result 313 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukushima, Shinnosuke| Hagiya, Hideharu| Yamamoto, Yukichika| Oguni, Kohei| Hasegawa, Kou| Otsuka, Fumio| |
| Keywords | cryptococcal meningitis Cryptococcus neoformans neurosarcoidosis interleukin-6 |
| Published Date | 2023-08-15 |
| Publication Title | Internal Medicine |
| Volume | volume62 |
| Issue | issue16 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 2433 |
| End Page | 2435 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 36575015 |
| DOI | 10.2169/internalmedicine.0879-22 |
| Web of Science KeyUT | 001051476800001 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.0879-22 |
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| FullText URL | 77_4_395.pdf |
| Author | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| Keywords | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 395 |
| End Page | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| JaLCDOI | 10.18926/AMO/65741 |
|---|---|
| FullText URL | 77_4_359.pdf |
| Author | Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao| |
| Abstract | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. |
| Keywords | pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635135 |
| Web of Science KeyUT | 001163659800011 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Tanaka, Takehiro| Otsuka, Motoyuki| |
| Keywords | autoimmune gastritis esophagogastroduodenoscopy genetic predisposition lymphocyte oxidative stress |
| Published Date | 2023-06-21 |
| Publication Title | Current Issues in Molecular Biology |
| Volume | volume45 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 5263 |
| End Page | 5275 |
| ISSN | 1467-3037 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37504250 |
| DOI | 10.3390/cimb45070334 |
| Web of Science KeyUT | 001035130200001 |
| Related Url | isVersionOf https://doi.org/10.3390/cimb45070334 |
| FullText URL | fulltext20230629-02.pdf |
|---|---|
| Author | Murata, Hitoshi| Yasui, Yu| Oiso, Kazuma| Ochi, Toshiki| Tomonobu, Nahoko| Yamamoto, Ken-ichi| Kinoshita, Rie| Sakaguchi, Masakiyo| |
| Keywords | NMNAT2 SARM1 NAD+ STAT1/3 IFN-γ |
| Published Date | 2023-08 |
| Publication Title | Cellular Signalling |
| Volume | volume108 |
| Publisher | Elsevier BV |
| Start Page | 110717 |
| ISSN | 0898-6568 |
| NCID | AA10671314 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37187216 |
| DOI | 10.1016/j.cellsig.2023.110717 |
| Web of Science KeyUT | 001002867700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.cellsig.2023.110717 |
| FullText URL | K0006743_abstract_review.pdf K0006743_fulltext.pdf K0006743_other1.pdf K0006743_other2.PDF K0006743_summary.pdf |
|---|---|
| Author | MEGURI, Yusuke| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6743号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirami, Yuki| Nishimura, Midori Filiz| Urata, Tomohiro| Morimoto, Michiko| Maekawa, Yukina| Yoshino, Tadashi| Nishimura, Yoshito| Sato, Yasuharu| |
| Keywords | intravascular large B-cell lymphoma diffuse large B-cell lymphoma soluble interleukin-2 receptor lactate dehy-drogenase B symptoms |
| Published Date | 2023 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume63 |
| Issue | issue1 |
| Publisher | Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 25 |
| End Page | 31 |
| ISSN | 1346-4280 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 36843068 |
| DOI | 10.3960/jslrt.22043 |
| Web of Science KeyUT | 000937326000001 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.22043 |
| JaLCDOI | 10.18926/AMO/64360 |
|---|---|
| FullText URL | 77_1_37.pdf |
| Author | Yamanouchi, Kosho| Maeda, Shigeto| |
| Abstract | Systemic therapy for stage IV breast cancer is usually an initial treatment and is based on findings regarding biomarkers (e.g., hormone receptors and human epidermal growth factor receptor-2 [HER2]). However, the response to therapy and outcomes sometime differ among patients with similar prognostic factors including grade, hormone receptor, HER2, and more. We conducted retrospective analyses to evaluate the correlations between the overall survival (OS) of 46 stage IV breast cancer patients and (i) the peripheral absolute lymphocyte count (ALC) and (ii) composite blood cell markers. The peripheral blood cell markers included the neutrophil- to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), the systemic immune-inflammation index (SII), the systemic inflammation response index (SIRI), and the most recently introduced indicator, the pan-immune-inflammatory value (PIV). The SIRI and PIV showed prognostic impacts on the patients: those with a low SIRI or a low PIV showed significantly better OS than those with a high SIRI (5-year, 66.0% vs. 35.0%, p<0.05) or high PIV (5-year, 68.1% vs. 38.5%, p<0.05), respectively. This is the first report indicating the possible prognostic value of the PIV for OS in patients with stage IV breast cancer. Further studies with larger numbers of patients are necessary for further clarification. |
