result 139 件
| JaLCDOI | 10.18926/15148 |
|---|---|
| Title Alternative | 気管支喘息における末梢血白血球および気管支肺胞洗浄液中の細胞からのヒスタミンおよびロイコトリエンC(4),B(4)遊離と気道過敏性 |
| FullText URL | 065_009_016.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine| |
| Abstract | The proportions of cells in bronchoalveolar lavage (BAL) fluid, the release of histamine, leukotrienes C(4) and B(4) from leucocytes and BAL cells, and bronchial reactivity to methacholine were examined in 40 patients with asthma in relation to patient age. 1. The proportions of lymphocytes and neutrophils in BAL fluid were higher in older patients over age 60 than in younger patients between 20 and 49. The proportions of eosinophils and basophilic cells in BAL fluid were higher in younger patients than in older patients, and the difference in the proportion of BAL basophilic cells was significant between the two groups (p<0.05). 2. The release of histamine from BAL cells was significantly higher in younger patients than in older patients (p<0.001). The release of LTC(4) from BAL cells was higher in older patients compared to younger patients. 3. Bronchial reactivity to methacholine was higher in younger patients than in older patients. The number of patients reactive to low concentration of methacholine (390μg/mℓ or less) was larger in younger patients (12/16 ; 75.0%) than in older patients (5/14 ; 35.7%). These results suggest that bronchial hyperresponsiveness changes with aging, accompanied by changes in the release of chemical mediators from BAL cells and in the proportion of BAL cells. |
| Keywords | BAL cells (BAL細胞) histamine (ヒスタミン) leukotrienes (ロイコトリエン) bronchial hyperresponsiveness (気道過敏性) asthma (気管支喘息） |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307646 |
| JaLCDOI | 10.18926/15147 |
|---|---|
| Title Alternative | 気管支喘息における複合温泉療法と気道炎症反応 |
| FullText URL | 065_001_008.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine| |
| Abstract | Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307726 |
| JaLCDOI | 10.18926/15129 |
|---|---|
| FullText URL | 066_085_091.pdf |
| Author | Chowdhury Riaz| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Mizushima, Takaaki| Matsumoto, Shuji| Seno, Toshinobu| Ichimura, Mitsuko| Akiyama, Tsuneo| Yokota, Satoshi| |
| Abstract | Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307190 |
| JaLCDOI | 10.18926/15128 |
|---|---|
| Title Alternative | Collagen degradation and in the pathogenesis of dieseases |
| FullText URL | 066_078_084.pdf |
| Author | Ochi, Koji| Harada, Hideo| Chowdhury Riaz| Yamashita, Haruhiro| Ichimura, Mitsuko| Tanaka, Juntaro| Seno, Toshinobu| Matsumoto, Shuji| Mizushima, Takaaki| Yokota, Satoshi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 |
| Keywords | 線維化 (Fibrosis) コラーゲン (Collagen) TIMP (tissue inhibitor of metalloproteinase) MMP (matrix metalloproteinase) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 78 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307516 |
| JaLCDOI | 10.18926/15127 |
|---|---|
| Title Alternative | Spa therapy and quality of life in patients with bronchial asthma |
| FullText URL | 066_072_077.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | 気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる｡そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い｡このことが,また精神活動の低下へとつながる｡したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある｡かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される｡また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる｡すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される｡ |
| Keywords | 温泉療法 (spa therapy) 重症難治性喘息 (lntractable asthma) 運動 (exercise) 精神活動 (phychical activity) QOL |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 72 |
| End Page | 77 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307919 |
| JaLCDOI | 10.18926/15121 |
|---|---|
| Title Alternative | 気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連 |
| FullText URL | 066_030_036.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/㎗) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/㎗) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/㎗) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging. |
| Keywords | serum cortisol level (血清コーチゾール) bronchial asthma (気管支喘息) clinical asthma type (臨床病型) glucocorticoids (副腎皮質ホルモン) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 30 |
| End Page | 36 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307345 |
| JaLCDOI | 10.18926/15120 |
|---|---|
| Title Alternative | 老年者気管支喘息の各臨床病型における換気機能の特徴 |
