---|
| FullText URL | 75_3_373.pdf |
| Author | Yaylali, Guzin F.| Dedeoglu, Ozen | Topsakal, Senay| Herek, Duygu| Senol, Hande| |
| Abstract | Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis. |
| Keywords | body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 373 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176942 |
| Web of Science KeyUT | 000667147700013 |
| NAID | 120007089830 |
| JaLCDOI | 10.18926/AMO/62232 |
|---|---|
| FullText URL | 75_3_363.pdf |
| Author | Tanioka, Nohito| Shimizu, Hiroko| Omori, Emiko| Takahashi, Toru| Yamaoka, Masakazu| Morimatsu, Hiroshi| |
| Abstract | Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver. |
| Keywords | heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 372 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176941 |
| Web of Science KeyUT | 000667147700012 |
| NAID | 120007089829 |
