result 64 件
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Muraoka, Genya| Fujii, Yasuhiro| Liu, Keyue| Qiao, Handong| Wang, Dengli| Ousaka, Daiki| Oozawa, Susumu| Kasahara, Shingo| Nishibori, Masahiro| |
| Keywords | thoracoabdominal aortic aneurysm spinal cord ischemia–reperfusion injury high mobility group box 1 neuroprotection blood–spinal cord barrier aortic surgery |
| Published Date | 2025-09-05 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue17 |
| Publisher | MDPI AG |
| Start Page | 8643 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40943562 |
| DOI | 10.3390/ijms26178643 |
| Web of Science KeyUT | 001569785800001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26178643 |
| FullText URL | fulltext.pdf suppl.docx |
|---|---|
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Wake, Hidenori| Takahashi, Hideo| |
| Keywords | histidine-rich glycoprotein tumor necrosis factor-α integrin tube formation angiogenesis factor erythroid 2-related factor 2 |
| Published Date | 2025-03-21 |
| Publication Title | Frontiers in Pharmacology |
| Volume | volume16 |
| Publisher | Frontiers Media SA |
| Start Page | 1561628 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Hatipoglu, Nishinaka, Yaykasli, Mori, Watanabe, Toyomura, Nishibori, Hirohata, Wake and Takahashi. |
| File Version | publisher |
| PubMed ID | 40191430 |
| DOI | 10.3389/fphar.2025.1561628 |
| Web of Science KeyUT | 001458547300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2025.1561628 |
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Murata, Hitoshi| Ogawa, Kazuki| Yasui, Yu| Ochi, Toshiki| Tomonobu, Nahoko| Yamamoto, Ken-Ichi| Kinoshita, Rie| Wada, Yoji| Nakamura, Hiromichi| Nishibori, Masahiro| Sakaguchi, Masakiyo| |
| Keywords | SARM1 carnosol NAD+ axon degeneration peripheral neuropathy |
| Published Date | 2025-06-30 |
| Publication Title | Antioxidants |
| Volume | volume14 |
| Issue | issue7 |
| Publisher | MDPI AG |
| Start Page | 808 |
| ISSN | 2076-3921 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/antiox14070808 |
| Related Url | isVersionOf https://doi.org/10.3390/antiox14070808 |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| FullText URL | 79_3_157.pdf |
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| Keywords | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | srfa_114_001_010.pdf |
|---|---|
| Author | Saitoh, Kuniyuki| Murakami, Tomohiro| Nakamura, Yumi| Nishibori, Misa| Takagoshi, Yuki| Hirai, Yoshihiko| |
| Abstract | Eleven crops were cultivated: maize, sunflower, soybean, groundnuts, sesame, kenaf, barley, wheat, rice, potato, and sweet potato. The crop growth rate (CGR) and specific dark-respiration rate (Rs) were measured, and growth efficiency GE =CGR/(CGR+R) (R, respiratory loss) was calculated. In each crop, whole-plant Rs reached a maximum in the earlier stages of growth, declined rapidly until the early reproductive growth, and remained almost constant during the ripening period. The Rs of leaves was higher than that of stems during the reproductive growth period, except for maize and potato. The Rs of storage organs was highest in the earlier stages, followed by a rapid decline to similar or lower values than those of leaves and stems during the ripening period. The GE in whole plant was higher than 60% in wheat, maize, barley, sunflower, rice, kenaf, sesame, but lower in soybean, sweet potato and groundnuts, and lowest in potato, which was affected by the higher respiratory loss. The GE in whole plant during the reproductive growth period was significantly lower, which we attributed to increased maintenance costs due to the increase of non-assimilative organs, and decrease in the dry weight of vegetative organs. A positive correlation was observed between the carbohydrate content of storage organs and GE, indicating that a crop with higher carbohydrate content in storage organs tended to have a higher GE. Crops with higher protein and crude fat content in storage organs tended to have lower GE. The GE over the growing season was low for kenaf, a fiber crop which contains high molecular weight compounds such as lignin and cellulose, and lower for sesame, groundnuts, and soybean, which contain high oil and protein and have high respiration costs for the synthesis of storage materials, suggesting that these higher respiration costs are related to lower dry matter production and hence lower yields. |
| Keywords | Cereal crops Oil crops Crop growth rate Dark-respiration Growth efficiency Leguminous crops Nutrients composition Respiratory loss Root and tuber crops |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2025-02-01 |