| FullText URL | 066_021_029.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients. |
| Keywords | Ventilatory function (換気機能) Clinical asthma type (臨床病型) BAL cells (BAL細胞) aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 21 |
| End Page | 29 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308008 |
| JaLCDOI | 10.18926/15119 |
|---|---|
| Title Alternative | 気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― |
| FullText URL | 066_014_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/mℓ) comparted to that in nonatopic patients (0mcg/mℓ)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/mℓ) than in atopic patients (0.5ng/ mℓ), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. |
| Keywords | Histamine LTC4 BAL cells atopic asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307251 |
| JaLCDOI | 10.18926/15117 |
|---|---|
| Title Alternative | ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 |
| FullText URL | 066_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. |
| Keywords | Bronchial asthma House dust allergy Histamine release Bronchoalveolar cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307845 |
| JaLCDOI | 10.18926/15109 |
|---|---|
| Title Alternative | A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice |
| FullText URL | 067_121_125.pdf |
| Author | Yamamoto, Ryoichi| Ochi, Koji| Matsumura, Naoki| Tanaka, Juntaro| Kato, Tadahiro| Mizushima, Takaaki| Chowdhury Riaz| Harada, Hideo| Hasuoka, Hideaki| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | 膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ |
| Keywords | 膵嚢胞 (pancreatic cyst) 膵液 (pancreatic juice) K-ras遺伝子 (K-ras oncogene) 点突然変異 (point mutation) 細胞診 (cytology) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 121 |
| End Page | 125 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307457 |
| JaLCDOI | 10.18926/15096 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連 |
| FullText URL | 067_099_106.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation. |
| Keywords | Spa therapy (温泉療法) Airway inflammation (気道炎症反応) BAL eosinophilia (BAL好酸球増多) BAL neutrophilia (BAL好中球増多) Bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307894 |
| JaLCDOI | 10.18926/15095 |
|---|---|
| Title Alternative | Mechanisms of pancreatic fibrosis |
| FullText URL | 067_115_120.pdf |
| Author | Ochi, Koji| Chowdhury, Riaz| Ichimura, Mitsuko| Matsumura, Naoki| Tanaka, Juntaro| Mizushima, Takaaki| Yamamoto, Ryoichi| Harada, Hideo| Yokota, Satoshi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| |
| Abstract | 膵の線維化は慢性膵炎に特徴的な病理組織所見の一つであるが,その発生機序については不明な点か多い｡慢性膵炎はいったん発症すれば,進行性かつ非可逆性であるとされるが,その非可逆性に膵の線維化が関与するとされる｡膵の線維化の発生機序を明らかにし,線維化に対する根本的な治療法の確立が望まれるところである｡そこで,本稿では今後の膵の線維化の研究課題を明らかにする目的で,現在までの膵臓線維化の発生機序に関する知見を整理した｡ |
| Keywords | 膵臓 (pancreas) 線維化 (fibrosis) サイトカイン (cytokine) 慢性膵炎 (chronic pancreatitis) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 115 |
| End Page | 120 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307876 |
| JaLCDOI | 10.18926/15093 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 1.温泉療法の評価方法との関連 |
| FullText URL | 067_085_091.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma. |
| Keywords | complex spa therapy (複合温泉療法) clinical asthma type (臨床病型) ventilatory function (換気機能) bronchial hyperresponsiveness (気道過敏性) adrenocortical glands (副腎皮質) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307192 |
| JaLCDOI | 10.18926/15091 |
|---|---|
| Title Alternative | Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数 |
| FullText URL | 067_079_084.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging. |
| Keywords | Asthma classification (喘息分類) BAL lymphocytes (BALリンパ球) BAL neutrophils (BAL好中球) % V25 value Ⅱ型喘息 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307924 |
| JaLCDOI | 10.18926/15090 |
|---|---|
| Title Alternative | Gastro-biliary motility in patients with non-ulcer dyspepsia |
| FullText URL | 067_075_078.pdf |
| Author | Mizushima, Takaaki| Yamamoto, Ryoichi| Matsumura, Naoki| Chowdhury, Riaz| Kato, Tadahiro| Ochi, Koji| Tanaka, Juntaro| Harada, Hideo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | 現在,上腹部不定愁訴の原因は特定されていない｡その原因を解明するため,上腹部不定愁訴患者8人と健常対照者10人に対して液体食の胃排出能と,食事負荷による胆嚢収縮能を測定した｡胃排出時間,胆嚢収縮能はいずれも両者に有意な差は認められなかった｡健常対照者では胃排出時間と胆嚢収縮時間に有意な相関関係が認められたが,上腹部不定愁訴群では相関関係は認められなかった｡上腹部不定愁訴の原因として胃･胆嚢協調運動障害の存在が示唆 された。 |
| Keywords | 胃運動 (Gastric motility) 胆嚢運動 (Biliary motility) 不定愁訴 (indefinite complaint) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 75 |
