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FullText URL K0007168_abstract_review.pdf K0007168_summary.pdf
Author TANIMOTO, Yuki|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7168号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language Japanese
FullText URL fulltext20231223-01.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Yamada, Kiyoshi| Nose, Motoko| Tanimoto, Yasushi|
Keywords debridement eyelid lacrimal sac Mycobacterium abscessus nontuberculous mycobacteria
Published Date 2023-12-21
Publication Title Clinical Case Reports
Volume volume11
Issue issue12
Publisher Wiley
Start Page e8364
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 38130855
DOI 10.1002/ccr3.8364
Web of Science KeyUT 001128230600001
Related Url isVersionOf https://doi.org/10.1002/ccr3.8364
JaLCDOI 10.18926/AMO/64363
FullText URL 77_1_65.pdf
Author Sato, Ken| Takigawa, Nagio| Kubo, Toshio| Katayama, Hideki| Kishino, Daizo| Okada, Toshiaki| Hisamoto, Akiko| Mimoto, Junko| Ochi, Nobuaki| Yoshino, Tadashi| Ueoka, Hiroshi| Tanimoto, Mitsune| Maeda, Yoshionobu| Kiura, Katsuyuki|
Abstract We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors.
Keywords celecoxib cisplatin EGCG lung tumor polyphenon E
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849147
Web of Science KeyUT 000952992100004
JaLCDOI 10.18926/CTED/63315
Title Alternative A study of teachers’ sensitizing reflection
FullText URL cted_012_301.pdf
Author Tanimoto, Ryuichi| Sako, Haruko|
Abstract 教師教育研究における近年の課題として,「教師の指導技術を担保している思考過程を解明する。」「理論と実践の課題を解消する。」という二つが挙げられる。本研究では,これらを解決する糸口として,「感性」と「行為の中の省察」に着目した。理論と実践の両面から,「教師の感性的な省察力」について,質的に考察することを目的とし,「感性」の論点を整理するための文献研究と教師の省察力を観る実験を行った。本研究で得られた知見として,以下の3点が示唆された。①教師に求められる「感性」の働きには,非言語情報の認識と,その認識を元にした想像(イメージ)力の二つが重要であり,この二つには関連がある。②教師の「感性的な省察力」は段階を追った構造として捉えるものではなく,なだらかなスペクトラム(連続体)上で捉えられるべきものである。③「感性」は理性と二項対立的な概念でなく,一体化したものとして捉えられるべきものである。
Keywords 感性(sensitizing reflection) 省察(reflection) 教師教育(teacher education) 体育科教育(physical education)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2022-03-30
Volume volume12
Start Page 301
End Page 315
ISSN 2186-1323
language Japanese
Copyright Holders Copyright © 2022 岡山大学教師教育開発センター
File Version publisher
FullText URL fulltext.pdf
Author Wada, Koichiro| Araki, Motoo| Tanimoto, Ryuta| Sadahira, Takuya| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Nakajima, Hirochika| Acosta, Herik| Katayama, Satoshi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo|
Keywords Photodynamic diagnosis 5-Aminolevulinic acid ALA-PDD Upper urinary tract urothelial carcinoma VISERA ELITE video system
Published Date 2021-03-25
Publication Title BMC urology
Volume volume21
Issue issue1
Publisher BMC
Start Page 45
ISSN 1471-2490
NCID AA12035460
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33765999
DOI 10.1186/s12894-021-00819-2
NAID 120007008530
Web of Science KeyUT 000632906900001
Related Url isVersionOf https://doi.org/10.1186/s12894-021-00819-2
FullText URL K0006295_abstract_review.pdf K0006295_summary.pdf K0006295_fulltext.pdf
Author Tanimoto, Terutaka|
Published Date 2020-12-27
Content Type Thesis or Dissertation
Grant Number 甲第6295号
Granted Date 2020-12-27
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL fulltext.pdf
Author Senoo, Satoru| Miyahara, Nobuaki| Taniguchi, Akihiko| Oda, Naohiro| Itano, Junko| Higo, Hisao| Hara, Naofumi| Watanabe, Hiromi| Kano, Hirohisa| Suwaki, Toshimitsu| Fuchimoto, Yasuko| Kajimoto, Kazuhiro| Ichikawa, Hirohisa| Kudo, Kenichiro| Shibayama, Takuo| Tanimoto, Yasushi| Kuyama, Shoichi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| Okayama Respiratory Disease Study Group (ORDSG)|
Published Date 2020-08-27
Publication Title PLoS ONE
Volume volume15
Issue issue8
Publisher Public Library of Science
Start Page e0236935
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Senoo et al.