| Volume | volume114 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 2186-7755 |
| language | English |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gao, Shangze| Wang, Dengli| Liu, Keyue| Tomono, Yasuko| Fu, Li| Gao, Yuan| Takahashi, Yohei| Yata, Mariko| Nishibori, Masahiro| |
| Keywords | epidural hematoma HMGB1 inflammatory response |
| Published Date | 2024-05-28 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 5889 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38892076 |
| DOI | 10.3390/ijms25115889 |
| Web of Science KeyUT | 001245280300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25115889 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Murata, Hitoshi| Phoo, May Tha Zin| Ochi, Toshiki| Tomonobu, Nahoko| Yamamoto, Ken-ichi| Kinoshita, Rie| Miyazaki, Ikuko| Nishibori, Masahiro| Asanuma, Masato| Sakaguchi, Masakiyo| |
| Keywords | JNK PARK2 Parkinson’sdisease Phosphorylation SARM1 |
| Published Date | 2023-09-19 |
| Publication Title | The Journal of Biochemistry |
| Volume | volume174 |
| Issue | issue6 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 533 |
| End Page | 548 |
| ISSN | 0021-924X |
| NCID | AA00694073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37725528 |
| DOI | 10.1093/jb/mvad068 |
| Web of Science KeyUT | 001079972500001 |
| Related Url | isVersionOf https://doi.org/10.1093/jb/mvad068 |
| FullText URL | K0006912_abstract_review.pdf K0006912_fulltext.pdf K0006912_summary.pdf |
|---|---|
| Author | QIAO, HANDONG| |
| Published Date | 2023-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6912号 |
| Granted Date | 2023-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 The Authors. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Goyama, Takashi| Fujii, Yasuhiro| Muraoka, Genya| Nakatani, Tatsuyuki| Ousaka, Daiki| Imai, Yuichi| Kuwada, Noriaki| Tsuji, Tatsunori| Shuku, Takayuki| Uchida, Haruhito A.| Nishibori, Masahiro| Oozawa, Susumu| Kasahara, Shingo| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-35594-7| |
| Published Date | 2023-05-24 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 8386 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37225824 |
| DOI | 10.1038/s41598-023-35594-7 |
| Web of Science KeyUT | 000995835600021 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-35594-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bozlak, Elif| Radovic, Lara| Remer, Viktoria| Rigler, Doris| Allen, Lucy| Brem, Gottfried| Stalder, Gabrielle| Castaneda, Caitlin| Cothran, Gus| Raudsepp, Terje| Okuda, Yu| Moe, Kyaw Kyaw| Moe, Hla Hla| Kounnavongsa, Bounthavone| Keonouchanh, Soukanh| Van, Nguyen Huu| Vu, Van Hai| Shah, Manoj Kumar| Nishibori, Masahide| Kazymbet, Polat| Bakhtin, Meirat| Zhunushov, Asankadyr| Paul, Ripon Chandra| Dashnyam, Bumbein| Nozawa, Ken| Almarzook, Saria| Brockmann, Gudrun A.| Reissmann, Monika| Antczak, Douglas F.| Miller, Donald C.| Sadeghi, Raheleh| Butler-Wemken, Ines von| Kostaras, Nikos| Han, Haige| Manglai, Dugarjaviin| Abdurasulov, Abdugani| Sukhbaatar, Boldbaatar| Ropka-Molik, Katarzyna| Stefaniuk-Szmukier, Monika| Lopes, Maria Susana| Machado, Artur da Câmara| Kalashnikov, Valery V.| Kalinkova, Liliya| Zaitev, Alexander M.| Novoa-Bravo, Miguel| Lindgren, Gabriella| Brooks, Samantha| Rosa, Laura Patterson| Orlando, Ludovic| Juras, Rytis| Kunieda, Tetsuo| Wallner, Barbara| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-35539-0| |
| Published Date | 2023-06-02 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 8954 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37268661 |
| DOI | 10.1038/s41598-023-35539-0 |
| Web of Science KeyUT | 001000613900036 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-35539-0 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawanoue, Naoya| Kuroda, Kosuke| Yasuda, Hiroko| Oiwa, Masahiko| Suzuki, Satoshi| Wake, Hidenori| Hosoi, Hiroki| Nishibori, Masahiro| Morimatsu, Hiroshi| |
| Published Date | 2023-03-29 |
| Publication Title | PLoS ONE |
| Volume | volume18 |
| Issue | issue3 |
| Publisher | Public Library of Science |
| Start Page | e0283426 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Kawanoue et al. |
| File Version | publisher |
| PubMed ID | 36989333 |
| DOI | 10.1371/journal.pone.0283426 |
| Web of Science KeyUT | 000987475800001 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0283426 |
| FullText URL | K0006787_abstract_review.pdf K0006787_fulltext.pdf K0006787_summary.pdf |
|---|---|