| Keywords | breast cancer pan-immune-inflammatory value prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 43 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849144 |
| Web of Science KeyUT | 000952992100001 |
| FullText URL | fulltext20221122-1.pdf |
|---|---|
| Author | Nojima, Tsuyoshi| Obara, Takafumi| Yamamoto, Hirotsugu| Yumoto, Tetsuya| Igawa, Takuro| Aokage, Toshiyuki| Seya, Mizuki| Nakao, Atsunori| Naito, Hiromichi| |
| Published Date | 2022-11 |
| Publication Title | Surgery |
| Volume | volume172 |
| Issue | issue5 |
| Publisher | Elsevier BV |
| Start Page | 1522 |
| End Page | 1528 |
| ISSN | 0039-6060 |
| NCID | AA00853880 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s) |
| File Version | publisher |
| PubMed ID | 36088170 |
| DOI | 10.1016/j.surg.2022.07.021 |
| Web of Science KeyUT | 000875983900035 |
| Related Url | isVersionOf https://doi.org/10.1016/j.surg.2022.07.021 |
| JaLCDOI | 10.18926/AMO/64113 |
|---|---|
| FullText URL | 76_6_635.pdf |
| Author | Zhang, Cuicui| Ji, Yanan| Wang, Qin| Ruan, Lianying| |
| Abstract | To investigate the association between serum miR-338-3p levels and neonatal acute respiratory distress syndrome (ARDS) and its mechanism. The relative miR-338-3p expression in serum was detected by quantitative real-time RT-PCR. Interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) levels were detected by ELISAs. A receiver operating characteristic (ROC) curve analysis of serum miR-338-3p evaluated the diagnosis of miR-338-3p in neonatal ARDS. Pearson’s correlation analysis evaluated the correlation between serum miR-338-3p and neonatal ARDS clinical factors. Flow cytometry evaluated apoptosis, and a CCK-8 assay assessed cell viability. A luciferase assay evaluated the miR-338-3p/AKT3 relationship. The miR- 338-3p expression was decreased in neonatal ARDS patients and in lipopolysaccharide (LPS)-treated cells. The ROC curve showed the accuracy of miR-338-3p for evaluating neonatal ARDS patients. The correlation analysis demonstrated that miR-338-3p was related to PRISM-III, PaO2/FiO2, oxygenation index, IL-1β, IL-6, and TNF-α in neonatal ARDS patients. MiR-338-3p overexpression inhibited the secretion of inflammatory components, stifled cell apoptosis, and LPS-induced advanced cell viability. The double-luciferase reporter gene experiment confirmed that miR-338-3p negatively regulates AKT3 mRNA expression. Serum miR-338-3p levels were related to the diagnosis and severity of neonatal ARDS, which may be attributed to its regulatory effect on inflammatory response in ARDS. |
| Keywords | miR-338-3p AKT3 neonatal ARDS inflammation diagnosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 635 |
| End Page | 643 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549765 |
| Web of Science KeyUT | 000905195100003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ushio, Soichiro| Wada, Yudai| Nakamura, Mizuki| Matsumoto, Daiki| Hoshika, Kota| Shiromizu, Shoya| Iwata, Naohiro| Esumi, Satoru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Keywords | anxiolytic inflammation immunomodulation macrophages Kampo medicine |
| Published Date | 2022-08-12 |
| Publication Title | Frontiers In Pharmacology |
| Volume | volume13 |
| Publisher | Frontiers Media S.A. |
| Start Page | 890048 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Ushio, Wada, Nakamura, Matsumoto, Hoshika, Shiromizu, Iwata, Esumi, Kajizono, Kitamura and Sendo. |
| File Version | publisher |
| PubMed ID | 36034871 |
| DOI | 10.3389/fphar.2022.890048 |
| Web of Science KeyUT | 000860773600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2022.890048 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kataoka, Takahiro| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Tanaka, Ayumi| Yamaoka, Kiyonori| |
| Keywords | autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation |
| Published Date | 2022-08-26 |
| Publication Title | International Journal Of Environmental Research And Public Health |
| Volume | volume19 |
| Issue | issue17 |
| Publisher | MDPI |
| Start Page | 10632 |