File Version publisher
PubMed ID 32853277
DOI 10.1371/journal.pone.0236935
Web of Science KeyUT 000566948800009
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0236935
FullText URL fulltext.pdf figure.pptx
Author Higo, Hisao| Miyahara, Nobuaki| Taniguchi, Akihiko| Senoo, Satoru| Itano, Junko| Watanabe, Hiromi| Oda, Naohiro| Kayatani, Hiroe| Ichikawa, Hirohisa| Shibayama, Takuo| Kajimoto, Kazuhiro| Tanimoto, Yasushi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| OKAYAMA respiratory disease study group (ORDSG)|
Keywords Idiopathic pulmonary fibrosis High-resolution computed tomography Pirfenidone Forced vital capacity
Note This fulltext is available in Feb. 2021.|
Published Date 2020-02-23
Publication Title Respiratory Investigation
Volume volume58
Issue issue3
Publisher Elsevier
Start Page 185
End Page 189
ISSN 22125345
NCID AA12579673
Content Type Journal Article
language English
File Version author
PubMed ID 32102769
DOI 10.1016/j.resinv.2019.12.007
Web of Science KeyUT 000531841500009
Related Url isVersionOf https://doi.org/10.1016/j.resinv.2019.12.007
FullText URL fulltext.pdf
Author Nomura, Kaoru| Yamaguchi, Toshiyuki| Mori, Shoko| Fujikawa, Kohki| Nishiyama, Ken-ichi| Shimanouchi, Toshinori| Tanimoto, Yasushi| Morigaki, Kenichi| Shimamoto, Keiko|
Published Date 2019-07-09
Publication Title Biophysical Journal
Volume volume117
Issue issue1
Publisher elsevier
Start Page 99
End Page 110
ISSN 00063495
NCID AA00566095
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 Biophysical Society.
File Version publisher
PubMed ID 31164197
DOI 10.1016/j.bpj.2019.05.014
Web of Science KeyUT 000474550400012
Related Url isVersionOf https://doi.org/10.1016/j.bpj.2019.05.014
Title Alternative Report of the 15th Annual Meeting of the Japanese Society of Medical Oncology
FullText URL 129_207.pdf
Author Tanimoto, Mitsune|
Publication Title Journal of Okayama Medical Association
Published Date 2017-12-01
Volume volume129
Issue issue3
Start Page 207
End Page 209
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.129.207
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.207
NAID 40021393951
JaLCDOI 10.18926/AMO/55446
FullText URL 71_5_453.pdf
Author Taniguchi, Akihiko| Miyahara, Nobuaki| Oda, Naohiro| Morichika, Daisuke| Ichihara, Eiki| Oze, Isao| Tanimoto, Yasushi| Ichikawa, Hirohisa| Fujii, Utako| Tanimoto, Mitsune| Kanehiro, Arihiko| Kiura, Katsuyuki|
Abstract Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure.