| Author | ACOSTA GONZALEZ HERIK RODRIGO| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6787号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 The Authors. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gao, Shangze| Liu, Keyue| Ku, Wenhan| Wang, Dengli| Wake, Hidenori| Qiao, Handong| Teshigawara, Kiyoshi| Nishibori, Masahiro| |
| Keywords | Histamine HMGB1 vascular endothelial cell H-1 receptor hypotension |
| Published Date | 2022-10-05 |
| Publication Title | Frontiers In Immunology |
| Volume | volume13 |
| Publisher | Frontiers Media SA. |
| Start Page | 930683 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Gao, Liu, Ku, Wang, Wake, Qiao, Teshigawara and Nishibori. |
| File Version | publisher |
| PubMed ID | 36275732 |
| DOI | 10.3389/fimmu.2022.930683 |
| Web of Science KeyUT | 000873745300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.930683 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wang, Dengli| Ousaka, Daiki| Qiao, Handong| Wang, Ziyi| Zhao, Kun| Gao, Shangze| Liu, Keyue| Teshigawara, Kiyoshi| Takada, Kenzo| Nishibori, Masahiro| |
| Keywords | intracerebral hemorrhage HMGB1 antibody therapy non-human primate |
| Published Date | 2022-09-23 |
| Publication Title | Cells |
| Volume | volume11 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 2970 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36230933 |
| DOI | 10.3390/cells11192970 |
| Web of Science KeyUT | 000866922400001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11192970 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tomonobu, Nahoko| Kinoshita, Rie| Wake, Hidenori| Inoue, Yusuke| Ruma, I. Made Winarsa| Suzawa, Ken| Gohara, Yuma| Komalasari, Ni Luh Gede Yoni| Jiang, Fan| Murata, Hitoshi| Yamamoto, Ken-Ichi| Sumardika, I. Wayan| Chen, Youyi| Futami, Junichiro| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Toyooka, Shinichi| Nishibori, Masahiro| Sakaguchi, Masakiyo| |
| Keywords | S100A8/A9 HRG metastasis |
| Published Date | 2022-09-07 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 10300 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36142212 |
| DOI | 10.3390/ijms231810300 |
| Web of Science KeyUT | 000858719600001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231810300 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishibori, M.| |
| Keywords | Sepsis Histidine-rich glycoprotein (HRG) Neutrophil extracellular traps (NETs) Endotheliopathy COVID-19 |
| Published Date | 2022-09 |
| Publication Title | Journal Of Pharmacological Sciences |
| Volume | volume150 |
| Issue | issue1 |
| Publisher | Japanese Pharmacological Society |
| Start Page | 9 |
| End Page | 20 |
| ISSN | 1347-8613 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.jphs.2022.06.001 |
| Web of Science KeyUT | 000821353400002 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jphs.2022.06.001 |
| FullText URL | K0006584_abstract_review.pdf K0006584_fulltext.pdf K0006584_summary.pdf |
|---|---|
| Author | Nakata, Kentaro| |
| Published Date | 2022-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6584号 |
| Granted Date | 2022-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2021 The Authors. |
| JaLCDOI | 10.18926/AMO/62805 |
|---|---|
| FullText URL | 75_6_671.pdf |
| Author | Gao, Shangze| Nishibori, Masahiro| |
| Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many verte-brates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant and well-characterized protein having a multidomain structure that enable it to interact with many ligands, func-tion as an adaptor molecule, and participate in numerous physiological and pathological processes. As a plasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis and angiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plas-minogen) and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets). This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogen-esis in various pathological conditions. |
| Keywords | histidine-rich glycoprotein vascular biology coagulation angiogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 671 |
| End Page | 675 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955533 |
| Web of Science KeyUT | 000735297900001 |
| NAID | 120007180287 |
| Title Alternative | The 2020 Incentive Award of the Okayama Medical Association in General Medical Science (2020 Yuuki Prize) |
|---|---|
| FullText URL | 133_96.pdf |
| Author | Takahashi, Yohei| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2021-08-02 |
| Volume | volume133 |
| Issue | issue2 |
| Start Page | 96 |
| End Page | 98 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.133.96 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2021 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.133.96 |