| ISSN | 1660-4601 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36078348 |
| DOI | 10.3390/ijerph191710632 |
| Web of Science KeyUT | 000851073300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijerph191710632 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| FullText URL | 76_4_359.pdf |
| Author | Hiramatsu-Asano, Sumie| Wada, Jun| |
| Abstract | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| Keywords | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Meguri, Yusuke| Asano, Takeru| Yoshioka, Takanori| Iwamoto, Miki| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Kishi, Yuriko| Nakamura, Makoto| Sando, Yasuhisa| Kondo, Takumi| Sumii, Yuichi| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
| Keywords | regulatory T cell low-dose interleukin-2 therapy graft-versus-host disease graft-versus-leukemia effect transplantation tolerance |
| Published Date | 2022-08-02 |
| Publication Title | Frontiers In Immunology |
| Volume | volume13 |
| Publisher | Frontiers Media |
| Start Page | 891925 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka. |
| File Version | publisher |
| PubMed ID | 35983059 |
| DOI | 10.3389/fimmu.2022.891925 |
| Web of Science KeyUT | 000844642000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.891925 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Amioka, Naofumi| Miyoshi, Toru| Yonezawa, Tomoko| Kondo, Megumi| Akagi, Satoshi| Yoshida, Masashi| Saito, Yukihiro| Nakamura, Kazufumi| Ito, Hiroshi| |
| Keywords | pemafibrate angiotensin II abdominal aortic aneurysm oxidative stress catalase |
| Published Date | 2022-06-30 |
| Publication Title | Frontiers In Cardiovascular Medicine |
| Volume | volume9 |
| Publisher | Frontiers Media SA |
| Start Page | 904215 |
| ISSN | 2297-055X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Amioka, Miyoshi, Yonezawa, Kondo, Akagi, Yoshida, Saito, Nakamura and Ito. |
| File Version | publisher |
| PubMed ID | 35845076 |
| DOI | 10.3389/fcvm.2022.904215 |
| Web of Science KeyUT | 000826574900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcvm.2022.904215 |
| FullText URL | fulltext20220715-3.pdf |
|---|---|
| Author | Niman, Eito| Miyoshi, Kentaroh| Shiotani, Toshio| Toji, Tomohiro| Igawa, Takuro| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Toyooka, Shinichi| |
| Keywords | Lung transplantation (LTx) lung recruitment maneuver atelectasis protective procurement |
| Published Date | 2022-07-12 |
| Publication Title | Journal of Thoracic Disease |
| Publisher | AME Publishing Company |
| ISSN | 2072-1439 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Journal of Thoracic Disease. |
| File Version | publisher |
| DOI | 10.21037/jtd-22-226 |
| Web of Science KeyUT | 000821133100001 |
| Related Url | isVersionOf https://doi.org/10.21037/jtd-22-226 |
| JaLCDOI | 10.18926/AMO/63722 |
|---|---|
| FullText URL | 76_3_281.pdf |
| Author | Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong| |
| Abstract | Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions. |
| Keywords | periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 281 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790358 |
| Web of Science KeyUT | 000823568300007 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| FullText URL | 76_3_255.pdf |
| Author | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| Abstract | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| Keywords | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchida-Fukuhara, Yoko| Hattori, Takako| Fu, Shanqi| Kondo, Sei| Kuwahara, Miho| Fukuhara, Daiki| Islam, Md Monirul| Kataoka, Kota| Ekuni, Daisuke| Kubota, Satoshi| Morita, Manabu| Iikegame, Mika| Okamura, Hirohiko| |
| Keywords | maternal microbiome endochondral ossification fetal chondrocytes |
| Published Date | 2022-05-10 |
| Publication Title | Microorganisms |
| Volume | volume10 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1000 |
| ISSN | 2076-2607 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35630443 |
| DOI | 10.3390/microorganisms10051000 |
| Web of Science KeyUT | 000801692300001 |
| Related Url | isVersionOf https://doi.org/10.3390/microorganisms10051000 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Published Date | 2022-06-16 |
| Publication Title | Molecular Therapy-Oncolytics |
| Volume | volume25 |
| Publisher | Cell Press |
| Start Page | 249 |
| End Page | 261 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 35615263 |
| DOI | 10.1016/j.omto.2022.04.009 |
| Web of Science KeyUT | 000800437000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.04.009 |