Keywords chronic obstructive pulmonary disease β-blocker bisoprolol exacerbation heart failure
Amo Type Clinical Study Protocol
Publication Title Acta Medica Okayama
Published Date 2017-10
Volume volume71
Issue issue5
Publisher Okayama University Medical School
Start Page 453
End Page 457
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29042706
Author Tanimoto, Mitsune|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Article
Author Gotoda, Tatsuhiro| Kawano, Seiji| Kono, Yoshiyasu| Miura, Kou| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Shirakawad, Yasuhiro| Tabata, Masahiro| Tanimoto, Mitsune| Okada, Hiroyuki|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/54608
FullText URL 70_5_429.pdf
Author Asano, Takeru| Matsuoka, Ken-ichi| Iyama, Satoshi| Ohashi, Kazuteru| Inamoto, Yoshihiro| Ohwada, Chikako| Murata, Makoto| Satake, Atsushi| Yoshida, Chikamasa| Nakase, Koichi| Mori, Yasuo| Tanimoto, Mitsune|
Abstract Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT.
Keywords chronic GVHD allogeneic HSCT steroid refractory IL-2
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 429
End Page 433
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777442
Web of Science KeyUT 000388098700019
JaLCDOI 10.18926/AMO/54603
FullText URL 70_5_409.pdf
Author Maeda, Yoshinobu| Nishimori, Hisakazu| Inamoto, Yoshihiro| Nakamae, Hirohisa| Sawa, Masashi| Mori, Yasuo| Ohashi, Kazuteru| Fujiwara, Shin-ichiro| Tanimoto, Mitsune|
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD.
Keywords Am80 tamibarotene retinoid chronic GVHD steroid-refractory GVHD
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 409
End Page 412
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777437
Web of Science KeyUT 000388098700014
JaLCDOI 10.18926/AMO/54503
FullText URL 70_4_273.pdf
Author Makimoto, Go| Miyahara, Nobuaki| Yoshikawa, Mao| Taniguchi, Akihiko| Kanehiro, Arihiko| Tanimoto, Mitsune| Kiura, Katsuyuki|
Abstract Heerfordtʼs syndrome is a rare manifestation of sarcoidosis and is defined as a combination of facial palsy, parotid swelling, and uveitis, associated with a low-grade fever. We report a case of Heerfordtʼs syndrome presenting with a high fever and increased serum tumor necrosis factor alpha (TNF-α) levels. The patient had facial palsy, parotid swelling, uveitis, and swelling of the right supraclavicular and hilar lymph nodes. Corticosteroid therapy was initiated, and her symptoms soon resolved completely, in tandem with a decrease in TNF-α serum levels.
Keywords Heerfordtʼs syndrome sarcoidosis TNF-α
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 273
End Page 277
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549672
Web of Science KeyUT 000384748600007
JaLCDOI 10.18926/AMO/54499
FullText URL 70_4_243.pdf
Author Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki|
Abstract Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p<0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation.
Keywords vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 243
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549668
Web of Science KeyUT 000384748600003
Title Alternative The effectiveness of team-based learning (TBL) as a new teaching approach
FullText URL 128_125.pdf
Author Suno, Manabu|
Keywords アクティブラーニング(active learning) チーム基盤型学習(team-based learning) 問題基盤型学習(problem-based learning)
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 125
End Page 128
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.125
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.125
NAID 130005262530
Title Alternative The 55th Annual Meeting of the Japanese Society for Lymphoreticular Tissue Research
FullText URL 128_67.pdf
Author Tanimoto, Mitsune|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 67
End Page 68
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.67
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.67
NAID 130005149608
Title Alternative A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection
FullText URL 127_213.pdf
Author Yasui, Kazuya| Umeda, Yuzo| Kumano, Kenjiro| Tabata, Masahiro| Otsuka, Fumio| Yagi, Takahito| Fujiwara, Toshiyoshi|
Abstract A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected. The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs. On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.
Keywords 異所性褐色細胞腫(ectopic pheochromocytoma) 化学療法(chemo therapy) 131I-MIBG
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 213
End Page 218
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.213
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.213
NAID 130005116814