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Author Miyasou, Hideaki| Iwakawa, Kazuhide| Inagaki, Masaru| Kimura, Yuuji| Nishie, Manabu| Hamano, Ryousuke| Tokunaga, Naoyuki| Tunemitsu, Yousuke| Otsuka, Shinya| Iwagaki, Hiromi|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Kawahara, Masaki| Masuda, Masaharu|
Published Date 2012-02-01
Publication Title 岡山大学農学部学術報告
Volume volume101
Content Type Departmental Bulletin Paper
Author Otsuka, Shinzo|
Published Date 1927-07-31
Publication Title 岡山医学会雑誌
Volume volume39
Issue issue7
Content Type Journal Article
JaLCDOI 10.18926/bgeou/47111
FullText URL bgeou_147_135_144.pdf
Author Mimura, Yukari| Ogura, Toshio| Otsuka, Fumio|
Abstract Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects.
Keywords Graves' disease human-TRAb TSAb
Publication Title 岡山大学大学院教育学研究科研究集録
Published Date 2011-06-25
Volume volume147
Start Page 135
End Page 144
ISSN 1883-2423
language English
File Version publisher
NAID 120003551002
JaLCDOI 10.18926/AMO/47015
FullText URL 65_5_329.pdf
Author Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi|
Abstract It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR=4.50, 95%CI=1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids.
Keywords infection rheumatic disease glucocorticoids interstitial pneumonia risk factors
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2011-10
Volume volume65
Issue issue5
Publisher Okayama University Medical School
Start Page 329
End Page 334
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22037270
Web of Science KeyUT 000296116400007
Author Tsukamoto, Naoko| Otsuka, Fumio| Miyoshi, Tomoko| Inagaki, Kenichi| Nakamura, Eri| Suzuki, Jiro| Ogura, Toshio| Iwasaki, Yasumasa| Makino, Hirofumi|
Published Date 2011-01-30
Publication Title Molecular and Cellular Endocrinology
Volume volume332
Issue issue1-2
Content Type Journal Article
Author Momota, Ryusuke| Naito, Ichiro| Ninomiya, Yoshifumi| Ohtsuka, Aiji|
Published Date 2011-05
Publication Title Matrix Biology
Volume volume30
Issue issue4
Content Type Journal Article
Author Nishie, Manabu| Iwakawa, Kazuhide| Hamano, Ryousuke| Tokunaga, Naoyuki| Tunemitsu, Yousuke| Ootsuka, Shinya| Inagaki, Masaru| Iwagaki, Hiromi| Goubaru, Tomohiro| Fujita, Isao| Murakami, Takako| Tomoda, Jun|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Nishie, Manabu| Otsuka, Shinya| Tomoda, Jun| Fujiwara, Keishi|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Akiyama, Mari| Kobayashi, Katsuhiro| Yoshinaga, Harumi| Ohtsuka, Yoko|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Otsuka, Shinzo|
Published Date 1928-04-30
Publication Title 岡山医学会雑誌
Volume volume40
Issue issue4
Content Type Journal Article
Author Otsuka, S.|
Published Date 1929-05-31
Publication Title 岡山医学会雑誌
Volume volume41
Issue issue5
Content Type Journal Article
Author Ohtsuka, Shigeru| Terao, Hisafumi| Sugiu, Kizoh|
Published Date 1932-09-30
Publication Title 岡山医学会雑誌
Volume volume44
Issue issue9
Content Type Journal Article
Author Otsuka, Nobuo|
Published Date 1957-04-30
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue4
Content Type Journal Article
Author Otsuka, Nobuo|
Published Date 1957-04-30
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue4
Content Type Journal Article
Author Otsuka, Nobuo|
Published Date 1957-04-30
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue4
Content Type Journal Article
Author Otsuka, Toshiaki|
Published Date 2000-06-10
Publication Title 岡山大学経済学会雑誌
Volume volume32
Issue issue1
Content Type Article
JaLCDOI 10.18926/OER/40591
Title Alternative Dynamic Externalities of Industrial Agglomeration : A Survey
FullText URL oer_035_4_027_050.pdf
Author Otsuka, Akihiro|
Abstract This paper reviews existing literature on dynamic externalities which is the fountainhead of competitive advantages, and argues that rigorous theoretical and empirical analysis is needed to increase understanding of the role of technological spillovers in generating regional growth. Empirical analysis of knowledge spillovers is broadly performed in the field of industrial organization. Recently, a number of empirical analyses aiming at verifying technological spillovers accompanying R&D activity of companies have been conducted. In recent empirical literature on spatial agglomeration, many papers find evidence consistent with dynamic externalities. Especially, growing bodies of research have estimated the extent and type of dynamic externalities. Despite the different data sources used, methodologies are similar. As the survey of some methodologies has been carried out by McDonald (1997), this paper reviews the main empirical analyses of dynamic externalities as the complement−positioning.
Publication Title 岡山大学経済学会雑誌
Published Date 2004-03-10
Volume volume35
Issue issue4
Start Page 27
End Page 50
ISSN 0386-3069
language Japanese
File Version publisher
NAID 120002647269
Author Hamano, Ryosuke| Otsuka, Shinya| Kimura, Yuuji| Nishie, Manabu| Tokunaga, Naoyuki| Miyasou, Hideaki| Tsunemitu, Yousuke| Inagaki, Masaru| Iwakawa, Kazuhide| Iwagaki, Hiromi|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author Yamashita, Toru| Kamiya, Tatsushi| Deguchi, Kentaro| Inaba, Toshiki| Zhang, Hanzhe| Shang, Jingwei| Miyazaki, Kazunori| Ohtsuka, Aiji| Katayama, Yasuo| Abe, Koji|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article