| End Page | 78 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308012 |
| JaLCDOI | 10.18926/15089 |
|---|---|
| Title Alternative | Usefulness of retinol binding protein as a marker for the assessment of nutritional uptake for the preparation of colonosocpy |
| FullText URL | 067_071_074.pdf |
| Author | Kato, Tadahiro| Hasuoka, Hideaki| Ochi, Koji| Mizushima, Takaaki| Chowdhury Riaz| Matsumura, Naoki| Yamamoto, Ryoichi| Tanaka, Juntaro| Harada, Hideo| Akiyama, Tsuneo| Yokota, Satoshi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 大腸内視鏡検査の前処置を栄養面から評価する目的で前処置前後にrapid turnover proteinである血中レチノール結合蛋白の変動を検討した｡前日に普通食を用い,当日ニフレックを使用した10例,検査1日前に低残渣食を用いた27例,通常の前処置では良好な腸管洗浄が得られないために検査前2日間低残渣食を用いた27例の3群について,前処置開始前と検査終了後に血中レチノール結合蛋白の変動をみたところ,検査前2日間低残渣食服用群で有意の低下を認めた｡前日普通食群では検査前後で変化を認めず,1日低残渣食服用群では低下傾向を認めたが,有意差は認めなかった｡これまで前処置の成否は腸管洗浄度の面で評価されてきたが,血中レチノール結合蛋白を目標として用いることにより栄養面から評価することができることが考えられた。 |
| Keywords | レチノール結合蛋白 (retinol binding protein) 大腸内視鏡 (colonoscopy) 前処置 (preparation) 栄養評価 (nutritional assessment) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 71 |
| End Page | 74 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307681 |
| JaLCDOI | 10.18926/15088 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 |
| FullText URL | 067_063_070.pdf |
| Author | Hosaki, Yasuhiro| Nawa, Yuichiro| Takeuchi, Kazuaki| Tsugeno, Hirofumi| Ashida, Kozo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. |
| Keywords | Thermography (サーモグラフィー) Diabetes Mellitus (糖尿病) Peripheral Circulation (末梢循環) Cold Loading (冷水負荷) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307566 |
| JaLCDOI | 10.18926/15087 |
|---|---|
| Title Alternative | 気管支喘息症例に対する鼻腔内ステロイド療法 |
| FullText URL | 067_057_062.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Bronchial asthma is often accompanied with allergic rhinitis or chronic sinusitis. Mucosal abnormalities of sinonasal cavity may influence lower respiratory responses in patients with asthma. We experienced a case of 72-year-old woman with asthma, who had dyspnea on exertion and a large volume of expectoration of more than 100mℓ a day. Furthermore she had nasal symptoms (nasal obstruction and rhinorrea) with prominent post-nasal discharge. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa. Although her asthma symptoms such as wheezing and dyspnea improved by administration of bronchodialators, antiallergic agent, and beclomethason di isocyanate (BDI) accompanied with spa therapy after admission, the volume of expectoration revealed no decrease and her peak expiratory flow (PEF) didn't increase. The volume of expectoration and the PEF showed marked improvement after starting of intranasal glucocorticoid therapy. It is suggested from her clinical course that treatment with intranasal glucocorticoids is very important in asthmatic patients with mucosal abnormalities of sinonasal cavity. |
| Keywords | bronchial asthma (気管支喘息) rhinitis (鼻炎) intranasal steroid therapy (鼻腔内吸入ステロイド療法) expectoration (喀痰排出) peak expiratory flow (ピークフロー) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307814 |
| JaLCDOI | 10.18926/15041 |
|---|---|
| Title Alternative | Alcohol-induced pancreatitis |
| FullText URL | 062_052_070.pdf |
| Author | Harada, Hideo| Tanaka, Juntaro| Ochi, Koji| Matsumoto, Shuji| Seno, Toshinobu| lzushi, Michihiro| Tanizaki, Yoshiro| |
| Abstract | 膵炎のうちもっとも頻度が高いアルコール性膵炎（AIP）の疫学，臨床像および発生機序に関する従来の知見を総括した。AIPの大多数は慢性膵炎である。通常は長期にわたる多量の飲酒を背景に発症するが，遺伝的素因および食事因子も重要な役割を演じる。発症初期には血中膵酵素の上昇をともなう腹痛が病像を支配するが，進展すると膵外分泌不全による消化吸収障害と膵内分泌不全による糖尿病が病像を支配するようになる。アルコール性慢性膵炎は非アルコール性慢性膵炎にくらべて確診時にすでに進展した症例が多く，合併症が多く，進行が早く，予後が悪い。死亡の主たる原因は癌の併発と糖尿病の合併症で，膵炎の急性増悪発作がこれにつぐ。併発する癌のなかでは膵癌よりもむしろ上部気道および上部消化管の癌が多い。発生機序としてはDuctal－Plug説とToxic－Metabolic説が有力であるが，最近は細 胞内膵酵素活性化説とFree Radical説も注目をあびている。 |
| Keywords | アルコール性膵炎 (Alcohol－induced pancreatitis) 慢性膵炎 急性膵炎 |
| Publication Title | 環境病態研報告 |
| Published Date | 1991-08 |
| Volume | volume62 |
| Start Page | 52 |
| End Page | 70 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307918 |
| JaLCDOI | 10.18926/15008 |
|---|---|
| Title Alternative | 中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化 |
| FullText URL | 067_050_056.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/mℓ was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma. |
| Keywords | IgE RAST 吸入抗原 (inhalant Allergen) 気管支喘息 (Bronchial asthma) 加令 (aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 50 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307989 |
